Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHV2_LEIBR

TriTrypDb:

LbrM.30.0080 , LBRM2903_300005800

Length:

179

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHV2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	8	12	PF00656	0.774
CLV_C14_Caspase3-7	81	85	PF00656	0.714
CLV_PCSK_SKI1_1	111	115	PF00082	0.576
CLV_PCSK_SKI1_1	47	51	PF00082	0.661
DEG_Nend_UBRbox_3	1	3	PF02207	0.566
DOC_MAPK_MEF2A_6	118	126	PF00069	0.649
DOC_MAPK_MEF2A_6	32	41	PF00069	0.773
DOC_MAPK_MEF2A_6	61	69	PF00069	0.740
DOC_PP1_RVXF_1	45	51	PF00149	0.763
DOC_WW_Pin1_4	42	47	PF00397	0.772
DOC_WW_Pin1_4	92	97	PF00397	0.730
LIG_14-3-3_CanoR_1	173	179	PF00244	0.766
LIG_14-3-3_CanoR_1	47	57	PF00244	0.755
LIG_AP2alpha_2	169	171	PF02296	0.720
LIG_APCC_ABBA_1	120	125	PF00400	0.707
LIG_BIR_III_4	11	15	PF00653	0.759
LIG_BRCT_BRCA1_1	100	104	PF00533	0.736
LIG_BRCT_BRCA1_1	65	69	PF00533	0.735
LIG_EH1_1	72	80	PF00400	0.694
LIG_FHA_1	115	121	PF00498	0.623
LIG_FHA_1	93	99	PF00498	0.734
LIG_FHA_2	6	12	PF00498	0.772
LIG_LIR_Gen_1	101	112	PF02991	0.421
LIG_LIR_Gen_1	121	130	PF02991	0.701
LIG_LIR_Gen_1	86	97	PF02991	0.729
LIG_LIR_Nem_3	101	107	PF02991	0.416
LIG_LIR_Nem_3	121	126	PF02991	0.708
LIG_LIR_Nem_3	86	92	PF02991	0.615
LIG_PCNA_yPIPBox_3	160	173	PF02747	0.706
LIG_Pex14_2	100	104	PF04695	0.736
LIG_Pex14_2	69	73	PF04695	0.693
LIG_SH2_PTP2	123	126	PF00017	0.708
LIG_SH2_SRC	123	126	PF00017	0.708
LIG_SH2_SRC	55	58	PF00017	0.735
LIG_SH2_STAT5	123	126	PF00017	0.684
LIG_SH2_STAT5	148	151	PF00017	0.496
LIG_SH2_STAT5	55	58	PF00017	0.735
LIG_SH2_STAT5	91	94	PF00017	0.719
LIG_SH3_3	110	116	PF00018	0.738
LIG_SH3_3	62	68	PF00018	0.673
LIG_SUMO_SIM_anti_2	74	81	PF11976	0.711
LIG_SUMO_SIM_par_1	74	81	PF11976	0.711
LIG_SxIP_EBH_1	47	59	PF03271	0.752
MOD_CDK_SPK_2	42	47	PF00069	0.772
MOD_CK1_1	105	111	PF00069	0.720
MOD_GlcNHglycan	100	103	PF01048	0.519
MOD_GlcNHglycan	26	30	PF01048	0.772
MOD_GlcNHglycan	92	95	PF01048	0.719
MOD_GSK3_1	98	105	PF00069	0.739
MOD_NEK2_1	71	76	PF00069	0.680
MOD_NEK2_1	90	95	PF00069	0.415
MOD_NEK2_1	98	103	PF00069	0.604
MOD_PIKK_1	156	162	PF00454	0.664
MOD_PIKK_1	48	54	PF00454	0.760
MOD_PKA_2	105	111	PF00069	0.508
MOD_PKA_2	172	178	PF00069	0.754
MOD_Plk_1	63	69	PF00069	0.588
MOD_Plk_4	74	80	PF00069	0.564
MOD_Plk_4	85	91	PF00069	0.608
MOD_ProDKin_1	42	48	PF00069	0.768
MOD_ProDKin_1	92	98	PF00069	0.734
MOD_SUMO_for_1	31	34	PF00179	0.779
TRG_DiLeu_BaEn_2	124	130	PF01217	0.695
TRG_ENDOCYTIC_2	123	126	PF00928	0.708
TRG_ENDOCYTIC_2	135	138	PF00928	0.423
TRG_ER_diArg_1	18	21	PF00400	0.758

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEJ7	Leishmania donovani	96%	97%
A4I502	Leishmania infantum	96%	97%
E9B0D2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	97%
Q4Q7U9	Leishmania major	96%	100%