FoP_duplication domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHV4_LEIBR

TriTrypDb:

LbrM.30.0100 , LBRM2903_300006000

Length:

203

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHV4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.543
CLV_NRD_NRD_1	117	119	PF00675	0.410
CLV_NRD_NRD_1	133	135	PF00675	0.688
CLV_NRD_NRD_1	20	22	PF00675	0.560
CLV_NRD_NRD_1	32	34	PF00675	0.516
CLV_NRD_NRD_1	43	45	PF00675	0.518
CLV_NRD_NRD_1	65	67	PF00675	0.616
CLV_NRD_NRD_1	69	71	PF00675	0.709
CLV_NRD_NRD_1	80	82	PF00675	0.604
CLV_NRD_NRD_1	9	11	PF00675	0.468
CLV_NRD_NRD_1	97	99	PF00675	0.532
CLV_PCSK_FUR_1	115	119	PF00082	0.406
CLV_PCSK_FUR_1	17	21	PF00082	0.493
CLV_PCSK_FUR_1	29	33	PF00082	0.446
CLV_PCSK_FUR_1	95	99	PF00082	0.613
CLV_PCSK_KEX2_1	107	109	PF00082	0.543
CLV_PCSK_KEX2_1	117	119	PF00082	0.410
CLV_PCSK_KEX2_1	133	135	PF00082	0.688
CLV_PCSK_KEX2_1	19	21	PF00082	0.528
CLV_PCSK_KEX2_1	31	33	PF00082	0.497
CLV_PCSK_KEX2_1	43	45	PF00082	0.508
CLV_PCSK_KEX2_1	65	67	PF00082	0.616
CLV_PCSK_KEX2_1	69	71	PF00082	0.709
CLV_PCSK_KEX2_1	8	10	PF00082	0.467
CLV_PCSK_KEX2_1	80	82	PF00082	0.604
CLV_PCSK_KEX2_1	97	99	PF00082	0.532
CLV_PCSK_PC7_1	65	71	PF00082	0.499
CLV_PCSK_SKI1_1	85	89	PF00082	0.564
DEG_APCC_DBOX_1	7	15	PF00400	0.427
DOC_USP7_MATH_1	181	185	PF00917	0.601
LIG_14-3-3_CanoR_1	44	54	PF00244	0.513
LIG_BIR_II_1	1	5	PF00653	0.387
LIG_BRCT_BRCA1_1	78	82	PF00533	0.583
LIG_FHA_2	188	194	PF00498	0.572
LIG_FHA_2	50	56	PF00498	0.710
LIG_Integrin_RGD_1	72	74	PF01839	0.504
LIG_LIR_Apic_2	36	42	PF02991	0.585
LIG_Rb_pABgroove_1	9	17	PF01858	0.341
LIG_SH2_CRK	39	43	PF00017	0.578
LIG_SH2_STAT5	45	48	PF00017	0.509
LIG_TRAF2_1	190	193	PF00917	0.569
MOD_CK1_1	76	82	PF00069	0.483
MOD_CK1_1	91	97	PF00069	0.427
MOD_CK2_1	187	193	PF00069	0.583
MOD_CK2_1	49	55	PF00069	0.513
MOD_GlcNHglycan	22	25	PF01048	0.499
MOD_GlcNHglycan	82	85	PF01048	0.581
MOD_GlcNHglycan	90	93	PF01048	0.445
MOD_GSK3_1	165	172	PF00069	0.549
MOD_GSK3_1	45	52	PF00069	0.545
MOD_GSK3_1	76	83	PF00069	0.522
MOD_GSK3_1	87	94	PF00069	0.502
MOD_NEK2_1	139	144	PF00069	0.649
MOD_NEK2_1	151	156	PF00069	0.579
MOD_NEK2_1	88	93	PF00069	0.467
MOD_PIKK_1	59	65	PF00454	0.558
MOD_PKA_1	20	26	PF00069	0.500
MOD_PKA_1	80	86	PF00069	0.545
MOD_PKA_2	139	145	PF00069	0.738
MOD_PKA_2	165	171	PF00069	0.556
MOD_PKA_2	175	181	PF00069	0.532
MOD_PKA_2	20	26	PF00069	0.503
MOD_PKA_2	80	86	PF00069	0.696
MOD_PKA_2	88	94	PF00069	0.688
MOD_Plk_1	37	43	PF00069	0.440
TRG_ER_diArg_1	107	110	PF00400	0.578
TRG_ER_diArg_1	115	118	PF00400	0.424
TRG_ER_diArg_1	133	136	PF00400	0.629
TRG_ER_diArg_1	137	140	PF00400	0.525
TRG_ER_diArg_1	17	20	PF00400	0.513
TRG_ER_diArg_1	29	32	PF00400	0.473
TRG_ER_diArg_1	42	44	PF00400	0.451
TRG_ER_diArg_1	51	54	PF00400	0.513
TRG_ER_diArg_1	64	66	PF00400	0.570
TRG_ER_diArg_1	68	70	PF00400	0.588
TRG_ER_diArg_1	8	10	PF00400	0.473
TRG_ER_diArg_1	80	82	PF00400	0.616
TRG_ER_diArg_1	96	98	PF00400	0.482
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.700

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X2W4	Leishmania donovani	61%	89%
A0A422N639	Trypanosoma rangeli	43%	91%
A4I504	Leishmania infantum	61%	92%
E9B0D4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	89%
Q4Q7U6	Leishmania major	65%	100%