Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHU8_LEIBR

TriTrypDb:

LbrM.30.0040 , LBRM2903_300005400

Length:

239

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHU8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHU8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.631
CLV_NRD_NRD_1	155	157	PF00675	0.628
CLV_NRD_NRD_1	197	199	PF00675	0.641
CLV_NRD_NRD_1	204	206	PF00675	0.631
CLV_NRD_NRD_1	3	5	PF00675	0.708
CLV_NRD_NRD_1	7	9	PF00675	0.702
CLV_NRD_NRD_1	91	93	PF00675	0.635
CLV_PCSK_FUR_1	233	237	PF00082	0.524
CLV_PCSK_KEX2_1	117	119	PF00082	0.631
CLV_PCSK_KEX2_1	157	159	PF00082	0.620
CLV_PCSK_KEX2_1	197	199	PF00082	0.649
CLV_PCSK_KEX2_1	2	4	PF00082	0.714
CLV_PCSK_KEX2_1	235	237	PF00082	0.791
CLV_PCSK_KEX2_1	7	9	PF00082	0.702
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.620
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.791
CLV_PCSK_PC7_1	3	9	PF00082	0.743
CLV_PCSK_SKI1_1	175	179	PF00082	0.660
CLV_PCSK_SKI1_1	69	73	PF00082	0.585
CLV_PCSK_SKI1_1	7	11	PF00082	0.658
DEG_Nend_UBRbox_1	1	4	PF02207	0.620
DOC_CDC14_PxL_1	35	43	PF14671	0.623
DOC_CKS1_1	111	116	PF01111	0.620
DOC_CYCLIN_yCln2_LP_2	142	145	PF00134	0.616
DOC_MAPK_gen_1	197	203	PF00069	0.628
DOC_MAPK_gen_1	74	82	PF00069	0.666
DOC_PP1_RVXF_1	25	32	PF00149	0.635
DOC_PP2B_LxvP_1	142	145	PF13499	0.609
DOC_USP7_MATH_1	12	16	PF00917	0.540
DOC_USP7_UBL2_3	231	235	PF12436	0.660
DOC_WW_Pin1_4	110	115	PF00397	0.615
DOC_WW_Pin1_4	75	80	PF00397	0.642
DOC_WW_Pin1_4	8	13	PF00397	0.694
LIG_14-3-3_CanoR_1	13	17	PF00244	0.662
LIG_14-3-3_CanoR_1	98	102	PF00244	0.641
LIG_BRCT_BRCA1_1	14	18	PF00533	0.638
LIG_CtBP_PxDLS_1	144	148	PF00389	0.633
LIG_deltaCOP1_diTrp_1	161	169	PF00928	0.651
LIG_EH1_1	65	73	PF00400	0.675
LIG_eIF4E_1	132	138	PF01652	0.578
LIG_FHA_2	104	110	PF00498	0.617
LIG_LIR_Gen_1	103	110	PF02991	0.643
LIG_LIR_Gen_1	131	138	PF02991	0.578
LIG_LIR_Gen_1	150	160	PF02991	0.620
LIG_LIR_Nem_3	103	107	PF02991	0.635
LIG_LIR_Nem_3	113	119	PF02991	0.608
LIG_LIR_Nem_3	150	155	PF02991	0.668
LIG_Pex14_1	115	119	PF04695	0.634
LIG_Pex14_1	54	58	PF04695	0.608
LIG_Pex14_2	203	207	PF04695	0.598
LIG_SH2_STAP1	221	225	PF00017	0.605
LIG_SH2_STAT5	129	132	PF00017	0.505
LIG_SH2_STAT5	176	179	PF00017	0.626
LIG_SUMO_SIM_par_1	78	83	PF11976	0.628
LIG_TRAF2_1	106	109	PF00917	0.613
LIG_TRAF2_1	49	52	PF00917	0.680
MOD_CDK_SPK_2	8	13	PF00069	0.479
MOD_CDK_SPxxK_3	110	117	PF00069	0.621
MOD_CK1_1	11	17	PF00069	0.691
MOD_CK1_1	170	176	PF00069	0.648
MOD_CK1_1	97	103	PF00069	0.621
MOD_CK2_1	102	108	PF00069	0.618
MOD_CK2_1	75	81	PF00069	0.598
MOD_GlcNHglycan	139	142	PF01048	0.735
MOD_GlcNHglycan	171	175	PF01048	0.559
MOD_GlcNHglycan	221	224	PF01048	0.635
MOD_GSK3_1	219	226	PF00069	0.566
MOD_GSK3_1	8	15	PF00069	0.541
MOD_GSK3_1	96	103	PF00069	0.607
MOD_NEK2_1	137	142	PF00069	0.731
MOD_NEK2_1	210	215	PF00069	0.652
MOD_NEK2_2	12	17	PF00069	0.490
MOD_PKA_2	12	18	PF00069	0.489
MOD_PKA_2	97	103	PF00069	0.652
MOD_Plk_1	50	56	PF00069	0.718
MOD_Plk_2-3	167	173	PF00069	0.651
MOD_ProDKin_1	110	116	PF00069	0.618
MOD_ProDKin_1	75	81	PF00069	0.641
MOD_ProDKin_1	8	14	PF00069	0.697
MOD_SUMO_rev_2	202	207	PF00179	0.656
MOD_SUMO_rev_2	85	95	PF00179	0.608
TRG_DiLeu_BaEn_1	133	138	PF01217	0.576
TRG_ENDOCYTIC_2	132	135	PF00928	0.579
TRG_ENDOCYTIC_2	152	155	PF00928	0.432
TRG_ENDOCYTIC_2	192	195	PF00928	0.639
TRG_ENDOCYTIC_2	200	203	PF00928	0.594
TRG_ER_diArg_1	1	4	PF00400	0.714
TRG_ER_diArg_1	116	118	PF00400	0.632
TRG_ER_diArg_1	155	158	PF00400	0.627
TRG_ER_diArg_1	7	9	PF00400	0.702
TRG_NLS_MonoExtC_3	155	161	PF00514	0.624
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I128	Leptomonas seymouri	86%	100%
A0A0S4IVT3	Bodo saltans	54%	94%
A0A1X0P3S5	Trypanosomatidae	75%	100%
A0A3S7X2Z1	Leishmania donovani	92%	100%
A4I4Z8	Leishmania infantum	92%	100%
C9ZQE7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
E9B0C8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q7V6	Leishmania major	91%	100%