Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHV6_LEIBR

TriTrypDb:

LbrM.30.0120 , LBRM2903_300006600

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	10

Expansion

Sequence features

A4HHV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHV6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	281	285	PF00656	0.279
CLV_NRD_NRD_1	148	150	PF00675	0.608
CLV_NRD_NRD_1	186	188	PF00675	0.554
CLV_PCSK_KEX2_1	148	150	PF00082	0.491
CLV_PCSK_KEX2_1	186	188	PF00082	0.554
CLV_PCSK_SKI1_1	186	190	PF00082	0.495
CLV_PCSK_SKI1_1	264	268	PF00082	0.456
CLV_PCSK_SKI1_1	396	400	PF00082	0.412
CLV_PCSK_SKI1_1	420	424	PF00082	0.374
DEG_APCC_DBOX_1	404	412	PF00400	0.310
DEG_APCC_DBOX_1	82	90	PF00400	0.328
DEG_Nend_UBRbox_2	1	3	PF02207	0.633
DOC_ANK_TNKS_1	97	104	PF00023	0.331
DOC_CDC14_PxL_1	225	233	PF14671	0.489
DOC_CKS1_1	369	374	PF01111	0.554
DOC_CYCLIN_RxL_1	370	383	PF00134	0.329
DOC_CYCLIN_yCln2_LP_2	167	173	PF00134	0.330
DOC_MAPK_FxFP_2	410	413	PF00069	0.350
DOC_MAPK_gen_1	220	230	PF00069	0.283
DOC_MAPK_gen_1	384	391	PF00069	0.470
DOC_MAPK_gen_1	69	77	PF00069	0.564
DOC_MAPK_MEF2A_6	69	77	PF00069	0.555
DOC_PP4_FxxP_1	410	413	PF00568	0.593
DOC_USP7_MATH_1	133	137	PF00917	0.551
DOC_USP7_MATH_1	32	36	PF00917	0.524
DOC_USP7_MATH_2	170	176	PF00917	0.327
DOC_USP7_MATH_2	289	295	PF00917	0.489
DOC_WW_Pin1_4	124	129	PF00397	0.563
DOC_WW_Pin1_4	166	171	PF00397	0.541
DOC_WW_Pin1_4	368	373	PF00397	0.559
LIG_14-3-3_CanoR_1	148	155	PF00244	0.533
LIG_14-3-3_CanoR_1	186	195	PF00244	0.485
LIG_14-3-3_CanoR_1	241	246	PF00244	0.474
LIG_14-3-3_CanoR_1	258	267	PF00244	0.456
LIG_14-3-3_CanoR_1	375	380	PF00244	0.375
LIG_14-3-3_CanoR_1	396	401	PF00244	0.457
LIG_14-3-3_CanoR_1	405	409	PF00244	0.415
LIG_14-3-3_CanoR_1	420	425	PF00244	0.439
LIG_14-3-3_CanoR_1	72	78	PF00244	0.483
LIG_Actin_WH2_1	264	280	PF00022	0.533
LIG_Actin_WH2_2	273	290	PF00022	0.273
LIG_BRCT_BRCA1_1	406	410	PF00533	0.569
LIG_eIF4E_1	171	177	PF01652	0.320
LIG_FHA_1	149	155	PF00498	0.488
LIG_FHA_1	190	196	PF00498	0.484
LIG_FHA_1	231	237	PF00498	0.464
LIG_FHA_1	274	280	PF00498	0.535
LIG_FHA_1	298	304	PF00498	0.510
LIG_FHA_1	363	369	PF00498	0.513
LIG_FHA_1	390	396	PF00498	0.502
LIG_FHA_1	421	427	PF00498	0.435
LIG_FHA_1	65	71	PF00498	0.482
LIG_FHA_1	91	97	PF00498	0.408
LIG_FHA_2	230	236	PF00498	0.511
LIG_FHA_2	258	264	PF00498	0.519
LIG_FHA_2	358	364	PF00498	0.514
LIG_FHA_2	74	80	PF00498	0.537
LIG_LIR_Apic_2	196	200	PF02991	0.484
LIG_LIR_Apic_2	407	413	PF02991	0.579
LIG_LIR_Gen_1	290	299	PF02991	0.496
LIG_LIR_LC3C_4	175	178	PF02991	0.422
LIG_LIR_Nem_3	180	184	PF02991	0.541
LIG_LIR_Nem_3	290	295	PF02991	0.492
LIG_LIR_Nem_3	333	337	PF02991	0.467
LIG_LIR_Nem_3	51	57	PF02991	0.485
LIG_NRBOX	116	122	PF00104	0.475
LIG_Rb_LxCxE_1	378	394	PF01857	0.298
LIG_SH2_CRK	181	185	PF00017	0.548
LIG_SH2_CRK	334	338	PF00017	0.517
LIG_SH2_SRC	171	174	PF00017	0.342
LIG_SH2_STAT3	12	15	PF00017	0.447
LIG_SH2_STAT5	12	15	PF00017	0.509
LIG_SH2_STAT5	197	200	PF00017	0.510
LIG_SH2_STAT5	307	310	PF00017	0.507
LIG_SH2_STAT5	54	57	PF00017	0.556
LIG_SH3_3	162	168	PF00018	0.538
LIG_SH3_3	366	372	PF00018	0.414
LIG_SH3_4	199	206	PF00018	0.551
LIG_SUMO_SIM_anti_2	263	269	PF11976	0.502
LIG_SUMO_SIM_par_1	163	169	PF11976	0.496
LIG_SUMO_SIM_par_1	232	238	PF11976	0.505
LIG_SUMO_SIM_par_1	263	269	PF11976	0.326
LIG_SUMO_SIM_par_1	278	284	PF11976	0.471
LIG_SUMO_SIM_par_1	375	380	PF11976	0.424
LIG_SUMO_SIM_par_1	396	402	PF11976	0.508
LIG_SUMO_SIM_par_1	421	427	PF11976	0.328
LIG_TRAF2_1	46	49	PF00917	0.419
LIG_TYR_ITIM	332	337	PF00017	0.542
LIG_WRC_WIRS_1	292	297	PF05994	0.505
MOD_CDK_SPxxK_3	368	375	PF00069	0.301
MOD_CK1_1	119	125	PF00069	0.504
MOD_CK1_1	294	300	PF00069	0.493
MOD_CK1_1	333	339	PF00069	0.537
MOD_CK1_1	35	41	PF00069	0.542
MOD_CK1_1	7	13	PF00069	0.340
MOD_CK2_1	119	125	PF00069	0.522
MOD_CK2_1	153	159	PF00069	0.554
MOD_CK2_1	166	172	PF00069	0.443
MOD_CK2_1	240	246	PF00069	0.518
MOD_CK2_1	257	263	PF00069	0.538
MOD_CK2_1	377	383	PF00069	0.532
MOD_GlcNHglycan	121	124	PF01048	0.466
MOD_GlcNHglycan	140	143	PF01048	0.522
MOD_GlcNHglycan	144	147	PF01048	0.500
MOD_GlcNHglycan	155	158	PF01048	0.505
MOD_GlcNHglycan	37	40	PF01048	0.408
MOD_GlcNHglycan	49	53	PF01048	0.594
MOD_GlcNHglycan	61	64	PF01048	0.523
MOD_GSK3_1	107	114	PF00069	0.530
MOD_GSK3_1	129	136	PF00069	0.467
MOD_GSK3_1	138	145	PF00069	0.532
MOD_GSK3_1	230	237	PF00069	0.442
MOD_GSK3_1	266	273	PF00069	0.302
MOD_GSK3_1	287	294	PF00069	0.528
MOD_GSK3_1	399	406	PF00069	0.470
MOD_GSK3_1	418	425	PF00069	0.497
MOD_GSK3_1	44	51	PF00069	0.610
MOD_N-GLC_1	354	359	PF02516	0.485
MOD_N-GLC_1	389	394	PF02516	0.514
MOD_NEK2_1	212	217	PF00069	0.483
MOD_NEK2_1	234	239	PF00069	0.444
MOD_NEK2_1	257	262	PF00069	0.496
MOD_NEK2_1	330	335	PF00069	0.429
MOD_NEK2_1	354	359	PF00069	0.420
MOD_NEK2_1	377	382	PF00069	0.455
MOD_NEK2_1	389	394	PF00069	0.449
MOD_NEK2_1	401	406	PF00069	0.412
MOD_NEK2_1	418	423	PF00069	0.540
MOD_NEK2_1	73	78	PF00069	0.448
MOD_NEK2_2	250	255	PF00069	0.508
MOD_NEK2_2	64	69	PF00069	0.449
MOD_PIKK_1	133	139	PF00454	0.320
MOD_PIKK_1	199	205	PF00454	0.552
MOD_PIKK_1	266	272	PF00454	0.275
MOD_PIKK_1	294	300	PF00454	0.518
MOD_PIKK_1	44	50	PF00454	0.427
MOD_PIKK_1	90	96	PF00454	0.480
MOD_PKA_1	148	154	PF00069	0.476
MOD_PKA_1	186	192	PF00069	0.532
MOD_PKA_2	138	144	PF00069	0.482
MOD_PKA_2	147	153	PF00069	0.418
MOD_PKA_2	186	192	PF00069	0.540
MOD_PKA_2	240	246	PF00069	0.279
MOD_PKA_2	257	263	PF00069	0.507
MOD_PKA_2	287	293	PF00069	0.506
MOD_PKA_2	404	410	PF00069	0.448
MOD_PKB_1	42	50	PF00069	0.415
MOD_Plk_1	362	368	PF00069	0.502
MOD_Plk_4	111	117	PF00069	0.541
MOD_Plk_4	172	178	PF00069	0.528
MOD_Plk_4	212	218	PF00069	0.479
MOD_Plk_4	291	297	PF00069	0.477
MOD_Plk_4	32	38	PF00069	0.487
MOD_Plk_4	396	402	PF00069	0.338
MOD_ProDKin_1	124	130	PF00069	0.562
MOD_ProDKin_1	166	172	PF00069	0.544
MOD_ProDKin_1	368	374	PF00069	0.551
TRG_DiLeu_BaEn_1	172	177	PF01217	0.311
TRG_DiLeu_BaEn_1	263	268	PF01217	0.506
TRG_DiLeu_BaEn_2	290	296	PF01217	0.509
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.434
TRG_DiLeu_BaLyEn_6	261	266	PF01217	0.291
TRG_DiLeu_BaLyEn_6	369	374	PF01217	0.456
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.561
TRG_DiLeu_LyEn_5	180	185	PF01217	0.431
TRG_ENDOCYTIC_2	181	184	PF00928	0.559
TRG_ENDOCYTIC_2	334	337	PF00928	0.481
TRG_ENDOCYTIC_2	54	57	PF00928	0.478
TRG_ENDOCYTIC_2	97	100	PF00928	0.431
TRG_ER_diArg_1	185	187	PF00400	0.538
TRG_NES_CRM1_1	270	281	PF08389	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2N3	Leptomonas seymouri	47%	99%
A0A1X0P2E5	Trypanosomatidae	27%	100%
A0A3Q8IEP2	Leishmania donovani	78%	100%
A4I506	Leishmania infantum	78%	100%
C9ZQF6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	98%
E9B0D6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q7U4	Leishmania major	79%	100%
V5BLE7	Trypanosoma cruzi	27%	100%