START domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

START domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HHT0_LEIBR

TriTrypDb:

LbrM.29.2790 , LBRM2903_290034400

Length:

366

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHT0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	15
GO:0008289	lipid binding	2	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	24	26	PF00675	0.470
CLV_NRD_NRD_1	27	29	PF00675	0.477
CLV_PCSK_SKI1_1	15	19	PF00082	0.385
CLV_PCSK_SKI1_1	162	166	PF00082	0.302
CLV_PCSK_SKI1_1	207	211	PF00082	0.314
CLV_PCSK_SKI1_1	29	33	PF00082	0.216
CLV_PCSK_SKI1_1	334	338	PF00082	0.478
CLV_PCSK_SKI1_1	68	72	PF00082	0.406
DEG_APCC_DBOX_1	14	22	PF00400	0.412
DEG_Nend_UBRbox_2	1	3	PF02207	0.644
DEG_SCF_FBW7_1	295	300	PF00400	0.653
DEG_SPOP_SBC_1	297	301	PF00917	0.432
DOC_CDC14_PxL_1	70	78	PF14671	0.210
DOC_CKS1_1	236	241	PF01111	0.327
DOC_CYCLIN_RxL_1	23	35	PF00134	0.274
DOC_MAPK_DCC_7	68	78	PF00069	0.193
DOC_MAPK_gen_1	12	21	PF00069	0.450
DOC_MAPK_gen_1	25	32	PF00069	0.403
DOC_MAPK_gen_1	68	78	PF00069	0.213
DOC_MAPK_MEF2A_6	71	78	PF00069	0.210
DOC_PP4_FxxP_1	117	120	PF00568	0.282
DOC_USP7_MATH_1	174	178	PF00917	0.306
DOC_USP7_MATH_1	189	193	PF00917	0.245
DOC_USP7_MATH_1	254	258	PF00917	0.470
DOC_USP7_MATH_2	53	59	PF00917	0.193
DOC_USP7_UBL2_3	281	285	PF12436	0.489
DOC_WW_Pin1_4	235	240	PF00397	0.405
DOC_WW_Pin1_4	285	290	PF00397	0.567
DOC_WW_Pin1_4	293	298	PF00397	0.552
LIG_14-3-3_CanoR_1	360	365	PF00244	0.472
LIG_14-3-3_CanoR_1	88	92	PF00244	0.327
LIG_Actin_WH2_2	325	340	PF00022	0.543
LIG_BIR_III_4	267	271	PF00653	0.496
LIG_EH1_1	309	317	PF00400	0.539
LIG_eIF4E_1	310	316	PF01652	0.612
LIG_FHA_1	12	18	PF00498	0.352
LIG_FHA_1	177	183	PF00498	0.408
LIG_FHA_1	225	231	PF00498	0.491
LIG_FHA_1	311	317	PF00498	0.557
LIG_FHA_1	91	97	PF00498	0.406
LIG_FHA_2	134	140	PF00498	0.264
LIG_FHA_2	183	189	PF00498	0.251
LIG_FHA_2	342	348	PF00498	0.481
LIG_FHA_2	360	366	PF00498	0.521
LIG_FHA_2	87	93	PF00498	0.427
LIG_HCF-1_HBM_1	231	234	PF13415	0.440
LIG_LIR_Apic_2	166	172	PF02991	0.355
LIG_LIR_Apic_2	244	250	PF02991	0.371
LIG_LIR_Gen_1	125	133	PF02991	0.287
LIG_LIR_Gen_1	139	148	PF02991	0.344
LIG_LIR_Gen_1	14	24	PF02991	0.478
LIG_LIR_Gen_1	97	104	PF02991	0.360
LIG_LIR_Nem_3	131	135	PF02991	0.304
LIG_LIR_Nem_3	139	143	PF02991	0.339
LIG_LIR_Nem_3	217	223	PF02991	0.382
LIG_LIR_Nem_3	97	102	PF02991	0.390
LIG_PDZ_Class_2	361	366	PF00595	0.608
LIG_Pex14_1	243	247	PF04695	0.378
LIG_Pex14_1	38	42	PF04695	0.267
LIG_PTB_Apo_2	120	127	PF02174	0.305
LIG_PTB_Apo_2	134	141	PF02174	0.313
LIG_PTB_Phospho_1	134	140	PF10480	0.406
LIG_SH2_CRK	321	325	PF00017	0.432
LIG_SH2_CRK	79	83	PF00017	0.307
LIG_SH2_CRK	99	103	PF00017	0.327
LIG_SH2_NCK_1	99	103	PF00017	0.330
LIG_SH2_PTP2	169	172	PF00017	0.355
LIG_SH2_SRC	247	250	PF00017	0.485
LIG_SH2_STAP1	113	117	PF00017	0.282
LIG_SH2_STAP1	216	220	PF00017	0.479
LIG_SH2_STAT3	183	186	PF00017	0.310
LIG_SH2_STAT5	16	19	PF00017	0.422
LIG_SH2_STAT5	169	172	PF00017	0.289
LIG_SH2_STAT5	183	186	PF00017	0.261
LIG_SH2_STAT5	223	226	PF00017	0.426
LIG_SH2_STAT5	247	250	PF00017	0.492
LIG_SH2_STAT5	310	313	PF00017	0.397
LIG_SH2_STAT5	348	351	PF00017	0.409
LIG_SH2_STAT5	354	357	PF00017	0.400
LIG_SH3_2	150	155	PF14604	0.360
LIG_SH3_3	147	153	PF00018	0.366
LIG_SH3_3	303	309	PF00018	0.542
LIG_TYR_ITIM	77	82	PF00017	0.360
LIG_UBA3_1	18	26	PF00899	0.374
LIG_UBA3_1	349	353	PF00899	0.507
MOD_CDK_SPK_2	235	240	PF00069	0.346
MOD_CK1_1	163	169	PF00069	0.307
MOD_CK1_1	293	299	PF00069	0.570
MOD_CK1_1	37	43	PF00069	0.314
MOD_CK1_1	45	51	PF00069	0.256
MOD_CK2_1	128	134	PF00069	0.267
MOD_CK2_1	341	347	PF00069	0.520
MOD_GlcNHglycan	176	179	PF01048	0.328
MOD_GlcNHglycan	256	259	PF01048	0.543
MOD_GlcNHglycan	281	284	PF01048	0.703
MOD_GlcNHglycan	292	295	PF01048	0.503
MOD_GSK3_1	189	196	PF00069	0.282
MOD_GSK3_1	285	292	PF00069	0.495
MOD_GSK3_1	293	300	PF00069	0.456
MOD_GSK3_1	30	37	PF00069	0.321
MOD_GSK3_1	310	317	PF00069	0.625
MOD_GSK3_1	86	93	PF00069	0.179
MOD_N-GLC_1	143	148	PF02516	0.307
MOD_NEK2_1	133	138	PF00069	0.267
MOD_NEK2_1	290	295	PF00069	0.595
MOD_NEK2_1	298	303	PF00069	0.528
MOD_PIKK_1	176	182	PF00454	0.372
MOD_PIKK_1	42	48	PF00454	0.173
MOD_PK_1	160	166	PF00069	0.267
MOD_PK_1	226	232	PF00069	0.287
MOD_PKA_2	359	365	PF00069	0.461
MOD_PKA_2	64	70	PF00069	0.383
MOD_PKA_2	87	93	PF00069	0.327
MOD_Plk_1	224	230	PF00069	0.355
MOD_Plk_1	243	249	PF00069	0.487
MOD_Plk_1	332	338	PF00069	0.469
MOD_Plk_1	34	40	PF00069	0.297
MOD_Plk_4	193	199	PF00069	0.339
MOD_Plk_4	243	249	PF00069	0.261
MOD_ProDKin_1	235	241	PF00069	0.397
MOD_ProDKin_1	285	291	PF00069	0.565
MOD_ProDKin_1	293	299	PF00069	0.551
MOD_SUMO_rev_2	4	14	PF00179	0.594
MOD_SUMO_rev_2	44	54	PF00179	0.402
TRG_ENDOCYTIC_2	140	143	PF00928	0.428
TRG_ENDOCYTIC_2	16	19	PF00928	0.404
TRG_ENDOCYTIC_2	321	324	PF00928	0.424
TRG_ENDOCYTIC_2	79	82	PF00928	0.307
TRG_ENDOCYTIC_2	99	102	PF00928	0.327
TRG_ER_diArg_1	159	162	PF00400	0.302
TRG_NLS_MonoExtC_3	24	29	PF00514	0.240
TRG_NLS_MonoExtN_4	22	29	PF00514	0.260
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.330
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6J9	Leptomonas seymouri	74%	99%
A0A0S4KH88	Bodo saltans	48%	93%
A0A1X0P910	Trypanosomatidae	50%	97%
A0A3Q8IBA5	Leishmania donovani	37%	100%
A0A3Q8IJ21	Leishmania donovani	82%	100%
A0A3R7KCX0	Trypanosoma rangeli	49%	100%
A4I4Z0	Leishmania infantum	82%	100%
C9ZKK9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	99%
E9AED5	Leishmania major	83%	100%
E9ALF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9ANN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
Q4QGZ1	Leishmania major	36%	100%
Q9Y365	Homo sapiens	32%	100%
V5BC62	Trypanosoma cruzi	52%	100%