Putative actin-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

actin-like protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HHT1_LEIBR

TriTrypDb:

LbrM.29.2800 , LBRM2903_290034500

Length:

323

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005869	dynactin complex	3	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

A4HHT1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHT1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.413
CLV_NRD_NRD_1	23	25	PF00675	0.537
CLV_NRD_NRD_1	34	36	PF00675	0.314
CLV_PCSK_KEX2_1	202	204	PF00082	0.157
CLV_PCSK_KEX2_1	21	23	PF00082	0.510
CLV_PCSK_KEX2_1	34	36	PF00082	0.533
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.157
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.445
CLV_PCSK_SKI1_1	169	173	PF00082	0.253
CLV_PCSK_SKI1_1	211	215	PF00082	0.333
CLV_PCSK_SKI1_1	277	281	PF00082	0.308
DEG_APCC_DBOX_1	202	210	PF00400	0.349
DEG_COP1_1	179	188	PF00400	0.454
DEG_Nend_UBRbox_2	1	3	PF02207	0.349
DOC_CYCLIN_RxL_1	207	218	PF00134	0.357
DOC_MAPK_DCC_7	181	190	PF00069	0.459
DOC_MAPK_gen_1	21	31	PF00069	0.509
DOC_MAPK_HePTP_8	178	190	PF00069	0.459
DOC_MAPK_HePTP_8	19	31	PF00069	0.429
DOC_MAPK_MEF2A_6	181	190	PF00069	0.459
DOC_MAPK_MEF2A_6	22	31	PF00069	0.505
DOC_MAPK_MEF2A_6	61	70	PF00069	0.508
DOC_PP2B_LxvP_1	188	191	PF13499	0.469
DOC_USP7_MATH_1	191	195	PF00917	0.477
DOC_USP7_UBL2_3	21	25	PF12436	0.516
LIG_14-3-3_CanoR_1	142	147	PF00244	0.460
LIG_14-3-3_CanoR_1	169	178	PF00244	0.414
LIG_14-3-3_CanoR_1	235	243	PF00244	0.357
LIG_14-3-3_CanoR_1	268	276	PF00244	0.436
LIG_14-3-3_CanoR_1	34	42	PF00244	0.523
LIG_APCC_ABBA_1	195	200	PF00400	0.459
LIG_BRCT_BRCA1_1	232	236	PF00533	0.459
LIG_FHA_1	111	117	PF00498	0.426
LIG_FHA_1	146	152	PF00498	0.439
LIG_FHA_1	165	171	PF00498	0.412
LIG_FHA_1	2	8	PF00498	0.281
LIG_FHA_1	208	214	PF00498	0.500
LIG_FHA_1	216	222	PF00498	0.482
LIG_FHA_1	238	244	PF00498	0.494
LIG_FHA_1	65	71	PF00498	0.426
LIG_FHA_2	177	183	PF00498	0.441
LIG_FHA_2	187	193	PF00498	0.418
LIG_FHA_2	41	47	PF00498	0.447
LIG_LIR_Gen_1	239	250	PF02991	0.480
LIG_LIR_Gen_1	83	92	PF02991	0.472
LIG_LIR_Nem_3	119	125	PF02991	0.365
LIG_LIR_Nem_3	13	19	PF02991	0.376
LIG_LIR_Nem_3	239	245	PF02991	0.442
LIG_LIR_Nem_3	305	309	PF02991	0.531
LIG_LIR_Nem_3	83	89	PF02991	0.472
LIG_NRBOX	154	160	PF00104	0.508
LIG_NRBOX	67	73	PF00104	0.490
LIG_SH2_CRK	122	126	PF00017	0.365
LIG_SH2_CRK	16	20	PF00017	0.444
LIG_SH2_STAT5	101	104	PF00017	0.455
LIG_SH2_STAT5	41	44	PF00017	0.422
LIG_SH2_STAT5	5	8	PF00017	0.406
LIG_SUMO_SIM_anti_2	62	70	PF11976	0.452
LIG_SUMO_SIM_par_1	67	74	PF11976	0.470
LIG_TRAF2_1	163	166	PF00917	0.357
LIG_TRAF2_1	43	46	PF00917	0.357
LIG_TYR_ITIM	120	125	PF00017	0.365
LIG_TYR_ITIM	14	19	PF00017	0.429
LIG_UBA3_1	289	297	PF00899	0.426
MOD_CK1_1	145	151	PF00069	0.506
MOD_CK1_1	216	222	PF00069	0.508
MOD_CK1_1	237	243	PF00069	0.379
MOD_CK1_1	249	255	PF00069	0.513
MOD_CK1_1	77	83	PF00069	0.472
MOD_CK2_1	159	165	PF00069	0.436
MOD_CK2_1	174	180	PF00069	0.493
MOD_CK2_1	217	223	PF00069	0.560
MOD_CK2_1	40	46	PF00069	0.438
MOD_GlcNHglycan	112	116	PF01048	0.224
MOD_GlcNHglycan	161	164	PF01048	0.220
MOD_GlcNHglycan	251	254	PF01048	0.252
MOD_GlcNHglycan	269	272	PF01048	0.301
MOD_GlcNHglycan	284	287	PF01048	0.223
MOD_GlcNHglycan	56	59	PF01048	0.243
MOD_GSK3_1	134	141	PF00069	0.506
MOD_GSK3_1	170	177	PF00069	0.540
MOD_GSK3_1	213	220	PF00069	0.476
MOD_GSK3_1	230	237	PF00069	0.528
MOD_LATS_1	275	281	PF00433	0.508
MOD_NEK2_1	1	6	PF00069	0.304
MOD_NEK2_1	159	164	PF00069	0.451
MOD_NEK2_1	170	175	PF00069	0.405
MOD_NEK2_1	213	218	PF00069	0.492
MOD_NEK2_1	236	241	PF00069	0.519
MOD_NEK2_1	71	76	PF00069	0.438
MOD_NEK2_1	99	104	PF00069	0.410
MOD_NEK2_2	10	15	PF00069	0.316
MOD_NEK2_2	191	196	PF00069	0.508
MOD_PIKK_1	288	294	PF00454	0.419
MOD_PIKK_1	74	80	PF00454	0.459
MOD_PK_1	142	148	PF00069	0.508
MOD_PKA_2	141	147	PF00069	0.494
MOD_PKA_2	207	213	PF00069	0.509
MOD_PKA_2	234	240	PF00069	0.528
MOD_PKA_2	267	273	PF00069	0.557
MOD_PKA_2	33	39	PF00069	0.350
MOD_Plk_1	1	7	PF00069	0.299
MOD_Plk_1	164	170	PF00069	0.518
MOD_Plk_1	186	192	PF00069	0.512
MOD_Plk_1	237	243	PF00069	0.473
MOD_Plk_1	64	70	PF00069	0.472
MOD_Plk_2-3	59	65	PF00069	0.422
MOD_Plk_4	1	7	PF00069	0.377
MOD_Plk_4	191	197	PF00069	0.477
MOD_Plk_4	238	244	PF00069	0.461
MOD_Plk_4	246	252	PF00069	0.489
MOD_Plk_4	64	70	PF00069	0.421
MOD_Plk_4	80	86	PF00069	0.387
TRG_DiLeu_BaEn_1	154	159	PF01217	0.508
TRG_DiLeu_BaEn_1	166	171	PF01217	0.508
TRG_DiLeu_BaEn_1	64	69	PF01217	0.508
TRG_DiLeu_LyEn_5	154	159	PF01217	0.459
TRG_ENDOCYTIC_2	122	125	PF00928	0.365
TRG_ENDOCYTIC_2	16	19	PF00928	0.380
TRG_ENDOCYTIC_2	86	89	PF00928	0.508
TRG_NES_CRM1_1	292	305	PF08389	0.426
TRG_NLS_MonoExtC_3	20	25	PF00514	0.447
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.229

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Y8	Leptomonas seymouri	76%	100%
A0A0S4KG45	Bodo saltans	26%	89%
A0A0S4KJ86	Bodo saltans	27%	100%
A0A1X0NRG7	Trypanosomatidae	25%	83%
A0A1X0P9A3	Trypanosomatidae	37%	99%
A0A3S5IR27	Trypanosoma rangeli	38%	95%
A0A3S7X2U7	Leishmania donovani	84%	100%
A4I4Z1	Leishmania infantum	85%	100%
C9ZKK7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	99%
E9AKA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	90%
E9ALF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
P11426	Entamoeba histolytica	26%	86%
P12432	Trypanosoma brucei brucei	24%	86%
P42023	Pneumocystis carinii	26%	84%
P45889	Drosophila melanogaster	25%	86%
P53473	Strongylocentrotus purpuratus	24%	86%
P61162	Canis lupus familiaris	26%	86%
P61163	Homo sapiens	26%	86%
P61164	Mus musculus	26%	86%
P69004	Mesocentrotus franciscanus	24%	86%
P69005	Strongylocentrotus purpuratus	24%	86%
P85515	Rattus norvegicus	26%	86%
Q2U7A3	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	25%	86%
Q4FXC8	Leishmania major	85%	100%
Q4R6J9	Macaca fascicularis	26%	86%
Q54I79	Dictyostelium discoideum	27%	84%
Q55CU2	Dictyostelium discoideum	23%	86%
Q8R5C5	Mus musculus	26%	86%
V5BDL0	Trypanosoma cruzi	24%	86%
V5C0Q2	Trypanosoma cruzi	23%	83%
V5DTX0	Trypanosoma cruzi	37%	99%