RDD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HHU5_LEIBR

TriTrypDb:

LbrM.30.0010 , LBRM2903_300005100

Length:

165

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HHU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHU5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	5	9	PF00656	0.736
CLV_NRD_NRD_1	94	96	PF00675	0.451
CLV_PCSK_KEX2_1	46	48	PF00082	0.511
CLV_PCSK_KEX2_1	94	96	PF00082	0.451
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.528
CLV_PCSK_PC7_1	42	48	PF00082	0.541
CLV_PCSK_SKI1_1	128	132	PF00082	0.457
CLV_PCSK_SKI1_1	47	51	PF00082	0.500
CLV_PCSK_SKI1_1	85	89	PF00082	0.449
CLV_PCSK_SKI1_1	94	98	PF00082	0.328
DEG_SCF_FBW7_1	1	6	PF00400	0.670
DOC_CDC14_PxL_1	97	105	PF14671	0.447
DOC_CKS1_1	96	101	PF01111	0.378
DOC_CYCLIN_RxL_1	125	133	PF00134	0.535
DOC_CYCLIN_RxL_1	42	52	PF00134	0.541
DOC_MAPK_DCC_7	95	105	PF00069	0.449
DOC_MAPK_gen_1	94	102	PF00069	0.534
DOC_PP1_RVXF_1	45	52	PF00149	0.492
DOC_PP4_FxxP_1	113	116	PF00568	0.494
DOC_USP7_MATH_1	3	7	PF00917	0.738
DOC_USP7_MATH_1	79	83	PF00917	0.414
DOC_WW_Pin1_4	95	100	PF00397	0.368
LIG_14-3-3_CanoR_1	85	90	PF00244	0.504
LIG_BRCT_BRCA1_1	54	58	PF00533	0.536
LIG_BRCT_BRCA1_1	60	64	PF00533	0.424
LIG_CtBP_PxDLS_1	116	120	PF00389	0.546
LIG_FHA_1	149	155	PF00498	0.556
LIG_FHA_1	79	85	PF00498	0.555
LIG_FHA_2	3	9	PF00498	0.680
LIG_LIR_Gen_1	52	58	PF02991	0.534
LIG_LIR_Nem_3	52	56	PF02991	0.526
LIG_PCNA_yPIPBox_3	85	97	PF02747	0.564
LIG_Pex14_2	64	68	PF04695	0.531
LIG_SH2_CRK	53	57	PF00017	0.535
LIG_SH2_STAP1	53	57	PF00017	0.535
LIG_SH3_3	93	99	PF00018	0.457
LIG_SxIP_EBH_1	94	106	PF03271	0.489
MOD_CK1_1	52	58	PF00069	0.534
MOD_DYRK1A_RPxSP_1	95	99	PF00069	0.451
MOD_GlcNHglycan	10	13	PF01048	0.709
MOD_NEK2_1	49	54	PF00069	0.512
MOD_NEK2_1	58	63	PF00069	0.440
MOD_Plk_1	58	64	PF00069	0.476
MOD_Plk_4	101	107	PF00069	0.485
MOD_Plk_4	52	58	PF00069	0.460
MOD_Plk_4	79	85	PF00069	0.382
MOD_ProDKin_1	95	101	PF00069	0.362
MOD_SUMO_for_1	14	17	PF00179	0.713
TRG_DiLeu_BaEn_1	137	142	PF01217	0.552
TRG_DiLeu_BaLyEn_6	36	41	PF01217	0.555
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.539
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.447
TRG_ENDOCYTIC_2	53	56	PF00928	0.530
TRG_ER_diArg_1	37	40	PF00400	0.499
TRG_ER_diArg_1	93	95	PF00400	0.458
TRG_Pf-PMV_PEXEL_1	128	132	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8B1	Leptomonas seymouri	50%	99%
A0A1X0NJH0	Trypanosomatidae	26%	92%
A0A3R7KP70	Trypanosoma rangeli	27%	86%
D0A9N9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	92%
V5BI27	Trypanosoma cruzi	31%	86%