RAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHS7_LEIBR

TriTrypDb:

LbrM.29.2760 , LBRM2903_290034000

Length:

992

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHS7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.366
CLV_NRD_NRD_1	209	211	PF00675	0.402
CLV_NRD_NRD_1	7	9	PF00675	0.478
CLV_NRD_NRD_1	739	741	PF00675	0.447
CLV_NRD_NRD_1	953	955	PF00675	0.381
CLV_NRD_NRD_1	96	98	PF00675	0.367
CLV_PCSK_FUR_1	303	307	PF00082	0.291
CLV_PCSK_KEX2_1	102	104	PF00082	0.366
CLV_PCSK_KEX2_1	199	201	PF00082	0.482
CLV_PCSK_KEX2_1	209	211	PF00082	0.453
CLV_PCSK_KEX2_1	305	307	PF00082	0.397
CLV_PCSK_KEX2_1	519	521	PF00082	0.358
CLV_PCSK_KEX2_1	54	56	PF00082	0.290
CLV_PCSK_KEX2_1	7	9	PF00082	0.478
CLV_PCSK_KEX2_1	739	741	PF00082	0.455
CLV_PCSK_KEX2_1	953	955	PF00082	0.381
CLV_PCSK_KEX2_1	96	98	PF00082	0.330
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.453
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.311
CLV_PCSK_PC1ET2_1	519	521	PF00082	0.358
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.290
CLV_PCSK_SKI1_1	106	110	PF00082	0.403
CLV_PCSK_SKI1_1	236	240	PF00082	0.437
CLV_PCSK_SKI1_1	275	279	PF00082	0.414
CLV_PCSK_SKI1_1	298	302	PF00082	0.423
CLV_PCSK_SKI1_1	410	414	PF00082	0.365
CLV_PCSK_SKI1_1	513	517	PF00082	0.315
CLV_PCSK_SKI1_1	526	530	PF00082	0.330
CLV_PCSK_SKI1_1	545	549	PF00082	0.296
CLV_PCSK_SKI1_1	566	570	PF00082	0.371
CLV_PCSK_SKI1_1	574	578	PF00082	0.280
CLV_PCSK_SKI1_1	7	11	PF00082	0.476
CLV_PCSK_SKI1_1	80	84	PF00082	0.343
CLV_PCSK_SKI1_1	821	825	PF00082	0.320
CLV_PCSK_SKI1_1	920	924	PF00082	0.452
CLV_PCSK_SKI1_1	975	979	PF00082	0.490
DEG_APCC_DBOX_1	235	243	PF00400	0.654
DEG_APCC_DBOX_1	573	581	PF00400	0.635
DEG_APCC_DBOX_1	672	680	PF00400	0.630
DEG_APCC_DBOX_1	79	87	PF00400	0.578
DEG_APCC_DBOX_1	820	828	PF00400	0.494
DEG_Nend_Nbox_1	1	3	PF02207	0.767
DEG_SPOP_SBC_1	787	791	PF00917	0.498
DOC_ANK_TNKS_1	772	779	PF00023	0.688
DOC_CKS1_1	693	698	PF01111	0.614
DOC_CYCLIN_RxL_1	272	282	PF00134	0.651
DOC_CYCLIN_RxL_1	5	13	PF00134	0.645
DOC_CYCLIN_yCln2_LP_2	271	274	PF00134	0.645
DOC_CYCLIN_yCln2_LP_2	588	591	PF00134	0.511
DOC_CYCLIN_yCln2_LP_2	687	693	PF00134	0.554
DOC_CYCLIN_yCln2_LP_2	762	768	PF00134	0.471
DOC_CYCLIN_yCln2_LP_2	848	854	PF00134	0.519
DOC_MAPK_gen_1	102	111	PF00069	0.575
DOC_MAPK_gen_1	243	252	PF00069	0.628
DOC_MAPK_gen_1	5	14	PF00069	0.674
DOC_MAPK_gen_1	519	527	PF00069	0.545
DOC_MAPK_gen_1	862	871	PF00069	0.383
DOC_MAPK_MEF2A_6	5	14	PF00069	0.673
DOC_MAPK_MEF2A_6	520	529	PF00069	0.639
DOC_MAPK_MEF2A_6	755	764	PF00069	0.468
DOC_MAPK_MEF2A_6	862	871	PF00069	0.357
DOC_MAPK_NFAT4_5	7	15	PF00069	0.551
DOC_PP2B_LxvP_1	271	274	PF13499	0.569
DOC_PP2B_LxvP_1	588	591	PF13499	0.511
DOC_PP2B_LxvP_1	686	689	PF13499	0.679
DOC_PP2B_LxvP_1	762	765	PF13499	0.618
DOC_PP2B_LxvP_1	769	772	PF13499	0.617
DOC_PP4_FxxP_1	648	651	PF00568	0.669
DOC_USP7_MATH_1	110	114	PF00917	0.604
DOC_USP7_MATH_1	40	44	PF00917	0.760
DOC_USP7_MATH_1	537	541	PF00917	0.657
DOC_USP7_MATH_1	582	586	PF00917	0.638
DOC_USP7_MATH_1	748	752	PF00917	0.609
DOC_USP7_MATH_1	82	86	PF00917	0.566
DOC_USP7_MATH_1	852	856	PF00917	0.397
DOC_USP7_MATH_1	918	922	PF00917	0.659
DOC_USP7_MATH_2	765	771	PF00917	0.657
DOC_WW_Pin1_4	181	186	PF00397	0.485
DOC_WW_Pin1_4	230	235	PF00397	0.666
DOC_WW_Pin1_4	36	41	PF00397	0.698
DOC_WW_Pin1_4	689	694	PF00397	0.721
DOC_WW_Pin1_4	90	95	PF00397	0.619
LIG_14-3-3_CanoR_1	141	150	PF00244	0.626
LIG_14-3-3_CanoR_1	167	172	PF00244	0.549
LIG_14-3-3_CanoR_1	17	25	PF00244	0.686
LIG_14-3-3_CanoR_1	27	37	PF00244	0.766
LIG_14-3-3_CanoR_1	306	315	PF00244	0.543
LIG_14-3-3_CanoR_1	385	393	PF00244	0.562
LIG_14-3-3_CanoR_1	436	444	PF00244	0.463
LIG_14-3-3_CanoR_1	545	551	PF00244	0.590
LIG_14-3-3_CanoR_1	566	576	PF00244	0.658
LIG_14-3-3_CanoR_1	673	679	PF00244	0.612
LIG_14-3-3_CanoR_1	739	744	PF00244	0.618
LIG_14-3-3_CanoR_1	783	788	PF00244	0.513
LIG_14-3-3_CanoR_1	96	105	PF00244	0.587
LIG_APCC_ABBA_1	129	134	PF00400	0.636
LIG_BIR_III_2	533	537	PF00653	0.628
LIG_BRCT_BRCA1_1	17	21	PF00533	0.664
LIG_BRCT_BRCA1_1	309	313	PF00533	0.461
LIG_BRCT_BRCA1_1	712	716	PF00533	0.474
LIG_BRCT_BRCA1_1	813	817	PF00533	0.618
LIG_BRCT_BRCA1_1	843	847	PF00533	0.444
LIG_CaM_NSCaTE_8	556	563	PF13499	0.623
LIG_deltaCOP1_diTrp_1	655	662	PF00928	0.473
LIG_EH1_1	726	734	PF00400	0.474
LIG_eIF4E_1	727	733	PF01652	0.471
LIG_EVH1_2	717	721	PF00568	0.632
LIG_FHA_1	124	130	PF00498	0.571
LIG_FHA_1	158	164	PF00498	0.597
LIG_FHA_1	187	193	PF00498	0.468
LIG_FHA_1	259	265	PF00498	0.559
LIG_FHA_1	376	382	PF00498	0.554
LIG_FHA_1	432	438	PF00498	0.591
LIG_FHA_1	458	464	PF00498	0.608
LIG_FHA_1	509	515	PF00498	0.573
LIG_FHA_1	570	576	PF00498	0.584
LIG_FHA_1	777	783	PF00498	0.598
LIG_FHA_2	280	286	PF00498	0.669
LIG_FHA_2	352	358	PF00498	0.661
LIG_FHA_2	611	617	PF00498	0.613
LIG_FHA_2	82	88	PF00498	0.633
LIG_GBD_Chelix_1	465	473	PF00786	0.387
LIG_GBD_Chelix_1	542	550	PF00786	0.408
LIG_LIR_Apic_2	646	651	PF02991	0.665
LIG_LIR_Apic_2	65	71	PF02991	0.619
LIG_LIR_Gen_1	186	195	PF02991	0.633
LIG_LIR_Gen_1	453	461	PF02991	0.569
LIG_LIR_Gen_1	655	665	PF02991	0.508
LIG_LIR_Gen_1	759	769	PF02991	0.469
LIG_LIR_Gen_1	897	908	PF02991	0.565
LIG_LIR_Gen_1	942	951	PF02991	0.580
LIG_LIR_LC3C_4	803	807	PF02991	0.449
LIG_LIR_Nem_3	18	24	PF02991	0.662
LIG_LIR_Nem_3	186	191	PF02991	0.635
LIG_LIR_Nem_3	424	430	PF02991	0.606
LIG_LIR_Nem_3	453	457	PF02991	0.578
LIG_LIR_Nem_3	623	628	PF02991	0.598
LIG_LIR_Nem_3	703	707	PF02991	0.523
LIG_LIR_Nem_3	759	764	PF02991	0.530
LIG_LIR_Nem_3	844	850	PF02991	0.485
LIG_LIR_Nem_3	855	861	PF02991	0.440
LIG_LIR_Nem_3	883	889	PF02991	0.476
LIG_LIR_Nem_3	897	903	PF02991	0.586
LIG_LIR_Nem_3	929	934	PF02991	0.598
LIG_LIR_Nem_3	942	947	PF02991	0.403
LIG_MLH1_MIPbox_1	18	22	PF16413	0.609
LIG_NRBOX	292	298	PF00104	0.663
LIG_NRBOX	511	517	PF00104	0.600
LIG_NRBOX	682	688	PF00104	0.668
LIG_Pex14_2	183	187	PF04695	0.658
LIG_Pex14_2	662	666	PF04695	0.627
LIG_Rb_pABgroove_1	248	256	PF01858	0.654
LIG_REV1ctd_RIR_1	883	892	PF16727	0.557
LIG_RPA_C_Fungi	735	747	PF08784	0.548
LIG_SH2_CRK	809	813	PF00017	0.467
LIG_SH2_NCK_1	454	458	PF00017	0.619
LIG_SH2_PTP2	68	71	PF00017	0.611
LIG_SH2_PTP2	877	880	PF00017	0.485
LIG_SH2_SRC	114	117	PF00017	0.341
LIG_SH2_SRC	68	71	PF00017	0.611
LIG_SH2_STAP1	859	863	PF00017	0.537
LIG_SH2_STAP1	889	893	PF00017	0.500
LIG_SH2_STAT5	114	117	PF00017	0.515
LIG_SH2_STAT5	165	168	PF00017	0.311
LIG_SH2_STAT5	375	378	PF00017	0.406
LIG_SH2_STAT5	430	433	PF00017	0.518
LIG_SH2_STAT5	68	71	PF00017	0.611
LIG_SH2_STAT5	727	730	PF00017	0.404
LIG_SH2_STAT5	761	764	PF00017	0.410
LIG_SH2_STAT5	792	795	PF00017	0.354
LIG_SH2_STAT5	877	880	PF00017	0.446
LIG_SH3_3	144	150	PF00018	0.366
LIG_SH3_3	325	331	PF00018	0.559
LIG_SH3_3	34	40	PF00018	0.747
LIG_SH3_3	426	432	PF00018	0.503
LIG_SH3_3	487	493	PF00018	0.337
LIG_SH3_3	647	653	PF00018	0.559
LIG_SH3_3	687	693	PF00018	0.644
LIG_SH3_3	870	876	PF00018	0.357
LIG_SH3_3	930	936	PF00018	0.600
LIG_SUMO_SIM_anti_2	268	273	PF11976	0.574
LIG_SUMO_SIM_anti_2	569	579	PF11976	0.307
LIG_SUMO_SIM_par_1	167	173	PF11976	0.510
LIG_SUMO_SIM_par_1	618	623	PF11976	0.322
LIG_TRAF2_1	911	914	PF00917	0.535
LIG_TRFH_1	847	851	PF08558	0.401
LIG_TYR_ITIM	163	168	PF00017	0.286
LIG_TYR_ITIM	702	707	PF00017	0.537
LIG_TYR_ITIM	764	769	PF00017	0.524
LIG_WW_3	272	276	PF00397	0.532
LIG_WW_3	493	497	PF00397	0.511
MOD_CDC14_SPxK_1	93	96	PF00782	0.522
MOD_CDK_SPxK_1	230	236	PF00069	0.423
MOD_CDK_SPxK_1	90	96	PF00069	0.523
MOD_CDK_SPxxK_3	692	699	PF00069	0.516
MOD_CDK_SPxxK_3	90	97	PF00069	0.483
MOD_CK1_1	170	176	PF00069	0.516
MOD_CK1_1	179	185	PF00069	0.441
MOD_CK1_1	265	271	PF00069	0.548
MOD_CK1_1	348	354	PF00069	0.392
MOD_CK1_1	386	392	PF00069	0.398
MOD_CK1_1	570	576	PF00069	0.563
MOD_CK1_1	677	683	PF00069	0.532
MOD_CK1_1	692	698	PF00069	0.501
MOD_CK1_1	734	740	PF00069	0.549
MOD_CK1_1	751	757	PF00069	0.583
MOD_CK1_1	786	792	PF00069	0.563
MOD_CK1_1	840	846	PF00069	0.376
MOD_CK1_1	92	98	PF00069	0.316
MOD_CK2_1	155	161	PF00069	0.603
MOD_CK2_1	191	197	PF00069	0.557
MOD_CK2_1	279	285	PF00069	0.576
MOD_CK2_1	351	357	PF00069	0.546
MOD_CK2_1	610	616	PF00069	0.508
MOD_CK2_1	81	87	PF00069	0.544
MOD_CK2_1	908	914	PF00069	0.590
MOD_Cter_Amidation	737	740	PF01082	0.313
MOD_GlcNHglycan	119	123	PF01048	0.341
MOD_GlcNHglycan	18	21	PF01048	0.678
MOD_GlcNHglycan	331	334	PF01048	0.552
MOD_GlcNHglycan	369	372	PF01048	0.476
MOD_GlcNHglycan	388	392	PF01048	0.333
MOD_GlcNHglycan	475	478	PF01048	0.476
MOD_GlcNHglycan	490	493	PF01048	0.490
MOD_GlcNHglycan	539	542	PF01048	0.484
MOD_GlcNHglycan	584	587	PF01048	0.460
MOD_GlcNHglycan	597	600	PF01048	0.316
MOD_GlcNHglycan	750	753	PF01048	0.514
MOD_GlcNHglycan	785	788	PF01048	0.488
MOD_GlcNHglycan	802	805	PF01048	0.470
MOD_GlcNHglycan	813	816	PF01048	0.395
MOD_GlcNHglycan	818	821	PF01048	0.271
MOD_GlcNHglycan	843	846	PF01048	0.338
MOD_GlcNHglycan	852	855	PF01048	0.473
MOD_GlcNHglycan	894	897	PF01048	0.590
MOD_GlcNHglycan	910	913	PF01048	0.468
MOD_GlcNHglycan	980	983	PF01048	0.630
MOD_GSK3_1	258	265	PF00069	0.499
MOD_GSK3_1	344	351	PF00069	0.384
MOD_GSK3_1	36	43	PF00069	0.591
MOD_GSK3_1	383	390	PF00069	0.622
MOD_GSK3_1	457	464	PF00069	0.549
MOD_GSK3_1	537	544	PF00069	0.524
MOD_GSK3_1	566	573	PF00069	0.470
MOD_GSK3_1	620	627	PF00069	0.329
MOD_GSK3_1	674	681	PF00069	0.502
MOD_GSK3_1	778	785	PF00069	0.551
MOD_GSK3_1	811	818	PF00069	0.318
MOD_GSK3_1	837	844	PF00069	0.373
MOD_GSK3_1	850	857	PF00069	0.350
MOD_GSK3_1	92	99	PF00069	0.436
MOD_N-GLC_1	230	235	PF02516	0.385
MOD_N-GLC_1	413	418	PF02516	0.510
MOD_N-GLC_1	461	466	PF02516	0.478
MOD_NEK2_1	1	6	PF00069	0.582
MOD_NEK2_1	10	15	PF00069	0.506
MOD_NEK2_1	257	262	PF00069	0.467
MOD_NEK2_1	278	283	PF00069	0.448
MOD_NEK2_1	313	318	PF00069	0.418
MOD_NEK2_1	344	349	PF00069	0.471
MOD_NEK2_1	413	418	PF00069	0.437
MOD_NEK2_1	473	478	PF00069	0.450
MOD_NEK2_1	488	493	PF00069	0.532
MOD_NEK2_1	503	508	PF00069	0.492
MOD_NEK2_1	546	551	PF00069	0.553
MOD_NEK2_1	610	615	PF00069	0.490
MOD_NEK2_1	624	629	PF00069	0.279
MOD_NEK2_1	678	683	PF00069	0.489
MOD_NEK2_1	710	715	PF00069	0.486
MOD_NEK2_1	723	728	PF00069	0.450
MOD_NEK2_1	816	821	PF00069	0.435
MOD_NEK2_1	880	885	PF00069	0.397
MOD_NEK2_1	89	94	PF00069	0.443
MOD_NEK2_1	907	912	PF00069	0.382
MOD_NEK2_1	949	954	PF00069	0.508
MOD_NEK2_2	508	513	PF00069	0.383
MOD_NEK2_2	778	783	PF00069	0.594
MOD_NEK2_2	918	923	PF00069	0.586
MOD_PIKK_1	141	147	PF00454	0.531
MOD_PIKK_1	263	269	PF00454	0.481
MOD_PIKK_1	375	381	PF00454	0.445
MOD_PIKK_1	561	567	PF00454	0.339
MOD_PK_1	167	173	PF00069	0.425
MOD_PK_1	739	745	PF00069	0.522
MOD_PKA_1	739	745	PF00069	0.558
MOD_PKA_1	96	102	PF00069	0.410
MOD_PKA_2	16	22	PF00069	0.647
MOD_PKA_2	367	373	PF00069	0.524
MOD_PKA_2	384	390	PF00069	0.345
MOD_PKA_2	739	745	PF00069	0.496
MOD_PKA_2	782	788	PF00069	0.586
MOD_PKA_2	96	102	PF00069	0.393
MOD_Plk_1	413	419	PF00069	0.491
MOD_Plk_1	461	467	PF00069	0.502
MOD_Plk_1	570	576	PF00069	0.568
MOD_Plk_1	620	626	PF00069	0.558
MOD_Plk_1	658	664	PF00069	0.451
MOD_Plk_4	10	16	PF00069	0.628
MOD_Plk_4	110	116	PF00069	0.473
MOD_Plk_4	125	131	PF00069	0.388
MOD_Plk_4	620	626	PF00069	0.485
MOD_Plk_4	643	649	PF00069	0.475
MOD_Plk_4	674	680	PF00069	0.432
MOD_Plk_4	723	729	PF00069	0.489
MOD_Plk_4	739	745	PF00069	0.517
MOD_Plk_4	756	762	PF00069	0.423
MOD_Plk_4	788	794	PF00069	0.384
MOD_Plk_4	854	860	PF00069	0.548
MOD_Plk_4	881	887	PF00069	0.380
MOD_ProDKin_1	181	187	PF00069	0.328
MOD_ProDKin_1	230	236	PF00069	0.588
MOD_ProDKin_1	36	42	PF00069	0.633
MOD_ProDKin_1	689	695	PF00069	0.662
MOD_ProDKin_1	90	96	PF00069	0.523
MOD_SUMO_rev_2	193	201	PF00179	0.590
TRG_DiLeu_BaEn_1	396	401	PF01217	0.340
TRG_DiLeu_BaEn_1	433	438	PF01217	0.482
TRG_DiLeu_BaEn_1	484	489	PF01217	0.512
TRG_DiLeu_BaEn_1	703	708	PF01217	0.410
TRG_DiLeu_BaEn_2	794	800	PF01217	0.333
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.527
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.582
TRG_DiLeu_BaLyEn_6	542	547	PF01217	0.552
TRG_DiLeu_BaLyEn_6	876	881	PF01217	0.369
TRG_DiLeu_LyEn_5	433	438	PF01217	0.482
TRG_ENDOCYTIC_2	165	168	PF00928	0.273
TRG_ENDOCYTIC_2	454	457	PF00928	0.353
TRG_ENDOCYTIC_2	704	707	PF00928	0.368
TRG_ENDOCYTIC_2	761	764	PF00928	0.466
TRG_ENDOCYTIC_2	766	769	PF00928	0.487
TRG_ENDOCYTIC_2	877	880	PF00928	0.477
TRG_ENDOCYTIC_2	944	947	PF00928	0.507
TRG_ER_diArg_1	102	104	PF00400	0.487
TRG_ER_diArg_1	208	210	PF00400	0.401
TRG_ER_diArg_1	739	741	PF00400	0.590
TRG_ER_diArg_1	863	866	PF00400	0.500
TRG_Pf-PMV_PEXEL_1	102	107	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	513	517	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	566	571	PF00026	0.366
TRG_Pf-PMV_PEXEL_1	626	630	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	920	925	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY92	Leptomonas seymouri	46%	98%
A0A1X0P9B3	Trypanosomatidae	24%	99%
A0A3S7X2T5	Leishmania donovani	78%	100%
A0A422NEU9	Trypanosoma rangeli	26%	99%
A4I4X8	Leishmania infantum	78%	100%
C9ZKL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	97%
E9AED2	Leishmania major	77%	100%
E9ALF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%