Ribonuclease inhibitor-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribonuclease inhibitor-like protein

Species:

Leishmania braziliensis

UniProt:

A4HHT8_LEIBR

TriTrypDb:

LbrM.29.2870 , LBRM2903_290036500

Length:

735

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	16
GO:0042995	cell projection	2	16
GO:0043226	organelle	2	16
GO:0043227	membrane-bounded organelle	3	16
GO:0110165	cellular anatomical entity	1	17
GO:0120025	plasma membrane bounded cell projection	3	16
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1

Expansion

Sequence features

A4HHT8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHT8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	702	706	PF00656	0.528
CLV_NRD_NRD_1	257	259	PF00675	0.277
CLV_NRD_NRD_1	410	412	PF00675	0.216
CLV_NRD_NRD_1	591	593	PF00675	0.426
CLV_NRD_NRD_1	604	606	PF00675	0.388
CLV_NRD_NRD_1	671	673	PF00675	0.469
CLV_NRD_NRD_1	729	731	PF00675	0.629
CLV_PCSK_KEX2_1	195	197	PF00082	0.367
CLV_PCSK_KEX2_1	257	259	PF00082	0.277
CLV_PCSK_KEX2_1	579	581	PF00082	0.421
CLV_PCSK_KEX2_1	591	593	PF00082	0.426
CLV_PCSK_KEX2_1	604	606	PF00082	0.392
CLV_PCSK_KEX2_1	645	647	PF00082	0.479
CLV_PCSK_KEX2_1	671	673	PF00082	0.496
CLV_PCSK_KEX2_1	729	731	PF00082	0.625
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.367
CLV_PCSK_PC1ET2_1	579	581	PF00082	0.509
CLV_PCSK_PC1ET2_1	645	647	PF00082	0.532
CLV_PCSK_SKI1_1	220	224	PF00082	0.393
CLV_PCSK_SKI1_1	288	292	PF00082	0.254
CLV_PCSK_SKI1_1	406	410	PF00082	0.262
CLV_PCSK_SKI1_1	459	463	PF00082	0.426
CLV_PCSK_SKI1_1	547	551	PF00082	0.544
CLV_PCSK_SKI1_1	57	61	PF00082	0.567
CLV_PCSK_SKI1_1	605	609	PF00082	0.361
CLV_PCSK_SKI1_1	672	676	PF00082	0.453
CLV_PCSK_SKI1_1	730	734	PF00082	0.729
CLV_Separin_Metazoa	254	258	PF03568	0.370
CLV_Separin_Metazoa	321	325	PF03568	0.370
CLV_Separin_Metazoa	588	592	PF03568	0.320
DEG_Nend_UBRbox_2	1	3	PF02207	0.621
DEG_ODPH_VHL_1	124	137	PF01847	0.268
DEG_SCF_FBW7_2	244	250	PF00400	0.489
DOC_CKS1_1	244	249	PF01111	0.483
DOC_CKS1_1	5	10	PF01111	0.719
DOC_CYCLIN_RxL_1	217	227	PF00134	0.416
DOC_CYCLIN_yClb5_NLxxxL_5	489	498	PF00134	0.300
DOC_MAPK_gen_1	195	205	PF00069	0.371
DOC_MAPK_gen_1	257	267	PF00069	0.186
DOC_MAPK_gen_1	442	451	PF00069	0.463
DOC_MAPK_gen_1	485	494	PF00069	0.413
DOC_MAPK_gen_1	512	522	PF00069	0.309
DOC_MAPK_HePTP_8	193	205	PF00069	0.300
DOC_MAPK_MEF2A_6	196	205	PF00069	0.304
DOC_PP1_RVXF_1	128	135	PF00149	0.373
DOC_PP2B_LxvP_1	549	552	PF13499	0.454
DOC_PP4_FxxP_1	147	150	PF00568	0.443
DOC_USP7_UBL2_3	481	485	PF12436	0.387
DOC_USP7_UBL2_3	543	547	PF12436	0.417
DOC_WW_Pin1_4	243	248	PF00397	0.497
DOC_WW_Pin1_4	4	9	PF00397	0.657
LIG_14-3-3_CanoR_1	170	175	PF00244	0.410
LIG_14-3-3_CanoR_1	196	201	PF00244	0.406
LIG_14-3-3_CanoR_1	264	272	PF00244	0.402
LIG_14-3-3_CanoR_1	288	295	PF00244	0.302
LIG_14-3-3_CanoR_1	50	59	PF00244	0.555
LIG_14-3-3_CanoR_1	512	518	PF00244	0.312
LIG_14-3-3_CanoR_1	629	635	PF00244	0.513
LIG_14-3-3_CanoR_1	712	718	PF00244	0.628
LIG_Actin_WH2_2	25	40	PF00022	0.425
LIG_APCC_ABBAyCdc20_2	198	204	PF00400	0.300
LIG_BRCT_BRCA1_1	2	6	PF00533	0.472
LIG_BRCT_BRCA1_1	507	511	PF00533	0.364
LIG_BRCT_BRCA1_1	55	59	PF00533	0.695
LIG_Clathr_ClatBox_1	200	204	PF01394	0.371
LIG_CtBP_PxDLS_1	476	481	PF00389	0.488
LIG_FHA_1	20	26	PF00498	0.570
LIG_FHA_1	378	384	PF00498	0.346
LIG_FHA_1	424	430	PF00498	0.323
LIG_FHA_1	5	11	PF00498	0.428
LIG_FHA_1	546	552	PF00498	0.566
LIG_FHA_1	634	640	PF00498	0.439
LIG_FHA_1	65	71	PF00498	0.567
LIG_FHA_1	658	664	PF00498	0.540
LIG_FHA_2	105	111	PF00498	0.478
LIG_FHA_2	316	322	PF00498	0.463
LIG_FHA_2	357	363	PF00498	0.407
LIG_FHA_2	606	612	PF00498	0.514
LIG_FHA_2	645	651	PF00498	0.526
LIG_FHA_2	693	699	PF00498	0.507
LIG_LIR_Apic_2	318	323	PF02991	0.364
LIG_LIR_Gen_1	131	140	PF02991	0.403
LIG_LIR_Gen_1	351	360	PF02991	0.320
LIG_LIR_Gen_1	521	532	PF02991	0.327
LIG_LIR_Gen_1	86	95	PF02991	0.463
LIG_LIR_Nem_3	131	137	PF02991	0.395
LIG_LIR_Nem_3	250	255	PF02991	0.404
LIG_LIR_Nem_3	351	355	PF02991	0.329
LIG_LIR_Nem_3	426	431	PF02991	0.206
LIG_LIR_Nem_3	521	527	PF02991	0.316
LIG_LIR_Nem_3	86	90	PF02991	0.435
LIG_MYND_1	71	75	PF01753	0.663
LIG_PCNA_yPIPBox_3	402	412	PF02747	0.436
LIG_SH2_GRB2like	428	431	PF00017	0.224
LIG_SH2_STAP1	44	48	PF00017	0.620
LIG_SH2_STAP1	529	533	PF00017	0.311
LIG_SH2_STAP1	80	84	PF00017	0.556
LIG_SH2_STAT3	44	47	PF00017	0.548
LIG_SH2_STAT5	326	329	PF00017	0.396
LIG_SH2_STAT5	352	355	PF00017	0.372
LIG_SH2_STAT5	428	431	PF00017	0.224
LIG_SH3_3	20	26	PF00018	0.634
LIG_SUMO_SIM_par_1	173	178	PF11976	0.287
LIG_SUMO_SIM_par_1	226	232	PF11976	0.317
LIG_TYR_ITIM	350	355	PF00017	0.399
LIG_WRC_WIRS_1	84	89	PF05994	0.465
MOD_CK1_1	404	410	PF00069	0.352
MOD_CK1_1	53	59	PF00069	0.678
MOD_CK1_1	545	551	PF00069	0.556
MOD_CK1_1	618	624	PF00069	0.440
MOD_CK1_1	728	734	PF00069	0.676
MOD_CK2_1	279	285	PF00069	0.433
MOD_CK2_1	307	313	PF00069	0.441
MOD_CK2_1	315	321	PF00069	0.443
MOD_CK2_1	356	362	PF00069	0.350
MOD_CK2_1	605	611	PF00069	0.422
MOD_CK2_1	711	717	PF00069	0.579
MOD_GlcNHglycan	138	141	PF01048	0.406
MOD_GlcNHglycan	176	180	PF01048	0.175
MOD_GlcNHglycan	2	5	PF01048	0.511
MOD_GlcNHglycan	281	284	PF01048	0.371
MOD_GlcNHglycan	362	366	PF01048	0.382
MOD_GlcNHglycan	372	375	PF01048	0.368
MOD_GlcNHglycan	617	620	PF01048	0.446
MOD_GlcNHglycan	713	716	PF01048	0.582
MOD_GlcNHglycan	730	733	PF01048	0.464
MOD_GSK3_1	284	291	PF00069	0.154
MOD_GSK3_1	370	377	PF00069	0.370
MOD_GSK3_1	633	640	PF00069	0.519
MOD_GSK3_1	644	651	PF00069	0.494
MOD_LATS_1	286	292	PF00433	0.154
MOD_N-GLC_1	196	201	PF02516	0.249
MOD_N-GLC_1	224	229	PF02516	0.342
MOD_N-GLC_1	265	270	PF02516	0.319
MOD_N-GLC_1	293	298	PF02516	0.294
MOD_N-GLC_1	401	406	PF02516	0.411
MOD_N-GLC_1	429	434	PF02516	0.327
MOD_N-GLC_1	464	469	PF02516	0.324
MOD_N-GLC_1	485	490	PF02516	0.252
MOD_N-GLC_1	513	518	PF02516	0.279
MOD_N-GLC_1	545	550	PF02516	0.547
MOD_N-GLC_1	637	642	PF02516	0.387
MOD_N-GLC_2	458	460	PF02516	0.476
MOD_NEK2_1	175	180	PF00069	0.250
MOD_NEK2_1	265	270	PF00069	0.311
MOD_NEK2_1	279	284	PF00069	0.303
MOD_NEK2_1	293	298	PF00069	0.246
MOD_NEK2_1	372	377	PF00069	0.336
MOD_NEK2_1	423	428	PF00069	0.295
MOD_NEK2_1	436	441	PF00069	0.319
MOD_NEK2_1	51	56	PF00069	0.662
MOD_NEK2_1	520	525	PF00069	0.205
MOD_NEK2_1	644	649	PF00069	0.622
MOD_NEK2_2	33	38	PF00069	0.596
MOD_PK_1	170	176	PF00069	0.379
MOD_PK_1	411	417	PF00069	0.210
MOD_PKA_1	411	417	PF00069	0.502
MOD_PKA_2	628	634	PF00069	0.467
MOD_PKA_2	711	717	PF00069	0.573
MOD_PKA_2	728	734	PF00069	0.528
MOD_Plk_1	102	108	PF00069	0.445
MOD_Plk_1	196	202	PF00069	0.249
MOD_Plk_1	224	230	PF00069	0.341
MOD_Plk_1	356	362	PF00069	0.433
MOD_Plk_1	401	407	PF00069	0.384
MOD_Plk_1	429	435	PF00069	0.322
MOD_Plk_1	485	491	PF00069	0.253
MOD_Plk_1	513	519	PF00069	0.300
MOD_Plk_1	520	526	PF00069	0.300
MOD_Plk_1	545	551	PF00069	0.552
MOD_Plk_2-3	356	362	PF00069	0.219
MOD_Plk_4	170	176	PF00069	0.346
MOD_Plk_4	224	230	PF00069	0.331
MOD_Plk_4	374	380	PF00069	0.290
MOD_Plk_4	404	410	PF00069	0.413
MOD_Plk_4	423	429	PF00069	0.191
MOD_Plk_4	545	551	PF00069	0.575
MOD_ProDKin_1	243	249	PF00069	0.492
MOD_ProDKin_1	4	10	PF00069	0.659
MOD_SUMO_for_1	706	709	PF00179	0.633
MOD_SUMO_rev_2	702	708	PF00179	0.614
TRG_DiLeu_BaLyEn_6	109	114	PF01217	0.451
TRG_DiLeu_BaLyEn_6	684	689	PF01217	0.551
TRG_ENDOCYTIC_2	172	175	PF00928	0.322
TRG_ENDOCYTIC_2	352	355	PF00928	0.363
TRG_ENDOCYTIC_2	524	527	PF00928	0.319
TRG_ER_diArg_1	256	258	PF00400	0.231
TRG_ER_diArg_1	590	592	PF00400	0.435
TRG_ER_diArg_1	603	605	PF00400	0.421
TRG_ER_diArg_1	670	672	PF00400	0.506
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	605	609	PF00026	0.405
TRG_Pf-PMV_PEXEL_1	675	679	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	690	694	PF00026	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I557	Leptomonas seymouri	70%	100%
A0A0S4IPG0	Bodo saltans	44%	97%
A0A0S4JDM4	Bodo saltans	24%	100%
A0A0S4JL02	Bodo saltans	24%	99%
A0A1X0P9A4	Trypanosomatidae	49%	100%
A0A3Q8IEN3	Leishmania donovani	83%	100%
A0A422MZT7	Trypanosoma rangeli	22%	84%
A0A422NEU0	Trypanosoma rangeli	48%	99%
A4I4Y7	Leishmania infantum	84%	100%
C9ZHZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	99%
C9ZKJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	97%
E9AEE3	Leishmania major	82%	100%
E9ALE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
Q95VZ3	Dictyostelium discoideum	22%	70%
V5AZQ5	Trypanosoma cruzi	25%	100%
V5BC66	Trypanosoma cruzi	51%	100%