RNA binding protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HHU3_LEIBR

TriTrypDb:

LbrM.29.2920 , LBRM2903_290021200

Length:

922

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HHU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHU3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6
GO:0003727	single-stranded RNA binding	5	1
GO:0003729	mRNA binding	5	1
GO:0003730	mRNA 3'-UTR binding	6	1
GO:0008143	poly(A) binding	7	1
GO:0008187	poly-pyrimidine tract binding	6	1
GO:0008266	poly(U) RNA binding	7	1
GO:0070717	poly-purine tract binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	598	602	PF00656	0.546
CLV_NRD_NRD_1	298	300	PF00675	0.514
CLV_NRD_NRD_1	310	312	PF00675	0.398
CLV_NRD_NRD_1	405	407	PF00675	0.616
CLV_NRD_NRD_1	671	673	PF00675	0.709
CLV_NRD_NRD_1	810	812	PF00675	0.658
CLV_PCSK_KEX2_1	404	406	PF00082	0.605
CLV_PCSK_KEX2_1	671	673	PF00082	0.575
CLV_PCSK_KEX2_1	810	812	PF00082	0.658
CLV_PCSK_KEX2_1	821	823	PF00082	0.566
CLV_PCSK_PC1ET2_1	821	823	PF00082	0.668
CLV_PCSK_SKI1_1	313	317	PF00082	0.462
CLV_PCSK_SKI1_1	342	346	PF00082	0.332
CLV_PCSK_SKI1_1	406	410	PF00082	0.612
CLV_PCSK_SKI1_1	615	619	PF00082	0.541
CLV_PCSK_SKI1_1	98	102	PF00082	0.527
DEG_SCF_FBW7_1	176	182	PF00400	0.673
DEG_SCF_FBW7_1	35	41	PF00400	0.664
DEG_SCF_FBW7_1	433	439	PF00400	0.610
DEG_SCF_FBW7_1	848	854	PF00400	0.531
DEG_SCF_FBW7_1	872	879	PF00400	0.692
DEG_SPOP_SBC_1	179	183	PF00917	0.587
DEG_SPOP_SBC_1	199	203	PF00917	0.510
DEG_SPOP_SBC_1	555	559	PF00917	0.632
DOC_CKS1_1	104	109	PF01111	0.532
DOC_CKS1_1	165	170	PF01111	0.635
DOC_CKS1_1	176	181	PF01111	0.569
DOC_CKS1_1	208	213	PF01111	0.653
DOC_CKS1_1	35	40	PF01111	0.659
DOC_CKS1_1	433	438	PF01111	0.663
DOC_CKS1_1	459	464	PF01111	0.532
DOC_CKS1_1	504	509	PF01111	0.584
DOC_CKS1_1	848	853	PF01111	0.529
DOC_CYCLIN_RxL_1	95	106	PF00134	0.530
DOC_CYCLIN_yCln2_LP_2	143	149	PF00134	0.618
DOC_MAPK_gen_1	311	319	PF00069	0.464
DOC_MAPK_MEF2A_6	133	140	PF00069	0.681
DOC_MAPK_MEF2A_6	311	319	PF00069	0.464
DOC_MAPK_MEF2A_6	699	708	PF00069	0.546
DOC_MAPK_NFAT4_5	312	320	PF00069	0.459
DOC_PP1_RVXF_1	358	365	PF00149	0.532
DOC_PP2B_LxvP_1	173	176	PF13499	0.540
DOC_PP4_FxxP_1	165	168	PF00568	0.628
DOC_USP7_MATH_1	287	291	PF00917	0.446
DOC_USP7_MATH_1	385	389	PF00917	0.502
DOC_USP7_MATH_1	399	403	PF00917	0.413
DOC_USP7_MATH_1	436	440	PF00917	0.568
DOC_USP7_MATH_1	474	478	PF00917	0.585
DOC_USP7_MATH_1	555	559	PF00917	0.632
DOC_USP7_MATH_1	688	692	PF00917	0.661
DOC_USP7_MATH_1	707	711	PF00917	0.594
DOC_USP7_MATH_1	768	772	PF00917	0.574
DOC_USP7_MATH_1	805	809	PF00917	0.628
DOC_USP7_MATH_1	912	916	PF00917	0.622
DOC_USP7_MATH_2	211	217	PF00917	0.579
DOC_USP7_UBL2_3	312	316	PF12436	0.481
DOC_WW_Pin1_4	103	108	PF00397	0.616
DOC_WW_Pin1_4	11	16	PF00397	0.665
DOC_WW_Pin1_4	116	121	PF00397	0.746
DOC_WW_Pin1_4	164	169	PF00397	0.700
DOC_WW_Pin1_4	175	180	PF00397	0.700
DOC_WW_Pin1_4	182	187	PF00397	0.601
DOC_WW_Pin1_4	200	205	PF00397	0.534
DOC_WW_Pin1_4	207	212	PF00397	0.625
DOC_WW_Pin1_4	31	36	PF00397	0.699
DOC_WW_Pin1_4	348	353	PF00397	0.532
DOC_WW_Pin1_4	429	434	PF00397	0.689
DOC_WW_Pin1_4	458	463	PF00397	0.581
DOC_WW_Pin1_4	472	477	PF00397	0.636
DOC_WW_Pin1_4	503	508	PF00397	0.624
DOC_WW_Pin1_4	516	521	PF00397	0.606
DOC_WW_Pin1_4	531	536	PF00397	0.534
DOC_WW_Pin1_4	551	556	PF00397	0.512
DOC_WW_Pin1_4	620	625	PF00397	0.654
DOC_WW_Pin1_4	637	642	PF00397	0.560
DOC_WW_Pin1_4	676	681	PF00397	0.705
DOC_WW_Pin1_4	722	727	PF00397	0.633
DOC_WW_Pin1_4	795	800	PF00397	0.630
DOC_WW_Pin1_4	83	88	PF00397	0.522
DOC_WW_Pin1_4	847	852	PF00397	0.546
DOC_WW_Pin1_4	872	877	PF00397	0.689
DOC_WW_Pin1_4	897	902	PF00397	0.695
LIG_14-3-3_CanoR_1	28	35	PF00244	0.684
LIG_14-3-3_CanoR_1	342	347	PF00244	0.532
LIG_14-3-3_CanoR_1	46	54	PF00244	0.533
LIG_14-3-3_CanoR_1	699	705	PF00244	0.602
LIG_14-3-3_CanoR_1	811	820	PF00244	0.513
LIG_14-3-3_CanoR_1	91	95	PF00244	0.582
LIG_Actin_WH2_2	77	93	PF00022	0.525
LIG_AP2alpha_2	238	240	PF02296	0.532
LIG_APCC_ABBA_1	237	242	PF00400	0.493
LIG_APCC_ABBA_1	344	349	PF00400	0.532
LIG_APCC_ABBA_1	364	369	PF00400	0.400
LIG_BIR_III_2	473	477	PF00653	0.520
LIG_BRCT_BRCA1_1	573	577	PF00533	0.607
LIG_BRCT_BRCA1_1	613	617	PF00533	0.673
LIG_BRCT_BRCA1_1	659	663	PF00533	0.556
LIG_BRCT_BRCA1_1	704	708	PF00533	0.685
LIG_BRCT_BRCA1_1	778	782	PF00533	0.681
LIG_FHA_1	135	141	PF00498	0.611
LIG_FHA_1	188	194	PF00498	0.721
LIG_FHA_1	2	8	PF00498	0.537
LIG_FHA_1	215	221	PF00498	0.393
LIG_FHA_1	258	264	PF00498	0.532
LIG_FHA_1	348	354	PF00498	0.532
LIG_FHA_1	35	41	PF00498	0.544
LIG_FHA_1	687	693	PF00498	0.566
LIG_FHA_1	701	707	PF00498	0.511
LIG_FHA_1	784	790	PF00498	0.692
LIG_FHA_1	876	882	PF00498	0.692
LIG_FHA_2	208	214	PF00498	0.665
LIG_IBAR_NPY_1	911	913	PF08397	0.661
LIG_LIR_Apic_2	487	493	PF02991	0.587
LIG_LIR_LC3C_4	290	295	PF02991	0.500
LIG_LIR_Nem_3	194	199	PF02991	0.615
LIG_LIR_Nem_3	238	243	PF02991	0.603
LIG_LIR_Nem_3	260	265	PF02991	0.532
LIG_LIR_Nem_3	332	338	PF02991	0.532
LIG_LYPXL_yS_3	196	199	PF13949	0.615
LIG_MYND_1	146	150	PF01753	0.631
LIG_PDZ_Class_2	917	922	PF00595	0.651
LIG_PTB_Apo_2	907	914	PF02174	0.671
LIG_PTB_Phospho_1	907	913	PF10480	0.676
LIG_Rb_pABgroove_1	231	239	PF01858	0.532
LIG_SH2_CRK	338	342	PF00017	0.517
LIG_SH2_CRK	585	589	PF00017	0.532
LIG_SH2_CRK	909	913	PF00017	0.673
LIG_SH2_GRB2like	908	911	PF00017	0.687
LIG_SH2_NCK_1	490	494	PF00017	0.653
LIG_SH2_NCK_1	650	654	PF00017	0.559
LIG_SH2_NCK_1	909	913	PF00017	0.673
LIG_SH2_SRC	490	493	PF00017	0.627
LIG_SH2_STAP1	265	269	PF00017	0.532
LIG_SH2_STAT3	105	108	PF00017	0.727
LIG_SH2_STAT3	538	541	PF00017	0.554
LIG_SH2_STAT5	105	108	PF00017	0.715
LIG_SH2_STAT5	367	370	PF00017	0.532
LIG_SH3_1	430	436	PF00018	0.687
LIG_SH3_2	694	699	PF14604	0.611
LIG_SH3_3	144	150	PF00018	0.761
LIG_SH3_3	173	179	PF00018	0.672
LIG_SH3_3	205	211	PF00018	0.774
LIG_SH3_3	32	38	PF00018	0.675
LIG_SH3_3	430	436	PF00018	0.652
LIG_SH3_3	456	462	PF00018	0.546
LIG_SH3_3	489	495	PF00018	0.624
LIG_SH3_3	501	507	PF00018	0.563
LIG_SH3_3	638	644	PF00018	0.636
LIG_SH3_3	677	683	PF00018	0.585
LIG_SH3_3	689	695	PF00018	0.597
LIG_SH3_3	703	709	PF00018	0.542
LIG_SH3_3	81	87	PF00018	0.550
LIG_SH3_3	842	848	PF00018	0.621
LIG_SUMO_SIM_anti_2	759	767	PF11976	0.533
LIG_SUMO_SIM_anti_2	834	840	PF11976	0.514
LIG_SUMO_SIM_par_1	136	141	PF11976	0.604
LIG_SUMO_SIM_par_1	16	21	PF11976	0.645
LIG_SUMO_SIM_par_1	860	865	PF11976	0.704
LIG_TRAF2_1	855	858	PF00917	0.548
LIG_WRC_WIRS_1	588	593	PF05994	0.517
MOD_CDC14_SPxK_1	534	537	PF00782	0.672
MOD_CDK_SPxK_1	531	537	PF00069	0.677
MOD_CDK_SPxxK_3	795	802	PF00069	0.710
MOD_CK1_1	181	187	PF00069	0.679
MOD_CK1_1	226	232	PF00069	0.431
MOD_CK1_1	31	37	PF00069	0.701
MOD_CK1_1	411	417	PF00069	0.497
MOD_CK1_1	429	435	PF00069	0.610
MOD_CK1_1	475	481	PF00069	0.644
MOD_CK1_1	525	531	PF00069	0.560
MOD_CK1_1	554	560	PF00069	0.633
MOD_CK1_1	56	62	PF00069	0.671
MOD_CK1_1	586	592	PF00069	0.611
MOD_CK1_1	657	663	PF00069	0.594
MOD_CK1_1	702	708	PF00069	0.683
MOD_CK1_1	725	731	PF00069	0.704
MOD_CK1_1	763	769	PF00069	0.664
MOD_CK1_1	771	777	PF00069	0.609
MOD_CK1_1	83	89	PF00069	0.558
MOD_CK1_1	832	838	PF00069	0.653
MOD_CK1_1	879	885	PF00069	0.567
MOD_CK1_1	895	901	PF00069	0.553
MOD_CK1_1	914	920	PF00069	0.526
MOD_CK2_1	189	195	PF00069	0.696
MOD_CK2_1	207	213	PF00069	0.644
MOD_CK2_1	862	868	PF00069	0.704
MOD_GlcNHglycan	125	128	PF01048	0.561
MOD_GlcNHglycan	169	172	PF01048	0.633
MOD_GlcNHglycan	30	33	PF01048	0.637
MOD_GlcNHglycan	40	43	PF01048	0.684
MOD_GlcNHglycan	438	441	PF01048	0.549
MOD_GlcNHglycan	47	50	PF01048	0.618
MOD_GlcNHglycan	514	517	PF01048	0.699
MOD_GlcNHglycan	558	561	PF01048	0.563
MOD_GlcNHglycan	578	582	PF01048	0.520
MOD_GlcNHglycan	585	588	PF01048	0.593
MOD_GlcNHglycan	607	610	PF01048	0.576
MOD_GlcNHglycan	61	64	PF01048	0.541
MOD_GlcNHglycan	645	648	PF01048	0.689
MOD_GlcNHglycan	659	662	PF01048	0.558
MOD_GlcNHglycan	665	668	PF01048	0.507
MOD_GlcNHglycan	686	689	PF01048	0.694
MOD_GlcNHglycan	709	712	PF01048	0.539
MOD_GlcNHglycan	766	769	PF01048	0.617
MOD_GlcNHglycan	783	786	PF01048	0.533
MOD_GlcNHglycan	829	832	PF01048	0.666
MOD_GlcNHglycan	864	867	PF01048	0.635
MOD_GlcNHglycan	868	872	PF01048	0.644
MOD_GlcNHglycan	886	889	PF01048	0.590
MOD_GlcNHglycan	902	905	PF01048	0.542
MOD_GSK3_1	118	125	PF00069	0.674
MOD_GSK3_1	174	181	PF00069	0.779
MOD_GSK3_1	187	194	PF00069	0.567
MOD_GSK3_1	198	205	PF00069	0.596
MOD_GSK3_1	209	216	PF00069	0.530
MOD_GSK3_1	27	34	PF00069	0.698
MOD_GSK3_1	428	435	PF00069	0.667
MOD_GSK3_1	512	519	PF00069	0.601
MOD_GSK3_1	551	558	PF00069	0.696
MOD_GSK3_1	573	580	PF00069	0.515
MOD_GSK3_1	583	590	PF00069	0.489
MOD_GSK3_1	59	66	PF00069	0.635
MOD_GSK3_1	591	598	PF00069	0.489
MOD_GSK3_1	601	608	PF00069	0.524
MOD_GSK3_1	626	633	PF00069	0.644
MOD_GSK3_1	663	670	PF00069	0.659
MOD_GSK3_1	684	691	PF00069	0.603
MOD_GSK3_1	707	714	PF00069	0.641
MOD_GSK3_1	721	728	PF00069	0.572
MOD_GSK3_1	756	763	PF00069	0.637
MOD_GSK3_1	76	83	PF00069	0.572
MOD_GSK3_1	764	771	PF00069	0.631
MOD_GSK3_1	772	779	PF00069	0.561
MOD_GSK3_1	793	800	PF00069	0.636
MOD_GSK3_1	827	834	PF00069	0.629
MOD_GSK3_1	847	854	PF00069	0.524
MOD_GSK3_1	867	874	PF00069	0.639
MOD_GSK3_1	875	882	PF00069	0.600
MOD_GSK3_1	884	891	PF00069	0.559
MOD_GSK3_1	895	902	PF00069	0.562
MOD_GSK3_1	911	918	PF00069	0.546
MOD_LATS_1	26	32	PF00433	0.689
MOD_N-GLC_1	187	192	PF02516	0.704
MOD_N-GLC_1	56	61	PF02516	0.548
MOD_N-GLC_1	627	632	PF02516	0.551
MOD_N-GLC_1	657	662	PF02516	0.682
MOD_N-GLC_1	827	832	PF02516	0.669
MOD_N-GLC_1	882	887	PF02516	0.686
MOD_NEK2_1	1	6	PF00069	0.545
MOD_NEK2_1	189	194	PF00069	0.622
MOD_NEK2_1	324	329	PF00069	0.446
MOD_NEK2_1	398	403	PF00069	0.530
MOD_NEK2_1	438	443	PF00069	0.551
MOD_NEK2_1	45	50	PF00069	0.671
MOD_NEK2_1	484	489	PF00069	0.541
MOD_NEK2_1	510	515	PF00069	0.691
MOD_NEK2_1	577	582	PF00069	0.540
MOD_NEK2_1	591	596	PF00069	0.494
MOD_NEK2_1	618	623	PF00069	0.677
MOD_NEK2_1	663	668	PF00069	0.699
MOD_NEK2_1	700	705	PF00069	0.645
MOD_NEK2_1	715	720	PF00069	0.613
MOD_NEK2_1	80	85	PF00069	0.556
MOD_NEK2_1	862	867	PF00069	0.702
MOD_NEK2_1	90	95	PF00069	0.565
MOD_NEK2_2	385	390	PF00069	0.367
MOD_PIKK_1	399	405	PF00454	0.558
MOD_PK_1	3	9	PF00069	0.535
MOD_PK_1	496	502	PF00069	0.554
MOD_PKA_2	263	269	PF00069	0.573
MOD_PKA_2	27	33	PF00069	0.684
MOD_PKA_2	45	51	PF00069	0.542
MOD_PKA_2	495	501	PF00069	0.539
MOD_PKA_2	711	717	PF00069	0.556
MOD_PKA_2	839	845	PF00069	0.520
MOD_PKA_2	90	96	PF00069	0.529
MOD_Plk_1	187	193	PF00069	0.805
MOD_Plk_1	324	330	PF00069	0.517
MOD_Plk_1	354	360	PF00069	0.431
MOD_Plk_1	496	502	PF00069	0.554
MOD_Plk_1	56	62	PF00069	0.548
MOD_Plk_1	627	633	PF00069	0.554
MOD_Plk_1	771	777	PF00069	0.640
MOD_Plk_1	882	888	PF00069	0.687
MOD_Plk_1	98	104	PF00069	0.530
MOD_Plk_4	354	360	PF00069	0.431
MOD_Plk_4	414	420	PF00069	0.518
MOD_Plk_4	438	444	PF00069	0.551
MOD_Plk_4	76	82	PF00069	0.567
MOD_Plk_4	760	766	PF00069	0.536
MOD_Plk_4	772	778	PF00069	0.508
MOD_Plk_4	90	96	PF00069	0.640
MOD_ProDKin_1	103	109	PF00069	0.614
MOD_ProDKin_1	11	17	PF00069	0.658
MOD_ProDKin_1	116	122	PF00069	0.746
MOD_ProDKin_1	164	170	PF00069	0.703
MOD_ProDKin_1	175	181	PF00069	0.705
MOD_ProDKin_1	182	188	PF00069	0.601
MOD_ProDKin_1	200	206	PF00069	0.533
MOD_ProDKin_1	207	213	PF00069	0.615
MOD_ProDKin_1	31	37	PF00069	0.701
MOD_ProDKin_1	348	354	PF00069	0.532
MOD_ProDKin_1	429	435	PF00069	0.689
MOD_ProDKin_1	458	464	PF00069	0.580
MOD_ProDKin_1	472	478	PF00069	0.630
MOD_ProDKin_1	503	509	PF00069	0.618
MOD_ProDKin_1	516	522	PF00069	0.606
MOD_ProDKin_1	531	537	PF00069	0.537
MOD_ProDKin_1	551	557	PF00069	0.513
MOD_ProDKin_1	620	626	PF00069	0.657
MOD_ProDKin_1	637	643	PF00069	0.559
MOD_ProDKin_1	676	682	PF00069	0.706
MOD_ProDKin_1	722	728	PF00069	0.633
MOD_ProDKin_1	795	801	PF00069	0.631
MOD_ProDKin_1	83	89	PF00069	0.522
MOD_ProDKin_1	847	853	PF00069	0.543
MOD_ProDKin_1	872	878	PF00069	0.691
MOD_ProDKin_1	897	903	PF00069	0.694
TRG_DiLeu_BaLyEn_6	357	362	PF01217	0.532
TRG_ENDOCYTIC_2	196	199	PF00928	0.615
TRG_ENDOCYTIC_2	338	341	PF00928	0.517
TRG_ENDOCYTIC_2	585	588	PF00928	0.535
TRG_ENDOCYTIC_2	73	76	PF00928	0.517
TRG_ER_diArg_1	404	406	PF00400	0.605
TRG_ER_diArg_1	809	811	PF00400	0.667
TRG_ER_diArg_1	905	908	PF00400	0.694
TRG_NES_CRM1_1	356	370	PF08389	0.532
TRG_NLS_Bipartite_1	299	315	PF00514	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X2K7	Leishmania donovani	69%	100%
A4I4J5	Leishmania infantum	70%	100%
E9ADZ4	Leishmania major	71%	99%
E9ALT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%