Putative serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HHS9_LEIBR

TriTrypDb:

LbrM.29.2780 , LBRM2903_290034200

Length:

324

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HHS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHS9

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016310	phosphorylation	5	10
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0004674	protein serine/threonine kinase activity	4	5
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0004713	protein tyrosine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	162	164	PF00675	0.355
CLV_NRD_NRD_1	204	206	PF00675	0.386
CLV_NRD_NRD_1	23	25	PF00675	0.583
CLV_NRD_NRD_1	272	274	PF00675	0.419
CLV_NRD_NRD_1	299	301	PF00675	0.479
CLV_PCSK_KEX2_1	162	164	PF00082	0.362
CLV_PCSK_KEX2_1	204	206	PF00082	0.356
CLV_PCSK_KEX2_1	23	25	PF00082	0.583
CLV_PCSK_KEX2_1	272	274	PF00082	0.419
CLV_PCSK_KEX2_1	292	294	PF00082	0.517
CLV_PCSK_KEX2_1	299	301	PF00082	0.504
CLV_PCSK_KEX2_1	68	70	PF00082	0.353
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.368
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.353
CLV_PCSK_SKI1_1	292	296	PF00082	0.543
DEG_APCC_DBOX_1	304	312	PF00400	0.526
DEG_Nend_UBRbox_4	1	3	PF02207	0.455
DOC_ANK_TNKS_1	39	46	PF00023	0.205
DOC_MAPK_gen_1	23	29	PF00069	0.427
DOC_PP2B_LxvP_1	122	125	PF13499	0.458
DOC_USP7_MATH_1	22	26	PF00917	0.695
DOC_USP7_MATH_1	43	47	PF00917	0.215
DOC_USP7_MATH_1	86	90	PF00917	0.425
DOC_WW_Pin1_4	205	210	PF00397	0.370
DOC_WW_Pin1_4	252	257	PF00397	0.376
LIG_14-3-3_CanoR_1	23	28	PF00244	0.631
LIG_BRCT_BRCA1_1	254	258	PF00533	0.425
LIG_BRCT_BRCA1_1	4	8	PF00533	0.594
LIG_deltaCOP1_diTrp_1	100	109	PF00928	0.356
LIG_eIF4E_1	206	212	PF01652	0.425
LIG_FHA_1	130	136	PF00498	0.458
LIG_FHA_1	178	184	PF00498	0.324
LIG_FHA_1	232	238	PF00498	0.341
LIG_FHA_1	24	30	PF00498	0.545
LIG_FHA_2	236	242	PF00498	0.427
LIG_FHA_2	281	287	PF00498	0.517
LIG_LIR_Apic_2	203	209	PF02991	0.313
LIG_LIR_Gen_1	255	266	PF02991	0.425
LIG_LIR_Gen_1	275	285	PF02991	0.127
LIG_LIR_Gen_1	56	64	PF02991	0.360
LIG_LIR_Nem_3	192	197	PF02991	0.425
LIG_LIR_Nem_3	255	261	PF02991	0.357
LIG_LIR_Nem_3	275	280	PF02991	0.127
LIG_LIR_Nem_3	44	50	PF02991	0.317
LIG_LIR_Nem_3	56	60	PF02991	0.304
LIG_PCNA_yPIPBox_3	259	273	PF02747	0.205
LIG_SH2_STAT5	98	101	PF00017	0.353
LIG_SH3_3	215	221	PF00018	0.389
LIG_Sin3_3	258	265	PF02671	0.458
LIG_SUMO_SIM_par_1	25	30	PF11976	0.610
MOD_CK1_1	231	237	PF00069	0.462
MOD_CK1_1	25	31	PF00069	0.580
MOD_CK1_1	264	270	PF00069	0.341
MOD_CK1_1	287	293	PF00069	0.380
MOD_CK2_1	235	241	PF00069	0.385
MOD_CK2_1	272	278	PF00069	0.393
MOD_CK2_1	280	286	PF00069	0.492
MOD_GlcNHglycan	20	23	PF01048	0.571
MOD_GlcNHglycan	241	246	PF01048	0.363
MOD_GlcNHglycan	274	277	PF01048	0.425
MOD_GlcNHglycan	4	7	PF01048	0.703
MOD_GSK3_1	18	25	PF00069	0.581
MOD_GSK3_1	2	9	PF00069	0.588
MOD_GSK3_1	231	238	PF00069	0.341
MOD_GSK3_1	280	287	PF00069	0.405
MOD_GSK3_1	30	37	PF00069	0.307
MOD_GSK3_1	317	324	PF00069	0.709
MOD_NEK2_1	135	140	PF00069	0.344
MOD_NEK2_1	177	182	PF00069	0.464
MOD_NEK2_1	235	240	PF00069	0.278
MOD_NEK2_1	261	266	PF00069	0.425
MOD_PKA_1	23	29	PF00069	0.427
MOD_PKA_1	272	278	PF00069	0.419
MOD_PKA_2	22	28	PF00069	0.545
MOD_PKA_2	272	278	PF00069	0.386
MOD_PKA_2	30	36	PF00069	0.570
MOD_Plk_4	166	172	PF00069	0.425
MOD_Plk_4	231	237	PF00069	0.240
MOD_Plk_4	261	267	PF00069	0.434
MOD_Plk_4	284	290	PF00069	0.360
MOD_ProDKin_1	205	211	PF00069	0.370
MOD_ProDKin_1	252	258	PF00069	0.376
MOD_SUMO_for_1	155	158	PF00179	0.356
MOD_SUMO_rev_2	149	157	PF00179	0.386
TRG_DiLeu_BaLyEn_6	290	295	PF01217	0.441
TRG_ER_diArg_1	161	163	PF00400	0.408
TRG_ER_diArg_1	204	206	PF00400	0.386
TRG_ER_diArg_1	272	274	PF00400	0.419
TRG_ER_diArg_1	299	301	PF00400	0.514
TRG_Pf-PMV_PEXEL_1	163	168	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	299	303	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P215	Leptomonas seymouri	27%	100%
A0A0N0P2X9	Leptomonas seymouri	28%	99%
A0A0N0P3N5	Leptomonas seymouri	23%	76%
A0A0N0P7D2	Leptomonas seymouri	25%	100%
A0A0N0P8X6	Leptomonas seymouri	23%	84%
A0A0N1HT76	Leptomonas seymouri	25%	72%
A0A0N1I3G0	Leptomonas seymouri	25%	80%
A0A0N1I4Y7	Leptomonas seymouri	25%	96%
A0A0N1I6T8	Leptomonas seymouri	25%	100%
A0A0N1PC01	Leptomonas seymouri	67%	98%
A0A0N1PC31	Leptomonas seymouri	26%	83%
A0A0N1PD05	Leptomonas seymouri	26%	72%
A0A0S4IHW4	Bodo saltans	23%	72%
A0A0S4IQX7	Bodo saltans	23%	84%
A0A0S4IX86	Bodo saltans	25%	75%
A0A0S4J3Y5	Bodo saltans	26%	75%
A0A0S4J4B3	Bodo saltans	23%	72%
A0A0S4JCG2	Bodo saltans	27%	72%
A0A0S4JHA7	Bodo saltans	29%	70%
A0A0S4JPZ1	Bodo saltans	24%	72%
A0A0S4JU73	Bodo saltans	27%	68%
A0A0S4JUJ2	Bodo saltans	26%	100%
A0A0S4KEA4	Bodo saltans	32%	80%
A0A0S4KN74	Bodo saltans	27%	99%
A0A1X0NFW4	Trypanosomatidae	25%	68%
A0A1X0NIA0	Trypanosomatidae	27%	75%
A0A1X0NLC8	Trypanosomatidae	29%	68%
A0A1X0NQ63	Trypanosomatidae	25%	100%
A0A1X0NRZ9	Trypanosomatidae	25%	88%
A0A1X0P020	Trypanosomatidae	26%	84%
A0A1X0P3X8	Trypanosomatidae	25%	100%
A0A1X0P549	Trypanosomatidae	24%	68%
A0A1X0P919	Trypanosomatidae	27%	87%
A0A1X0P963	Trypanosomatidae	25%	67%
A0A1X0P9V2	Trypanosomatidae	48%	90%
A0A3Q8IDY1	Leishmania donovani	25%	72%
A0A3Q8IFW0	Leishmania donovani	22%	76%
A0A3Q8INQ4	Leishmania donovani	26%	83%
A0A3R7KCZ4	Trypanosoma rangeli	23%	80%
A0A3R7KRP1	Trypanosoma rangeli	27%	68%
A0A3R7M5C7	Trypanosoma rangeli	25%	100%
A0A3R7MHW5	Trypanosoma rangeli	26%	81%
A0A3R7NKI8	Trypanosoma rangeli	24%	100%
A0A3S5H606	Leishmania donovani	26%	100%
A0A3S5IRC3	Trypanosoma rangeli	28%	87%
A0A3S7WP41	Leishmania donovani	27%	100%
A0A3S7X2W9	Leishmania donovani	83%	100%
A0A3S7X6T8	Leishmania donovani	24%	72%
A0A3S7X7Y2	Leishmania donovani	26%	84%
A0A422NEU6	Trypanosoma rangeli	45%	96%
A0A422NUF0	Trypanosoma rangeli	29%	81%
A0A422P0N6	Trypanosoma rangeli	25%	100%
A4H4A1	Leishmania braziliensis	27%	100%
A4H539	Leishmania braziliensis	25%	100%
A4HAS1	Leishmania braziliensis	24%	84%
A4HCD7	Leishmania braziliensis	26%	76%
A4HFI2	Leishmania braziliensis	24%	99%
A4HHP8	Leishmania braziliensis	24%	72%
A4HJW2	Leishmania braziliensis	22%	76%
A4HLR0	Leishmania braziliensis	24%	72%
A4HSH7	Leishmania infantum	27%	100%
A4HTB4	Leishmania infantum	26%	100%
A4I1T4	Leishmania infantum	26%	83%
A4I4W3	Leishmania infantum	25%	72%
A4I4Y0	Leishmania infantum	83%	100%
A4I7C4	Leishmania infantum	22%	76%
A4I960	Leishmania infantum	24%	72%
A4I9Y5	Leishmania infantum	26%	84%
A4K2M3	Papio anubis	24%	67%
A4K2P5	Colobus guereza	24%	67%
A4K2Q5	Otolemur garnettii	24%	67%
A4K2S1	Lemur catta	24%	67%
A4K2T0	Macaca mulatta	24%	67%
A4K2W5	Aotus nancymaae	24%	67%
A4K2Y1	Chlorocebus aethiops	24%	67%
A9RWC9	Physcomitrium patens	25%	92%
B0LT89	Rattus norvegicus	25%	75%
C9ZKZ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	69%
C9ZL78	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	77%
C9ZN29	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	67%
C9ZSI7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZUK8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZW46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	68%
C9ZWI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	75%
D0A5Q8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D0A8X3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	88%
E9AEB1	Leishmania major	25%	72%
E9AED4	Leishmania major	81%	100%
E9AFZ2	Leishmania major	24%	68%
E9AKG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9ALA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9ALF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9ALH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	72%
E9ASL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	67%
E9AXW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	83%
E9AZL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B296	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	73%
E9B2B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	76%
E9B436	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	72%
E9B4Z4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	84%
O00506	Homo sapiens	25%	76%
O14305	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	69%
O14328	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	68%
O14733	Homo sapiens	28%	77%
O35942	Mus musculus	26%	73%
O43293	Homo sapiens	25%	71%
O61122	Dictyostelium discoideum	26%	68%
O61125	Dictyostelium discoideum	22%	70%
O61267	Drosophila melanogaster	25%	68%
O94768	Homo sapiens	27%	87%
P11275	Rattus norvegicus	26%	68%
P11798	Mus musculus	26%	68%
P22517	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	72%
P51953	Carassius auratus	25%	94%
P51955	Homo sapiens	26%	73%
Q00534	Homo sapiens	26%	99%
Q00771	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	27%	78%
Q03428	Trypanosoma brucei brucei	26%	75%
Q07192	Xenopus laevis	24%	73%
Q08942	Trypanosoma brucei brucei	26%	75%
Q09170	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	70%
Q13043	Homo sapiens	24%	67%
Q20085	Caenorhabditis elegans	24%	69%
Q21307	Caenorhabditis elegans	27%	93%
Q2HJF7	Bos taurus	26%	66%
Q3SWY6	Bos taurus	27%	76%
Q4KSH7	Rattus norvegicus	28%	77%
Q4Q2Z2	Leishmania major	25%	84%
Q4Q3Y9	Leishmania major	24%	72%
Q4Q5T9	Leishmania major	22%	76%
Q4Q5W2	Leishmania major	24%	73%
Q4Q9K2	Leishmania major	25%	84%
Q4QBQ2	Leishmania major	28%	91%
Q4QIJ7	Leishmania major	26%	100%
Q4QJE7	Leishmania major	27%	100%
Q52WX2	Homo sapiens	24%	76%
Q54E34	Dictyostelium discoideum	29%	92%
Q54JG7	Dictyostelium discoideum	24%	67%
Q55BN8	Dictyostelium discoideum	27%	78%
Q5E9L6	Bos taurus	24%	67%
Q5HZ38	Arabidopsis thaliana	26%	80%
Q5RCC4	Pongo abelii	26%	68%
Q5ZJK4	Gallus gallus	23%	67%
Q5ZKI0	Gallus gallus	26%	68%
Q64261	Mus musculus	28%	99%
Q6BVA0	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	25%	79%
Q6CWQ4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	90%
Q6P3Q4	Xenopus tropicalis	25%	67%
Q6PA14	Xenopus laevis	25%	67%
Q6Z8C8	Oryza sativa subsp. japonica	25%	71%
Q755C4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	26%	88%
Q7T6Y1	Acanthamoeba polyphaga mimivirus	24%	100%
Q8BG48	Mus musculus	26%	87%
Q8MYQ1	Caenorhabditis elegans	27%	73%
Q8QZX0	Mus musculus	24%	78%
Q8RWC9	Arabidopsis thaliana	27%	73%
Q91XS8	Rattus norvegicus	26%	87%
Q925K9	Mus musculus	28%	100%
Q93V58	Arabidopsis thaliana	26%	82%
Q99JT2	Mus musculus	24%	78%
Q99KH8	Mus musculus	25%	75%
Q9BXA6	Homo sapiens	28%	100%
Q9DG02	Xenopus laevis	26%	68%
Q9ESG9	Mus musculus	30%	66%
Q9JI11	Mus musculus	24%	67%
Q9JJX8	Mus musculus	23%	78%
Q9LQQ9	Arabidopsis thaliana	25%	89%
Q9LT35	Arabidopsis thaliana	27%	78%
Q9NY57	Homo sapiens	23%	78%
Q9P1W9	Homo sapiens	29%	100%
Q9P289	Homo sapiens	24%	78%
Q9S7U9	Arabidopsis thaliana	24%	89%
Q9UQM7	Homo sapiens	26%	68%
Q9VWQ2	Drosophila melanogaster	28%	67%
Q9Y6E0	Homo sapiens	25%	73%
Q9Y899	Emericella nidulans	25%	80%
Q9Z2W1	Mus musculus	25%	76%
Q9Z335	Rattus norvegicus	25%	78%
V5B871	Trypanosoma cruzi	23%	76%
V5B8E0	Trypanosoma cruzi	29%	92%
V5B9R6	Trypanosoma cruzi	25%	92%
V5BG98	Trypanosoma cruzi	26%	100%
V5BNV8	Trypanosoma cruzi	24%	100%
V5BQF4	Trypanosoma cruzi	26%	87%
V5BSM0	Trypanosoma cruzi	45%	77%
V5BV49	Trypanosoma cruzi	24%	100%
V5D579	Trypanosoma cruzi	25%	75%