Putative mitotic cyclin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitotic cyclin, putative

Species:

Leishmania braziliensis

UniProt:

A4HHV3_LEIBR

TriTrypDb:

LbrM.30.0090 , LBRM2903_300005900

Length:

420

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	7	1
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1902554	serine/threonine protein kinase complex	6	1
GO:1902911	protein kinase complex	5	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4HHV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHV3

Function

Biological processes
Term	Name	Level	Count
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	6	1
GO:0001932	regulation of protein phosphorylation	7	1
GO:0009987	cellular process	1	1
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0022402	cell cycle process	2	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031399	regulation of protein modification process	6	1
GO:0042325	regulation of phosphorylation	7	1
GO:0043549	regulation of kinase activity	5	1
GO:0044770	cell cycle phase transition	3	1
GO:0044772	mitotic cell cycle phase transition	4	1
GO:0045859	regulation of protein kinase activity	6	1
GO:0050789	regulation of biological process	2	1
GO:0050790	regulation of catalytic activity	3	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051174	regulation of phosphorus metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051338	regulation of transferase activity	4	1
GO:0051726	regulation of cell cycle	4	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0071900	regulation of protein serine/threonine kinase activity	7	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903047	mitotic cell cycle process	3	1
GO:1904029	regulation of cyclin-dependent protein kinase activity	5	1

Molecular functions
Term	Name	Level	Count
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	5	1
GO:0019207	kinase regulator activity	3	1
GO:0019887	protein kinase regulator activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0098772	molecular function regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.267
CLV_NRD_NRD_1	140	142	PF00675	0.470
CLV_NRD_NRD_1	283	285	PF00675	0.554
CLV_NRD_NRD_1	359	361	PF00675	0.302
CLV_NRD_NRD_1	417	419	PF00675	0.370
CLV_NRD_NRD_1	72	74	PF00675	0.452
CLV_PCSK_KEX2_1	283	285	PF00082	0.537
CLV_PCSK_KEX2_1	359	361	PF00082	0.350
CLV_PCSK_KEX2_1	417	419	PF00082	0.370
CLV_PCSK_KEX2_1	63	65	PF00082	0.541
CLV_PCSK_KEX2_1	72	74	PF00082	0.526
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.391
CLV_PCSK_SKI1_1	283	287	PF00082	0.516
CLV_PCSK_SKI1_1	359	363	PF00082	0.347
CLV_PCSK_SKI1_1	388	392	PF00082	0.423
CLV_PCSK_SKI1_1	42	46	PF00082	0.486
CLV_PCSK_SKI1_1	51	55	PF00082	0.430
CLV_PCSK_SKI1_1	73	77	PF00082	0.491
DEG_APCC_DBOX_1	264	272	PF00400	0.354
DEG_APCC_DBOX_1	283	291	PF00400	0.236
DEG_APCC_DBOX_1	358	366	PF00400	0.491
DOC_CYCLIN_yCln2_LP_2	19	25	PF00134	0.438
DOC_MAPK_DCC_7	168	176	PF00069	0.229
DOC_MAPK_gen_1	51	61	PF00069	0.262
DOC_MAPK_MEF2A_6	168	176	PF00069	0.229
DOC_MAPK_MEF2A_6	218	225	PF00069	0.357
DOC_MAPK_MEF2A_6	89	97	PF00069	0.257
DOC_PP2B_PxIxI_1	171	177	PF00149	0.212
DOC_PP2B_PxIxI_1	202	208	PF00149	0.255
DOC_PP4_FxxP_1	38	41	PF00568	0.430
DOC_USP7_MATH_1	401	405	PF00917	0.568
DOC_USP7_UBL2_3	47	51	PF12436	0.316
DOC_WW_Pin1_4	349	354	PF00397	0.427
LIG_14-3-3_CanoR_1	218	224	PF00244	0.415
LIG_14-3-3_CanoR_1	265	275	PF00244	0.382
LIG_14-3-3_CanoR_1	333	338	PF00244	0.403
LIG_14-3-3_CanoR_1	89	94	PF00244	0.325
LIG_14-3-3_CterR_2	417	420	PF00244	0.548
LIG_Actin_WH2_2	126	143	PF00022	0.249
LIG_Actin_WH2_2	75	91	PF00022	0.249
LIG_BIR_II_1	1	5	PF00653	0.416
LIG_BRCT_BRCA1_1	16	20	PF00533	0.418
LIG_BRCT_BRCA1_1	403	407	PF00533	0.465
LIG_eIF4E_1	181	187	PF01652	0.353
LIG_FHA_1	267	273	PF00498	0.356
LIG_FHA_1	320	326	PF00498	0.355
LIG_FHA_1	372	378	PF00498	0.551
LIG_FHA_1	74	80	PF00498	0.249
LIG_FHA_1	90	96	PF00498	0.249
LIG_FHA_2	228	234	PF00498	0.292
LIG_FHA_2	295	301	PF00498	0.405
LIG_FHA_2	325	331	PF00498	0.285
LIG_FHA_2	391	397	PF00498	0.613
LIG_IRF3_LxIS_1	365	372	PF10401	0.538
LIG_LIR_Apic_2	36	41	PF02991	0.462
LIG_LIR_Gen_1	219	225	PF02991	0.368
LIG_LIR_Gen_1	303	310	PF02991	0.347
LIG_LIR_Gen_1	330	338	PF02991	0.203
LIG_LIR_Nem_3	219	223	PF02991	0.369
LIG_LIR_Nem_3	303	307	PF02991	0.349
LIG_LIR_Nem_3	330	334	PF02991	0.236
LIG_LIR_Nem_3	339	344	PF02991	0.287
LIG_PCNA_PIPBox_1	232	241	PF02747	0.354
LIG_Pex14_2	256	260	PF04695	0.385
LIG_PTB_Apo_2	175	182	PF02174	0.266
LIG_PTB_Phospho_1	175	181	PF10480	0.266
LIG_SH2_CRK	246	250	PF00017	0.256
LIG_SH2_CRK	335	339	PF00017	0.403
LIG_SH2_PTP2	304	307	PF00017	0.376
LIG_SH2_SRC	170	173	PF00017	0.370
LIG_SH2_STAP1	246	250	PF00017	0.311
LIG_SH2_STAT5	103	106	PF00017	0.332
LIG_SH2_STAT5	151	154	PF00017	0.200
LIG_SH2_STAT5	170	173	PF00017	0.382
LIG_SH2_STAT5	181	184	PF00017	0.233
LIG_SH2_STAT5	304	307	PF00017	0.376
LIG_SH2_STAT5	337	340	PF00017	0.417
LIG_SH2_STAT5	413	416	PF00017	0.561
LIG_SUMO_SIM_anti_2	2	10	PF11976	0.425
LIG_SUMO_SIM_anti_2	206	211	PF11976	0.315
LIG_SUMO_SIM_anti_2	219	227	PF11976	0.323
LIG_SUMO_SIM_anti_2	57	63	PF11976	0.261
LIG_SUMO_SIM_par_1	142	148	PF11976	0.292
LIG_SUMO_SIM_par_1	312	319	PF11976	0.323
LIG_TRAF2_1	158	161	PF00917	0.333
LIG_TRAF2_1	197	200	PF00917	0.318
LIG_UBA3_1	44	51	PF00899	0.292
MOD_CDC14_SPxK_1	352	355	PF00782	0.564
MOD_CDK_SPxK_1	349	355	PF00069	0.431
MOD_CK1_1	12	18	PF00069	0.435
MOD_CK1_1	227	233	PF00069	0.380
MOD_CK1_1	289	295	PF00069	0.394
MOD_CK1_1	309	315	PF00069	0.370
MOD_CK1_1	336	342	PF00069	0.312
MOD_CK1_1	57	63	PF00069	0.350
MOD_CK2_1	294	300	PF00069	0.413
MOD_CK2_1	324	330	PF00069	0.285
MOD_CK2_1	33	39	PF00069	0.352
MOD_CK2_1	390	396	PF00069	0.598
MOD_GlcNHglycan	239	242	PF01048	0.587
MOD_GlcNHglycan	370	374	PF01048	0.355
MOD_GSK3_1	288	295	PF00069	0.406
MOD_GSK3_1	390	397	PF00069	0.513
MOD_GSK3_1	6	13	PF00069	0.407
MOD_NEK2_1	159	164	PF00069	0.195
MOD_NEK2_1	192	197	PF00069	0.426
MOD_NEK2_1	239	244	PF00069	0.357
MOD_NEK2_1	245	250	PF00069	0.456
MOD_NEK2_1	255	260	PF00069	0.354
MOD_NEK2_1	286	291	PF00069	0.335
MOD_NEK2_1	369	374	PF00069	0.521
MOD_NEK2_1	382	387	PF00069	0.471
MOD_NEK2_1	407	412	PF00069	0.595
MOD_NEK2_1	62	67	PF00069	0.249
MOD_NEK2_1	88	93	PF00069	0.249
MOD_NEK2_1	99	104	PF00069	0.249
MOD_PIKK_1	192	198	PF00454	0.401
MOD_PIKK_1	289	295	PF00454	0.438
MOD_PIKK_1	319	325	PF00454	0.349
MOD_PIKK_1	371	377	PF00454	0.568
MOD_PKA_2	300	306	PF00069	0.347
MOD_PKA_2	394	400	PF00069	0.578
MOD_PKA_2	407	413	PF00069	0.605
MOD_PKA_2	88	94	PF00069	0.332
MOD_Plk_1	159	165	PF00069	0.195
MOD_Plk_1	57	63	PF00069	0.307
MOD_Plk_4	159	165	PF00069	0.242
MOD_Plk_4	219	225	PF00069	0.397
MOD_Plk_4	267	273	PF00069	0.324
MOD_Plk_4	300	306	PF00069	0.354
MOD_Plk_4	333	339	PF00069	0.403
MOD_Plk_4	99	105	PF00069	0.307
MOD_ProDKin_1	349	355	PF00069	0.431
MOD_SUMO_for_1	128	131	PF00179	0.249
MOD_SUMO_for_1	34	37	PF00179	0.506
MOD_SUMO_rev_2	36	44	PF00179	0.422
TRG_DiLeu_BaEn_1	357	362	PF01217	0.559
TRG_DiLeu_LyEn_5	357	362	PF01217	0.559
TRG_ENDOCYTIC_2	181	184	PF00928	0.267
TRG_ENDOCYTIC_2	246	249	PF00928	0.264
TRG_ENDOCYTIC_2	304	307	PF00928	0.376
TRG_ENDOCYTIC_2	335	338	PF00928	0.426
TRG_ER_diArg_1	283	285	PF00400	0.354
TRG_ER_diArg_1	359	361	PF00400	0.502
TRG_ER_diArg_1	417	419	PF00400	0.570
TRG_ER_diArg_1	72	74	PF00400	0.297
TRG_NES_CRM1_1	136	148	PF08389	0.268
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	359	363	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8P2	Leptomonas seymouri	78%	100%
A0A0S4JZZ8	Bodo saltans	46%	99%
A0A1X0P2F8	Trypanosomatidae	46%	100%
A0A3Q8IHJ8	Leishmania donovani	91%	100%
A4I503	Leishmania infantum	91%	100%
C9ZQF2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	93%
E9B0D3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q7U8	Leishmania major	90%	100%