DUF4200 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4200), putative

Species:

Leishmania braziliensis

UniProt:

A4HHR6_LEIBR

TriTrypDb:

LbrM.29.2650 , LBRM2903_290035300

Length:

350

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	3
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

A4HHR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHR6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.610
CLV_C14_Caspase3-7	46	50	PF00656	0.621
CLV_NRD_NRD_1	127	129	PF00675	0.242
CLV_NRD_NRD_1	200	202	PF00675	0.357
CLV_NRD_NRD_1	222	224	PF00675	0.403
CLV_NRD_NRD_1	256	258	PF00675	0.412
CLV_NRD_NRD_1	58	60	PF00675	0.201
CLV_NRD_NRD_1	77	79	PF00675	0.288
CLV_PCSK_FUR_1	220	224	PF00082	0.460
CLV_PCSK_KEX2_1	113	115	PF00082	0.199
CLV_PCSK_KEX2_1	186	188	PF00082	0.425
CLV_PCSK_KEX2_1	222	224	PF00082	0.420
CLV_PCSK_KEX2_1	58	60	PF00082	0.208
CLV_PCSK_KEX2_1	71	73	PF00082	0.220
CLV_PCSK_KEX2_1	77	79	PF00082	0.241
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.207
CLV_PCSK_PC1ET2_1	186	188	PF00082	0.404
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.220
CLV_PCSK_PC7_1	182	188	PF00082	0.492
CLV_PCSK_SKI1_1	116	120	PF00082	0.239
CLV_PCSK_SKI1_1	187	191	PF00082	0.488
CLV_PCSK_SKI1_1	246	250	PF00082	0.373
CLV_PCSK_SKI1_1	257	261	PF00082	0.408
CLV_PCSK_SKI1_1	282	286	PF00082	0.306
DEG_SPOP_SBC_1	7	11	PF00917	0.379
DOC_MAPK_gen_1	113	123	PF00069	0.501
DOC_MAPK_gen_1	126	135	PF00069	0.396
DOC_MAPK_gen_1	211	218	PF00069	0.370
DOC_MAPK_gen_1	220	230	PF00069	0.350
DOC_MAPK_gen_1	56	64	PF00069	0.329
DOC_USP7_MATH_1	42	46	PF00917	0.623
DOC_USP7_MATH_1	47	51	PF00917	0.591
DOC_USP7_UBL2_3	254	258	PF12436	0.428
DOC_WW_Pin1_4	17	22	PF00397	0.373
DOC_WW_Pin1_4	3	8	PF00397	0.388
LIG_14-3-3_CanoR_1	187	192	PF00244	0.339
LIG_14-3-3_CanoR_1	201	209	PF00244	0.351
LIG_14-3-3_CanoR_1	211	217	PF00244	0.367
LIG_14-3-3_CanoR_1	220	230	PF00244	0.512
LIG_14-3-3_CanoR_1	267	274	PF00244	0.407
LIG_Actin_WH2_2	44	60	PF00022	0.461
LIG_BIR_II_1	1	5	PF00653	0.396
LIG_FHA_1	137	143	PF00498	0.419
LIG_FHA_1	193	199	PF00498	0.342
LIG_FHA_1	223	229	PF00498	0.534
LIG_FHA_1	264	270	PF00498	0.477
LIG_FHA_1	27	33	PF00498	0.430
LIG_FHA_1	274	280	PF00498	0.428
LIG_FHA_2	188	194	PF00498	0.336
LIG_FHA_2	201	207	PF00498	0.349
LIG_FHA_2	35	41	PF00498	0.435
LIG_LIR_Apic_2	176	181	PF02991	0.371
LIG_LIR_Gen_1	12	21	PF02991	0.394
LIG_LIR_Gen_1	146	156	PF02991	0.510
LIG_LIR_Gen_1	160	170	PF02991	0.499
LIG_LIR_Gen_1	240	248	PF02991	0.392
LIG_LIR_Gen_1	315	322	PF02991	0.384
LIG_LIR_Nem_3	12	18	PF02991	0.396
LIG_LIR_Nem_3	160	165	PF02991	0.427
LIG_LIR_Nem_3	240	244	PF02991	0.418
LIG_LIR_Nem_3	315	320	PF02991	0.409
LIG_LRP6_Inhibitor_1	107	113	PF00058	0.210
LIG_PCNA_PIPBox_1	97	106	PF02747	0.399
LIG_PCNA_yPIPBox_3	93	104	PF02747	0.402
LIG_Pex14_1	286	290	PF04695	0.455
LIG_SH2_CRK	104	108	PF00017	0.399
LIG_SH2_CRK	15	19	PF00017	0.397
LIG_SH2_SRC	178	181	PF00017	0.431
LIG_SH2_STAP1	15	19	PF00017	0.397
LIG_SH2_STAP1	280	284	PF00017	0.365
LIG_SH2_STAT3	134	137	PF00017	0.504
LIG_SH2_STAT5	134	137	PF00017	0.531
LIG_TRAF2_1	122	125	PF00917	0.441
MOD_CDC14_SPxK_1	20	23	PF00782	0.392
MOD_CDK_SPxK_1	17	23	PF00069	0.395
MOD_CK1_1	240	246	PF00069	0.576
MOD_CK1_1	263	269	PF00069	0.421
MOD_CK1_1	270	276	PF00069	0.393
MOD_CK1_1	6	12	PF00069	0.382
MOD_CK2_1	200	206	PF00069	0.368
MOD_CK2_1	34	40	PF00069	0.433
MOD_GlcNHglycan	289	293	PF01048	0.452
MOD_GlcNHglycan	345	348	PF01048	0.588
MOD_GlcNHglycan	45	48	PF01048	0.623
MOD_GSK3_1	240	247	PF00069	0.329
MOD_GSK3_1	261	268	PF00069	0.392
MOD_GSK3_1	284	291	PF00069	0.331
MOD_GSK3_1	3	10	PF00069	0.385
MOD_GSK3_1	43	50	PF00069	0.404
MOD_NEK2_1	1	6	PF00069	0.413
MOD_NEK2_1	209	214	PF00069	0.505
MOD_NEK2_1	244	249	PF00069	0.305
MOD_NEK2_1	8	13	PF00069	0.388
MOD_NEK2_1	96	101	PF00069	0.472
MOD_PIKK_1	136	142	PF00454	0.423
MOD_PIKK_1	151	157	PF00454	0.330
MOD_PIKK_1	200	206	PF00454	0.362
MOD_PIKK_1	338	344	PF00454	0.497
MOD_PKA_1	222	228	PF00069	0.512
MOD_PKA_2	200	206	PF00069	0.358
MOD_PKA_2	212	218	PF00069	0.358
MOD_PKA_2	221	227	PF00069	0.512
MOD_PKB_1	220	228	PF00069	0.512
MOD_PKB_1	293	301	PF00069	0.389
MOD_Plk_1	192	198	PF00069	0.484
MOD_Plk_4	316	322	PF00069	0.408
MOD_Plk_4	96	102	PF00069	0.441
MOD_ProDKin_1	17	23	PF00069	0.375
MOD_ProDKin_1	3	9	PF00069	0.385
MOD_SUMO_rev_2	109	115	PF00179	0.444
MOD_SUMO_rev_2	146	154	PF00179	0.437
MOD_SUMO_rev_2	253	259	PF00179	0.376
TRG_ENDOCYTIC_2	103	106	PF00928	0.439
TRG_ENDOCYTIC_2	15	18	PF00928	0.395
TRG_ENDOCYTIC_2	156	159	PF00928	0.531
TRG_ENDOCYTIC_2	162	165	PF00928	0.531
TRG_ER_diArg_1	210	213	PF00400	0.508
TRG_ER_diArg_1	220	223	PF00400	0.517
TRG_ER_diArg_1	57	59	PF00400	0.233
TRG_ER_diArg_1	77	79	PF00400	0.478
TRG_Pf-PMV_PEXEL_1	196	200	PF00026	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBZ4	Leptomonas seymouri	83%	100%
A0A0S4JBA5	Bodo saltans	51%	100%
A0A1X0NNL1	Trypanosomatidae	58%	100%
A0A3S5H6N0	Leishmania donovani	90%	100%
A0A422NNY8	Trypanosoma rangeli	60%	100%
A4HVF9	Leishmania infantum	90%	100%
A7S8T5	Nematostella vectensis	27%	100%
B0BMJ2	Xenopus tropicalis	27%	100%
D0A6V1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AP58	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
M1V4Y8	Chlamydomonas reinhardtii	31%	100%
Q4QGD0	Leishmania major	89%	100%
Q6NTM6	Xenopus laevis	26%	100%
V5ATV5	Trypanosoma cruzi	58%	100%