FYVE-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3',5'-cyclic nucleotide phosphodiesterase, putative

Species:

Leishmania braziliensis

UniProt:

A4HHS5_LEIBR

TriTrypDb:

LbrM.29.2740 , LBRM2903_290033800

Length:

1081

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHS5

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	7
GO:0009987	cellular process	1	7
GO:0050789	regulation of biological process	2	7
GO:0050794	regulation of cellular process	3	7
GO:0065007	biological regulation	1	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004112	cyclic-nucleotide phosphodiesterase activity	6	7
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	7	7
GO:0005488	binding	1	7
GO:0008081	phosphoric diester hydrolase activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	882	886	PF00656	0.495
CLV_NRD_NRD_1	1004	1006	PF00675	0.646
CLV_NRD_NRD_1	124	126	PF00675	0.450
CLV_NRD_NRD_1	228	230	PF00675	0.643
CLV_NRD_NRD_1	442	444	PF00675	0.523
CLV_NRD_NRD_1	69	71	PF00675	0.443
CLV_NRD_NRD_1	940	942	PF00675	0.548
CLV_PCSK_KEX2_1	1004	1006	PF00082	0.643
CLV_PCSK_KEX2_1	124	126	PF00082	0.450
CLV_PCSK_KEX2_1	26	28	PF00082	0.411
CLV_PCSK_KEX2_1	442	444	PF00082	0.556
CLV_PCSK_KEX2_1	640	642	PF00082	0.404
CLV_PCSK_KEX2_1	893	895	PF00082	0.508
CLV_PCSK_KEX2_1	940	942	PF00082	0.548
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.411
CLV_PCSK_PC1ET2_1	640	642	PF00082	0.411
CLV_PCSK_PC1ET2_1	893	895	PF00082	0.508
CLV_PCSK_SKI1_1	1005	1009	PF00082	0.642
CLV_PCSK_SKI1_1	1046	1050	PF00082	0.549
CLV_PCSK_SKI1_1	261	265	PF00082	0.664
CLV_PCSK_SKI1_1	436	440	PF00082	0.501
CLV_PCSK_SKI1_1	866	870	PF00082	0.792
CLV_PCSK_SKI1_1	896	900	PF00082	0.646
CLV_PCSK_SKI1_1	906	910	PF00082	0.616
DEG_APCC_DBOX_1	452	460	PF00400	0.545
DEG_APCC_DBOX_1	810	818	PF00400	0.261
DEG_APCC_KENBOX_2	33	37	PF00400	0.411
DEG_SPOP_SBC_1	97	101	PF00917	0.641
DOC_CDC14_PxL_1	543	551	PF14671	0.557
DOC_CKS1_1	691	696	PF01111	0.513
DOC_CYCLIN_RxL_1	1000	1012	PF00134	0.521
DOC_MAPK_DCC_7	1056	1064	PF00069	0.494
DOC_MAPK_gen_1	229	236	PF00069	0.439
DOC_MAPK_HePTP_8	568	580	PF00069	0.551
DOC_MAPK_MEF2A_6	1056	1064	PF00069	0.494
DOC_MAPK_MEF2A_6	571	580	PF00069	0.550
DOC_MAPK_MEF2A_6	752	760	PF00069	0.513
DOC_PP1_RVXF_1	212	218	PF00149	0.471
DOC_PP1_RVXF_1	639	646	PF00149	0.411
DOC_PP4_FxxP_1	820	823	PF00568	0.411
DOC_PP4_FxxP_1	859	862	PF00568	0.551
DOC_USP7_MATH_1	154	158	PF00917	0.598
DOC_USP7_MATH_1	161	165	PF00917	0.561
DOC_USP7_MATH_1	197	201	PF00917	0.622
DOC_USP7_MATH_1	291	295	PF00917	0.565
DOC_USP7_MATH_1	361	365	PF00917	0.575
DOC_USP7_MATH_1	389	393	PF00917	0.404
DOC_USP7_MATH_1	397	401	PF00917	0.379
DOC_USP7_MATH_1	502	506	PF00917	0.718
DOC_USP7_MATH_1	516	520	PF00917	0.457
DOC_USP7_MATH_1	655	659	PF00917	0.513
DOC_USP7_MATH_1	801	805	PF00917	0.513
DOC_USP7_MATH_1	929	933	PF00917	0.614
DOC_USP7_MATH_1	985	989	PF00917	0.514
DOC_USP7_UBL2_3	892	896	PF12436	0.474
DOC_WW_Pin1_4	1055	1060	PF00397	0.733
DOC_WW_Pin1_4	500	505	PF00397	0.555
DOC_WW_Pin1_4	690	695	PF00397	0.513
DOC_WW_Pin1_4	797	802	PF00397	0.513
DOC_WW_Pin1_4	834	839	PF00397	0.411
DOC_WW_Pin1_4	84	89	PF00397	0.580
LIG_14-3-3_CanoR_1	27	31	PF00244	0.411
LIG_14-3-3_CanoR_1	329	335	PF00244	0.539
LIG_14-3-3_CanoR_1	396	406	PF00244	0.388
LIG_14-3-3_CanoR_1	475	481	PF00244	0.417
LIG_14-3-3_CanoR_1	586	593	PF00244	0.572
LIG_14-3-3_CanoR_1	663	667	PF00244	0.325
LIG_14-3-3_CanoR_1	672	682	PF00244	0.375
LIG_14-3-3_CanoR_1	70	77	PF00244	0.387
LIG_14-3-3_CanoR_1	726	731	PF00244	0.513
LIG_14-3-3_CanoR_1	805	810	PF00244	0.513
LIG_14-3-3_CanoR_1	940	944	PF00244	0.706
LIG_14-3-3_CanoR_1	954	960	PF00244	0.552
LIG_14-3-3_CanoR_1	989	997	PF00244	0.747
LIG_APCC_ABBA_1	580	585	PF00400	0.586
LIG_BIR_II_1	1	5	PF00653	0.660
LIG_BRCT_BRCA1_1	657	661	PF00533	0.513
LIG_CaM_IQ_9	165	181	PF13499	0.474
LIG_CaM_NSCaTE_8	480	487	PF13499	0.682
LIG_Clathr_ClatBox_1	814	818	PF01394	0.261
LIG_deltaCOP1_diTrp_1	550	554	PF00928	0.492
LIG_DLG_GKlike_1	805	813	PF00625	0.513
LIG_FHA_1	1073	1079	PF00498	0.685
LIG_FHA_1	121	127	PF00498	0.693
LIG_FHA_1	146	152	PF00498	0.488
LIG_FHA_1	262	268	PF00498	0.661
LIG_FHA_1	315	321	PF00498	0.612
LIG_FHA_1	691	697	PF00498	0.513
LIG_FHA_1	704	710	PF00498	0.382
LIG_FHA_1	741	747	PF00498	0.377
LIG_FHA_1	867	873	PF00498	0.545
LIG_FHA_1	879	885	PF00498	0.451
LIG_FHA_1	900	906	PF00498	0.630
LIG_FHA_1	907	913	PF00498	0.627
LIG_FHA_1	954	960	PF00498	0.565
LIG_FHA_1	975	981	PF00498	0.671
LIG_FHA_1	989	995	PF00498	0.563
LIG_FHA_2	1050	1056	PF00498	0.542
LIG_FHA_2	117	123	PF00498	0.421
LIG_FHA_2	136	142	PF00498	0.321
LIG_FHA_2	252	258	PF00498	0.462
LIG_FHA_2	30	36	PF00498	0.479
LIG_FHA_2	353	359	PF00498	0.631
LIG_FHA_2	523	529	PF00498	0.616
LIG_FHA_2	554	560	PF00498	0.441
LIG_FHA_2	634	640	PF00498	0.411
LIG_FHA_2	697	703	PF00498	0.378
LIG_FHA_2	85	91	PF00498	0.739
LIG_FHA_2	877	883	PF00498	0.508
LIG_FHA_2	909	915	PF00498	0.566
LIG_FHA_2	98	104	PF00498	0.609
LIG_FHA_2	994	1000	PF00498	0.522
LIG_GBD_Chelix_1	1063	1071	PF00786	0.445
LIG_GBD_Chelix_1	398	406	PF00786	0.384
LIG_GBD_Chelix_1	986	994	PF00786	0.744
LIG_IBAR_NPY_1	606	608	PF08397	0.333
LIG_LIR_Apic_2	732	737	PF02991	0.513
LIG_LIR_Apic_2	818	823	PF02991	0.411
LIG_LIR_Apic_2	856	862	PF02991	0.663
LIG_LIR_Gen_1	1052	1062	PF02991	0.519
LIG_LIR_Gen_1	529	540	PF02991	0.382
LIG_LIR_Gen_1	553	560	PF02991	0.587
LIG_LIR_Gen_1	665	673	PF02991	0.298
LIG_LIR_Gen_1	686	696	PF02991	0.408
LIG_LIR_Nem_3	1052	1057	PF02991	0.543
LIG_LIR_Nem_3	529	535	PF02991	0.624
LIG_LIR_Nem_3	553	557	PF02991	0.589
LIG_LIR_Nem_3	667	673	PF02991	0.353
LIG_LIR_Nem_3	686	691	PF02991	0.353
LIG_LIR_Nem_3	710	714	PF02991	0.513
LIG_MYND_3	546	550	PF01753	0.542
LIG_NRBOX	132	138	PF00104	0.543
LIG_OCRL_FandH_1	722	734	PF00620	0.513
LIG_PCNA_yPIPBox_3	124	137	PF02747	0.574
LIG_Pex14_2	816	820	PF04695	0.411
LIG_Rb_pABgroove_1	819	827	PF01858	0.402
LIG_REV1ctd_RIR_1	28	37	PF16727	0.411
LIG_RPA_C_Fungi	882	894	PF08784	0.485
LIG_SH2_CRK	622	626	PF00017	0.402
LIG_SH2_GRB2like	608	611	PF00017	0.411
LIG_SH2_PTP2	532	535	PF00017	0.379
LIG_SH2_SRC	470	473	PF00017	0.649
LIG_SH2_STAP1	281	285	PF00017	0.652
LIG_SH2_STAP1	744	748	PF00017	0.513
LIG_SH2_STAT3	327	330	PF00017	0.562
LIG_SH2_STAT5	1035	1038	PF00017	0.780
LIG_SH2_STAT5	532	535	PF00017	0.379
LIG_SH2_STAT5	849	852	PF00017	0.610
LIG_SH3_1	795	801	PF00018	0.513
LIG_SH3_3	1054	1060	PF00018	0.609
LIG_SH3_3	2	8	PF00018	0.612
LIG_SH3_3	508	514	PF00018	0.535
LIG_SH3_3	795	801	PF00018	0.411
LIG_TRAF2_1	238	241	PF00917	0.697
LIG_TRAF2_1	377	380	PF00917	0.393
LIG_TRAF2_1	469	472	PF00917	0.652
LIG_TRAF2_1	737	740	PF00917	0.261
LIG_TRAF2_1	852	855	PF00917	0.641
LIG_TRAF2_1	979	982	PF00917	0.622
LIG_TYR_ITIM	530	535	PF00017	0.620
LIG_UBA3_1	133	140	PF00899	0.537
LIG_UBA3_1	55	62	PF00899	0.261
LIG_UBA3_1	631	640	PF00899	0.411
MOD_CDC14_SPxK_1	837	840	PF00782	0.513
MOD_CDK_SPxK_1	834	840	PF00069	0.513
MOD_CK1_1	235	241	PF00069	0.654
MOD_CK1_1	29	35	PF00069	0.312
MOD_CK1_1	314	320	PF00069	0.397
MOD_CK1_1	47	53	PF00069	0.511
MOD_CK1_1	476	482	PF00069	0.419
MOD_CK1_1	800	806	PF00069	0.513
MOD_CK1_1	834	840	PF00069	0.474
MOD_CK1_1	932	938	PF00069	0.713
MOD_CK1_1	942	948	PF00069	0.665
MOD_CK1_1	988	994	PF00069	0.646
MOD_CK2_1	1066	1072	PF00069	0.684
MOD_CK2_1	235	241	PF00069	0.700
MOD_CK2_1	251	257	PF00069	0.454
MOD_CK2_1	266	272	PF00069	0.622
MOD_CK2_1	29	35	PF00069	0.479
MOD_CK2_1	352	358	PF00069	0.633
MOD_CK2_1	466	472	PF00069	0.575
MOD_CK2_1	522	528	PF00069	0.625
MOD_CK2_1	553	559	PF00069	0.488
MOD_CK2_1	633	639	PF00069	0.411
MOD_CK2_1	701	707	PF00069	0.468
MOD_CK2_1	726	732	PF00069	0.513
MOD_CK2_1	75	81	PF00069	0.585
MOD_CK2_1	876	882	PF00069	0.768
MOD_CK2_1	943	949	PF00069	0.639
MOD_CK2_1	97	103	PF00069	0.633
MOD_CK2_1	993	999	PF00069	0.528
MOD_CMANNOS	477	480	PF00535	0.670
MOD_Cter_Amidation	24	27	PF01082	0.290
MOD_GlcNHglycan	1068	1071	PF01048	0.577
MOD_GlcNHglycan	1075	1078	PF01048	0.582
MOD_GlcNHglycan	156	159	PF01048	0.633
MOD_GlcNHglycan	16	19	PF01048	0.411
MOD_GlcNHglycan	163	166	PF01048	0.600
MOD_GlcNHglycan	194	197	PF01048	0.614
MOD_GlcNHglycan	218	222	PF01048	0.417
MOD_GlcNHglycan	225	228	PF01048	0.392
MOD_GlcNHglycan	237	240	PF01048	0.370
MOD_GlcNHglycan	317	320	PF01048	0.633
MOD_GlcNHglycan	332	335	PF01048	0.485
MOD_GlcNHglycan	363	366	PF01048	0.650
MOD_GlcNHglycan	49	52	PF01048	0.411
MOD_GlcNHglycan	498	501	PF01048	0.693
MOD_GlcNHglycan	58	61	PF01048	0.411
MOD_GlcNHglycan	805	808	PF01048	0.416
MOD_GSK3_1	1034	1041	PF00069	0.778
MOD_GSK3_1	116	123	PF00069	0.469
MOD_GSK3_1	135	142	PF00069	0.325
MOD_GSK3_1	26	33	PF00069	0.405
MOD_GSK3_1	291	298	PF00069	0.683
MOD_GSK3_1	311	318	PF00069	0.318
MOD_GSK3_1	397	404	PF00069	0.615
MOD_GSK3_1	43	50	PF00069	0.485
MOD_GSK3_1	496	503	PF00069	0.761
MOD_GSK3_1	740	747	PF00069	0.371
MOD_GSK3_1	797	804	PF00069	0.513
MOD_GSK3_1	866	873	PF00069	0.792
MOD_GSK3_1	92	99	PF00069	0.646
MOD_GSK3_1	928	935	PF00069	0.691
MOD_GSK3_1	939	946	PF00069	0.582
MOD_N-GLC_1	1028	1033	PF02516	0.597
MOD_N-GLC_1	129	134	PF02516	0.559
MOD_N-GLC_1	673	678	PF02516	0.261
MOD_NEK2_1	116	121	PF00069	0.477
MOD_NEK2_1	360	365	PF00069	0.654
MOD_NEK2_1	43	48	PF00069	0.411
MOD_NEK2_1	463	468	PF00069	0.648
MOD_NEK2_1	595	600	PF00069	0.542
MOD_NEK2_1	696	701	PF00069	0.411
MOD_NEK2_1	953	958	PF00069	0.601
MOD_NEK2_2	51	56	PF00069	0.358
MOD_PIKK_1	401	407	PF00454	0.641
MOD_PIKK_1	585	591	PF00454	0.333
MOD_PIKK_1	673	679	PF00454	0.261
MOD_PIKK_1	69	75	PF00454	0.437
MOD_PIKK_1	899	905	PF00454	0.466
MOD_PIKK_1	9	15	PF00454	0.389
MOD_PKA_1	26	32	PF00069	0.411
MOD_PKA_2	178	184	PF00069	0.486
MOD_PKA_2	26	32	PF00069	0.411
MOD_PKA_2	585	591	PF00069	0.585
MOD_PKA_2	662	668	PF00069	0.325
MOD_PKA_2	69	75	PF00069	0.419
MOD_PKA_2	939	945	PF00069	0.669
MOD_PKA_2	953	959	PF00069	0.429
MOD_PKA_2	988	994	PF00069	0.672
MOD_PKB_1	904	912	PF00069	0.603
MOD_Plk_1	129	135	PF00069	0.562
MOD_Plk_1	217	223	PF00069	0.642
MOD_Plk_1	232	238	PF00069	0.644
MOD_Plk_1	291	297	PF00069	0.676
MOD_Plk_1	673	679	PF00069	0.421
MOD_Plk_1	744	750	PF00069	0.377
MOD_Plk_1	929	935	PF00069	0.507
MOD_Plk_2-3	352	358	PF00069	0.633
MOD_Plk_2-3	553	559	PF00069	0.590
MOD_Plk_2-3	740	746	PF00069	0.513
MOD_Plk_4	129	135	PF00069	0.562
MOD_Plk_4	266	272	PF00069	0.453
MOD_Plk_4	476	482	PF00069	0.419
MOD_Plk_4	51	57	PF00069	0.402
MOD_Plk_4	522	528	PF00069	0.625
MOD_Plk_4	719	725	PF00069	0.411
MOD_Plk_4	726	732	PF00069	0.411
MOD_Plk_4	754	760	PF00069	0.424
MOD_ProDKin_1	1055	1061	PF00069	0.728
MOD_ProDKin_1	500	506	PF00069	0.557
MOD_ProDKin_1	690	696	PF00069	0.513
MOD_ProDKin_1	797	803	PF00069	0.513
MOD_ProDKin_1	834	840	PF00069	0.411
MOD_ProDKin_1	84	90	PF00069	0.584
MOD_SUMO_for_1	1065	1068	PF00179	0.708
MOD_SUMO_for_1	213	216	PF00179	0.679
MOD_SUMO_for_1	390	393	PF00179	0.645
MOD_SUMO_rev_2	101	109	PF00179	0.723
MOD_SUMO_rev_2	256	260	PF00179	0.442
MOD_SUMO_rev_2	735	743	PF00179	0.513
MOD_SUMO_rev_2	945	953	PF00179	0.485
TRG_DiLeu_BaEn_1	129	134	PF01217	0.549
TRG_DiLeu_BaEn_1	433	438	PF01217	0.652
TRG_DiLeu_BaEn_1	565	570	PF01217	0.611
TRG_DiLeu_BaEn_1	710	715	PF01217	0.513
TRG_DiLeu_BaEn_4	240	246	PF01217	0.599
TRG_DiLeu_BaEn_4	379	385	PF01217	0.396
TRG_ENDOCYTIC_2	532	535	PF00928	0.632
TRG_ENDOCYTIC_2	622	625	PF00928	0.411
TRG_ER_diArg_1	124	127	PF00400	0.450
TRG_ER_diArg_1	382	385	PF00400	0.402
TRG_ER_diArg_1	441	443	PF00400	0.436
TRG_NES_CRM1_1	373	387	PF08389	0.392
TRG_NES_CRM1_1	813	826	PF08389	0.402
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.647
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.721
TRG_Pf-PMV_PEXEL_1	368	373	PF00026	0.468
TRG_Pf-PMV_PEXEL_1	396	401	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	736	740	PF00026	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I536	Leptomonas seymouri	44%	90%
A0A3S7X2S6	Leishmania donovani	74%	100%
A4I4X6	Leishmania infantum	74%	100%
E9AED0	Leishmania major	73%	100%
E9ALF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%