Alpha tubulin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Alpha tubulin

Gene product:

alpha tubulin

Species:

Leishmania braziliensis

UniProt:

A4HHS1_LEIBR

TriTrypDb:

LbrM.29.2700 , LBRM2903_130007500

Length:

259

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	6
GO:0099080	supramolecular complex	2	6
GO:0099081	supramolecular polymer	3	6
GO:0099512	supramolecular fiber	4	6
GO:0099513	polymeric cytoskeletal fiber	5	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HHS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHS1

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	6
GO:0009987	cellular process	1	6

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0005198	structural molecule activity	1	6
GO:0005200	structural constituent of cytoskeleton	2	6
GO:0005488	binding	1	6
GO:0005525	GTP binding	5	6
GO:0017076	purine nucleotide binding	4	6
GO:0019001	guanyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032561	guanyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	59	63	PF00656	0.644
CLV_PCSK_KEX2_1	146	148	PF00082	0.277
CLV_PCSK_KEX2_1	209	211	PF00082	0.437
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.277
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.437
CLV_PCSK_SKI1_1	18	22	PF00082	0.649
CLV_PCSK_SKI1_1	209	213	PF00082	0.425
CLV_PCSK_SKI1_1	5	9	PF00082	0.658
DEG_APCC_DBOX_1	229	237	PF00400	0.443
DEG_MDM2_SWIB_1	50	58	PF02201	0.642
DOC_MAPK_gen_1	14	24	PF00069	0.695
DOC_MAPK_gen_1	144	151	PF00069	0.477
DOC_MAPK_MEF2A_6	17	24	PF00069	0.685
DOC_PP1_RVXF_1	145	152	PF00149	0.477
DOC_PP1_RVXF_1	70	76	PF00149	0.348
DOC_PP2B_LxvP_1	8	11	PF13499	0.677
LIG_CAP-Gly_1	253	259	PF01302	0.651
LIG_deltaCOP1_diTrp_1	153	159	PF00928	0.477
LIG_eIF4E_1	120	126	PF01652	0.477
LIG_FHA_1	63	69	PF00498	0.553
LIG_FHA_1	98	104	PF00498	0.588
LIG_FHA_2	109	115	PF00498	0.464
LIG_FHA_2	32	38	PF00498	0.704
LIG_Integrin_RGD_1	128	130	PF01839	0.277
LIG_LIR_Gen_1	194	203	PF02991	0.473
LIG_LIR_Gen_1	237	248	PF02991	0.459
LIG_LIR_Nem_3	194	199	PF02991	0.473
LIG_LIR_Nem_3	21	27	PF02991	0.688
LIG_LIR_Nem_3	237	243	PF02991	0.430
LIG_LIR_Nem_3	78	83	PF02991	0.495
LIG_LYPXL_yS_3	70	73	PF13949	0.357
LIG_Pex14_2	50	54	PF04695	0.579
LIG_PTB_Apo_2	98	105	PF02174	0.477
LIG_SH2_CRK	165	169	PF00017	0.477
LIG_SH2_CRK	80	84	PF00017	0.495
LIG_SH2_NCK_1	240	244	PF00017	0.450
LIG_SH2_SRC	165	168	PF00017	0.477
LIG_SH2_SRC	240	243	PF00017	0.448
LIG_SH2_SRC	80	83	PF00017	0.495
LIG_SH2_STAP1	207	211	PF00017	0.429
LIG_SH2_STAT3	90	93	PF00017	0.495
LIG_SH2_STAT5	216	219	PF00017	0.452
LIG_SH3_3	100	106	PF00018	0.477
LIG_SH3_3	40	46	PF00018	0.655
LIG_SH3_3	65	71	PF00018	0.558
LIG_TRAF2_1	251	254	PF00917	0.783
LIG_TYR_ITIM	68	73	PF00017	0.497
LIG_TYR_ITSM	76	83	PF00017	0.495
MOD_CK2_1	31	37	PF00069	0.708
MOD_CK2_1	99	105	PF00069	0.518
MOD_Cter_Amidation	15	18	PF01082	0.719
MOD_GlcNHglycan	14	17	PF01048	0.721
MOD_GlcNHglycan	246	249	PF01048	0.557
MOD_GlcNHglycan	29	32	PF01048	0.685
MOD_GSK3_1	23	30	PF00069	0.687
MOD_GSK3_1	58	65	PF00069	0.576
MOD_LATS_1	117	123	PF00433	0.547
MOD_N-GLC_1	187	192	PF02516	0.267
MOD_NEK2_1	205	210	PF00069	0.424
MOD_NEK2_1	27	32	PF00069	0.711
MOD_NEK2_1	60	65	PF00069	0.588
MOD_NEK2_1	75	80	PF00069	0.412
MOD_NEK2_2	139	144	PF00069	0.477
MOD_PIKK_1	31	37	PF00454	0.708
MOD_PIKK_1	60	66	PF00454	0.645
MOD_Plk_1	187	193	PF00069	0.467
MOD_Plk_2-3	92	98	PF00069	0.495
MOD_Plk_4	166	172	PF00069	0.466
MOD_Plk_4	99	105	PF00069	0.534
MOD_SUMO_rev_2	194	203	PF00179	0.477
TRG_ENDOCYTIC_2	240	243	PF00928	0.448
TRG_ENDOCYTIC_2	70	73	PF00928	0.344
TRG_ENDOCYTIC_2	80	83	PF00928	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IVQ1	Bodo saltans	83%	100%
A0A0S4KMQ2	Bodo saltans	94%	100%
A0A3S7X6J0	Leishmania donovani	34%	100%
A4HLD1	Leishmania braziliensis	34%	100%
A4HLD6	Leishmania braziliensis	32%	97%
C9ZIG1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	93%	100%
C9ZIG6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	90%	85%
P09642	Gallus gallus	79%	80%
P09643	Gallus gallus	77%	80%
P09645	Gallus gallus	80%	80%
P18700	Strongylocentrotus purpuratus	34%	89%
P20364	Daucus carota	33%	82%
P24635	Octopus vulgaris	81%	100%
P25862	Avena sativa	34%	67%
P33624	Anemia phyllitidis	81%	71%
P33632	Anemia phyllitidis	31%	100%
P41386	Haliotis discus	35%	76%