Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHT4_LEIBR

TriTrypDb:

LbrM.29.2830 , LBRM2903_290034800

Length:

204

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHT4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHT4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	183	185	PF00675	0.341
DEG_APCC_DBOX_1	99	107	PF00400	0.406
DEG_SPOP_SBC_1	200	204	PF00917	0.440
DOC_USP7_MATH_1	8	12	PF00917	0.457
DOC_WW_Pin1_4	113	118	PF00397	0.393
DOC_WW_Pin1_4	123	128	PF00397	0.327
DOC_WW_Pin1_4	13	18	PF00397	0.428
LIG_14-3-3_CanoR_1	184	190	PF00244	0.397
LIG_14-3-3_CterR_2	199	204	PF00244	0.639
LIG_APCC_ABBA_1	155	160	PF00400	0.480
LIG_APCC_ABBA_1	187	192	PF00400	0.406
LIG_FHA_1	110	116	PF00498	0.337
LIG_FHA_1	18	24	PF00498	0.442
LIG_LIR_Apic_2	112	117	PF02991	0.465
LIG_LIR_Gen_1	188	198	PF02991	0.437
LIG_LIR_Gen_1	60	67	PF02991	0.472
LIG_LIR_Gen_1	79	89	PF02991	0.447
LIG_LIR_Nem_3	60	64	PF02991	0.454
LIG_LIR_Nem_3	79	85	PF02991	0.460
LIG_LYPXL_SIV_4	81	89	PF13949	0.228
LIG_Pex14_1	28	32	PF04695	0.362
LIG_Pex14_2	190	194	PF04695	0.426
LIG_SH2_CRK	51	55	PF00017	0.507
LIG_SH2_CRK	82	86	PF00017	0.364
LIG_SH2_SRC	102	105	PF00017	0.413
LIG_SH2_STAP1	82	86	PF00017	0.364
LIG_SH2_STAT5	102	105	PF00017	0.484
LIG_SH3_3	114	120	PF00018	0.503
MOD_CDK_SPK_2	113	118	PF00069	0.483
MOD_CK1_1	175	181	PF00069	0.358
MOD_CK1_1	62	68	PF00069	0.483
MOD_CK1_1	77	83	PF00069	0.467
MOD_GlcNHglycan	149	152	PF01048	0.376
MOD_GlcNHglycan	177	180	PF01048	0.384
MOD_GlcNHglycan	79	82	PF01048	0.266
MOD_GSK3_1	109	116	PF00069	0.339
MOD_GSK3_1	13	20	PF00069	0.456
MOD_GSK3_1	140	147	PF00069	0.425
MOD_GSK3_1	168	175	PF00069	0.440
MOD_GSK3_1	28	35	PF00069	0.426
MOD_GSK3_1	39	46	PF00069	0.455
MOD_LATS_1	197	203	PF00433	0.533
MOD_NEK2_1	165	170	PF00069	0.424
MOD_NEK2_1	32	37	PF00069	0.311
MOD_PKA_2	140	146	PF00069	0.395
MOD_PKA_2	175	181	PF00069	0.406
MOD_PKA_2	198	204	PF00069	0.430
MOD_Plk_1	59	65	PF00069	0.374
MOD_Plk_4	109	115	PF00069	0.365
MOD_Plk_4	185	191	PF00069	0.456
MOD_Plk_4	28	34	PF00069	0.489
MOD_Plk_4	39	45	PF00069	0.442
MOD_Plk_4	8	14	PF00069	0.562
MOD_ProDKin_1	113	119	PF00069	0.400
MOD_ProDKin_1	123	129	PF00069	0.329
MOD_ProDKin_1	13	19	PF00069	0.417
TRG_ENDOCYTIC_2	51	54	PF00928	0.533
TRG_ENDOCYTIC_2	82	85	PF00928	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I852	Leptomonas seymouri	80%	100%
A0A1X0P9Y9	Trypanosomatidae	51%	93%
A0A3R7MK58	Trypanosoma rangeli	59%	100%
A0A3S7X2U9	Leishmania donovani	94%	100%
A4I4Z4	Leishmania infantum	94%	100%
C9ZKK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AED9	Leishmania major	93%	100%
E9ALE7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BCE2	Trypanosoma cruzi	57%	100%