N-acetyltransferase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHS3_LEIBR

TriTrypDb:

LbrM.29.2720 , LBRM2903_290036100

Length:

264

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0031248	protein acetyltransferase complex	3	10
GO:0031414	N-terminal protein acetyltransferase complex	4	10
GO:0031415	NatA complex	5	10
GO:0032991	protein-containing complex	1	10
GO:0140535	intracellular protein-containing complex	2	10
GO:1902493	acetyltransferase complex	4	10
GO:1902494	catalytic complex	2	10
GO:1990234	transferase complex	3	10
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HHS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHS3

Function

Biological processes
Term	Name	Level	Count
GO:0006473	protein acetylation	6	10
GO:0006474	N-terminal protein amino acid acetylation	5	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0019538	protein metabolic process	3	10
GO:0031365	N-terminal protein amino acid modification	5	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0043543	protein acylation	5	10
GO:0044238	primary metabolic process	2	10
GO:0051604	protein maturation	4	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004596	peptide alpha-N-acetyltransferase activity	8	10
GO:0008080	N-acetyltransferase activity	6	10
GO:0016407	acetyltransferase activity	5	10
GO:0016410	N-acyltransferase activity	5	10
GO:0016740	transferase activity	2	10
GO:0016746	acyltransferase activity	3	10
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	10
GO:0034212	peptide N-acetyltransferase activity	7	10
GO:1990189	peptide-serine-alpha-N-acetyltransferase activity	9	1
GO:1990190	peptide-glutamate-alpha-N-acetyltransferase activity	9	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.269
CLV_NRD_NRD_1	168	170	PF00675	0.475
CLV_NRD_NRD_1	4	6	PF00675	0.316
CLV_NRD_NRD_1	82	84	PF00675	0.266
CLV_PCSK_KEX2_1	165	167	PF00082	0.452
CLV_PCSK_KEX2_1	257	259	PF00082	0.687
CLV_PCSK_KEX2_1	4	6	PF00082	0.316
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.452
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.687
CLV_PCSK_SKI1_1	149	153	PF00082	0.382
CLV_PCSK_SKI1_1	205	209	PF00082	0.725
CLV_PCSK_SKI1_1	4	8	PF00082	0.332
DEG_Nend_UBRbox_3	1	3	PF02207	0.372
DOC_MAPK_gen_1	165	176	PF00069	0.371
DOC_MAPK_MEF2A_6	169	176	PF00069	0.668
DOC_USP7_UBL2_3	201	205	PF12436	0.578
LIG_14-3-3_CanoR_1	169	173	PF00244	0.458
LIG_14-3-3_CanoR_1	4	9	PF00244	0.341
LIG_14-3-3_CanoR_1	50	54	PF00244	0.361
LIG_14-3-3_CanoR_1	93	97	PF00244	0.269
LIG_APCC_ABBA_1	120	125	PF00400	0.245
LIG_BIR_III_4	226	230	PF00653	0.441
LIG_Clathr_ClatBox_1	222	226	PF01394	0.523
LIG_eIF4E_1	30	36	PF01652	0.361
LIG_FHA_1	169	175	PF00498	0.438
LIG_FHA_2	5	11	PF00498	0.331
LIG_FHA_2	93	99	PF00498	0.305
LIG_LIR_Gen_1	104	112	PF02991	0.170
LIG_LIR_Nem_3	104	110	PF02991	0.170
LIG_LIR_Nem_3	126	132	PF02991	0.321
LIG_LIR_Nem_3	37	41	PF02991	0.269
LIG_SH2_CRK	107	111	PF00017	0.305
LIG_SH2_CRK	33	37	PF00017	0.281
LIG_SH2_STAP1	103	107	PF00017	0.170
LIG_SH2_STAT3	12	15	PF00017	0.326
LIG_SH2_STAT3	43	46	PF00017	0.361
LIG_SH2_STAT5	107	110	PF00017	0.305
LIG_SH2_STAT5	160	163	PF00017	0.406
LIG_SH2_STAT5	43	46	PF00017	0.296
LIG_SH2_STAT5	55	58	PF00017	0.245
LIG_SUMO_SIM_anti_2	74	81	PF11976	0.245
LIG_SUMO_SIM_par_1	171	177	PF11976	0.438
LIG_UBA3_1	222	230	PF00899	0.607
LIG_WRC_WIRS_1	148	153	PF05994	0.412
MOD_CK2_1	208	214	PF00069	0.586
MOD_CK2_1	92	98	PF00069	0.269
MOD_Cter_Amidation	198	201	PF01082	0.635
MOD_Cter_Amidation	255	258	PF01082	0.697
MOD_GlcNHglycan	209	213	PF01048	0.598
MOD_GlcNHglycan	242	245	PF01048	0.760
MOD_GlcNHglycan	248	251	PF01048	0.676
MOD_GlcNHglycan	259	262	PF01048	0.556
MOD_NEK2_1	14	19	PF00069	0.372
MOD_NEK2_1	92	97	PF00069	0.269
MOD_PKA_1	257	263	PF00069	0.685
MOD_PKA_1	4	10	PF00069	0.334
MOD_PKA_2	112	118	PF00069	0.245
MOD_PKA_2	168	174	PF00069	0.447
MOD_PKA_2	257	263	PF00069	0.651
MOD_PKA_2	4	10	PF00069	0.334
MOD_PKA_2	49	55	PF00069	0.361
MOD_PKA_2	92	98	PF00069	0.295
MOD_Plk_4	147	153	PF00069	0.526
MOD_Plk_4	156	162	PF00069	0.266
MOD_SUMO_rev_2	159	167	PF00179	0.449
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.465
TRG_ENDOCYTIC_2	107	110	PF00928	0.305
TRG_ENDOCYTIC_2	32	35	PF00928	0.286
TRG_ER_diArg_1	3	5	PF00400	0.328
TRG_Pf-PMV_PEXEL_1	20	24	PF00026	0.322

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P642	Leptomonas seymouri	75%	100%
A0A0S4JB69	Bodo saltans	64%	93%
A0A1X0NPT1	Trypanosomatidae	62%	100%
A0A3R7M1B7	Trypanosoma rangeli	57%	100%
A0A3S7WSC5	Leishmania donovani	93%	100%
A4HDU9	Leishmania braziliensis	27%	100%
A4HVG9	Leishmania infantum	93%	100%
E9AP60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
P07347	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	100%
P41227	Homo sapiens	46%	100%
Q2KI14	Bos taurus	49%	100%
Q3UX61	Mus musculus	49%	100%
Q4QGC8	Leishmania major	95%	100%