Protein YIPF

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein YIPF

Gene product:

Yip1 domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HHV9_LEIBR

TriTrypDb:

LbrM.30.0150 , LBRM2903_300006900

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	12
GO:0016020	membrane	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4HHV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHV9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0016192	vesicle-mediated transport	4	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0019899	enzyme binding	3	12
GO:0031267	small GTPase binding	5	12
GO:0051020	GTPase binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.301
CLV_PCSK_SKI1_1	59	63	PF00082	0.284
DEG_APCC_DBOX_1	58	66	PF00400	0.497
DEG_Nend_UBRbox_3	1	3	PF02207	0.539
DOC_CYCLIN_yClb5_NLxxxL_5	181	190	PF00134	0.465
DOC_CYCLIN_yCln2_LP_2	116	122	PF00134	0.421
DOC_MAPK_MEF2A_6	248	256	PF00069	0.465
DOC_PP2B_LxvP_1	72	75	PF13499	0.562
DOC_USP7_MATH_1	10	14	PF00917	0.638
DOC_USP7_MATH_1	131	135	PF00917	0.354
DOC_USP7_MATH_1	33	37	PF00917	0.670
DOC_USP7_UBL2_3	144	148	PF12436	0.152
DOC_WW_Pin1_4	8	13	PF00397	0.650
LIG_14-3-3_CanoR_1	64	70	PF00244	0.510
LIG_Actin_WH2_2	49	66	PF00022	0.482
LIG_BRCT_BRCA1_1	267	271	PF00533	0.281
LIG_deltaCOP1_diTrp_1	80	85	PF00928	0.554
LIG_FHA_1	127	133	PF00498	0.308
LIG_FHA_1	191	197	PF00498	0.433
LIG_FHA_1	229	235	PF00498	0.304
LIG_FHA_1	56	62	PF00498	0.485
LIG_FHA_1	9	15	PF00498	0.737
LIG_FHA_2	100	106	PF00498	0.635
LIG_FHA_2	187	193	PF00498	0.453
LIG_FHA_2	242	248	PF00498	0.513
LIG_LIR_Apic_2	42	48	PF02991	0.603
LIG_LIR_Gen_1	124	133	PF02991	0.247
LIG_LIR_Gen_1	160	171	PF02991	0.391
LIG_LIR_Gen_1	217	228	PF02991	0.361
LIG_LIR_Gen_1	230	241	PF02991	0.203
LIG_LIR_Nem_3	115	120	PF02991	0.437
LIG_LIR_Nem_3	124	130	PF02991	0.284
LIG_LIR_Nem_3	160	166	PF02991	0.391
LIG_LIR_Nem_3	217	223	PF02991	0.361
LIG_LIR_Nem_3	230	236	PF02991	0.192
LIG_LIR_Nem_3	266	272	PF02991	0.275
LIG_LIR_Nem_3	41	47	PF02991	0.535
LIG_PALB2_WD40_1	246	254	PF16756	0.513
LIG_PDZ_Class_2	273	278	PF00595	0.277
LIG_Pex14_1	152	156	PF04695	0.210
LIG_Pex14_1	229	233	PF04695	0.262
LIG_Pex14_1	45	49	PF04695	0.477
LIG_Pex14_2	269	273	PF04695	0.254
LIG_Pex14_2	49	53	PF04695	0.468
LIG_REV1ctd_RIR_1	271	278	PF16727	0.369
LIG_SH2_CRK	163	167	PF00017	0.410
LIG_SH2_CRK	169	173	PF00017	0.347
LIG_SH2_NCK_1	163	167	PF00017	0.323
LIG_SH2_STAP1	154	158	PF00017	0.250
LIG_SH2_STAP1	163	167	PF00017	0.280
LIG_SH2_STAP1	199	203	PF00017	0.247
LIG_SH2_STAT5	142	145	PF00017	0.315
LIG_SH2_STAT5	167	170	PF00017	0.252
LIG_SH2_STAT5	233	236	PF00017	0.282
LIG_SH2_STAT5	272	275	PF00017	0.251
LIG_SH3_3	16	22	PF00018	0.634
LIG_SH3_3	68	74	PF00018	0.540
LIG_SH3_3	9	15	PF00018	0.622
LIG_SUMO_SIM_anti_2	129	134	PF11976	0.341
LIG_SUMO_SIM_anti_2	205	211	PF11976	0.391
LIG_SUMO_SIM_par_1	128	134	PF11976	0.343
LIG_TRAF2_1	102	105	PF00917	0.655
LIG_TYR_ITIM	161	166	PF00017	0.391
LIG_TYR_ITSM	229	236	PF00017	0.341
LIG_UBA3_1	136	144	PF00899	0.323
LIG_UBA3_1	234	243	PF00899	0.323
MOD_CK1_1	157	163	PF00069	0.227
MOD_CK1_1	36	42	PF00069	0.566
MOD_CK2_1	241	247	PF00069	0.513
MOD_CK2_1	99	105	PF00069	0.650
MOD_CMANNOS	239	242	PF00535	0.221
MOD_GlcNHglycan	4	7	PF01048	0.405
MOD_GlcNHglycan	8	11	PF01048	0.403
MOD_GSK3_1	122	129	PF00069	0.261
MOD_GSK3_1	131	138	PF00069	0.228
MOD_GSK3_1	186	193	PF00069	0.426
MOD_GSK3_1	2	9	PF00069	0.634
MOD_GSK3_1	39	46	PF00069	0.527
MOD_N-GLC_1	85	90	PF02516	0.443
MOD_NEK2_1	126	131	PF00069	0.296
MOD_NEK2_1	190	195	PF00069	0.475
MOD_NEK2_1	241	246	PF00069	0.459
MOD_NEK2_1	263	268	PF00069	0.282
MOD_NEK2_1	63	68	PF00069	0.491
MOD_NEK2_1	85	90	PF00069	0.651
MOD_NEK2_2	197	202	PF00069	0.247
MOD_PIKK_1	33	39	PF00454	0.724
MOD_PKA_2	63	69	PF00069	0.496
MOD_Plk_1	154	160	PF00069	0.239
MOD_Plk_1	85	91	PF00069	0.631
MOD_Plk_1	99	105	PF00069	0.695
MOD_Plk_2-3	99	105	PF00069	0.664
MOD_Plk_4	122	128	PF00069	0.271
MOD_Plk_4	197	203	PF00069	0.286
MOD_ProDKin_1	8	14	PF00069	0.652
TRG_DiLeu_BaEn_2	246	252	PF01217	0.513
TRG_ENDOCYTIC_2	117	120	PF00928	0.410
TRG_ENDOCYTIC_2	163	166	PF00928	0.391
TRG_ENDOCYTIC_2	169	172	PF00928	0.330
TRG_ENDOCYTIC_2	199	202	PF00928	0.291
TRG_ENDOCYTIC_2	233	236	PF00928	0.307
TRG_ENDOCYTIC_2	50	53	PF00928	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG17	Leptomonas seymouri	72%	77%
A0A0S4JRK9	Bodo saltans	61%	84%
A0A1X0P3E9	Trypanosomatidae	65%	76%
A0A3Q8IBR6	Leishmania donovani	90%	80%
A0A422N136	Trypanosoma rangeli	55%	79%
A4I509	Leishmania infantum	90%	80%
C9ZQG2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	78%
E9B0D9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	80%
Q4Q7U1	Leishmania major	88%	100%
Q54TS4	Dictyostelium discoideum	30%	80%
Q5RBL0	Pongo abelii	28%	91%
Q6P6G5	Rattus norvegicus	27%	91%
Q91VU1	Mus musculus	28%	91%
Q99LP8	Mus musculus	32%	89%
Q9BWQ6	Homo sapiens	32%	88%
Q9Y548	Homo sapiens	27%	91%
V5BLF2	Trypanosoma cruzi	60%	83%