LeishMANIAdb
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N-acetyltransferase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
N-acetyltransferase domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HHS3_LEIBR
TriTrypDb:
LbrM.29.2720 , LBRM2903_290036100
Length:
264

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 1
GO:0016020 membrane 2 1
GO:0031248 protein acetyltransferase complex 3 10
GO:0031414 N-terminal protein acetyltransferase complex 4 10
GO:0031415 NatA complex 5 10
GO:0032991 protein-containing complex 1 10
GO:0110165 cellular anatomical entity 1 2
GO:0140535 intracellular protein-containing complex 2 10
GO:1902493 acetyltransferase complex 4 10
GO:1902494 catalytic complex 2 10
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Expansion

Sequence features

A4HHS3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHS3

Function

Biological processes
TermNameLevelCount
GO:0006473 protein acetylation 6 10
GO:0006474 N-terminal protein amino acid acetylation 5 10
GO:0006807 nitrogen compound metabolic process 2 10
GO:0008152 metabolic process 1 10
GO:0019538 protein metabolic process 3 10
GO:0031365 N-terminal protein amino acid modification 5 10
GO:0036211 protein modification process 4 10
GO:0043170 macromolecule metabolic process 3 10
GO:0043412 macromolecule modification 4 10
GO:0043543 protein acylation 5 10
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 10
GO:0004596 peptide alpha-N-acetyltransferase activity 8 10
GO:0008080 N-acetyltransferase activity 6 10
GO:0016407 acetyltransferase activity 5 10
GO:0016410 N-acyltransferase activity 5 10
GO:0016740 transferase activity 2 10
GO:0016746 acyltransferase activity 3 10
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 10
GO:0034212 peptide N-acetyltransferase activity 7 10
GO:1990189 peptide-serine-alpha-N-acetyltransferase activity 9 1
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 112 114 PF00675 0.269
CLV_NRD_NRD_1 168 170 PF00675 0.475
CLV_NRD_NRD_1 4 6 PF00675 0.316
CLV_NRD_NRD_1 82 84 PF00675 0.266
CLV_PCSK_KEX2_1 165 167 PF00082 0.452
CLV_PCSK_KEX2_1 257 259 PF00082 0.687
CLV_PCSK_KEX2_1 4 6 PF00082 0.316
CLV_PCSK_PC1ET2_1 165 167 PF00082 0.452
CLV_PCSK_PC1ET2_1 257 259 PF00082 0.687
CLV_PCSK_SKI1_1 149 153 PF00082 0.382
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P642 Leptomonas seymouri 75% 100%
A0A0S4JB69 Bodo saltans 64% 93%
A0A1X0NPT1 Trypanosomatidae 62% 100%
A0A3R7M1B7 Trypanosoma rangeli 57% 100%
A0A3S7WSC5 Leishmania donovani 93% 100%
A4HDU9 Leishmania braziliensis 27% 100%
A4HVG9 Leishmania infantum 93% 100%
E9AP60 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
P07347 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 39% 100%
P41227 Homo sapiens 46% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS