Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHV1_LEIBR

TriTrypDb:

LbrM.30.0070 , LBRM2903_300005700

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HHV1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHV1

PDB structure(s): 7aih_Ap , 7am2_Ap , 7ane_Ap

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	164	166	PF00675	0.479
CLV_NRD_NRD_1	190	192	PF00675	0.492
CLV_PCSK_KEX2_1	172	174	PF00082	0.483
CLV_PCSK_KEX2_1	93	95	PF00082	0.438
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.437
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.438
CLV_PCSK_SKI1_1	60	64	PF00082	0.412
CLV_PCSK_SKI1_1	97	101	PF00082	0.406
DEG_APCC_DBOX_1	172	180	PF00400	0.395
DEG_APCC_DBOX_1	59	67	PF00400	0.450
DEG_Nend_UBRbox_1	1	4	PF02207	0.473
DOC_CKS1_1	13	18	PF01111	0.496
DOC_MAPK_gen_1	172	178	PF00069	0.558
DOC_MAPK_gen_1	57	66	PF00069	0.396
DOC_PP1_RVXF_1	207	213	PF00149	0.409
DOC_USP7_MATH_2	72	78	PF00917	0.483
DOC_WW_Pin1_4	12	17	PF00397	0.479
LIG_BRCT_BRCA1_1	160	164	PF00533	0.600
LIG_BRCT_BRCA1_2	160	166	PF00533	0.342
LIG_FHA_1	140	146	PF00498	0.625
LIG_FHA_1	185	191	PF00498	0.432
LIG_FHA_1	53	59	PF00498	0.446
LIG_FHA_2	169	175	PF00498	0.528
LIG_LIR_Gen_1	105	116	PF02991	0.411
LIG_LIR_Gen_1	127	136	PF02991	0.451
LIG_LIR_Nem_3	105	111	PF02991	0.400
LIG_LIR_Nem_3	127	132	PF02991	0.488
LIG_LIR_Nem_3	144	149	PF02991	0.573
LIG_LIR_Nem_3	197	203	PF02991	0.406
LIG_Pex14_2	5	9	PF04695	0.345
LIG_SH2_CRK	146	150	PF00017	0.588
LIG_SH2_STAP1	160	164	PF00017	0.488
LIG_SH2_STAT3	68	71	PF00017	0.385
LIG_SH2_STAT5	200	203	PF00017	0.392
LIG_SH3_3	10	16	PF00018	0.426
LIG_TRAF2_1	30	33	PF00917	0.590
LIG_TYR_ITIM	201	206	PF00017	0.421
LIG_WRC_WIRS_1	108	113	PF05994	0.417
MOD_CK1_1	158	164	PF00069	0.558
MOD_CK2_1	150	156	PF00069	0.517
MOD_CK2_1	168	174	PF00069	0.482
MOD_CK2_1	74	80	PF00069	0.487
MOD_GlcNHglycan	146	149	PF01048	0.521
MOD_GlcNHglycan	152	155	PF01048	0.498
MOD_GlcNHglycan	156	160	PF01048	0.480
MOD_GSK3_1	150	157	PF00069	0.548
MOD_GSK3_1	232	239	PF00069	0.598
MOD_LATS_1	175	181	PF00433	0.580
MOD_N-GLC_1	21	26	PF02516	0.555
MOD_N-GLC_1	38	43	PF02516	0.591
MOD_NEK2_1	218	223	PF00069	0.555
MOD_NEK2_1	62	67	PF00069	0.360
MOD_NEK2_2	160	165	PF00069	0.603
MOD_PIKK_1	139	145	PF00454	0.609
MOD_PKA_2	52	58	PF00069	0.506
MOD_Plk_1	155	161	PF00069	0.495
MOD_Plk_1	21	27	PF00069	0.468
MOD_Plk_2-3	74	80	PF00069	0.487
MOD_Plk_4	62	68	PF00069	0.358
MOD_Plk_4	74	80	PF00069	0.325
MOD_ProDKin_1	12	18	PF00069	0.490
TRG_DiLeu_BaEn_1	131	136	PF01217	0.537
TRG_DiLeu_BaEn_1	174	179	PF01217	0.579
TRG_DiLeu_LyEn_5	174	179	PF01217	0.579
TRG_ENDOCYTIC_2	146	149	PF00928	0.577
TRG_ENDOCYTIC_2	203	206	PF00928	0.418
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMG2	Leptomonas seymouri	84%	100%
A0A0N1PDB1	Leptomonas seymouri	28%	96%
A0A0S4IZI9	Bodo saltans	26%	100%
A0A0S4JXP9	Bodo saltans	58%	78%
A0A1X0NWE3	Trypanosomatidae	28%	97%
A0A1X0P2D2	Trypanosomatidae	66%	97%
A0A3S7WW24	Leishmania donovani	30%	97%
A0A3S7X2W2	Leishmania donovani	91%	100%
A0A422N627	Trypanosoma rangeli	64%	96%
A0A422NJN4	Trypanosoma rangeli	27%	95%
A4HYP5	Leishmania infantum	30%	97%
A4I501	Leishmania infantum	92%	100%
C9ZI86	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	98%
C9ZQF0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	79%
E9AIC3	Leishmania braziliensis	29%	97%
E9AUL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	97%
E9B0D1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q7V3	Leishmania major	91%	100%
Q4QCX4	Leishmania major	32%	100%
V5BCA8	Trypanosoma cruzi	65%	96%
V5BVG0	Trypanosoma cruzi	28%	99%