DAZ-associated protein 2

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHS6_LEIBR

TriTrypDb:

LbrM.29.2750 , LBRM2903_290033900

Length:

309

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHS6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	5	7	PF00675	0.610
DEG_COP1_1	200	208	PF00400	0.527
DEG_SPOP_SBC_1	143	147	PF00917	0.502
DEG_SPOP_SBC_1	170	174	PF00917	0.601
DOC_CKS1_1	205	210	PF01111	0.521
DOC_CKS1_1	295	300	PF01111	0.534
DOC_PP2B_LxvP_1	191	194	PF13499	0.525
DOC_PP2B_LxvP_1	51	54	PF13499	0.600
DOC_PP4_FxxP_1	79	82	PF00568	0.657
DOC_PP4_MxPP_1	97	100	PF00568	0.612
DOC_USP7_MATH_1	114	118	PF00917	0.628
DOC_USP7_MATH_1	12	16	PF00917	0.625
DOC_USP7_MATH_1	143	147	PF00917	0.518
DOC_USP7_MATH_1	170	174	PF00917	0.655
DOC_USP7_MATH_1	206	210	PF00917	0.594
DOC_USP7_MATH_1	216	220	PF00917	0.627
DOC_USP7_MATH_1	254	258	PF00917	0.706
DOC_USP7_MATH_1	286	290	PF00917	0.611
DOC_WW_Pin1_4	108	113	PF00397	0.663
DOC_WW_Pin1_4	144	149	PF00397	0.600
DOC_WW_Pin1_4	165	170	PF00397	0.599
DOC_WW_Pin1_4	189	194	PF00397	0.633
DOC_WW_Pin1_4	204	209	PF00397	0.680
DOC_WW_Pin1_4	294	299	PF00397	0.536
DOC_WW_Pin1_4	52	57	PF00397	0.455
DOC_WW_Pin1_4	62	67	PF00397	0.452
DOC_WW_Pin1_4	68	73	PF00397	0.471
DOC_WW_Pin1_4	86	91	PF00397	0.569
LIG_AP2alpha_2	240	242	PF02296	0.534
LIG_BIR_III_2	34	38	PF00653	0.565
LIG_BRCT_BRCA1_1	191	195	PF00533	0.669
LIG_CSL_BTD_1	92	95	PF09270	0.584
LIG_CtBP_PxDLS_1	188	192	PF00389	0.528
LIG_FHA_1	145	151	PF00498	0.513
LIG_FHA_1	173	179	PF00498	0.545
LIG_FHA_1	297	303	PF00498	0.611
LIG_FHA_2	219	225	PF00498	0.579
LIG_FHA_2	295	301	PF00498	0.553
LIG_LIR_Nem_3	25	30	PF02991	0.497
LIG_MYND_1	189	193	PF01753	0.530
LIG_SH2_CRK	133	137	PF00017	0.516
LIG_SH2_CRK	64	68	PF00017	0.511
LIG_SH2_NCK_1	253	257	PF00017	0.597
LIG_SH2_PTP2	128	131	PF00017	0.433
LIG_SH2_STAT3	115	118	PF00017	0.619
LIG_SH2_STAT3	60	63	PF00017	0.541
LIG_SH2_STAT5	115	118	PF00017	0.630
LIG_SH2_STAT5	128	131	PF00017	0.461
LIG_SH2_STAT5	171	174	PF00017	0.673
LIG_SH3_3	126	132	PF00018	0.594
LIG_SH3_3	202	208	PF00018	0.706
LIG_SH3_3	226	232	PF00018	0.643
LIG_SH3_3	235	241	PF00018	0.592
LIG_SH3_3	244	250	PF00018	0.530
LIG_SH3_3	46	52	PF00018	0.470
LIG_SH3_3	53	59	PF00018	0.445
LIG_SH3_3	96	102	PF00018	0.545
LIG_SUMO_SIM_par_1	268	275	PF11976	0.512
LIG_TRAF2_1	266	269	PF00917	0.493
LIG_WRC_WIRS_1	27	32	PF05994	0.491
MOD_CK1_1	106	112	PF00069	0.507
MOD_CK1_1	200	206	PF00069	0.662
MOD_CK1_1	219	225	PF00069	0.524
MOD_CK1_1	22	28	PF00069	0.581
MOD_CK1_1	272	278	PF00069	0.669
MOD_CK1_1	289	295	PF00069	0.515
MOD_CK2_1	218	224	PF00069	0.578
MOD_GlcNHglycan	158	161	PF01048	0.706
MOD_GlcNHglycan	182	185	PF01048	0.821
MOD_GlcNHglycan	208	211	PF01048	0.618
MOD_GlcNHglycan	224	228	PF01048	0.470
MOD_GlcNHglycan	256	259	PF01048	0.611
MOD_GSK3_1	139	146	PF00069	0.488
MOD_GSK3_1	165	172	PF00069	0.608
MOD_GSK3_1	178	185	PF00069	0.732
MOD_GSK3_1	197	204	PF00069	0.614
MOD_GSK3_1	219	226	PF00069	0.654
MOD_GSK3_1	22	29	PF00069	0.680
MOD_GSK3_1	248	255	PF00069	0.658
MOD_GSK3_1	82	89	PF00069	0.617
MOD_N-GLC_1	106	111	PF02516	0.648
MOD_N-GLC_1	189	194	PF02516	0.669
MOD_N-GLC_1	201	206	PF02516	0.592
MOD_NEK2_1	1	6	PF00069	0.560
MOD_NEK2_1	139	144	PF00069	0.630
MOD_NEK2_1	150	155	PF00069	0.557
MOD_NEK2_1	178	183	PF00069	0.622
MOD_NEK2_1	77	82	PF00069	0.511
MOD_PIKK_1	114	120	PF00454	0.617
MOD_PIKK_1	12	18	PF00454	0.533
MOD_PIKK_1	248	254	PF00454	0.543
MOD_PIKK_1	286	292	PF00454	0.672
MOD_PKA_2	22	28	PF00069	0.569
MOD_Plk_1	106	112	PF00069	0.649
MOD_Plk_1	201	207	PF00069	0.523
MOD_Plk_1	223	229	PF00069	0.643
MOD_Plk_1	43	49	PF00069	0.476
MOD_Plk_4	231	237	PF00069	0.495
MOD_Plk_4	26	32	PF00069	0.491
MOD_Plk_4	43	49	PF00069	0.499
MOD_ProDKin_1	108	114	PF00069	0.660
MOD_ProDKin_1	144	150	PF00069	0.602
MOD_ProDKin_1	165	171	PF00069	0.602
MOD_ProDKin_1	189	195	PF00069	0.634
MOD_ProDKin_1	204	210	PF00069	0.679
MOD_ProDKin_1	294	300	PF00069	0.538
MOD_ProDKin_1	52	58	PF00069	0.454
MOD_ProDKin_1	62	68	PF00069	0.451
MOD_ProDKin_1	86	92	PF00069	0.572
TRG_DiLeu_BaEn_1	43	48	PF01217	0.478
TRG_ENDOCYTIC_2	128	131	PF00928	0.517
TRG_ENDOCYTIC_2	39	42	PF00928	0.490
TRG_ENDOCYTIC_2	64	67	PF00928	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCA0	Leptomonas seymouri	43%	99%
A0A3S7X2X0	Leishmania donovani	69%	100%
A4I4X7	Leishmania infantum	69%	100%
E9AED1	Leishmania major	68%	100%
E9ALF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%