Alkyldihydroxyacetonephosphate synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

alkyldihydroxyacetonephosphate synthase

Species:

Leishmania braziliensis

UniProt:

A4HHV7_LEIBR

TriTrypDb:

LbrM.30.0130 , LBRM2903_300006700

Length:

621

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHV7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHV7

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006662	glycerol ether metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0008611	ether lipid biosynthetic process	5	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0018904	ether metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0046485	ether lipid metabolic process	4	1
GO:0046504	glycerol ether biosynthetic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0097384	cellular lipid biosynthetic process	4	1
GO:1901503	ether biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008609	alkylglycerone-phosphate synthase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	8
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0050660	flavin adenine dinucleotide binding	4	12
GO:0071949	FAD binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	128	130	PF00675	0.368
CLV_NRD_NRD_1	193	195	PF00675	0.267
CLV_PCSK_KEX2_1	193	195	PF00082	0.297
CLV_PCSK_SKI1_1	206	210	PF00082	0.441
CLV_PCSK_SKI1_1	269	273	PF00082	0.252
CLV_PCSK_SKI1_1	376	380	PF00082	0.246
CLV_PCSK_SKI1_1	46	50	PF00082	0.350
CLV_PCSK_SKI1_1	472	476	PF00082	0.252
CLV_PCSK_SKI1_1	517	521	PF00082	0.276
CLV_PCSK_SKI1_1	95	99	PF00082	0.319
DEG_SCF_FBW7_1	276	283	PF00400	0.375
DOC_CKS1_1	270	275	PF01111	0.252
DOC_CKS1_1	277	282	PF01111	0.368
DOC_CYCLIN_RxL_1	46	53	PF00134	0.457
DOC_CYCLIN_RxL_1	599	609	PF00134	0.555
DOC_CYCLIN_yClb1_LxF_4	49	55	PF00134	0.459
DOC_CYCLIN_yClb5_NLxxxL_5	49	55	PF00134	0.479
DOC_MAPK_gen_1	183	190	PF00069	0.256
DOC_MAPK_gen_1	193	201	PF00069	0.244
DOC_MAPK_gen_1	419	426	PF00069	0.171
DOC_MAPK_gen_1	46	54	PF00069	0.328
DOC_MAPK_gen_1	514	523	PF00069	0.277
DOC_MAPK_gen_1	599	608	PF00069	0.471
DOC_MAPK_MEF2A_6	158	166	PF00069	0.252
DOC_MAPK_MEF2A_6	183	192	PF00069	0.256
DOC_MAPK_MEF2A_6	514	523	PF00069	0.393
DOC_PP1_RVXF_1	15	21	PF00149	0.378
DOC_PP1_RVXF_1	602	609	PF00149	0.559
DOC_USP7_MATH_1	248	252	PF00917	0.252
DOC_USP7_MATH_1	280	284	PF00917	0.414
DOC_USP7_MATH_1	365	369	PF00917	0.171
DOC_USP7_MATH_1	430	434	PF00917	0.183
DOC_USP7_MATH_1	552	556	PF00917	0.304
DOC_USP7_MATH_1	616	620	PF00917	0.550
DOC_USP7_MATH_2	589	595	PF00917	0.513
DOC_USP7_MATH_2	65	71	PF00917	0.332
DOC_USP7_UBL2_3	572	576	PF12436	0.395
DOC_WW_Pin1_4	269	274	PF00397	0.292
DOC_WW_Pin1_4	276	281	PF00397	0.405
DOC_WW_Pin1_4	400	405	PF00397	0.447
DOC_WW_Pin1_4	584	589	PF00397	0.464
DOC_WW_Pin1_4	69	74	PF00397	0.404
LIG_14-3-3_CanoR_1	185	191	PF00244	0.312
LIG_14-3-3_CanoR_1	206	211	PF00244	0.395
LIG_14-3-3_CanoR_1	357	361	PF00244	0.287
LIG_14-3-3_CanoR_1	528	534	PF00244	0.395
LIG_14-3-3_CanoR_1	7	15	PF00244	0.449
LIG_AP2alpha_2	179	181	PF02296	0.388
LIG_APCC_ABBA_1	348	353	PF00400	0.252
LIG_APCC_ABBA_1	519	524	PF00400	0.225
LIG_BRCT_BRCA1_1	405	409	PF00533	0.171
LIG_EVH1_1	585	589	PF00568	0.483
LIG_FHA_1	171	177	PF00498	0.252
LIG_FHA_1	210	216	PF00498	0.401
LIG_FHA_1	272	278	PF00498	0.346
LIG_FHA_1	283	289	PF00498	0.491
LIG_FHA_1	306	312	PF00498	0.301
LIG_FHA_1	345	351	PF00498	0.314
LIG_FHA_1	458	464	PF00498	0.295
LIG_FHA_1	535	541	PF00498	0.322
LIG_FHA_2	311	317	PF00498	0.523
LIG_FHA_2	8	14	PF00498	0.536
LIG_LIR_Apic_2	321	326	PF02991	0.252
LIG_LIR_Apic_2	555	560	PF02991	0.395
LIG_LIR_Gen_1	112	122	PF02991	0.220
LIG_LIR_Gen_1	236	246	PF02991	0.287
LIG_LIR_Gen_1	329	340	PF02991	0.349
LIG_LIR_Gen_1	452	462	PF02991	0.312
LIG_LIR_Gen_1	605	616	PF02991	0.438
LIG_LIR_Gen_1	96	106	PF02991	0.438
LIG_LIR_Nem_3	112	118	PF02991	0.223
LIG_LIR_Nem_3	13	18	PF02991	0.331
LIG_LIR_Nem_3	236	242	PF02991	0.284
LIG_LIR_Nem_3	255	261	PF02991	0.149
LIG_LIR_Nem_3	298	304	PF02991	0.273
LIG_LIR_Nem_3	329	335	PF02991	0.242
LIG_LIR_Nem_3	452	457	PF02991	0.312
LIG_LIR_Nem_3	53	59	PF02991	0.470
LIG_LIR_Nem_3	96	101	PF02991	0.440
LIG_MYND_1	69	73	PF01753	0.542
LIG_PDZ_Class_1	616	621	PF00595	0.606
LIG_Pex14_1	454	458	PF04695	0.252
LIG_Pex14_1	553	557	PF04695	0.252
LIG_Pex14_2	224	228	PF04695	0.328
LIG_Pex14_2	328	332	PF04695	0.267
LIG_SH2_CRK	115	119	PF00017	0.339
LIG_SH2_CRK	15	19	PF00017	0.384
LIG_SH2_CRK	239	243	PF00017	0.287
LIG_SH2_CRK	421	425	PF00017	0.304
LIG_SH2_CRK	439	443	PF00017	0.252
LIG_SH2_CRK	557	561	PF00017	0.334
LIG_SH2_NCK_1	439	443	PF00017	0.252
LIG_SH2_NCK_1	548	552	PF00017	0.267
LIG_SH2_SRC	237	240	PF00017	0.274
LIG_SH2_SRC	548	551	PF00017	0.268
LIG_SH2_STAP1	336	340	PF00017	0.408
LIG_SH2_STAP1	464	468	PF00017	0.267
LIG_SH2_STAT5	237	240	PF00017	0.287
LIG_SH2_STAT5	323	326	PF00017	0.379
LIG_SH2_STAT5	336	339	PF00017	0.384
LIG_SH2_STAT5	443	446	PF00017	0.253
LIG_SH2_STAT5	506	509	PF00017	0.252
LIG_SH3_1	583	589	PF00018	0.436
LIG_SH3_3	159	165	PF00018	0.267
LIG_SH3_3	211	217	PF00018	0.267
LIG_SH3_3	267	273	PF00018	0.267
LIG_SH3_3	583	589	PF00018	0.412
LIG_SUMO_SIM_anti_2	148	154	PF11976	0.366
LIG_SUMO_SIM_anti_2	394	399	PF11976	0.294
LIG_SUMO_SIM_par_1	186	191	PF11976	0.252
LIG_SUMO_SIM_par_1	197	202	PF11976	0.252
LIG_TRAF2_1	3	6	PF00917	0.629
LIG_TYR_ITIM	546	551	PF00017	0.308
LIG_UBA3_1	51	57	PF00899	0.249
LIG_UBA3_1	521	526	PF00899	0.346
LIG_UBA3_1	565	572	PF00899	0.317
LIG_UBA3_1	97	103	PF00899	0.253
LIG_WRC_WIRS_1	207	212	PF05994	0.346
LIG_WRC_WIRS_1	325	330	PF05994	0.257
LIG_WRC_WIRS_1	378	383	PF05994	0.422
LIG_WRC_WIRS_1	506	511	PF05994	0.252
LIG_WW_3	587	591	PF00397	0.504
MOD_CDC14_SPxK_1	587	590	PF00782	0.496
MOD_CDK_SPxK_1	584	590	PF00069	0.466
MOD_CK2_1	310	316	PF00069	0.527
MOD_CK2_1	365	371	PF00069	0.254
MOD_CK2_1	377	383	PF00069	0.297
MOD_CK2_1	591	597	PF00069	0.429
MOD_CK2_1	7	13	PF00069	0.561
MOD_CK2_1	73	79	PF00069	0.287
MOD_CMANNOS	20	23	PF00535	0.296
MOD_GlcNHglycan	250	253	PF01048	0.288
MOD_GlcNHglycan	332	335	PF01048	0.306
MOD_GlcNHglycan	494	497	PF01048	0.284
MOD_GlcNHglycan	510	513	PF01048	0.375
MOD_GlcNHglycan	593	596	PF01048	0.574
MOD_GSK3_1	202	209	PF00069	0.329
MOD_GSK3_1	233	240	PF00069	0.252
MOD_GSK3_1	248	255	PF00069	0.252
MOD_GSK3_1	276	283	PF00069	0.408
MOD_GSK3_1	330	337	PF00069	0.225
MOD_GSK3_1	361	368	PF00069	0.279
MOD_GSK3_1	458	465	PF00069	0.325
MOD_GSK3_1	534	541	PF00069	0.287
MOD_GSK3_1	67	74	PF00069	0.337
MOD_N-GLC_1	170	175	PF02516	0.267
MOD_N-GLC_1	538	543	PF02516	0.255
MOD_N-GLC_1	591	596	PF02516	0.492
MOD_NEK2_1	101	106	PF00069	0.417
MOD_NEK2_1	356	361	PF00069	0.372
MOD_NEK2_1	447	452	PF00069	0.306
MOD_NEK2_1	458	463	PF00069	0.221
MOD_NEK2_1	505	510	PF00069	0.281
MOD_NEK2_1	534	539	PF00069	0.309
MOD_NEK2_1	565	570	PF00069	0.359
MOD_PIKK_1	101	107	PF00454	0.406
MOD_PIKK_1	462	468	PF00454	0.395
MOD_PKA_2	202	208	PF00069	0.366
MOD_PKA_2	248	254	PF00069	0.252
MOD_PKA_2	356	362	PF00069	0.252
MOD_PKA_2	527	533	PF00069	0.359
MOD_PKA_2	6	12	PF00069	0.383
MOD_Plk_1	101	107	PF00069	0.410
MOD_Plk_1	305	311	PF00069	0.332
MOD_Plk_1	365	371	PF00069	0.392
MOD_Plk_1	458	464	PF00069	0.252
MOD_Plk_4	233	239	PF00069	0.346
MOD_Plk_4	365	371	PF00069	0.289
MOD_Plk_4	377	383	PF00069	0.281
MOD_Plk_4	458	464	PF00069	0.268
MOD_ProDKin_1	269	275	PF00069	0.292
MOD_ProDKin_1	276	282	PF00069	0.407
MOD_ProDKin_1	400	406	PF00069	0.447
MOD_ProDKin_1	584	590	PF00069	0.471
MOD_ProDKin_1	69	75	PF00069	0.396
MOD_SUMO_for_1	309	312	PF00179	0.304
MOD_SUMO_rev_2	104	112	PF00179	0.457
MOD_SUMO_rev_2	312	319	PF00179	0.404
MOD_SUMO_rev_2	511	519	PF00179	0.266
MOD_SUMO_rev_2	591	600	PF00179	0.350
TRG_DiLeu_BaLyEn_6	369	374	PF01217	0.281
TRG_ENDOCYTIC_2	115	118	PF00928	0.299
TRG_ENDOCYTIC_2	122	125	PF00928	0.285
TRG_ENDOCYTIC_2	15	18	PF00928	0.347
TRG_ENDOCYTIC_2	226	229	PF00928	0.252
TRG_ENDOCYTIC_2	239	242	PF00928	0.278
TRG_ENDOCYTIC_2	258	261	PF00928	0.149
TRG_ENDOCYTIC_2	421	424	PF00928	0.304
TRG_ENDOCYTIC_2	506	509	PF00928	0.252
TRG_ENDOCYTIC_2	548	551	PF00928	0.308
TRG_ENDOCYTIC_2	56	59	PF00928	0.474
TRG_ER_diArg_1	126	129	PF00400	0.295
TRG_ER_diArg_1	183	186	PF00400	0.280
TRG_ER_diArg_1	192	194	PF00400	0.219
TRG_Pf-PMV_PEXEL_1	317	321	PF00026	0.244
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	604	609	PF00026	0.571
TRG_PTS1	618	621	PF00515	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE88	Leptomonas seymouri	24%	100%
A0A0N1PEY1	Leptomonas seymouri	81%	100%
A0A0S4IT80	Bodo saltans	23%	100%
A0A0S4JD99	Bodo saltans	22%	100%
A0A0S4JV88	Bodo saltans	63%	98%
A0A1X0P026	Trypanosomatidae	23%	100%
A0A1X0P2J0	Trypanosomatidae	59%	100%
A0A3Q8IDH3	Leishmania donovani	25%	100%
A0A3Q8IDH5	Leishmania donovani	24%	100%
A0A3Q8IRN9	Leishmania donovani	88%	100%
A0A422N649	Trypanosoma rangeli	61%	100%
A4HFX9	Leishmania braziliensis	22%	100%
A4I309	Leishmania infantum	24%	100%
A4I481	Leishmania infantum	25%	100%
A4I507	Leishmania infantum	88%	100%
A4VGK4	Pseudomonas stutzeri (strain A1501)	22%	100%
C9ZQF7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9ADI2	Leishmania major	23%	100%
E9ADN0	Leishmania major	23%	100%
E9AM50	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AZA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B0D7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
F1QXM5	Danio rerio	24%	100%
O00116	Homo sapiens	30%	94%
O23240	Arabidopsis thaliana	24%	100%
O45218	Caenorhabditis elegans	29%	100%
O96759	Dictyostelium discoideum	38%	100%
O97157	Trypanosoma brucei brucei	58%	100%
P0AEP9	Escherichia coli (strain K12)	22%	100%
P0AEQ0	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	22%	100%
P0DV35	Xanthomonas citri pv. viticola (strain LMG 965 / NCPPB 2475 / ICMP 3867 / CFBP 7660)	23%	100%
P32891	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
P94535	Bacillus subtilis (strain 168)	24%	100%
P97275	Cavia porcellus	31%	94%
Q12627	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	100%
Q46911	Escherichia coli (strain K12)	25%	100%
Q7TNG8	Mus musculus	24%	100%
Q7YWB6	Leishmania major	87%	100%
Q86WU2	Homo sapiens	22%	100%
Q8C0I1	Mus musculus	31%	96%
Q8X7S0	Escherichia coli O157:H7	25%	100%
Q94AX4	Arabidopsis thaliana	23%	100%
Q9EQR2	Rattus norvegicus	30%	96%
Q9V778	Drosophila melanogaster	30%	98%
V5BCB2	Trypanosoma cruzi	62%	100%