Transmembrane protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised protein family (UPF0220), putative

Species:

Leishmania braziliensis

UniProt:

A4HHU9_LEIBR

TriTrypDb:

LbrM.30.0050 , LBRM2903_300005500

Length:

141

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HHU9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHU9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0007034	vacuolar transport	4	1
GO:0009987	cellular process	1	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0032509	endosome transport via multivesicular body sorting pathway	5	1
GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	6	1
GO:0045324	late endosome to vacuole transport	5	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0071985	multivesicular body sorting pathway	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.548
CLV_PCSK_KEX2_1	133	135	PF00082	0.545
CLV_PCSK_SKI1_1	75	79	PF00082	0.490
DEG_Nend_UBRbox_2	1	3	PF02207	0.386
DOC_CYCLIN_RxL_1	72	81	PF00134	0.361
DOC_MAPK_gen_1	106	115	PF00069	0.508
DOC_MAPK_MEF2A_6	106	115	PF00069	0.490
DOC_MAPK_MEF2A_6	73	80	PF00069	0.361
DOC_PP1_RVXF_1	73	80	PF00149	0.308
DOC_USP7_MATH_1	111	115	PF00917	0.441
DOC_WW_Pin1_4	60	65	PF00397	0.344
LIG_14-3-3_CanoR_1	133	141	PF00244	0.211
LIG_APCC_ABBA_1	21	26	PF00400	0.374
LIG_FHA_1	10	16	PF00498	0.382
LIG_FHA_1	124	130	PF00498	0.401
LIG_FHA_1	51	57	PF00498	0.418
LIG_LIR_Gen_1	38	49	PF02991	0.414
LIG_LIR_Gen_1	81	90	PF02991	0.425
LIG_LIR_Nem_3	38	44	PF02991	0.414
LIG_MYND_1	6	10	PF01753	0.474
LIG_Pex14_1	82	86	PF04695	0.218
LIG_SH2_CRK	118	122	PF00017	0.339
LIG_SH2_STAP1	118	122	PF00017	0.444
LIG_SH2_STAT5	100	103	PF00017	0.554
LIG_SH2_STAT5	118	121	PF00017	0.155
LIG_SH3_3	3	9	PF00018	0.466
LIG_TYR_ITIM	116	121	PF00017	0.339
MOD_CK1_1	81	87	PF00069	0.382
MOD_CK2_1	32	38	PF00069	0.411
MOD_CK2_1	60	66	PF00069	0.344
MOD_GSK3_1	129	136	PF00069	0.286
MOD_GSK3_1	81	88	PF00069	0.449
MOD_GSK3_1	98	105	PF00069	0.373
MOD_NEK2_1	129	134	PF00069	0.267
MOD_NEK2_1	78	83	PF00069	0.375
MOD_NEK2_1	85	90	PF00069	0.341
MOD_NEK2_1	98	103	PF00069	0.155
MOD_PK_1	33	39	PF00069	0.411
MOD_PKA_1	133	139	PF00069	0.211
MOD_PKA_2	133	139	PF00069	0.211
MOD_Plk_1	33	39	PF00069	0.411
MOD_Plk_4	111	117	PF00069	0.370
MOD_Plk_4	124	130	PF00069	0.373
MOD_Plk_4	17	23	PF00069	0.432
MOD_Plk_4	78	84	PF00069	0.416
MOD_ProDKin_1	60	66	PF00069	0.344
TRG_ENDOCYTIC_2	118	121	PF00928	0.339
TRG_ER_diArg_1	133	135	PF00400	0.348
TRG_ER_diArg_1	73	76	PF00400	0.361

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM91	Leptomonas seymouri	72%	98%
A0A0S4IVS2	Bodo saltans	32%	91%
A0A1X0P3F9	Trypanosomatidae	44%	100%
A0A3Q8IDZ8	Leishmania donovani	80%	100%
A0A422N652	Trypanosoma rangeli	42%	100%
A4I4Z9	Leishmania infantum	81%	100%
E9B0C9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q7V5	Leishmania major	78%	100%