Beta_helix domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Right handed beta helix region, putative

Species:

Leishmania braziliensis

UniProt:

A4HHS8_LEIBR

TriTrypDb:

LbrM.29.2770 , LBRM2903_290034100

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHS8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	199	201	PF00675	0.302
CLV_NRD_NRD_1	93	95	PF00675	0.274
DOC_MAPK_gen_1	200	206	PF00069	0.313
DOC_MAPK_RevD_3	80	95	PF00069	0.217
DOC_USP7_MATH_1	57	61	PF00917	0.639
DOC_WW_Pin1_4	24	29	PF00397	0.325
DOC_WW_Pin1_4	269	274	PF00397	0.449
LIG_14-3-3_CanoR_1	215	220	PF00244	0.475
LIG_APCC_ABBA_1	179	184	PF00400	0.417
LIG_FHA_1	117	123	PF00498	0.414
LIG_FHA_1	262	268	PF00498	0.501
LIG_FHA_1	29	35	PF00498	0.395
LIG_FHA_1	3	9	PF00498	0.445
LIG_FHA_1	40	46	PF00498	0.412
LIG_FHA_1	61	67	PF00498	0.517
LIG_FHA_1	71	77	PF00498	0.328
LIG_FHA_2	25	31	PF00498	0.309
LIG_LIR_Nem_3	143	147	PF02991	0.435
LIG_LIR_Nem_3	176	182	PF02991	0.314
LIG_LIR_Nem_3	218	224	PF02991	0.522
LIG_REV1ctd_RIR_1	225	235	PF16727	0.377
LIG_SH2_STAP1	183	187	PF00017	0.441
LIG_SH2_STAT5	138	141	PF00017	0.329
LIG_SH2_STAT5	205	208	PF00017	0.289
LIG_SH3_3	4	10	PF00018	0.549
LIG_SUMO_SIM_par_1	118	125	PF11976	0.303
LIG_SUMO_SIM_par_1	262	269	PF11976	0.318
LIG_SUMO_SIM_par_1	30	35	PF11976	0.350
MOD_CK1_1	235	241	PF00069	0.379
MOD_CK1_1	269	275	PF00069	0.390
MOD_CK1_1	60	66	PF00069	0.673
MOD_CK2_1	140	146	PF00069	0.308
MOD_GlcNHglycan	237	240	PF01048	0.451
MOD_GlcNHglycan	261	264	PF01048	0.476
MOD_GlcNHglycan	268	271	PF01048	0.551
MOD_GlcNHglycan	34	37	PF01048	0.547
MOD_GSK3_1	118	125	PF00069	0.204
MOD_GSK3_1	238	245	PF00069	0.409
MOD_GSK3_1	24	31	PF00069	0.481
MOD_GSK3_1	62	69	PF00069	0.512
MOD_N-GLC_1	47	52	PF02516	0.415
MOD_N-GLC_1	78	83	PF02516	0.349
MOD_NEK2_1	140	145	PF00069	0.356
MOD_NEK2_1	227	232	PF00069	0.404
MOD_NEK2_1	23	28	PF00069	0.328
MOD_NEK2_1	242	247	PF00069	0.299
MOD_NEK2_1	39	44	PF00069	0.504
MOD_NEK2_1	47	52	PF00069	0.458
MOD_NEK2_2	118	123	PF00069	0.308
MOD_PIKK_1	145	151	PF00454	0.302
MOD_PKA_2	66	72	PF00069	0.383
MOD_Plk_1	39	45	PF00069	0.375
MOD_Plk_1	47	53	PF00069	0.323
MOD_Plk_1	78	84	PF00069	0.308
MOD_Plk_2-3	192	198	PF00069	0.289
MOD_Plk_4	2	8	PF00069	0.488
MOD_Plk_4	28	34	PF00069	0.464
MOD_Plk_4	66	72	PF00069	0.498
MOD_ProDKin_1	24	30	PF00069	0.316
MOD_ProDKin_1	269	275	PF00069	0.450
TRG_DiLeu_BaEn_1	41	46	PF01217	0.248

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL58	Leptomonas seymouri	56%	99%
A0A0S4KFM6	Bodo saltans	38%	100%
A0A1X0P907	Trypanosomatidae	48%	100%
A0A3Q8IDZ0	Leishmania donovani	81%	100%
A0A422NEU4	Trypanosoma rangeli	47%	100%
A4I4X9	Leishmania infantum	81%	100%
C9ZKL1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AED3	Leishmania major	82%	100%
E9ALF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
V5C239	Trypanosoma cruzi	47%	100%