CYCLIN domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHT9_LEIBR

TriTrypDb:

LbrM.29.2880 , LBRM2903_290036600

Length:

244

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHT9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHT9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	91	95	PF00656	0.529
CLV_NRD_NRD_1	234	236	PF00675	0.566
CLV_NRD_NRD_1	41	43	PF00675	0.507
CLV_PCSK_KEX2_1	234	236	PF00082	0.566
CLV_PCSK_KEX2_1	41	43	PF00082	0.458
CLV_PCSK_SKI1_1	150	154	PF00082	0.327
CLV_PCSK_SKI1_1	179	183	PF00082	0.497
CLV_PCSK_SKI1_1	235	239	PF00082	0.507
CLV_PCSK_SKI1_1	41	45	PF00082	0.463
DEG_APCC_DBOX_1	128	136	PF00400	0.536
DEG_APCC_DBOX_1	234	242	PF00400	0.571
DOC_CYCLIN_RxL_1	38	46	PF00134	0.470
DOC_MAPK_gen_1	129	137	PF00069	0.542
DOC_MAPK_gen_1	234	240	PF00069	0.551
DOC_PP1_RVXF_1	131	138	PF00149	0.594
DOC_PP4_FxxP_1	137	140	PF00568	0.500
DOC_PP4_FxxP_1	50	53	PF00568	0.547
DOC_USP7_MATH_1	32	36	PF00917	0.533
DOC_USP7_MATH_1	57	61	PF00917	0.500
DOC_USP7_MATH_1	88	92	PF00917	0.369
DOC_USP7_MATH_2	140	146	PF00917	0.426
DOC_USP7_UBL2_3	22	26	PF12436	0.638
LIG_14-3-3_CanoR_1	133	138	PF00244	0.454
LIG_14-3-3_CanoR_1	42	48	PF00244	0.473
LIG_BRCT_BRCA1_1	144	148	PF00533	0.530
LIG_BRCT_BRCA1_1	164	168	PF00533	0.492
LIG_deltaCOP1_diTrp_1	80	87	PF00928	0.461
LIG_FHA_1	155	161	PF00498	0.443
LIG_FHA_1	173	179	PF00498	0.526
LIG_FHA_1	180	186	PF00498	0.490
LIG_FHA_1	19	25	PF00498	0.714
LIG_FHA_2	197	203	PF00498	0.481
LIG_FHA_2	228	234	PF00498	0.422
LIG_FHA_2	25	31	PF00498	0.474
LIG_FHA_2	62	68	PF00498	0.649
LIG_FHA_2	75	81	PF00498	0.482
LIG_GBD_Chelix_1	114	122	PF00786	0.343
LIG_LIR_Apic_2	136	140	PF02991	0.497
LIG_LIR_Gen_1	105	115	PF02991	0.393
LIG_LIR_Gen_1	145	156	PF02991	0.579
LIG_LIR_Gen_1	46	53	PF02991	0.491
LIG_LIR_Nem_3	105	110	PF02991	0.365
LIG_LIR_Nem_3	145	151	PF02991	0.523
LIG_LIR_Nem_3	46	50	PF02991	0.431
LIG_Pex14_1	112	116	PF04695	0.351
LIG_Pex14_1	170	174	PF04695	0.507
LIG_Pex14_1	40	44	PF04695	0.481
LIG_Pex14_1	83	87	PF04695	0.424
LIG_PTB_Apo_2	101	108	PF02174	0.502
LIG_SH2_NCK_1	164	168	PF00017	0.453
LIG_SH2_STAP1	164	168	PF00017	0.453
LIG_SH2_STAP1	174	178	PF00017	0.513
LIG_SH2_STAT3	127	130	PF00017	0.508
LIG_SH2_STAT5	127	130	PF00017	0.508
LIG_SH2_STAT5	174	177	PF00017	0.495
LIG_SH2_STAT5	180	183	PF00017	0.386
LIG_SH2_STAT5	236	239	PF00017	0.519
LIG_SH2_STAT5	47	50	PF00017	0.512
LIG_TRAF2_1	199	202	PF00917	0.307
LIG_WRC_WIRS_1	134	139	PF05994	0.376
MOD_CK2_1	196	202	PF00069	0.485
MOD_CK2_1	227	233	PF00069	0.427
MOD_GlcNHglycan	90	93	PF01048	0.443
MOD_GSK3_1	20	27	PF00069	0.668
MOD_GSK3_1	57	64	PF00069	0.578
MOD_GSK3_1	74	81	PF00069	0.452
MOD_N-GLC_1	142	147	PF02516	0.518
MOD_NEK2_1	122	127	PF00069	0.494
MOD_NEK2_1	159	164	PF00069	0.415
MOD_NEK2_1	172	177	PF00069	0.442
MOD_NEK2_1	196	201	PF00069	0.454
MOD_NEK2_1	20	25	PF00069	0.629
MOD_NEK2_1	43	48	PF00069	0.394
MOD_NEK2_1	87	92	PF00069	0.550
MOD_NEK2_2	174	179	PF00069	0.517
MOD_PIKK_1	154	160	PF00454	0.490
MOD_PIKK_1	214	220	PF00454	0.290
MOD_PIKK_1	48	54	PF00454	0.555
MOD_PKA_2	188	194	PF00069	0.458
MOD_PKB_1	131	139	PF00069	0.601
MOD_Plk_1	172	178	PF00069	0.472
MOD_Plk_2-3	61	67	PF00069	0.613
MOD_Plk_4	108	114	PF00069	0.436
MOD_Plk_4	133	139	PF00069	0.626
MOD_Plk_4	180	186	PF00069	0.336
MOD_Plk_4	43	49	PF00069	0.462
MOD_Plk_4	78	84	PF00069	0.522
TRG_DiLeu_BaEn_4	202	208	PF01217	0.503
TRG_ENDOCYTIC_2	47	50	PF00928	0.512
TRG_ER_diArg_1	128	131	PF00400	0.514
TRG_ER_diArg_1	192	195	PF00400	0.562
TRG_ER_diArg_1	234	236	PF00400	0.566
TRG_ER_diArg_1	40	42	PF00400	0.507
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.309
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCM0	Leptomonas seymouri	56%	100%
A0A1X0P8Z9	Trypanosomatidae	35%	94%
A0A3S7X2Y0	Leishmania donovani	81%	100%
A0A422NET6	Trypanosoma rangeli	29%	90%
A4I4Y6	Leishmania infantum	81%	100%
C9ZKJ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	81%
E9AEE4	Leishmania major	81%	100%