Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHT7_LEIBR

TriTrypDb:

LbrM.29.2860

Length:

192

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HHT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHT7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	161	163	PF00675	0.577
CLV_NRD_NRD_1	22	24	PF00675	0.432
CLV_NRD_NRD_1	7	9	PF00675	0.378
CLV_PCSK_KEX2_1	161	163	PF00082	0.606
CLV_PCSK_KEX2_1	22	24	PF00082	0.431
CLV_PCSK_SKI1_1	162	166	PF00082	0.608
CLV_PCSK_SKI1_1	8	12	PF00082	0.382
DEG_SCF_FBW7_1	164	169	PF00400	0.435
DOC_CYCLIN_RxL_1	5	16	PF00134	0.613
DOC_CYCLIN_yCln2_LP_2	34	40	PF00134	0.566
DOC_PP1_RVXF_1	6	13	PF00149	0.636
DOC_USP7_MATH_1	166	170	PF00917	0.423
DOC_WW_Pin1_4	162	167	PF00397	0.404
LIG_BIR_II_1	1	5	PF00653	0.623
LIG_BRCT_BRCA1_1	1	5	PF00533	0.635
LIG_BRCT_BRCA1_1	105	109	PF00533	0.274
LIG_deltaCOP1_diTrp_1	75	82	PF00928	0.436
LIG_FHA_1	117	123	PF00498	0.476
LIG_FHA_1	178	184	PF00498	0.348
LIG_FHA_1	66	72	PF00498	0.660
LIG_Integrin_RGD_1	14	16	PF01839	0.324
LIG_LIR_Apic_2	175	179	PF02991	0.379
LIG_LIR_Gen_1	137	147	PF02991	0.237
LIG_LIR_Gen_1	169	178	PF02991	0.393
LIG_LIR_Nem_3	137	142	PF02991	0.303
LIG_LIR_Nem_3	169	173	PF02991	0.387
LIG_LIR_Nem_3	182	188	PF02991	0.372
LIG_LRP6_Inhibitor_1	87	93	PF00058	0.185
LIG_MLH1_MIPbox_1	105	109	PF16413	0.274
LIG_MYND_1	33	37	PF01753	0.523
LIG_NRBOX	6	12	PF00104	0.639
LIG_PALB2_WD40_1	49	57	PF16756	0.495
LIG_Pex14_1	78	82	PF04695	0.271
LIG_SH2_CRK	170	174	PF00017	0.393
LIG_SH2_CRK	188	192	PF00017	0.406
LIG_SH2_CRK	31	35	PF00017	0.602
LIG_SH2_CRK	89	93	PF00017	0.289
LIG_SH2_GRB2like	88	91	PF00017	0.289
LIG_SH2_PTP2	176	179	PF00017	0.372
LIG_SH2_SRC	145	148	PF00017	0.336
LIG_SH2_SRC	176	179	PF00017	0.372
LIG_SH2_STAP1	181	185	PF00017	0.407
LIG_SH2_STAT5	176	179	PF00017	0.413
LIG_SH3_3	184	190	PF00018	0.377
LIG_SH3_3	37	43	PF00018	0.650
LIG_TYR_ITIM	186	191	PF00017	0.395
LIG_TYR_ITIM	87	92	PF00017	0.404
LIG_WRC_WIRS_1	60	65	PF05994	0.636
LIG_WW_1	178	181	PF00397	0.315
MOD_CDK_SPxK_1	162	168	PF00069	0.439
MOD_CK1_1	62	68	PF00069	0.631
MOD_GlcNHglycan	1	4	PF01048	0.446
MOD_GlcNHglycan	105	108	PF01048	0.252
MOD_GlcNHglycan	125	128	PF01048	0.441
MOD_GlcNHglycan	49	52	PF01048	0.369
MOD_GSK3_1	112	119	PF00069	0.185
MOD_GSK3_1	162	169	PF00069	0.420
MOD_GSK3_1	58	65	PF00069	0.636
MOD_NEK2_1	1	6	PF00069	0.599
MOD_NEK2_1	123	128	PF00069	0.556
MOD_NEK2_1	59	64	PF00069	0.562
MOD_NEK2_1	82	87	PF00069	0.185
MOD_NEK2_2	134	139	PF00069	0.185
MOD_NEK2_2	88	93	PF00069	0.376
MOD_Plk_4	134	140	PF00069	0.233
MOD_Plk_4	42	48	PF00069	0.566
MOD_Plk_4	59	65	PF00069	0.451
MOD_ProDKin_1	162	168	PF00069	0.407
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.600
TRG_ENDOCYTIC_2	170	173	PF00928	0.395
TRG_ENDOCYTIC_2	188	191	PF00928	0.400
TRG_ENDOCYTIC_2	31	34	PF00928	0.580
TRG_ENDOCYTIC_2	89	92	PF00928	0.289
TRG_ER_diArg_1	160	162	PF00400	0.397
TRG_ER_diArg_1	71	74	PF00400	0.534
TRG_ER_FFAT_2	61	68	PF00635	0.465
TRG_Pf-PMV_PEXEL_1	8	13	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZV8	Leptomonas seymouri	74%	100%
A0A0S4KHT2	Bodo saltans	40%	94%
A0A1X0P8Y9	Trypanosomatidae	60%	99%
A0A3Q8IHI8	Leishmania donovani	84%	100%
A4I4Y8	Leishmania infantum	84%	100%
C9ZKK1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	98%
E9AEE1	Leishmania major	84%	100%
E9ALE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BXI8	Trypanosoma cruzi	58%	99%