Putative class 3 lipase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Triglyceride lipase, putative

Species:

Leishmania braziliensis

UniProt:

A4HHR9_LEIBR

TriTrypDb:

LbrM.29.2680 , LBRM2903_290035600

Length:

804

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHR9

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0008152	metabolic process	1	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0003824	catalytic activity	1	1
GO:0004806	triglyceride lipase activity	5	1
GO:0016298	lipase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0052689	carboxylic ester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	702	706	PF00656	0.652
CLV_NRD_NRD_1	115	117	PF00675	0.297
CLV_NRD_NRD_1	386	388	PF00675	0.552
CLV_NRD_NRD_1	737	739	PF00675	0.560
CLV_NRD_NRD_1	741	743	PF00675	0.430
CLV_PCSK_KEX2_1	115	117	PF00082	0.319
CLV_PCSK_KEX2_1	156	158	PF00082	0.499
CLV_PCSK_KEX2_1	737	739	PF00082	0.640
CLV_PCSK_KEX2_1	741	743	PF00082	0.499
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.499
CLV_PCSK_PC7_1	111	117	PF00082	0.366
CLV_PCSK_PC7_1	737	743	PF00082	0.522
CLV_PCSK_SKI1_1	252	256	PF00082	0.497
CLV_PCSK_SKI1_1	265	269	PF00082	0.477
CLV_PCSK_SKI1_1	275	279	PF00082	0.455
CLV_PCSK_SKI1_1	741	745	PF00082	0.487
DEG_APCC_DBOX_1	274	282	PF00400	0.465
DEG_SPOP_SBC_1	550	554	PF00917	0.684
DEG_SPOP_SBC_1	583	587	PF00917	0.518
DOC_CYCLIN_RxL_1	249	259	PF00134	0.505
DOC_CYCLIN_RxL_1	272	279	PF00134	0.409
DOC_MAPK_gen_1	338	346	PF00069	0.460
DOC_MAPK_gen_1	375	382	PF00069	0.437
DOC_PP1_RVXF_1	323	329	PF00149	0.396
DOC_PP2B_LxvP_1	290	293	PF13499	0.481
DOC_PP2B_LxvP_1	320	323	PF13499	0.449
DOC_PP2B_LxvP_1	449	452	PF13499	0.417
DOC_PP2B_LxvP_1	467	470	PF13499	0.417
DOC_PP2B_LxvP_1	9	12	PF13499	0.504
DOC_USP7_MATH_1	120	124	PF00917	0.364
DOC_USP7_MATH_1	408	412	PF00917	0.339
DOC_USP7_MATH_1	41	45	PF00917	0.513
DOC_USP7_MATH_1	527	531	PF00917	0.592
DOC_USP7_MATH_1	549	553	PF00917	0.699
DOC_USP7_MATH_1	563	567	PF00917	0.700
DOC_USP7_MATH_1	583	587	PF00917	0.611
DOC_USP7_MATH_1	590	594	PF00917	0.664
DOC_USP7_MATH_1	683	687	PF00917	0.630
DOC_USP7_MATH_1	733	737	PF00917	0.604
DOC_WW_Pin1_4	613	618	PF00397	0.646
DOC_WW_Pin1_4	713	718	PF00397	0.752
LIG_14-3-3_CanoR_1	265	272	PF00244	0.514
LIG_14-3-3_CanoR_1	275	281	PF00244	0.458
LIG_14-3-3_CanoR_1	309	317	PF00244	0.402
LIG_14-3-3_CanoR_1	348	354	PF00244	0.501
LIG_14-3-3_CanoR_1	375	381	PF00244	0.442
LIG_14-3-3_CanoR_1	502	511	PF00244	0.546
LIG_14-3-3_CanoR_1	516	522	PF00244	0.495
LIG_14-3-3_CanoR_1	569	577	PF00244	0.772
LIG_14-3-3_CanoR_1	741	749	PF00244	0.463
LIG_Actin_WH2_2	295	311	PF00022	0.415
LIG_BIR_III_2	705	709	PF00653	0.541
LIG_BRCT_BRCA1_1	597	601	PF00533	0.572
LIG_BRCT_BRCA1_1	626	630	PF00533	0.452
LIG_eIF4E_1	437	443	PF01652	0.378
LIG_FHA_1	186	192	PF00498	0.459
LIG_FHA_1	266	272	PF00498	0.504
LIG_FHA_1	294	300	PF00498	0.462
LIG_FHA_1	337	343	PF00498	0.438
LIG_FHA_1	348	354	PF00498	0.448
LIG_FHA_1	377	383	PF00498	0.675
LIG_FHA_1	420	426	PF00498	0.408
LIG_FHA_1	504	510	PF00498	0.588
LIG_FHA_1	537	543	PF00498	0.496
LIG_FHA_1	553	559	PF00498	0.554
LIG_FHA_1	683	689	PF00498	0.441
LIG_FHA_1	96	102	PF00498	0.394
LIG_FHA_2	243	249	PF00498	0.439
LIG_FHA_2	316	322	PF00498	0.450
LIG_FHA_2	354	360	PF00498	0.643
LIG_FHA_2	363	369	PF00498	0.564
LIG_FHA_2	570	576	PF00498	0.611
LIG_FHA_2	608	614	PF00498	0.699
LIG_FHA_2	645	651	PF00498	0.591
LIG_FHA_2	714	720	PF00498	0.652
LIG_FHA_2	724	730	PF00498	0.682
LIG_Integrin_RGD_1	157	159	PF01839	0.504
LIG_LIR_Gen_1	315	323	PF02991	0.450
LIG_LIR_Gen_1	339	349	PF02991	0.473
LIG_LIR_Gen_1	351	361	PF02991	0.481
LIG_LIR_Gen_1	406	416	PF02991	0.406
LIG_LIR_Gen_1	418	425	PF02991	0.424
LIG_LIR_Gen_1	434	443	PF02991	0.198
LIG_LIR_Gen_1	483	494	PF02991	0.336
LIG_LIR_Gen_1	598	609	PF02991	0.495
LIG_LIR_Nem_3	248	254	PF02991	0.465
LIG_LIR_Nem_3	3	9	PF02991	0.507
LIG_LIR_Nem_3	315	320	PF02991	0.461
LIG_LIR_Nem_3	343	349	PF02991	0.438
LIG_LIR_Nem_3	351	357	PF02991	0.484
LIG_LIR_Nem_3	406	412	PF02991	0.406
LIG_LIR_Nem_3	418	424	PF02991	0.424
LIG_LIR_Nem_3	434	440	PF02991	0.401
LIG_LIR_Nem_3	483	489	PF02991	0.328
LIG_LIR_Nem_3	598	604	PF02991	0.531
LIG_LIR_Nem_3	744	749	PF02991	0.455
LIG_LIR_Nem_3	766	772	PF02991	0.377
LIG_PDZ_Class_1	799	804	PF00595	0.395
LIG_Pex14_1	486	490	PF04695	0.303
LIG_Pex14_2	251	255	PF04695	0.366
LIG_PTB_Apo_2	489	496	PF02174	0.357
LIG_PTB_Phospho_1	489	495	PF10480	0.357
LIG_SH2_CRK	421	425	PF00017	0.311
LIG_SH2_CRK	749	753	PF00017	0.335
LIG_SH2_CRK	757	761	PF00017	0.400
LIG_SH2_NCK_1	475	479	PF00017	0.354
LIG_SH2_SRC	258	261	PF00017	0.271
LIG_SH2_STAP1	258	262	PF00017	0.422
LIG_SH2_STAP1	304	308	PF00017	0.406
LIG_SH2_STAP1	421	425	PF00017	0.417
LIG_SH2_STAT5	131	134	PF00017	0.338
LIG_SH2_STAT5	167	170	PF00017	0.515
LIG_SH2_STAT5	27	30	PF00017	0.488
LIG_SH2_STAT5	289	292	PF00017	0.486
LIG_SH2_STAT5	317	320	PF00017	0.443
LIG_SH2_STAT5	421	424	PF00017	0.417
LIG_SH2_STAT5	437	440	PF00017	0.417
LIG_SH2_STAT5	640	643	PF00017	0.470
LIG_SH2_STAT5	759	762	PF00017	0.445
LIG_SH3_3	199	205	PF00018	0.477
LIG_SH3_3	402	408	PF00018	0.417
LIG_SH3_3	653	659	PF00018	0.505
LIG_SH3_3	71	77	PF00018	0.519
LIG_SH3_3	727	733	PF00018	0.669
LIG_SH3_3	8	14	PF00018	0.550
LIG_SUMO_SIM_par_1	295	301	PF11976	0.555
LIG_SxIP_EBH_1	295	309	PF03271	0.465
LIG_TYR_ITIM	285	290	PF00017	0.440
MOD_CK1_1	240	246	PF00069	0.456
MOD_CK1_1	44	50	PF00069	0.684
MOD_CK1_1	5	11	PF00069	0.683
MOD_CK1_1	520	526	PF00069	0.555
MOD_CK1_1	552	558	PF00069	0.722
MOD_CK1_1	624	630	PF00069	0.609
MOD_CK1_1	657	663	PF00069	0.487
MOD_CK1_1	686	692	PF00069	0.681
MOD_CK2_1	242	248	PF00069	0.534
MOD_CK2_1	315	321	PF00069	0.347
MOD_CK2_1	353	359	PF00069	0.496
MOD_CK2_1	362	368	PF00069	0.680
MOD_CK2_1	408	414	PF00069	0.354
MOD_CK2_1	550	556	PF00069	0.777
MOD_CK2_1	569	575	PF00069	0.655
MOD_CK2_1	607	613	PF00069	0.571
MOD_CK2_1	713	719	PF00069	0.671
MOD_GlcNHglycan	2	5	PF01048	0.550
MOD_GlcNHglycan	238	242	PF01048	0.452
MOD_GlcNHglycan	282	285	PF01048	0.385
MOD_GlcNHglycan	417	420	PF01048	0.372
MOD_GlcNHglycan	46	49	PF01048	0.733
MOD_GlcNHglycan	566	569	PF01048	0.541
MOD_GlcNHglycan	586	589	PF01048	0.746
MOD_GlcNHglycan	592	595	PF01048	0.730
MOD_GlcNHglycan	597	600	PF01048	0.773
MOD_GlcNHglycan	626	630	PF01048	0.709
MOD_GlcNHglycan	655	659	PF01048	0.507
MOD_GlcNHglycan	685	688	PF01048	0.611
MOD_GlcNHglycan	702	705	PF01048	0.787
MOD_GSK3_1	237	244	PF00069	0.513
MOD_GSK3_1	276	283	PF00069	0.367
MOD_GSK3_1	293	300	PF00069	0.408
MOD_GSK3_1	349	356	PF00069	0.573
MOD_GSK3_1	37	44	PF00069	0.595
MOD_GSK3_1	415	422	PF00069	0.367
MOD_GSK3_1	519	526	PF00069	0.652
MOD_GSK3_1	550	557	PF00069	0.545
MOD_GSK3_1	564	571	PF00069	0.475
MOD_GSK3_1	621	628	PF00069	0.675
MOD_GSK3_1	640	647	PF00069	0.601
MOD_GSK3_1	65	72	PF00069	0.612
MOD_GSK3_1	682	689	PF00069	0.651
MOD_GSK3_1	711	718	PF00069	0.539
MOD_GSK3_1	758	765	PF00069	0.426
MOD_GSK3_1	84	91	PF00069	0.293
MOD_N-GLC_1	293	298	PF02516	0.451
MOD_N-GLC_1	624	629	PF02516	0.667
MOD_N-GLC_1	711	716	PF02516	0.539
MOD_NEK2_1	237	242	PF00069	0.509
MOD_NEK2_1	25	30	PF00069	0.703
MOD_NEK2_1	280	285	PF00069	0.363
MOD_NEK2_1	308	313	PF00069	0.422
MOD_NEK2_1	463	468	PF00069	0.420
MOD_NEK2_1	517	522	PF00069	0.584
MOD_OFUCOSY	179	184	PF10250	0.393
MOD_OFUCOSY	95	100	PF10250	0.472
MOD_PIKK_1	200	206	PF00454	0.467
MOD_PIKK_1	242	248	PF00454	0.420
MOD_PIKK_1	27	33	PF00454	0.493
MOD_PKA_1	741	747	PF00069	0.471
MOD_PKA_2	308	314	PF00069	0.396
MOD_PKA_2	315	321	PF00069	0.317
MOD_PKA_2	347	353	PF00069	0.442
MOD_PKA_2	37	43	PF00069	0.515
MOD_PKA_2	501	507	PF00069	0.417
MOD_PKA_2	564	570	PF00069	0.709
MOD_PKA_2	683	689	PF00069	0.571
MOD_PKA_2	741	747	PF00069	0.471
MOD_Plk_1	293	299	PF00069	0.455
MOD_Plk_1	62	68	PF00069	0.487
MOD_Plk_1	625	631	PF00069	0.651
MOD_Plk_1	711	717	PF00069	0.696
MOD_Plk_1	777	783	PF00069	0.534
MOD_Plk_2-3	315	321	PF00069	0.461
MOD_Plk_2-3	62	68	PF00069	0.487
MOD_Plk_4	144	150	PF00069	0.489
MOD_Plk_4	197	203	PF00069	0.477
MOD_Plk_4	276	282	PF00069	0.388
MOD_Plk_4	315	321	PF00069	0.360
MOD_Plk_4	349	355	PF00069	0.545
MOD_Plk_4	408	414	PF00069	0.478
MOD_Plk_4	419	425	PF00069	0.396
MOD_Plk_4	520	526	PF00069	0.573
MOD_Plk_4	527	533	PF00069	0.708
MOD_Plk_4	69	75	PF00069	0.578
MOD_Plk_4	691	697	PF00069	0.570
MOD_Plk_4	777	783	PF00069	0.529
MOD_ProDKin_1	613	619	PF00069	0.644
MOD_ProDKin_1	713	719	PF00069	0.750
MOD_SUMO_rev_2	714	723	PF00179	0.521
TRG_DiLeu_BaEn_2	690	696	PF01217	0.489
TRG_DiLeu_BaLyEn_6	458	463	PF01217	0.367
TRG_DiLeu_BaLyEn_6	467	472	PF01217	0.350
TRG_ENDOCYTIC_2	131	134	PF00928	0.373
TRG_ENDOCYTIC_2	258	261	PF00928	0.413
TRG_ENDOCYTIC_2	287	290	PF00928	0.431
TRG_ENDOCYTIC_2	317	320	PF00928	0.426
TRG_ENDOCYTIC_2	421	424	PF00928	0.311
TRG_ENDOCYTIC_2	437	440	PF00928	0.303
TRG_ENDOCYTIC_2	749	752	PF00928	0.384
TRG_ENDOCYTIC_2	757	760	PF00928	0.474
TRG_ER_diArg_1	104	107	PF00400	0.359
TRG_ER_diArg_1	337	340	PF00400	0.591
TRG_ER_diArg_1	678	681	PF00400	0.447
TRG_ER_diArg_1	737	739	PF00400	0.619
TRG_ER_diArg_1	741	743	PF00400	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7D8	Leptomonas seymouri	53%	95%
A0A1X0P712	Trypanosomatidae	36%	100%
A0A3Q8I9H1	Leishmania donovani	79%	100%
A0A3R7KT67	Trypanosoma rangeli	39%	100%
A0A3S7WSB8	Leishmania donovani	28%	100%
A4HVF6	Leishmania infantum	79%	100%
E9AP55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QGD3	Leishmania major	77%	100%
V5AKR6	Trypanosoma cruzi	39%	100%