MATH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MATH domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HHV0_LEIBR

TriTrypDb:

LbrM.30.0060 , LBRM2903_300005600

Length:

761

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHV0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.665
CLV_C14_Caspase3-7	125	129	PF00656	0.641
CLV_NRD_NRD_1	133	135	PF00675	0.486
CLV_NRD_NRD_1	140	142	PF00675	0.468
CLV_NRD_NRD_1	143	145	PF00675	0.467
CLV_NRD_NRD_1	153	155	PF00675	0.320
CLV_NRD_NRD_1	186	188	PF00675	0.573
CLV_NRD_NRD_1	40	42	PF00675	0.449
CLV_NRD_NRD_1	582	584	PF00675	0.469
CLV_NRD_NRD_1	600	602	PF00675	0.345
CLV_NRD_NRD_1	634	636	PF00675	0.456
CLV_PCSK_FUR_1	141	145	PF00082	0.490
CLV_PCSK_KEX2_1	135	137	PF00082	0.485
CLV_PCSK_KEX2_1	140	142	PF00082	0.465
CLV_PCSK_KEX2_1	143	145	PF00082	0.458
CLV_PCSK_KEX2_1	624	626	PF00082	0.487
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.485
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.465
CLV_PCSK_PC1ET2_1	624	626	PF00082	0.571
CLV_PCSK_PC7_1	136	142	PF00082	0.604
CLV_PCSK_PC7_1	620	626	PF00082	0.563
CLV_PCSK_SKI1_1	154	158	PF00082	0.473
CLV_PCSK_SKI1_1	187	191	PF00082	0.608
CLV_PCSK_SKI1_1	34	38	PF00082	0.461
CLV_PCSK_SKI1_1	355	359	PF00082	0.347
CLV_PCSK_SKI1_1	584	588	PF00082	0.450
CLV_PCSK_SKI1_1	602	606	PF00082	0.444
CLV_PCSK_SKI1_1	684	688	PF00082	0.508
CLV_PCSK_SKI1_1	698	702	PF00082	0.425
CLV_PCSK_SKI1_1	92	96	PF00082	0.679
CLV_Separin_Metazoa	35	39	PF03568	0.464
DEG_APCC_DBOX_1	33	41	PF00400	0.592
DEG_APCC_KENBOX_2	666	670	PF00400	0.507
DEG_SCF_FBW7_1	195	202	PF00400	0.727
DEG_SCF_FBW7_1	733	739	PF00400	0.664
DEG_SPOP_SBC_1	177	181	PF00917	0.479
DEG_SPOP_SBC_1	199	203	PF00917	0.594
DOC_CKS1_1	196	201	PF01111	0.727
DOC_CKS1_1	544	549	PF01111	0.608
DOC_CKS1_1	733	738	PF01111	0.661
DOC_CYCLIN_yClb5_NLxxxL_5	443	452	PF00134	0.390
DOC_MAPK_gen_1	358	366	PF00069	0.349
DOC_MAPK_gen_1	397	405	PF00069	0.435
DOC_MAPK_gen_1	710	718	PF00069	0.581
DOC_MAPK_MEF2A_6	359	368	PF00069	0.361
DOC_MAPK_MEF2A_6	458	465	PF00069	0.285
DOC_MAPK_NFAT4_5	458	466	PF00069	0.271
DOC_MIT_MIM_1	657	667	PF04212	0.559
DOC_PP1_RVXF_1	399	406	PF00149	0.424
DOC_PP2B_LxvP_1	324	327	PF13499	0.560
DOC_PP4_FxxP_1	170	173	PF00568	0.445
DOC_PP4_FxxP_1	233	236	PF00568	0.378
DOC_PP4_FxxP_1	405	408	PF00568	0.378
DOC_SPAK_OSR1_1	404	408	PF12202	0.305
DOC_USP7_MATH_1	720	724	PF00917	0.610
DOC_USP7_MATH_1	736	740	PF00917	0.511
DOC_USP7_MATH_1	75	79	PF00917	0.550
DOC_USP7_UBL2_3	123	127	PF12436	0.550
DOC_USP7_UBL2_3	355	359	PF12436	0.390
DOC_USP7_UBL2_3	624	628	PF12436	0.574
DOC_WW_Pin1_4	195	200	PF00397	0.612
DOC_WW_Pin1_4	437	442	PF00397	0.290
DOC_WW_Pin1_4	543	548	PF00397	0.586
DOC_WW_Pin1_4	732	737	PF00397	0.664
LIG_14-3-3_CanoR_1	174	178	PF00244	0.493
LIG_14-3-3_CanoR_1	219	227	PF00244	0.634
LIG_14-3-3_CanoR_1	254	263	PF00244	0.556
LIG_14-3-3_CanoR_1	3	8	PF00244	0.480
LIG_14-3-3_CanoR_1	404	408	PF00244	0.468
LIG_14-3-3_CanoR_1	661	666	PF00244	0.558
LIG_14-3-3_CanoR_1	703	711	PF00244	0.461
LIG_14-3-3_CanoR_1	752	757	PF00244	0.413
LIG_14-3-3_CanoR_1	86	94	PF00244	0.713
LIG_Actin_WH2_2	227	245	PF00022	0.428
LIG_Actin_WH2_2	302	319	PF00022	0.438
LIG_Actin_WH2_2	342	360	PF00022	0.338
LIG_BRCT_BRCA1_1	304	308	PF00533	0.432
LIG_BRCT_BRCA1_1	439	443	PF00533	0.271
LIG_CaM_IQ_9	704	719	PF13499	0.349
LIG_deltaCOP1_diTrp_1	503	508	PF00928	0.271
LIG_FHA_1	229	235	PF00498	0.519
LIG_FHA_1	290	296	PF00498	0.521
LIG_FHA_1	420	426	PF00498	0.373
LIG_FHA_1	466	472	PF00498	0.271
LIG_FHA_1	531	537	PF00498	0.271
LIG_FHA_1	749	755	PF00498	0.627
LIG_FHA_2	123	129	PF00498	0.656
LIG_FHA_2	192	198	PF00498	0.727
LIG_FHA_2	256	262	PF00498	0.475
LIG_FHA_2	309	315	PF00498	0.536
LIG_FHA_2	454	460	PF00498	0.404
LIG_FHA_2	524	530	PF00498	0.404
LIG_FHA_2	546	552	PF00498	0.624
LIG_FHA_2	591	597	PF00498	0.503
LIG_FHA_2	598	604	PF00498	0.504
LIG_FHA_2	624	630	PF00498	0.574
LIG_FHA_2	64	70	PF00498	0.479
LIG_FHA_2	85	91	PF00498	0.576
LIG_FHA_2	93	99	PF00498	0.542
LIG_GBD_Chelix_1	360	368	PF00786	0.462
LIG_GBD_Chelix_1	693	701	PF00786	0.475
LIG_LIR_Apic_2	231	236	PF02991	0.388
LIG_LIR_Gen_1	17	28	PF02991	0.460
LIG_LIR_Gen_1	334	345	PF02991	0.343
LIG_LIR_Gen_1	374	385	PF02991	0.412
LIG_LIR_Gen_1	417	428	PF02991	0.365
LIG_LIR_Gen_1	442	453	PF02991	0.413
LIG_LIR_Gen_1	494	503	PF02991	0.358
LIG_LIR_Gen_1	505	515	PF02991	0.189
LIG_LIR_Gen_1	609	619	PF02991	0.492
LIG_LIR_Gen_1	723	733	PF02991	0.582
LIG_LIR_Gen_1	751	761	PF02991	0.564
LIG_LIR_Nem_3	17	23	PF02991	0.405
LIG_LIR_Nem_3	374	380	PF02991	0.398
LIG_LIR_Nem_3	417	423	PF02991	0.359
LIG_LIR_Nem_3	442	448	PF02991	0.289
LIG_LIR_Nem_3	505	511	PF02991	0.271
LIG_LIR_Nem_3	52	56	PF02991	0.404
LIG_LIR_Nem_3	609	615	PF02991	0.494
LIG_LIR_Nem_3	62	67	PF02991	0.390
LIG_LIR_Nem_3	723	728	PF02991	0.546
LIG_LIR_Nem_3	751	756	PF02991	0.653
LIG_SH2_CRK	164	168	PF00017	0.474
LIG_SH2_CRK	20	24	PF00017	0.434
LIG_SH2_CRK	64	68	PF00017	0.412
LIG_SH2_STAP1	725	729	PF00017	0.658
LIG_SH2_STAT3	464	467	PF00017	0.286
LIG_SH2_STAT5	464	467	PF00017	0.313
LIG_SH2_STAT5	56	59	PF00017	0.526
LIG_SH3_2	169	174	PF14604	0.570
LIG_SH3_3	166	172	PF00018	0.532
LIG_SH3_3	730	736	PF00018	0.619
LIG_SH3_4	355	362	PF00018	0.383
LIG_SH3_CIN85_PxpxPR_1	169	174	PF14604	0.437
LIG_SUMO_SIM_anti_2	363	368	PF11976	0.443
LIG_SUMO_SIM_par_1	235	241	PF11976	0.517
LIG_SUMO_SIM_par_1	537	542	PF11976	0.342
LIG_TYR_ITSM	16	23	PF00017	0.415
LIG_UBA3_1	36	42	PF00899	0.488
LIG_UBA3_1	44	51	PF00899	0.481
LIG_UBA3_1	452	458	PF00899	0.271
LIG_UBA3_1	570	578	PF00899	0.586
LIG_WRC_WIRS_1	420	425	PF05994	0.313
LIG_WW_3	171	175	PF00397	0.567
MOD_CDK_SPxxK_3	543	550	PF00069	0.575
MOD_CK1_1	180	186	PF00069	0.494
MOD_CK1_1	200	206	PF00069	0.679
MOD_CK1_1	217	223	PF00069	0.570
MOD_CK1_1	238	244	PF00069	0.402
MOD_CK1_1	319	325	PF00069	0.620
MOD_CK1_1	347	353	PF00069	0.481
MOD_CK1_1	429	435	PF00069	0.404
MOD_CK1_1	485	491	PF00069	0.385
MOD_CK1_1	498	504	PF00069	0.270
MOD_CK1_1	5	11	PF00069	0.504
MOD_CK1_1	755	761	PF00069	0.498
MOD_CK2_1	191	197	PF00069	0.620
MOD_CK2_1	202	208	PF00069	0.540
MOD_CK2_1	255	261	PF00069	0.474
MOD_CK2_1	3	9	PF00069	0.519
MOD_CK2_1	453	459	PF00069	0.404
MOD_CK2_1	545	551	PF00069	0.612
MOD_CK2_1	590	596	PF00069	0.558
MOD_CK2_1	623	629	PF00069	0.571
MOD_CK2_1	720	726	PF00069	0.600
MOD_CK2_1	736	742	PF00069	0.540
MOD_GlcNHglycan	247	250	PF01048	0.425
MOD_GlcNHglycan	497	500	PF01048	0.404
MOD_GlcNHglycan	72	75	PF01048	0.420
MOD_GlcNHglycan	77	80	PF01048	0.498
MOD_GSK3_1	117	124	PF00069	0.612
MOD_GSK3_1	173	180	PF00069	0.442
MOD_GSK3_1	191	198	PF00069	0.681
MOD_GSK3_1	199	206	PF00069	0.603
MOD_GSK3_1	210	217	PF00069	0.459
MOD_GSK3_1	290	297	PF00069	0.641
MOD_GSK3_1	453	460	PF00069	0.424
MOD_GSK3_1	491	498	PF00069	0.298
MOD_GSK3_1	602	609	PF00069	0.517
MOD_GSK3_1	63	70	PF00069	0.471
MOD_GSK3_1	657	664	PF00069	0.522
MOD_GSK3_1	672	679	PF00069	0.461
MOD_GSK3_1	720	727	PF00069	0.575
MOD_GSK3_1	732	739	PF00069	0.558
MOD_GSK3_1	744	751	PF00069	0.540
MOD_N-GLC_1	371	376	PF02516	0.424
MOD_N-GLC_1	426	431	PF02516	0.271
MOD_N-GLC_1	84	89	PF02516	0.684
MOD_NEK2_1	122	127	PF00069	0.461
MOD_NEK2_1	14	19	PF00069	0.472
MOD_NEK2_1	215	220	PF00069	0.663
MOD_NEK2_1	308	313	PF00069	0.402
MOD_NEK2_1	316	321	PF00069	0.376
MOD_NEK2_1	36	41	PF00069	0.450
MOD_NEK2_1	448	453	PF00069	0.315
MOD_NEK2_1	465	470	PF00069	0.271
MOD_NEK2_1	475	480	PF00069	0.303
MOD_NEK2_1	63	68	PF00069	0.457
MOD_NEK2_1	672	677	PF00069	0.502
MOD_NEK2_2	15	20	PF00069	0.402
MOD_NEK2_2	173	178	PF00069	0.472
MOD_NEK2_2	419	424	PF00069	0.447
MOD_PIKK_1	210	216	PF00454	0.502
MOD_PIKK_1	261	267	PF00454	0.390
MOD_PIKK_1	491	497	PF00454	0.271
MOD_PIKK_1	498	504	PF00454	0.271
MOD_PIKK_1	602	608	PF00454	0.468
MOD_PIKK_1	623	629	PF00454	0.571
MOD_PIKK_1	677	683	PF00454	0.475
MOD_PIKK_1	704	710	PF00454	0.557
MOD_PK_1	724	730	PF00069	0.634
MOD_PKA_1	154	160	PF00069	0.492
MOD_PKA_2	173	179	PF00069	0.500
MOD_PKA_2	2	8	PF00069	0.491
MOD_PKA_2	218	224	PF00069	0.678
MOD_PKA_2	253	259	PF00069	0.573
MOD_PKA_2	403	409	PF00069	0.563
MOD_PKA_2	606	612	PF00069	0.500
MOD_PKA_2	85	91	PF00069	0.687
MOD_PKB_1	134	142	PF00069	0.607
MOD_PKB_1	618	626	PF00069	0.563
MOD_Plk_1	362	368	PF00069	0.508
MOD_Plk_1	426	432	PF00069	0.271
MOD_Plk_1	485	491	PF00069	0.271
MOD_Plk_1	528	534	PF00069	0.349
MOD_Plk_1	748	754	PF00069	0.633
MOD_Plk_2-3	530	536	PF00069	0.271
MOD_Plk_2-3	744	750	PF00069	0.669
MOD_Plk_4	15	21	PF00069	0.406
MOD_Plk_4	319	325	PF00069	0.475
MOD_Plk_4	344	350	PF00069	0.459
MOD_Plk_4	362	368	PF00069	0.476
MOD_Plk_4	67	73	PF00069	0.397
MOD_Plk_4	724	730	PF00069	0.634
MOD_ProDKin_1	195	201	PF00069	0.612
MOD_ProDKin_1	437	443	PF00069	0.290
MOD_ProDKin_1	543	549	PF00069	0.594
MOD_ProDKin_1	732	738	PF00069	0.663
MOD_SUMO_for_1	586	589	PF00179	0.476
MOD_SUMO_for_1	665	668	PF00179	0.442
MOD_SUMO_rev_2	115	125	PF00179	0.693
MOD_SUMO_rev_2	147	157	PF00179	0.514
MOD_SUMO_rev_2	25	32	PF00179	0.597
MOD_SUMO_rev_2	322	332	PF00179	0.499
MOD_SUMO_rev_2	43	53	PF00179	0.369
MOD_SUMO_rev_2	591	600	PF00179	0.572
MOD_SUMO_rev_2	617	626	PF00179	0.560
MOD_SUMO_rev_2	653	660	PF00179	0.495
MOD_SUMO_rev_2	690	700	PF00179	0.469
TRG_DiLeu_BaEn_1	146	151	PF01217	0.454
TRG_ENDOCYTIC_2	164	167	PF00928	0.547
TRG_ENDOCYTIC_2	20	23	PF00928	0.396
TRG_ENDOCYTIC_2	612	615	PF00928	0.494
TRG_ENDOCYTIC_2	64	67	PF00928	0.412
TRG_ENDOCYTIC_2	725	728	PF00928	0.557
TRG_ER_diArg_1	141	144	PF00400	0.557
TRG_NES_CRM1_1	314	329	PF08389	0.413
TRG_NES_CRM1_1	530	542	PF08389	0.314
TRG_NLS_MonoCore_2	139	144	PF00514	0.547
TRG_NLS_MonoExtC_3	139	144	PF00514	0.547
TRG_NLS_MonoExtC_3	582	587	PF00514	0.431
TRG_NLS_MonoExtN_4	399	405	PF00514	0.438
TRG_NLS_MonoExtN_4	583	588	PF00514	0.432
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.746
TRG_Pf-PMV_PEXEL_1	38	43	PF00026	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG40	Leptomonas seymouri	87%	100%
A0A1X0P2N7	Trypanosomatidae	59%	100%
A0A3Q8IJ33	Leishmania donovani	95%	100%
A0A3R7ME83	Trypanosoma rangeli	56%	98%
A4I500	Leishmania infantum	95%	100%
C9ZQE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	99%
E9B0D0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q7V4	Leishmania major	94%	100%
V5BLE1	Trypanosoma cruzi	57%	99%