FYVE-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Lipase (class 3), putative

Species:

Leishmania braziliensis

UniProt:

A4HHS0_LEIBR

TriTrypDb:

LbrM.29.2690 , LBRM2903_130007100

Length:

776

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHS0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHS0

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	7
GO:0008152	metabolic process	1	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	270	274	PF00656	0.504
CLV_C14_Caspase3-7	56	60	PF00656	0.560
CLV_NRD_NRD_1	222	224	PF00675	0.513
CLV_NRD_NRD_1	328	330	PF00675	0.368
CLV_NRD_NRD_1	393	395	PF00675	0.526
CLV_NRD_NRD_1	432	434	PF00675	0.354
CLV_NRD_NRD_1	578	580	PF00675	0.538
CLV_NRD_NRD_1	728	730	PF00675	0.392
CLV_PCSK_KEX2_1	222	224	PF00082	0.513
CLV_PCSK_KEX2_1	267	269	PF00082	0.526
CLV_PCSK_KEX2_1	29	31	PF00082	0.590
CLV_PCSK_KEX2_1	393	395	PF00082	0.526
CLV_PCSK_KEX2_1	578	580	PF00082	0.378
CLV_PCSK_KEX2_1	728	730	PF00082	0.392
CLV_PCSK_KEX2_1	75	77	PF00082	0.665
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.526
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.538
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.665
CLV_PCSK_SKI1_1	2	6	PF00082	0.592
CLV_PCSK_SKI1_1	329	333	PF00082	0.328
CLV_PCSK_SKI1_1	394	398	PF00082	0.374
CLV_PCSK_SKI1_1	469	473	PF00082	0.377
CLV_PCSK_SKI1_1	764	768	PF00082	0.423
DEG_APCC_DBOX_1	328	336	PF00400	0.387
DEG_APCC_DBOX_1	393	401	PF00400	0.364
DEG_APCC_DBOX_1	504	512	PF00400	0.403
DEG_Nend_UBRbox_1	1	4	PF02207	0.591
DEG_SCF_FBW7_1	16	21	PF00400	0.558
DEG_SPOP_SBC_1	11	15	PF00917	0.575
DEG_SPOP_SBC_1	471	475	PF00917	0.235
DOC_CYCLIN_RxL_1	153	162	PF00134	0.516
DOC_CYCLIN_RxL_1	326	334	PF00134	0.435
DOC_MAPK_gen_1	329	335	PF00069	0.355
DOC_MAPK_gen_1	469	479	PF00069	0.403
DOC_MAPK_gen_1	505	513	PF00069	0.335
DOC_MAPK_MEF2A_6	241	249	PF00069	0.426
DOC_MAPK_MEF2A_6	462	470	PF00069	0.378
DOC_MAPK_MEF2A_6	505	513	PF00069	0.403
DOC_MAPK_MEF2A_6	747	754	PF00069	0.546
DOC_PP1_RVXF_1	154	161	PF00149	0.519
DOC_PP1_RVXF_1	381	388	PF00149	0.565
DOC_PP4_FxxP_1	376	379	PF00568	0.376
DOC_PP4_FxxP_1	513	516	PF00568	0.403
DOC_PP4_FxxP_1	704	707	PF00568	0.440
DOC_PP4_FxxP_1	724	727	PF00568	0.297
DOC_USP7_MATH_1	11	15	PF00917	0.556
DOC_USP7_MATH_1	129	133	PF00917	0.428
DOC_USP7_MATH_1	269	273	PF00917	0.560
DOC_USP7_MATH_1	285	289	PF00917	0.446
DOC_USP7_MATH_1	309	313	PF00917	0.383
DOC_USP7_MATH_1	341	345	PF00917	0.343
DOC_USP7_MATH_1	348	352	PF00917	0.379
DOC_USP7_MATH_1	386	390	PF00917	0.493
DOC_USP7_MATH_1	445	449	PF00917	0.280
DOC_USP7_MATH_1	519	523	PF00917	0.377
DOC_USP7_MATH_2	407	413	PF00917	0.299
DOC_USP7_UBL2_3	638	642	PF12436	0.746
DOC_WW_Pin1_4	110	115	PF00397	0.521
DOC_WW_Pin1_4	12	17	PF00397	0.593
DOC_WW_Pin1_4	217	222	PF00397	0.420
DOC_WW_Pin1_4	241	246	PF00397	0.425
DOC_WW_Pin1_4	295	300	PF00397	0.402
DOC_WW_Pin1_4	344	349	PF00397	0.409
DOC_WW_Pin1_4	498	503	PF00397	0.380
DOC_WW_Pin1_4	703	708	PF00397	0.453
LIG_14-3-3_CanoR_1	144	154	PF00244	0.623
LIG_14-3-3_CanoR_1	165	170	PF00244	0.567
LIG_14-3-3_CanoR_1	19	27	PF00244	0.553
LIG_14-3-3_CanoR_1	393	401	PF00244	0.389
LIG_14-3-3_CanoR_1	462	467	PF00244	0.403
LIG_14-3-3_CanoR_1	469	479	PF00244	0.326
LIG_14-3-3_CanoR_1	653	663	PF00244	0.534
LIG_14-3-3_CanoR_1	8	16	PF00244	0.618
LIG_Actin_WH2_2	350	367	PF00022	0.448
LIG_Actin_WH2_2	456	471	PF00022	0.403
LIG_AP2alpha_2	716	718	PF02296	0.293
LIG_APCC_ABBA_1	588	593	PF00400	0.362
LIG_BIR_III_2	631	635	PF00653	0.580
LIG_BIR_III_4	684	688	PF00653	0.524
LIG_CSL_BTD_1	724	727	PF09270	0.374
LIG_eIF4E_1	551	557	PF01652	0.345
LIG_FHA_1	242	248	PF00498	0.441
LIG_FHA_1	345	351	PF00498	0.469
LIG_FHA_1	380	386	PF00498	0.374
LIG_FHA_1	401	407	PF00498	0.544
LIG_FHA_1	491	497	PF00498	0.320
LIG_FHA_1	563	569	PF00498	0.441
LIG_FHA_1	89	95	PF00498	0.320
LIG_FHA_2	125	131	PF00498	0.473
LIG_FHA_2	248	254	PF00498	0.381
LIG_FHA_2	260	266	PF00498	0.487
LIG_FHA_2	296	302	PF00498	0.462
LIG_FHA_2	372	378	PF00498	0.399
LIG_FHA_2	54	60	PF00498	0.559
LIG_Integrin_isoDGR_2	86	88	PF01839	0.363
LIG_LIR_Apic_2	374	379	PF02991	0.375
LIG_LIR_Apic_2	512	516	PF02991	0.318
LIG_LIR_Gen_1	148	158	PF02991	0.353
LIG_LIR_Gen_1	167	177	PF02991	0.399
LIG_LIR_Gen_1	234	240	PF02991	0.417
LIG_LIR_Gen_1	288	294	PF02991	0.581
LIG_LIR_Gen_1	370	379	PF02991	0.506
LIG_LIR_Gen_1	584	594	PF02991	0.366
LIG_LIR_LC3C_4	419	422	PF02991	0.318
LIG_LIR_Nem_3	148	154	PF02991	0.413
LIG_LIR_Nem_3	167	172	PF02991	0.381
LIG_LIR_Nem_3	234	238	PF02991	0.421
LIG_LIR_Nem_3	370	376	PF02991	0.468
LIG_LIR_Nem_3	382	387	PF02991	0.408
LIG_LIR_Nem_3	584	590	PF02991	0.348
LIG_LIR_Nem_3	698	704	PF02991	0.535
LIG_LIR_Nem_3	716	721	PF02991	0.351
LIG_PCNA_yPIPBox_3	520	534	PF02747	0.325
LIG_Pex14_2	720	724	PF04695	0.281
LIG_SH2_CRK	169	173	PF00017	0.442
LIG_SH2_CRK	360	364	PF00017	0.402
LIG_SH2_GRB2like	290	293	PF00017	0.415
LIG_SH2_NCK_1	169	173	PF00017	0.610
LIG_SH2_SRC	235	238	PF00017	0.397
LIG_SH2_SRC	551	554	PF00017	0.410
LIG_SH2_SRC	769	772	PF00017	0.417
LIG_SH2_STAP1	187	191	PF00017	0.518
LIG_SH2_STAP1	290	294	PF00017	0.580
LIG_SH2_STAP1	34	38	PF00017	0.543
LIG_SH2_STAT5	339	342	PF00017	0.383
LIG_SH2_STAT5	551	554	PF00017	0.410
LIG_SH2_STAT5	64	67	PF00017	0.542
LIG_SH2_STAT5	769	772	PF00017	0.414
LIG_SH2_STAT5	81	84	PF00017	0.353
LIG_SH3_2	24	29	PF14604	0.538
LIG_SH3_3	190	196	PF00018	0.600
LIG_SH3_3	21	27	PF00018	0.548
LIG_SH3_3	215	221	PF00018	0.356
LIG_SH3_3	224	230	PF00018	0.364
LIG_SH3_3	591	597	PF00018	0.419
LIG_SH3_3	641	647	PF00018	0.740
LIG_SH3_3	711	717	PF00018	0.380
LIG_SUMO_SIM_par_1	173	178	PF11976	0.471
LIG_TRAF2_1	298	301	PF00917	0.402
LIG_TRAF2_2	644	649	PF00917	0.573
LIG_TYR_ITIM	233	238	PF00017	0.373
LIG_WRC_WIRS_1	248	253	PF05994	0.358
MOD_CDC14_SPxK_1	220	223	PF00782	0.327
MOD_CDK_SPK_2	14	19	PF00069	0.556
MOD_CDK_SPK_2	217	222	PF00069	0.356
MOD_CDK_SPxK_1	217	223	PF00069	0.353
MOD_CDK_SPxxK_3	110	117	PF00069	0.346
MOD_CDK_SPxxK_3	12	19	PF00069	0.557
MOD_CDK_SPxxK_3	498	505	PF00069	0.338
MOD_CDK_SPxxK_3	703	710	PF00069	0.428
MOD_CK1_1	113	119	PF00069	0.427
MOD_CK1_1	134	140	PF00069	0.378
MOD_CK1_1	14	20	PF00069	0.590
MOD_CK1_1	272	278	PF00069	0.562
MOD_CK1_1	321	327	PF00069	0.371
MOD_CK1_1	344	350	PF00069	0.379
MOD_CK1_1	388	394	PF00069	0.457
MOD_CK1_1	412	418	PF00069	0.324
MOD_CK1_1	55	61	PF00069	0.544
MOD_CK1_1	558	564	PF00069	0.466
MOD_CK1_1	62	68	PF00069	0.520
MOD_CK1_1	674	680	PF00069	0.596
MOD_CK1_1	7	13	PF00069	0.605
MOD_CK1_1	745	751	PF00069	0.467
MOD_CK2_1	231	237	PF00069	0.375
MOD_CK2_1	247	253	PF00069	0.375
MOD_CK2_1	259	265	PF00069	0.504
MOD_CK2_1	295	301	PF00069	0.622
MOD_CK2_1	309	315	PF00069	0.395
MOD_CK2_1	470	476	PF00069	0.451
MOD_CK2_1	519	525	PF00069	0.235
MOD_Cter_Amidation	265	268	PF01082	0.529
MOD_Cter_Amidation	27	30	PF01082	0.524
MOD_Cter_Amidation	576	579	PF01082	0.386
MOD_GlcNHglycan	188	192	PF01048	0.520
MOD_GlcNHglycan	287	290	PF01048	0.520
MOD_GlcNHglycan	307	310	PF01048	0.420
MOD_GlcNHglycan	311	314	PF01048	0.426
MOD_GlcNHglycan	320	323	PF01048	0.386
MOD_GlcNHglycan	343	347	PF01048	0.415
MOD_GlcNHglycan	388	391	PF01048	0.395
MOD_GlcNHglycan	394	397	PF01048	0.394
MOD_GlcNHglycan	447	450	PF01048	0.235
MOD_GlcNHglycan	557	560	PF01048	0.474
MOD_GlcNHglycan	575	578	PF01048	0.484
MOD_GlcNHglycan	619	622	PF01048	0.628
MOD_GlcNHglycan	771	774	PF01048	0.458
MOD_GlcNHglycan	9	12	PF01048	0.598
MOD_GSK3_1	130	137	PF00069	0.356
MOD_GSK3_1	14	21	PF00069	0.570
MOD_GSK3_1	243	250	PF00069	0.617
MOD_GSK3_1	305	312	PF00069	0.403
MOD_GSK3_1	313	320	PF00069	0.374
MOD_GSK3_1	344	351	PF00069	0.471
MOD_GSK3_1	367	374	PF00069	0.338
MOD_GSK3_1	385	392	PF00069	0.419
MOD_GSK3_1	436	443	PF00069	0.469
MOD_GSK3_1	487	494	PF00069	0.413
MOD_GSK3_1	55	62	PF00069	0.735
MOD_GSK3_1	551	558	PF00069	0.542
MOD_GSK3_1	6	13	PF00069	0.606
MOD_GSK3_1	612	619	PF00069	0.520
MOD_GSK3_1	647	654	PF00069	0.616
MOD_GSK3_1	670	677	PF00069	0.576
MOD_GSK3_1	88	95	PF00069	0.331
MOD_N-GLC_1	11	16	PF02516	0.592
MOD_N-GLC_1	260	265	PF02516	0.658
MOD_N-GLC_1	367	372	PF02516	0.353
MOD_N-GLC_1	412	417	PF02516	0.317
MOD_N-GLC_1	519	524	PF02516	0.270
MOD_N-GLC_1	610	615	PF02516	0.571
MOD_N-GLC_1	671	676	PF02516	0.570
MOD_N-GLC_2	150	152	PF02516	0.357
MOD_NEK2_1	164	169	PF00069	0.534
MOD_NEK2_1	259	264	PF00069	0.712
MOD_NEK2_1	293	298	PF00069	0.614
MOD_NEK2_1	318	323	PF00069	0.572
MOD_NEK2_1	331	336	PF00069	0.364
MOD_NEK2_1	4	9	PF00069	0.602
MOD_NEK2_1	509	514	PF00069	0.511
MOD_NEK2_1	53	58	PF00069	0.519
MOD_NEK2_1	555	560	PF00069	0.468
MOD_NEK2_1	612	617	PF00069	0.527
MOD_NEK2_1	670	675	PF00069	0.522
MOD_NEK2_1	758	763	PF00069	0.310
MOD_NEK2_2	131	136	PF00069	0.361
MOD_NEK2_2	671	676	PF00069	0.537
MOD_OFUCOSY	123	128	PF10250	0.373
MOD_OFUCOSY	224	229	PF10250	0.417
MOD_OFUCOSY	99	104	PF10250	0.472
MOD_PIKK_1	159	165	PF00454	0.536
MOD_PIKK_1	313	319	PF00454	0.397
MOD_PKA_1	637	643	PF00069	0.774
MOD_PKA_2	124	130	PF00069	0.384
MOD_PKA_2	143	149	PF00069	0.445
MOD_PKA_2	164	170	PF00069	0.566
MOD_PKA_2	18	24	PF00069	0.552
MOD_PKA_2	364	370	PF00069	0.431
MOD_PKA_2	392	398	PF00069	0.426
MOD_PKA_2	7	13	PF00069	0.576
MOD_Plk_1	175	181	PF00069	0.488
MOD_Plk_1	260	266	PF00069	0.531
MOD_Plk_1	272	278	PF00069	0.440
MOD_Plk_1	412	418	PF00069	0.324
MOD_Plk_1	519	525	PF00069	0.270
MOD_Plk_1	610	616	PF00069	0.573
MOD_Plk_1	671	677	PF00069	0.537
MOD_Plk_2-3	371	377	PF00069	0.413
MOD_Plk_4	243	249	PF00069	0.535
MOD_Plk_4	331	337	PF00069	0.323
MOD_Plk_4	462	468	PF00069	0.490
MOD_Plk_4	487	493	PF00069	0.329
MOD_Plk_4	551	557	PF00069	0.457
MOD_Plk_4	59	65	PF00069	0.533
MOD_ProDKin_1	110	116	PF00069	0.519
MOD_ProDKin_1	12	18	PF00069	0.586
MOD_ProDKin_1	217	223	PF00069	0.417
MOD_ProDKin_1	241	247	PF00069	0.420
MOD_ProDKin_1	295	301	PF00069	0.401
MOD_ProDKin_1	344	350	PF00069	0.407
MOD_ProDKin_1	498	504	PF00069	0.380
MOD_ProDKin_1	703	709	PF00069	0.444
MOD_SUMO_for_1	416	419	PF00179	0.337
MOD_SUMO_rev_2	263	269	PF00179	0.519
MOD_SUMO_rev_2	631	640	PF00179	0.581
MOD_SUMO_rev_2	682	688	PF00179	0.526
MOD_SUMO_rev_2	698	704	PF00179	0.427
MOD_SUMO_rev_2	735	740	PF00179	0.335
TRG_DiLeu_BaLyEn_6	359	364	PF01217	0.328
TRG_DiLeu_BaLyEn_6	513	518	PF01217	0.431
TRG_ENDOCYTIC_2	169	172	PF00928	0.433
TRG_ENDOCYTIC_2	235	238	PF00928	0.383
TRG_ENDOCYTIC_2	290	293	PF00928	0.583
TRG_ENDOCYTIC_2	360	363	PF00928	0.401
TRG_ENDOCYTIC_2	721	724	PF00928	0.393
TRG_ER_diArg_1	221	223	PF00400	0.511
TRG_ER_diArg_1	381	384	PF00400	0.401
TRG_ER_diArg_1	578	580	PF00400	0.378
TRG_ER_diArg_1	727	729	PF00400	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5R6	Leptomonas seymouri	45%	99%
A0A3S7WSB8	Leishmania donovani	54%	100%
A4HVG0	Leishmania infantum	52%	96%
E9AP54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
Q4QGD4	Leishmania major	52%	100%