Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HHU4_LEIBR

TriTrypDb:

LbrM.29.2930 , LBRM2903_290028800

Length:

467

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHU4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	173	175	PF00675	0.391
CLV_NRD_NRD_1	59	61	PF00675	0.309
CLV_PCSK_FUR_1	68	72	PF00082	0.445
CLV_PCSK_KEX2_1	175	177	PF00082	0.417
CLV_PCSK_KEX2_1	70	72	PF00082	0.379
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.417
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.379
CLV_PCSK_PC7_1	171	177	PF00082	0.382
CLV_PCSK_SKI1_1	193	197	PF00082	0.580
CLV_PCSK_SKI1_1	282	286	PF00082	0.587
CLV_PCSK_SKI1_1	456	460	PF00082	0.509
CLV_PCSK_SKI1_1	70	74	PF00082	0.320
CLV_PCSK_SKI1_1	91	95	PF00082	0.471
DEG_APCC_DBOX_1	281	289	PF00400	0.480
DEG_APCC_DBOX_1	367	375	PF00400	0.512
DEG_Nend_Nbox_1	1	3	PF02207	0.483
DEG_SPOP_SBC_1	244	248	PF00917	0.520
DEG_SPOP_SBC_1	328	332	PF00917	0.632
DOC_CYCLIN_yCln2_LP_2	459	465	PF00134	0.507
DOC_MAPK_gen_1	453	461	PF00069	0.507
DOC_MAPK_gen_1	68	75	PF00069	0.412
DOC_MAPK_HePTP_8	288	300	PF00069	0.476
DOC_MAPK_MEF2A_6	291	300	PF00069	0.478
DOC_MAPK_MEF2A_6	340	347	PF00069	0.530
DOC_MAPK_MEF2A_6	453	461	PF00069	0.507
DOC_PP1_RVXF_1	68	75	PF00149	0.316
DOC_USP7_MATH_1	187	191	PF00917	0.530
DOC_USP7_MATH_1	217	221	PF00917	0.770
DOC_USP7_MATH_1	233	237	PF00917	0.557
DOC_USP7_MATH_1	245	249	PF00917	0.614
DOC_USP7_MATH_1	256	260	PF00917	0.675
DOC_USP7_MATH_1	284	288	PF00917	0.671
DOC_USP7_MATH_1	328	332	PF00917	0.646
DOC_USP7_MATH_1	424	428	PF00917	0.539
DOC_USP7_MATH_1	440	444	PF00917	0.515
DOC_WW_Pin1_4	119	124	PF00397	0.467
DOC_WW_Pin1_4	199	204	PF00397	0.660
DOC_WW_Pin1_4	257	262	PF00397	0.690
DOC_WW_Pin1_4	432	437	PF00397	0.601
LIG_14-3-3_CanoR_1	262	272	PF00244	0.666
LIG_14-3-3_CanoR_1	291	297	PF00244	0.584
LIG_14-3-3_CanoR_1	336	343	PF00244	0.564
LIG_14-3-3_CanoR_1	377	385	PF00244	0.523
LIG_14-3-3_CanoR_1	416	421	PF00244	0.528
LIG_14-3-3_CanoR_1	428	434	PF00244	0.528
LIG_14-3-3_CanoR_1	43	48	PF00244	0.300
LIG_14-3-3_CanoR_1	456	462	PF00244	0.538
LIG_BIR_III_4	358	362	PF00653	0.526
LIG_BRCT_BRCA1_1	135	139	PF00533	0.328
LIG_BRCT_BRCA1_1	359	363	PF00533	0.559
LIG_BRCT_BRCA1_1	41	45	PF00533	0.443
LIG_BRCT_BRCA1_1	442	446	PF00533	0.545
LIG_Clathr_ClatBox_1	53	57	PF01394	0.332
LIG_CSL_BTD_1	433	436	PF09270	0.493
LIG_deltaCOP1_diTrp_1	411	420	PF00928	0.500
LIG_DLG_GKlike_1	43	51	PF00625	0.311
LIG_FAT_LD_1	285	293	PF03623	0.471
LIG_FHA_1	105	111	PF00498	0.380
LIG_FHA_1	162	168	PF00498	0.334
LIG_FHA_1	305	311	PF00498	0.508
LIG_FHA_1	336	342	PF00498	0.551
LIG_FHA_1	370	376	PF00498	0.533
LIG_FHA_1	77	83	PF00498	0.383
LIG_FHA_2	120	126	PF00498	0.450
LIG_FHA_2	281	287	PF00498	0.572
LIG_FHA_2	328	334	PF00498	0.546
LIG_FHA_2	378	384	PF00498	0.607
LIG_IBAR_NPY_1	423	425	PF08397	0.492
LIG_LIR_Gen_1	136	147	PF02991	0.393
LIG_LIR_Gen_1	42	53	PF02991	0.305
LIG_LIR_Nem_3	136	142	PF02991	0.429
LIG_LIR_Nem_3	42	48	PF02991	0.411
LIG_LIR_Nem_3	460	464	PF02991	0.507
LIG_NRBOX	284	290	PF00104	0.471
LIG_SH2_CRK	149	153	PF00017	0.297
LIG_SH2_NCK_1	41	45	PF00017	0.443
LIG_SH2_STAP1	12	16	PF00017	0.507
LIG_SH2_STAP1	149	153	PF00017	0.430
LIG_SH2_STAP1	41	45	PF00017	0.500
LIG_SH2_STAP1	425	429	PF00017	0.498
LIG_SH2_STAT5	317	320	PF00017	0.474
LIG_SH2_STAT5	425	428	PF00017	0.497
LIG_SH2_STAT5	47	50	PF00017	0.388
LIG_SH3_3	181	187	PF00018	0.494
LIG_SH3_3	258	264	PF00018	0.538
LIG_SH3_3	293	299	PF00018	0.683
LIG_SH3_3	305	311	PF00018	0.609
LIG_SUMO_SIM_par_1	306	312	PF11976	0.520
LIG_TRFH_1	420	424	PF08558	0.500
LIG_UBA3_1	34	40	PF00899	0.468
LIG_UBA3_1	445	454	PF00899	0.499
LIG_UBA3_1	53	61	PF00899	0.233
MOD_CDK_SPK_2	257	262	PF00069	0.549
MOD_CK1_1	209	215	PF00069	0.703
MOD_CK1_1	220	226	PF00069	0.786
MOD_CK1_1	246	252	PF00069	0.657
MOD_CK1_1	263	269	PF00069	0.614
MOD_CK1_1	357	363	PF00069	0.619
MOD_CK1_1	378	384	PF00069	0.589
MOD_CK1_1	432	438	PF00069	0.607
MOD_CK2_1	280	286	PF00069	0.578
MOD_CK2_1	327	333	PF00069	0.542
MOD_CK2_1	377	383	PF00069	0.528
MOD_CK2_1	8	14	PF00069	0.568
MOD_GlcNHglycan	144	147	PF01048	0.390
MOD_GlcNHglycan	179	182	PF01048	0.385
MOD_GlcNHglycan	239	242	PF01048	0.616
MOD_GlcNHglycan	253	257	PF01048	0.605
MOD_GlcNHglycan	275	278	PF01048	0.664
MOD_GlcNHglycan	358	362	PF01048	0.564
MOD_GlcNHglycan	440	443	PF01048	0.514
MOD_GSK3_1	207	214	PF00069	0.691
MOD_GSK3_1	217	224	PF00069	0.731
MOD_GSK3_1	233	240	PF00069	0.566
MOD_GSK3_1	243	250	PF00069	0.671
MOD_GSK3_1	252	259	PF00069	0.635
MOD_GSK3_1	268	275	PF00069	0.767
MOD_GSK3_1	280	287	PF00069	0.573
MOD_GSK3_1	312	319	PF00069	0.497
MOD_GSK3_1	350	357	PF00069	0.592
MOD_GSK3_1	39	46	PF00069	0.310
MOD_GSK3_1	4	11	PF00069	0.532
MOD_GSK3_1	424	431	PF00069	0.580
MOD_N-GLC_1	328	333	PF02516	0.621
MOD_NEK2_1	1	6	PF00069	0.597
MOD_NEK2_1	141	146	PF00069	0.449
MOD_NEK2_1	206	211	PF00069	0.587
MOD_NEK2_1	292	297	PF00069	0.582
MOD_NEK2_1	304	309	PF00069	0.512
MOD_NEK2_1	316	321	PF00069	0.485
MOD_NEK2_1	347	352	PF00069	0.629
MOD_PIKK_1	217	223	PF00454	0.758
MOD_PIKK_1	231	237	PF00454	0.530
MOD_PIKK_1	82	88	PF00454	0.326
MOD_PKA_2	335	341	PF00069	0.552
MOD_PKA_2	369	375	PF00069	0.544
MOD_PKA_2	378	384	PF00069	0.504
MOD_PKA_2	402	408	PF00069	0.487
MOD_Plk_1	133	139	PF00069	0.397
MOD_Plk_1	76	82	PF00069	0.347
MOD_Plk_4	148	154	PF00069	0.384
MOD_Plk_4	179	185	PF00069	0.478
MOD_Plk_4	284	290	PF00069	0.474
MOD_Plk_4	304	310	PF00069	0.435
MOD_Plk_4	312	318	PF00069	0.431
MOD_Plk_4	429	435	PF00069	0.519
MOD_ProDKin_1	119	125	PF00069	0.466
MOD_ProDKin_1	199	205	PF00069	0.664
MOD_ProDKin_1	257	263	PF00069	0.687
MOD_ProDKin_1	432	438	PF00069	0.600
MOD_SUMO_for_1	322	325	PF00179	0.502
MOD_SUMO_for_1	93	96	PF00179	0.431
MOD_SUMO_rev_2	383	390	PF00179	0.534
MOD_SUMO_rev_2	450	455	PF00179	0.593
TRG_ENDOCYTIC_2	149	152	PF00928	0.448
TRG_ER_diArg_1	112	115	PF00400	0.477
TRG_ER_diArg_1	173	176	PF00400	0.404
TRG_NLS_MonoExtC_3	452	457	PF00514	0.495
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3W2	Leptomonas seymouri	35%	85%
A0A3Q8IFH8	Leishmania donovani	57%	100%
A4I4T1	Leishmania infantum	57%	100%
E9AE84	Leishmania major	56%	100%
E9ALK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%