RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-RING finger domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HHR7_LEIBR

TriTrypDb:

LbrM.29.2660 , LBRM2903_290035400

Length:

504

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0000795	synaptonemal complex	3	6
GO:0099086	synaptonemal structure	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HHR7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHR7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006259	DNA metabolic process	4	6
GO:0006310	DNA recombination	5	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0007131	reciprocal meiotic recombination	3	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0022402	cell cycle process	2	6
GO:0022414	reproductive process	1	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0035825	homologous recombination	6	6
GO:0043170	macromolecule metabolic process	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044260	obsolete cellular macromolecule metabolic process	3	6
GO:0046483	heterocycle metabolic process	3	6
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:0140527	reciprocal homologous recombination	7	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:1903046	meiotic cell cycle process	2	6
GO:0006996	organelle organization	4	1
GO:0007129	homologous chromosome pairing at meiosis	4	1
GO:0016043	cellular component organization	3	1
GO:0016925	protein sumoylation	7	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043412	macromolecule modification	4	1
GO:0051276	chromosome organization	5	1
GO:0070192	chromosome organization involved in meiotic cell cycle	3	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016740	transferase activity	2	6
GO:0019787	ubiquitin-like protein transferase activity	3	6
GO:0019789	SUMO transferase activity	4	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:0005488	binding	1	3
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	347	351	PF00656	0.553
CLV_C14_Caspase3-7	436	440	PF00656	0.548
CLV_NRD_NRD_1	179	181	PF00675	0.617
CLV_NRD_NRD_1	198	200	PF00675	0.576
CLV_NRD_NRD_1	25	27	PF00675	0.451
CLV_NRD_NRD_1	337	339	PF00675	0.705
CLV_NRD_NRD_1	74	76	PF00675	0.461
CLV_NRD_NRD_1	86	88	PF00675	0.421
CLV_PCSK_FUR_1	23	27	PF00082	0.447
CLV_PCSK_KEX2_1	179	181	PF00082	0.612
CLV_PCSK_KEX2_1	197	199	PF00082	0.423
CLV_PCSK_KEX2_1	233	235	PF00082	0.449
CLV_PCSK_KEX2_1	25	27	PF00082	0.451
CLV_PCSK_KEX2_1	337	339	PF00082	0.705
CLV_PCSK_KEX2_1	369	371	PF00082	0.714
CLV_PCSK_KEX2_1	74	76	PF00082	0.461
CLV_PCSK_KEX2_1	86	88	PF00082	0.421
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.449
CLV_PCSK_PC1ET2_1	369	371	PF00082	0.714
CLV_PCSK_PC7_1	229	235	PF00082	0.426
CLV_PCSK_SKI1_1	182	186	PF00082	0.621
DEG_APCC_DBOX_1	181	189	PF00400	0.597
DEG_Nend_UBRbox_1	1	4	PF02207	0.477
DEG_SPOP_SBC_1	394	398	PF00917	0.534
DOC_CKS1_1	449	454	PF01111	0.704
DOC_CYCLIN_yCln2_LP_2	449	455	PF00134	0.705
DOC_MAPK_gen_1	86	94	PF00069	0.431
DOC_MAPK_MEF2A_6	383	391	PF00069	0.545
DOC_MAPK_MEF2A_6	61	69	PF00069	0.447
DOC_PP1_RVXF_1	442	448	PF00149	0.573
DOC_PP4_FxxP_1	494	497	PF00568	0.717
DOC_USP7_MATH_1	187	191	PF00917	0.445
DOC_USP7_MATH_1	208	212	PF00917	0.456
DOC_USP7_MATH_1	352	356	PF00917	0.628
DOC_USP7_MATH_1	394	398	PF00917	0.677
DOC_USP7_MATH_1	412	416	PF00917	0.543
DOC_USP7_MATH_1	421	425	PF00917	0.697
DOC_USP7_MATH_1	465	469	PF00917	0.622
DOC_USP7_MATH_1	470	474	PF00917	0.642
DOC_USP7_MATH_1	477	481	PF00917	0.644
DOC_USP7_MATH_1	6	10	PF00917	0.482
DOC_WW_Pin1_4	14	19	PF00397	0.472
DOC_WW_Pin1_4	244	249	PF00397	0.564
DOC_WW_Pin1_4	278	283	PF00397	0.716
DOC_WW_Pin1_4	322	327	PF00397	0.661
DOC_WW_Pin1_4	404	409	PF00397	0.713
DOC_WW_Pin1_4	448	453	PF00397	0.681
DOC_WW_Pin1_4	493	498	PF00397	0.716
LIG_14-3-3_CanoR_1	121	127	PF00244	0.341
LIG_14-3-3_CanoR_1	234	243	PF00244	0.700
LIG_14-3-3_CanoR_1	448	452	PF00244	0.539
LIG_14-3-3_CanoR_1	492	497	PF00244	0.689
LIG_14-3-3_CanoR_1	61	66	PF00244	0.486
LIG_14-3-3_CanoR_1	91	95	PF00244	0.404
LIG_Actin_WH2_2	468	486	PF00022	0.544
LIG_Clathr_ClatBox_1	141	145	PF01394	0.531
LIG_FHA_1	121	127	PF00498	0.327
LIG_FHA_1	161	167	PF00498	0.523
LIG_FHA_1	273	279	PF00498	0.723
LIG_FHA_1	299	305	PF00498	0.551
LIG_FHA_1	408	414	PF00498	0.548
LIG_FHA_1	448	454	PF00498	0.705
LIG_FHA_2	156	162	PF00498	0.467
LIG_LIR_Nem_3	93	97	PF02991	0.522
LIG_MYND_1	242	246	PF01753	0.545
LIG_MYND_1	485	489	PF01753	0.527
LIG_PDZ_Class_2	499	504	PF00595	0.511
LIG_SH2_CRK	139	143	PF00017	0.629
LIG_SH2_CRK	174	178	PF00017	0.588
LIG_SH2_STAT5	117	120	PF00017	0.462
LIG_SH2_STAT5	27	30	PF00017	0.454
LIG_SH3_1	294	300	PF00018	0.717
LIG_SH3_3	239	245	PF00018	0.793
LIG_SH3_3	294	300	PF00018	0.721
LIG_SH3_3	464	470	PF00018	0.595
LIG_TRAF2_1	53	56	PF00917	0.524
LIG_TRFH_1	481	485	PF08558	0.531
LIG_WRC_WIRS_1	471	476	PF05994	0.561
LIG_WW_2	242	245	PF00397	0.524
MOD_CDK_SPK_2	404	409	PF00069	0.687
MOD_CDK_SPK_2	493	498	PF00069	0.716
MOD_CK1_1	120	126	PF00069	0.463
MOD_CK1_1	313	319	PF00069	0.696
MOD_CK1_1	321	327	PF00069	0.640
MOD_CK1_1	362	368	PF00069	0.568
MOD_CK1_1	375	381	PF00069	0.580
MOD_CK2_1	155	161	PF00069	0.450
MOD_Cter_Amidation	72	75	PF01082	0.456
MOD_Cter_Amidation	84	87	PF01082	0.418
MOD_GlcNHglycan	282	285	PF01048	0.533
MOD_GlcNHglycan	301	304	PF01048	0.544
MOD_GlcNHglycan	320	323	PF01048	0.578
MOD_GlcNHglycan	354	357	PF01048	0.656
MOD_GlcNHglycan	361	364	PF01048	0.601
MOD_GlcNHglycan	439	442	PF01048	0.655
MOD_GlcNHglycan	7	11	PF01048	0.484
MOD_GSK3_1	225	232	PF00069	0.539
MOD_GSK3_1	313	320	PF00069	0.699
MOD_GSK3_1	322	329	PF00069	0.602
MOD_LATS_1	490	496	PF00433	0.551
MOD_N-GLC_2	19	21	PF02516	0.460
MOD_NEK2_1	359	364	PF00069	0.718
MOD_NEK2_1	447	452	PF00069	0.709
MOD_PIKK_1	166	172	PF00454	0.553
MOD_PIKK_1	187	193	PF00454	0.414
MOD_PIKK_1	234	240	PF00454	0.605
MOD_PIKK_1	32	38	PF00454	0.483
MOD_PIKK_1	377	383	PF00454	0.551
MOD_PK_1	61	67	PF00069	0.447
MOD_PKA_2	120	126	PF00069	0.335
MOD_PKA_2	228	234	PF00069	0.497
MOD_PKA_2	259	265	PF00069	0.783
MOD_PKA_2	313	319	PF00069	0.733
MOD_PKA_2	447	453	PF00069	0.540
MOD_PKA_2	483	489	PF00069	0.698
MOD_PKA_2	90	96	PF00069	0.392
MOD_PKB_1	370	378	PF00069	0.721
MOD_Plk_4	362	368	PF00069	0.787
MOD_Plk_4	470	476	PF00069	0.699
MOD_Plk_4	477	483	PF00069	0.608
MOD_ProDKin_1	14	20	PF00069	0.471
MOD_ProDKin_1	244	250	PF00069	0.566
MOD_ProDKin_1	278	284	PF00069	0.715
MOD_ProDKin_1	322	328	PF00069	0.664
MOD_ProDKin_1	404	410	PF00069	0.713
MOD_ProDKin_1	448	454	PF00069	0.680
MOD_ProDKin_1	493	499	PF00069	0.714
TRG_ENDOCYTIC_2	139	142	PF00928	0.623
TRG_ENDOCYTIC_2	174	177	PF00928	0.589
TRG_ER_diArg_1	178	180	PF00400	0.606
TRG_ER_diArg_1	197	199	PF00400	0.414
TRG_ER_diArg_1	22	25	PF00400	0.441
TRG_ER_diArg_1	74	76	PF00400	0.461
TRG_NLS_MonoExtC_3	368	374	PF00514	0.717

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WSB0	Leishmania donovani	65%	100%
A4HVF8	Leishmania infantum	65%	100%
E9AP57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
Q4QGD1	Leishmania major	64%	98%