RNA binding protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HHU3_LEIBR

TriTrypDb:

LbrM.29.2920 , LBRM2903_290021200

Length:

922

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

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Expansion

Sequence features

A4HHU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHU3

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0003727	single-stranded RNA binding	5	1
GO:0003729	mRNA binding	5	1
GO:0003730	mRNA 3'-UTR binding	6	1
GO:0005488	binding	1	6
GO:0008143	poly(A) binding	7	1
GO:0008187	poly-pyrimidine tract binding	6	1
GO:0008266	poly(U) RNA binding	7	1
GO:0070717	poly-purine tract binding	6	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	598	602	PF00656	0.546
CLV_NRD_NRD_1	298	300	PF00675	0.514
CLV_NRD_NRD_1	310	312	PF00675	0.398
CLV_NRD_NRD_1	405	407	PF00675	0.616
CLV_NRD_NRD_1	671	673	PF00675	0.709
CLV_NRD_NRD_1	810	812	PF00675	0.658
CLV_PCSK_KEX2_1	404	406	PF00082	0.605
CLV_PCSK_KEX2_1	671	673	PF00082	0.575
CLV_PCSK_KEX2_1	810	812	PF00082	0.658
CLV_PCSK_KEX2_1	821	823	PF00082	0.566

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X2K7	Leishmania donovani	69%	100%
A4I4J5	Leishmania infantum	70%	100%
E9ADZ4	Leishmania major	71%	99%
E9ALT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%

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