Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP48

Species:

Leishmania braziliensis

UniProt:

A4HHS4_LEIBR

TriTrypDb:

LbrM.29.2730 , LBRM2903_290036200

Length:

533

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HHS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHS4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0009987	cellular process	1	1
GO:0046907	intracellular transport	3	1
GO:0051169	nuclear transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.652
CLV_NRD_NRD_1	177	179	PF00675	0.642
CLV_NRD_NRD_1	466	468	PF00675	0.356
CLV_PCSK_FUR_1	175	179	PF00082	0.405
CLV_PCSK_KEX2_1	120	122	PF00082	0.608
CLV_PCSK_KEX2_1	177	179	PF00082	0.644
CLV_PCSK_KEX2_1	465	467	PF00082	0.372
CLV_PCSK_SKI1_1	160	164	PF00082	0.573
CLV_PCSK_SKI1_1	246	250	PF00082	0.337
CLV_PCSK_SKI1_1	289	293	PF00082	0.450
CLV_PCSK_SKI1_1	323	327	PF00082	0.507
DEG_APCC_DBOX_1	126	134	PF00400	0.676
DEG_Nend_Nbox_1	1	3	PF02207	0.546
DEG_SPOP_SBC_1	92	96	PF00917	0.578
DOC_CKS1_1	399	404	PF01111	0.497
DOC_CYCLIN_RxL_1	286	296	PF00134	0.279
DOC_MAPK_HePTP_8	430	442	PF00069	0.489
DOC_MAPK_MEF2A_6	433	442	PF00069	0.474
DOC_PP1_RVXF_1	148	155	PF00149	0.435
DOC_PP1_RVXF_1	232	239	PF00149	0.405
DOC_PP1_RVXF_1	287	293	PF00149	0.275
DOC_PP1_RVXF_1	321	327	PF00149	0.400
DOC_PP2B_PxIxI_1	435	441	PF00149	0.461
DOC_PP4_FxxP_1	154	157	PF00568	0.498
DOC_USP7_MATH_1	166	170	PF00917	0.436
DOC_USP7_MATH_1	176	180	PF00917	0.630
DOC_USP7_MATH_1	208	212	PF00917	0.468
DOC_USP7_MATH_1	264	268	PF00917	0.608
DOC_USP7_MATH_1	271	275	PF00917	0.633
DOC_USP7_MATH_1	294	298	PF00917	0.514
DOC_USP7_MATH_1	315	319	PF00917	0.322
DOC_USP7_MATH_1	393	397	PF00917	0.550
DOC_USP7_MATH_1	78	82	PF00917	0.695
DOC_WW_Pin1_4	378	383	PF00397	0.607
DOC_WW_Pin1_4	398	403	PF00397	0.501
LIG_14-3-3_CanoR_1	107	113	PF00244	0.666
LIG_14-3-3_CanoR_1	75	85	PF00244	0.728
LIG_Actin_WH2_2	145	162	PF00022	0.337
LIG_BRCT_BRCA1_1	380	384	PF00533	0.398
LIG_BRCT_BRCA1_1	416	420	PF00533	0.466
LIG_deltaCOP1_diTrp_1	235	241	PF00928	0.357
LIG_EH_1	434	438	PF12763	0.408
LIG_eIF4E_1	143	149	PF01652	0.495
LIG_FHA_1	143	149	PF00498	0.533
LIG_FHA_1	210	216	PF00498	0.431
LIG_FHA_1	339	345	PF00498	0.518
LIG_FHA_1	421	427	PF00498	0.438
LIG_FHA_1	472	478	PF00498	0.371
LIG_FHA_1	510	516	PF00498	0.489
LIG_FHA_2	112	118	PF00498	0.568
LIG_FHA_2	364	370	PF00498	0.397
LIG_FHA_2	457	463	PF00498	0.371
LIG_FHA_2	495	501	PF00498	0.259
LIG_GBD_Chelix_1	442	450	PF00786	0.504
LIG_Integrin_isoDGR_2	73	75	PF01839	0.515
LIG_LIR_Apic_2	151	157	PF02991	0.564
LIG_LIR_Gen_1	106	116	PF02991	0.528
LIG_LIR_Gen_1	194	203	PF02991	0.314
LIG_LIR_Gen_1	37	47	PF02991	0.518
LIG_LIR_Nem_3	106	112	PF02991	0.605
LIG_LIR_Nem_3	194	199	PF02991	0.441
LIG_LIR_Nem_3	35	39	PF02991	0.623
LIG_LIR_Nem_3	448	454	PF02991	0.538
LIG_LYPXL_S_1	46	50	PF13949	0.578
LIG_LYPXL_yS_3	47	50	PF13949	0.586
LIG_MLH1_MIPbox_1	416	420	PF16413	0.466
LIG_MYND_1	138	142	PF01753	0.512
LIG_NRBOX	258	264	PF00104	0.255
LIG_SH2_CRK	39	43	PF00017	0.603
LIG_SH2_CRK	451	455	PF00017	0.526
LIG_SH2_STAT5	143	146	PF00017	0.329
LIG_SH2_STAT5	419	422	PF00017	0.441
LIG_SH3_3	330	336	PF00018	0.570
LIG_SH3_3	339	345	PF00018	0.559
LIG_SH3_3	396	402	PF00018	0.455
LIG_SH3_3	43	49	PF00018	0.473
LIG_SH3_3	7	13	PF00018	0.456
LIG_SUMO_SIM_anti_2	372	377	PF11976	0.384
LIG_SUMO_SIM_par_1	340	346	PF11976	0.523
LIG_TRAF2_1	202	205	PF00917	0.410
LIG_WRC_WIRS_1	504	509	PF05994	0.405
MOD_CK1_1	111	117	PF00069	0.631
MOD_CK1_1	191	197	PF00069	0.255
MOD_CK1_1	267	273	PF00069	0.632
MOD_CK1_1	297	303	PF00069	0.544
MOD_CK1_1	444	450	PF00069	0.576
MOD_CK1_1	81	87	PF00069	0.737
MOD_CK2_1	111	117	PF00069	0.436
MOD_CK2_1	363	369	PF00069	0.388
MOD_CK2_1	456	462	PF00069	0.372
MOD_CK2_1	494	500	PF00069	0.264
MOD_CMANNOS	238	241	PF00535	0.459
MOD_GlcNHglycan	135	138	PF01048	0.620
MOD_GlcNHglycan	168	171	PF01048	0.396
MOD_GlcNHglycan	282	285	PF01048	0.538
MOD_GlcNHglycan	296	299	PF01048	0.466
MOD_GlcNHglycan	35	39	PF01048	0.580
MOD_GlcNHglycan	385	388	PF01048	0.532
MOD_GlcNHglycan	389	392	PF01048	0.472
MOD_GlcNHglycan	80	83	PF01048	0.742
MOD_GlcNHglycan	85	88	PF01048	0.748
MOD_GSK3_1	103	110	PF00069	0.671
MOD_GSK3_1	158	165	PF00069	0.558
MOD_GSK3_1	188	195	PF00069	0.490
MOD_GSK3_1	263	270	PF00069	0.410
MOD_GSK3_1	273	280	PF00069	0.432
MOD_GSK3_1	293	300	PF00069	0.322
MOD_GSK3_1	315	322	PF00069	0.526
MOD_GSK3_1	383	390	PF00069	0.524
MOD_GSK3_1	441	448	PF00069	0.430
MOD_GSK3_1	76	83	PF00069	0.692
MOD_N-GLC_1	66	71	PF02516	0.645
MOD_NEK2_1	133	138	PF00069	0.622
MOD_NEK2_1	148	153	PF00069	0.379
MOD_NEK2_1	192	197	PF00069	0.260
MOD_NEK2_1	363	368	PF00069	0.395
MOD_NEK2_1	420	425	PF00069	0.488
MOD_NEK2_1	445	450	PF00069	0.381
MOD_NEK2_1	461	466	PF00069	0.429
MOD_NEK2_1	66	71	PF00069	0.684
MOD_NEK2_1	93	98	PF00069	0.649
MOD_NEK2_2	158	163	PF00069	0.606
MOD_PKA_2	176	182	PF00069	0.552
MOD_PKA_2	185	191	PF00069	0.341
MOD_PKA_2	409	415	PF00069	0.495
MOD_PKA_2	76	82	PF00069	0.768
MOD_Plk_1	234	240	PF00069	0.255
MOD_Plk_1	271	277	PF00069	0.417
MOD_Plk_1	34	40	PF00069	0.610
MOD_Plk_4	150	156	PF00069	0.344
MOD_Plk_4	192	198	PF00069	0.382
MOD_Plk_4	234	240	PF00069	0.412
MOD_Plk_4	338	344	PF00069	0.482
MOD_Plk_4	414	420	PF00069	0.469
MOD_Plk_4	441	447	PF00069	0.520
MOD_Plk_4	511	517	PF00069	0.348
MOD_ProDKin_1	378	384	PF00069	0.615
MOD_ProDKin_1	398	404	PF00069	0.498
TRG_DiLeu_BaEn_1	473	478	PF01217	0.373
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.243
TRG_ENDOCYTIC_2	196	199	PF00928	0.468
TRG_ENDOCYTIC_2	39	42	PF00928	0.571
TRG_ENDOCYTIC_2	451	454	PF00928	0.542
TRG_ENDOCYTIC_2	47	50	PF00928	0.579
TRG_ER_diArg_1	120	123	PF00400	0.672
TRG_ER_diArg_1	174	177	PF00400	0.564
TRG_ER_diArg_1	376	379	PF00400	0.419
TRG_ER_diArg_1	465	467	PF00400	0.391
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	466	471	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6I3	Leptomonas seymouri	55%	100%
A0A0S4JJV4	Bodo saltans	26%	100%
A0A1X0NPX8	Trypanosomatidae	41%	100%
A0A3Q8ICS9	Leishmania donovani	83%	100%
A0A3R7KGG9	Trypanosoma rangeli	37%	100%
A4HVH0	Leishmania infantum	84%	100%
D0A6U9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AP59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QGC9	Leishmania major	84%	100%
V5D9X2	Trypanosoma cruzi	36%	100%