LeishMANIAdb
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Hydrolase_4 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Hydrolase_4 domain-containing protein
Gene product:
Alpha/beta hydrolase family, putative
Species:
Leishmania braziliensis
UniProt:
A4HHU6_LEIBR
TriTrypDb:
LbrM.30.0020 , LBRM2903_300005200
Length:
426

Annotations

LeishMANIAdb annotations

Posesses a conserved AB hydrolase domain. Due to the distribution of hydrophilic / hydrophobic amino acids, it likely only has a perimembrane helix, not a full TM one.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 25
NetGPI no yes: 0, no: 25
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

A4HHU6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHU6

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 2
GO:0008152 metabolic process 1 2
GO:0009987 cellular process 1 2
GO:0044237 cellular metabolic process 2 2
GO:0044238 primary metabolic process 2 2
GO:0044255 cellular lipid metabolic process 3 2
GO:0071704 organic substance metabolic process 2 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 4
GO:0016298 lipase activity 4 2
GO:0016787 hydrolase activity 2 4
GO:0016788 hydrolase activity, acting on ester bonds 3 2
GO:0034338 short-chain carboxylesterase activity 5 2
GO:0047372 acylglycerol lipase activity 5 2
GO:0052689 carboxylic ester hydrolase activity 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 282 284 PF00675 0.475
CLV_PCSK_KEX2_1 205 207 PF00082 0.528
CLV_PCSK_KEX2_1 282 284 PF00082 0.473
CLV_PCSK_PC1ET2_1 205 207 PF00082 0.511
CLV_PCSK_SKI1_1 127 131 PF00082 0.474
CLV_PCSK_SKI1_1 190 194 PF00082 0.417
CLV_PCSK_SKI1_1 286 290 PF00082 0.489
CLV_PCSK_SKI1_1 299 303 PF00082 0.443
CLV_PCSK_SKI1_1 322 326 PF00082 0.481
CLV_PCSK_SKI1_1 67 71 PF00082 0.507
DOC_CDC14_PxL_1 133 141 PF14671 0.287
DOC_CDC14_PxL_1 288 296 PF14671 0.318
DOC_CDC14_PxL_1 323 331 PF14671 0.338
DOC_CKS1_1 175 180 PF01111 0.296
DOC_CKS1_1 331 336 PF01111 0.314
DOC_MAPK_gen_1 127 136 PF00069 0.285
DOC_MAPK_gen_1 205 213 PF00069 0.217
DOC_MAPK_gen_1 23 31 PF00069 0.541
DOC_MAPK_gen_1 42 52 PF00069 0.281
DOC_MAPK_MEF2A_6 127 136 PF00069 0.284
DOC_MAPK_MEF2A_6 23 31 PF00069 0.545
DOC_MAPK_MEF2A_6 322 331 PF00069 0.338
DOC_PP1_RVXF_1 21 27 PF00149 0.509
DOC_PP2B_LxvP_1 134 137 PF13499 0.260
DOC_PP2B_LxvP_1 386 389 PF13499 0.283
DOC_PP4_FxxP_1 331 334 PF00568 0.278
DOC_PP4_FxxP_1 350 353 PF00568 0.365
DOC_USP7_MATH_1 140 144 PF00917 0.273
DOC_USP7_MATH_1 19 23 PF00917 0.466
DOC_USP7_MATH_1 5 9 PF00917 0.718
DOC_WW_Pin1_4 170 175 PF00397 0.252
DOC_WW_Pin1_4 292 297 PF00397 0.246
DOC_WW_Pin1_4 330 335 PF00397 0.297
DOC_WW_Pin1_4 339 344 PF00397 0.325
DOC_WW_Pin1_4 60 65 PF00397 0.226
LIG_14-3-3_CanoR_1 106 110 PF00244 0.251
LIG_14-3-3_CanoR_1 17 27 PF00244 0.580
LIG_14-3-3_CanoR_1 299 305 PF00244 0.326
LIG_14-3-3_CanoR_1 322 327 PF00244 0.329
LIG_Actin_WH2_2 28 44 PF00022 0.276
LIG_BIR_II_1 1 5 PF00653 0.657
LIG_deltaCOP1_diTrp_1 345 350 PF00928 0.229
LIG_FHA_1 143 149 PF00498 0.278
LIG_FHA_1 175 181 PF00498 0.268
LIG_FHA_1 184 190 PF00498 0.226
LIG_FHA_1 363 369 PF00498 0.310
LIG_FHA_1 55 61 PF00498 0.293
LIG_FHA_2 314 320 PF00498 0.248
LIG_FHA_2 331 337 PF00498 0.196
LIG_FHA_2 407 413 PF00498 0.362
LIG_LIR_Apic_2 328 334 PF02991 0.294
LIG_LIR_Apic_2 58 64 PF02991 0.400
LIG_LIR_Apic_2 79 83 PF02991 0.238
LIG_LIR_Gen_1 149 157 PF02991 0.345
LIG_LIR_Gen_1 319 327 PF02991 0.296
LIG_LIR_Gen_1 335 344 PF02991 0.207
LIG_LIR_Gen_1 44 52 PF02991 0.366
LIG_LIR_LC3C_4 34 37 PF02991 0.158
LIG_LIR_Nem_3 149 154 PF02991 0.324
LIG_LIR_Nem_3 319 323 PF02991 0.285
LIG_LIR_Nem_3 335 341 PF02991 0.171
LIG_LIR_Nem_3 44 50 PF02991 0.333
LIG_MYND_1 292 296 PF01753 0.338
LIG_NRP_CendR_1 425 426 PF00754 0.667
LIG_Pex14_1 346 350 PF04695 0.364
LIG_Pex14_2 47 51 PF04695 0.416
LIG_PTB_Apo_2 112 119 PF02174 0.372
LIG_PTB_Phospho_1 112 118 PF10480 0.248
LIG_REV1ctd_RIR_1 44 53 PF16727 0.448
LIG_SH2_CRK 61 65 PF00017 0.204
LIG_SH2_NCK_1 416 420 PF00017 0.267
LIG_SH2_NCK_1 80 84 PF00017 0.314
LIG_SH2_SRC 147 150 PF00017 0.317
LIG_SH2_STAP1 416 420 PF00017 0.394
LIG_SH2_STAT5 118 121 PF00017 0.376
LIG_SH2_STAT5 147 150 PF00017 0.249
LIG_SH2_STAT5 228 231 PF00017 0.274
LIG_SH2_STAT5 396 399 PF00017 0.296
LIG_SH3_3 244 250 PF00018 0.303
LIG_SH3_3 33 39 PF00018 0.289
MOD_CDK_SPK_2 174 179 PF00069 0.296
MOD_CDK_SPxxK_3 292 299 PF00069 0.233
MOD_CDK_SPxxK_3 60 67 PF00069 0.193
MOD_CK1_1 142 148 PF00069 0.194
MOD_CK1_1 375 381 PF00069 0.353
MOD_CK2_1 170 176 PF00069 0.316
MOD_CK2_1 339 345 PF00069 0.309
MOD_CK2_1 406 412 PF00069 0.339
MOD_CMANNOS 401 404 PF00535 0.504
MOD_GlcNHglycan 1 4 PF01048 0.534
MOD_GlcNHglycan 127 130 PF01048 0.554
MOD_GlcNHglycan 181 184 PF01048 0.468
MOD_GlcNHglycan 5 8 PF01048 0.497
MOD_GlcNHglycan 85 88 PF01048 0.512
MOD_GSK3_1 121 128 PF00069 0.332
MOD_GSK3_1 138 145 PF00069 0.227
MOD_GSK3_1 170 177 PF00069 0.260
MOD_GSK3_1 179 186 PF00069 0.256
MOD_GSK3_1 258 265 PF00069 0.263
MOD_GSK3_1 368 375 PF00069 0.422
MOD_GSK3_1 41 48 PF00069 0.570
MOD_GSK3_1 83 90 PF00069 0.302
MOD_NEK2_1 139 144 PF00069 0.271
MOD_NEK2_1 260 265 PF00069 0.285
MOD_NEK2_1 31 36 PF00069 0.333
MOD_NEK2_1 41 46 PF00069 0.514
MOD_PKA_1 282 288 PF00069 0.231
MOD_PKA_2 105 111 PF00069 0.322
MOD_PKA_2 282 288 PF00069 0.274
MOD_PKA_2 41 47 PF00069 0.594
MOD_PKA_2 53 59 PF00069 0.413
MOD_Plk_2-3 76 82 PF00069 0.224
MOD_Plk_4 264 270 PF00069 0.275
MOD_Plk_4 31 37 PF00069 0.247
MOD_Plk_4 372 378 PF00069 0.371
MOD_Plk_4 88 94 PF00069 0.280
MOD_ProDKin_1 170 176 PF00069 0.252
MOD_ProDKin_1 292 298 PF00069 0.246
MOD_ProDKin_1 330 336 PF00069 0.297
MOD_ProDKin_1 339 345 PF00069 0.327
MOD_ProDKin_1 60 66 PF00069 0.221
TRG_DiLeu_BaEn_1 176 181 PF01217 0.338
TRG_DiLeu_BaLyEn_6 10 15 PF01217 0.541
TRG_DiLeu_BaLyEn_6 319 324 PF01217 0.330
TRG_ENDOCYTIC_2 104 107 PF00928 0.346
TRG_ENDOCYTIC_2 338 341 PF00928 0.290
TRG_ER_diArg_1 424 426 PF00400 0.338

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5L7 Leptomonas seymouri 32% 94%
A0A0N1HZ60 Leptomonas seymouri 31% 92%
A0A0N1I523 Leptomonas seymouri 31% 96%
A0A0N1I5Q2 Leptomonas seymouri 31% 84%
A0A0N1I7U8 Leptomonas seymouri 60% 100%
A0A0S4JMS7 Bodo saltans 37% 99%
A0A0S4JTS9 Bodo saltans 37% 100%
A0A1X0NEW5 Trypanosomatidae 44% 100%
A0A1X0NSK7 Trypanosomatidae 44% 100%
A0A1X0NUZ6 Trypanosomatidae 27% 100%
A0A3S5H6J1 Leishmania donovani 31% 90%
A0A3S7X2V6 Leishmania donovani 79% 100%
A0A422NB49 Trypanosoma rangeli 44% 100%
A0A422NQC5 Trypanosoma rangeli 35% 97%
A4H6L0 Leishmania braziliensis 33% 100%
A4HUZ4 Leishmania infantum 31% 90%
A4I4Z6 Leishmania infantum 79% 100%
C9ZPB9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
E9ANM8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9ANM9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 90%
E9B0C6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 100%
P08910 Homo sapiens 26% 100%
P38295 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 30% 94%
P45524 Escherichia coli (strain K12) 29% 100%
P73879 Synechocystis sp. (strain PCC 6803 / Kazusa) 22% 100%
Q05AK6 Danio rerio 24% 100%
Q0VC00 Bos taurus 24% 100%
Q18610 Caenorhabditis elegans 23% 100%
Q24093 Drosophila melanogaster 24% 100%
Q3T0A0 Bos taurus 27% 100%
Q40863 Picea glauca 29% 93%
Q4Q7V8 Leishmania major 78% 100%
Q4QGZ4 Leishmania major 31% 100%
Q4QGZ5 Leishmania major 30% 100%
Q4R2Y9 Macaca fascicularis 26% 100%
Q54H38 Dictyostelium discoideum 29% 100%
Q5EA42 Bos taurus 26% 100%
Q5F2F2 Mus musculus 26% 93%
Q5RK23 Rattus norvegicus 25% 100%
Q6UXT9 Homo sapiens 25% 91%
Q802V6 Danio rerio 24% 99%
Q8WU67 Homo sapiens 25% 100%
Q91ZH7 Mus musculus 26% 100%
Q96SE0 Homo sapiens 25% 100%
Q9QXM0 Mus musculus 26% 100%
Q9QZC8 Mus musculus 25% 100%
V5AZF4 Trypanosoma cruzi 41% 100%
V5BBC2 Trypanosoma cruzi 36% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS