LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HHT2_LEIBR
TriTrypDb:
LbrM.29.2810 , LBRM2903_290034600 *
Length:
73

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 4
GO:0110165 cellular anatomical entity 1 4
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

A4HHT2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHT2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 1 3 PF00675 0.333
CLV_NRD_NRD_1 68 70 PF00675 0.622
CLV_PCSK_SKI1_1 2 6 PF00082 0.314
DEG_APCC_DBOX_1 21 29 PF00400 0.555
DEG_Nend_UBRbox_1 1 4 PF02207 0.495
DOC_CYCLIN_yCln2_LP_2 41 47 PF00134 0.309
DOC_MAPK_gen_1 11 18 PF00069 0.552
LIG_eIF4E_1 37 43 PF01652 0.222
LIG_LIR_Gen_1 30 37 PF02991 0.518
LIG_LIR_Nem_3 30 34 PF02991 0.621
LIG_SH2_CRK 37 41 PF00017 0.222
LIG_SH2_NCK_1 31 35 PF00017 0.483
LIG_SH2_PTP2 48 51 PF00017 0.369
LIG_SH2_SRC 31 34 PF00017 0.469
LIG_SH2_STAT5 37 40 PF00017 0.269
LIG_SH2_STAT5 48 51 PF00017 0.402
LIG_TYR_ITIM 46 51 PF00017 0.309
MOD_N-GLC_2 27 29 PF02516 0.370
MOD_NEK2_1 16 21 PF00069 0.630
TRG_ENDOCYTIC_2 31 34 PF00928 0.582
TRG_ENDOCYTIC_2 37 40 PF00928 0.346
TRG_ENDOCYTIC_2 48 51 PF00928 0.416
TRG_ER_diArg_1 13 16 PF00400 0.537
TRG_ER_diArg_1 20 23 PF00400 0.532
TRG_Pf-PMV_PEXEL_1 26 30 PF00026 0.272

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1ILG8 Leptomonas seymouri 69% 99%
A0A0S4KE22 Bodo saltans 39% 88%
A0A3S7X2U0 Leishmania donovani 79% 100%
A4I4Z2 Leishmania infantum 79% 100%
E9AED7 Leishmania major 78% 100%
E9ALE9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%
V5BXH7 Trypanosoma cruzi 48% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS