LeishMANIAdb
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Putative serine/threonine-protein kinase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative serine/threonine-protein kinase
Gene product:
serine/threonine-protein kinase Nek, putative
Species:
Leishmania braziliensis
UniProt:
A4HHR5_LEIBR
TriTrypDb:
LbrM.29.2640 , LBRM2903_290033600
Length:
517

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 24
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 52
NetGPI no yes: 0, no: 53
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 6
GO:0005634 nucleus 5 2
GO:0005654 nucleoplasm 2 1
GO:0005730 nucleolus 5 1
GO:0005737 cytoplasm 2 5
GO:0005815 microtubule organizing center 2 1
GO:0005829 cytosol 2 1
GO:0005956 protein kinase CK2 complex 3 1
GO:0032991 protein-containing complex 1 2
GO:0036064 ciliary basal body 3 1
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0061695 transferase complex, transferring phosphorus-containing groups 4 2
GO:0140535 intracellular protein-containing complex 2 2
GO:1902494 catalytic complex 2 2
GO:1902554 serine/threonine protein kinase complex 6 2
GO:1902911 protein kinase complex 5 2
GO:1990234 transferase complex 3 2
GO:0005930 axoneme 2 1
GO:0005952 cAMP-dependent protein kinase complex 3 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1

Expansion

Sequence features

A4HHR5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHR5

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 54
GO:0006793 phosphorus metabolic process 3 54
GO:0006796 phosphate-containing compound metabolic process 4 54
GO:0006807 nitrogen compound metabolic process 2 54
GO:0008152 metabolic process 1 54
GO:0009987 cellular process 1 54
GO:0016310 phosphorylation 5 54
GO:0019538 protein metabolic process 3 54
GO:0036211 protein modification process 4 54
GO:0043170 macromolecule metabolic process 3 54
GO:0043412 macromolecule modification 4 54
GO:0044237 cellular metabolic process 2 54
GO:0044238 primary metabolic process 2 54
GO:0071704 organic substance metabolic process 2 54
GO:1901564 organonitrogen compound metabolic process 3 54
GO:0018105 peptidyl-serine phosphorylation 6 3
GO:0018107 peptidyl-threonine phosphorylation 6 1
GO:0018193 peptidyl-amino acid modification 5 3
GO:0018209 peptidyl-serine modification 6 3
GO:0018210 peptidyl-threonine modification 6 1
GO:0050789 regulation of biological process 2 5
GO:0050794 regulation of cellular process 3 5
GO:0051726 regulation of cell cycle 4 1
GO:0065007 biological regulation 1 5
GO:0007165 signal transduction 2 4
GO:0035556 intracellular signal transduction 3 3
GO:0009266 response to temperature stimulus 3 1
GO:0009628 response to abiotic stimulus 2 1
GO:0050896 response to stimulus 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 54
GO:0003824 catalytic activity 1 54
GO:0004672 protein kinase activity 3 54
GO:0004674 protein serine/threonine kinase activity 4 43
GO:0005488 binding 1 54
GO:0005524 ATP binding 5 54
GO:0016301 kinase activity 4 54
GO:0016740 transferase activity 2 54
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 54
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 54
GO:0017076 purine nucleotide binding 4 54
GO:0030554 adenyl nucleotide binding 5 54
GO:0032553 ribonucleotide binding 3 54
GO:0032555 purine ribonucleotide binding 4 54
GO:0032559 adenyl ribonucleotide binding 5 54
GO:0035639 purine ribonucleoside triphosphate binding 4 54
GO:0036094 small molecule binding 2 54
GO:0043167 ion binding 2 54
GO:0043168 anion binding 3 54
GO:0097159 organic cyclic compound binding 2 54
GO:0097367 carbohydrate derivative binding 2 54
GO:0140096 catalytic activity, acting on a protein 2 54
GO:1901265 nucleoside phosphate binding 3 54
GO:1901363 heterocyclic compound binding 2 54
GO:0043169 cation binding 3 5
GO:0046872 metal ion binding 4 5
GO:0004707 MAP kinase activity 5 8
GO:0004690 cyclic nucleotide-dependent protein kinase activity 5 1
GO:0004691 cAMP-dependent protein kinase activity 6 1
GO:0004140 dephospho-CoA kinase activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 485 489 PF00656 0.488
CLV_C14_Caspase3-7 83 87 PF00656 0.173
CLV_NRD_NRD_1 215 217 PF00675 0.214
CLV_NRD_NRD_1 260 262 PF00675 0.296
CLV_NRD_NRD_1 404 406 PF00675 0.750
CLV_NRD_NRD_1 442 444 PF00675 0.437
CLV_PCSK_KEX2_1 215 217 PF00082 0.208
CLV_PCSK_KEX2_1 260 262 PF00082 0.381
CLV_PCSK_KEX2_1 403 405 PF00082 0.698
CLV_PCSK_KEX2_1 441 443 PF00082 0.422
CLV_PCSK_PC7_1 256 262 PF00082 0.304
CLV_PCSK_SKI1_1 142 146 PF00082 0.335
CLV_PCSK_SKI1_1 251 255 PF00082 0.292
CLV_PCSK_SKI1_1 385 389 PF00082 0.535
DOC_CKS1_1 179 184 PF01111 0.214
DOC_CYCLIN_RxL_1 429 438 PF00134 0.474
DOC_CYCLIN_yCln2_LP_2 214 220 PF00134 0.228
DOC_CYCLIN_yCln2_LP_2 272 278 PF00134 0.458
DOC_MAPK_gen_1 142 151 PF00069 0.312
DOC_MAPK_gen_1 58 65 PF00069 0.277
DOC_PP2B_LxvP_1 272 275 PF13499 0.388
DOC_PP4_FxxP_1 295 298 PF00568 0.383
DOC_USP7_MATH_1 383 387 PF00917 0.723
DOC_USP7_MATH_1 49 53 PF00917 0.334
DOC_USP7_MATH_1 85 89 PF00917 0.194
DOC_USP7_MATH_2 497 503 PF00917 0.462
DOC_USP7_UBL2_3 154 158 PF12436 0.240
DOC_USP7_UBL2_3 385 389 PF12436 0.542
DOC_WW_Pin1_4 178 183 PF00397 0.285
DOC_WW_Pin1_4 423 428 PF00397 0.483
DOC_WW_Pin1_4 493 498 PF00397 0.500
LIG_14-3-3_CanoR_1 429 433 PF00244 0.501
LIG_APCC_ABBA_1 268 273 PF00400 0.417
LIG_APCC_ABBAyCdc20_2 443 449 PF00400 0.436
LIG_BIR_II_1 1 5 PF00653 0.429
LIG_BRCT_BRCA1_1 146 150 PF00533 0.192
LIG_BRCT_BRCA1_1 443 447 PF00533 0.420
LIG_deltaCOP1_diTrp_1 200 208 PF00928 0.192
LIG_EH1_1 161 169 PF00400 0.304
LIG_FHA_1 115 121 PF00498 0.286
LIG_FHA_1 135 141 PF00498 0.251
LIG_FHA_1 144 150 PF00498 0.259
LIG_FHA_1 24 30 PF00498 0.242
LIG_FHA_1 498 504 PF00498 0.532
LIG_FHA_2 261 267 PF00498 0.235
LIG_FHA_2 357 363 PF00498 0.526
LIG_FHA_2 429 435 PF00498 0.515
LIG_FHA_2 488 494 PF00498 0.572
LIG_FHA_2 98 104 PF00498 0.257
LIG_LIR_Apic_2 181 187 PF02991 0.329
LIG_LIR_Apic_2 303 309 PF02991 0.414
LIG_LIR_Gen_1 14 21 PF02991 0.332
LIG_LIR_Gen_1 336 345 PF02991 0.441
LIG_LIR_Gen_1 94 101 PF02991 0.353
LIG_LIR_Nem_3 14 18 PF02991 0.335
LIG_LIR_Nem_3 27 33 PF02991 0.419
LIG_LIR_Nem_3 336 341 PF02991 0.431
LIG_LIR_Nem_3 94 98 PF02991 0.386
LIG_Pex14_2 77 81 PF04695 0.201
LIG_SH2_CRK 30 34 PF00017 0.346
LIG_SH2_STAP1 302 306 PF00017 0.404
LIG_SH2_STAT5 184 187 PF00017 0.306
LIG_SH2_STAT5 302 305 PF00017 0.447
LIG_SH2_STAT5 41 44 PF00017 0.220
LIG_SH2_STAT5 95 98 PF00017 0.425
LIG_SH3_3 273 279 PF00018 0.505
LIG_SH3_3 369 375 PF00018 0.713
LIG_SH3_3 66 72 PF00018 0.207
LIG_SUMO_SIM_anti_2 62 67 PF11976 0.274
LIG_SUMO_SIM_anti_2 88 94 PF11976 0.251
LIG_SUMO_SIM_par_1 456 463 PF11976 0.469
LIG_TRAF2_1 263 266 PF00917 0.226
LIG_TRAF2_1 52 55 PF00917 0.245
LIG_TRAF2_1 59 62 PF00917 0.275
LIG_WW_3 426 430 PF00397 0.465
MOD_CDC14_SPxK_1 426 429 PF00782 0.470
MOD_CDK_SPK_2 493 498 PF00069 0.488
MOD_CDK_SPxK_1 423 429 PF00069 0.479
MOD_CK1_1 2 8 PF00069 0.416
MOD_CK1_1 23 29 PF00069 0.253
MOD_CK1_1 277 283 PF00069 0.384
MOD_CK1_1 360 366 PF00069 0.605
MOD_CK1_1 398 404 PF00069 0.576
MOD_CK1_1 411 417 PF00069 0.531
MOD_CK1_1 487 493 PF00069 0.506
MOD_CK2_1 241 247 PF00069 0.203
MOD_CK2_1 260 266 PF00069 0.273
MOD_CK2_1 293 299 PF00069 0.378
MOD_CK2_1 356 362 PF00069 0.629
MOD_CK2_1 428 434 PF00069 0.644
MOD_CK2_1 487 493 PF00069 0.512
MOD_CK2_1 49 55 PF00069 0.298
MOD_GlcNHglycan 1 4 PF01048 0.626
MOD_GlcNHglycan 22 25 PF01048 0.319
MOD_GlcNHglycan 295 298 PF01048 0.370
MOD_GlcNHglycan 332 335 PF01048 0.569
MOD_GlcNHglycan 359 362 PF01048 0.565
MOD_GlcNHglycan 365 368 PF01048 0.558
MOD_GlcNHglycan 385 388 PF01048 0.635
MOD_GlcNHglycan 443 446 PF01048 0.583
MOD_GSK3_1 196 203 PF00069 0.241
MOD_GSK3_1 20 27 PF00069 0.384
MOD_GSK3_1 256 263 PF00069 0.233
MOD_GSK3_1 280 287 PF00069 0.401
MOD_GSK3_1 33 40 PF00069 0.296
MOD_GSK3_1 356 363 PF00069 0.573
MOD_GSK3_1 383 390 PF00069 0.620
MOD_GSK3_1 395 402 PF00069 0.569
MOD_GSK3_1 482 489 PF00069 0.487
MOD_GSK3_1 493 500 PF00069 0.481
MOD_N-GLC_1 33 38 PF02516 0.350
MOD_N-GLC_1 423 428 PF02516 0.486
MOD_N-GLC_1 49 54 PF02516 0.225
MOD_NEK2_1 144 149 PF00069 0.346
MOD_NEK2_1 150 155 PF00069 0.376
MOD_NEK2_1 300 305 PF00069 0.460
MOD_NEK2_1 341 346 PF00069 0.518
MOD_NEK2_1 464 469 PF00069 0.593
MOD_NEK2_1 77 82 PF00069 0.266
MOD_NEK2_2 428 433 PF00069 0.440
MOD_PIKK_1 280 286 PF00454 0.381
MOD_PKA_1 260 266 PF00069 0.266
MOD_PKA_1 388 394 PF00069 0.608
MOD_PKA_1 403 409 PF00069 0.682
MOD_PKA_1 44 50 PF00069 0.334
MOD_PKA_1 441 447 PF00069 0.480
MOD_PKA_2 260 266 PF00069 0.253
MOD_PKA_2 322 328 PF00069 0.461
MOD_PKA_2 403 409 PF00069 0.557
MOD_PKA_2 428 434 PF00069 0.546
MOD_PKA_2 441 447 PF00069 0.471
MOD_PKA_2 479 485 PF00069 0.503
MOD_PKA_2 77 83 PF00069 0.194
MOD_PKB_1 403 411 PF00069 0.510
MOD_Plk_1 242 248 PF00069 0.210
MOD_Plk_1 37 43 PF00069 0.202
MOD_Plk_1 395 401 PF00069 0.512
MOD_Plk_1 449 455 PF00069 0.457
MOD_Plk_1 487 493 PF00069 0.504
MOD_Plk_1 498 504 PF00069 0.464
MOD_Plk_1 85 91 PF00069 0.242
MOD_Plk_2-3 97 103 PF00069 0.288
MOD_Plk_4 163 169 PF00069 0.192
MOD_Plk_4 464 470 PF00069 0.443
MOD_Plk_4 499 505 PF00069 0.480
MOD_Plk_4 77 83 PF00069 0.229
MOD_ProDKin_1 178 184 PF00069 0.285
MOD_ProDKin_1 423 429 PF00069 0.481
MOD_ProDKin_1 493 499 PF00069 0.496
MOD_SUMO_for_1 173 176 PF00179 0.251
MOD_SUMO_for_1 59 62 PF00179 0.200
MOD_SUMO_rev_2 232 238 PF00179 0.213
TRG_DiLeu_BaEn_1 499 504 PF01217 0.462
TRG_DiLeu_BaLyEn_6 174 179 PF01217 0.172
TRG_DiLeu_BaLyEn_6 287 292 PF01217 0.390
TRG_ENDOCYTIC_2 15 18 PF00928 0.331
TRG_ENDOCYTIC_2 30 33 PF00928 0.380
TRG_ENDOCYTIC_2 95 98 PF00928 0.354
TRG_ER_diArg_1 107 110 PF00400 0.285
TRG_ER_diArg_1 214 216 PF00400 0.207
TRG_ER_diArg_1 260 262 PF00400 0.349
TRG_ER_diArg_1 288 291 PF00400 0.379
TRG_ER_diArg_1 403 405 PF00400 0.531
TRG_ER_diArg_1 441 443 PF00400 0.437
TRG_Pf-PMV_PEXEL_1 138 143 PF00026 0.381
TRG_Pf-PMV_PEXEL_1 290 294 PF00026 0.382
TRG_Pf-PMV_PEXEL_1 433 438 PF00026 0.480
TRG_PTS2 1 21 PF00400 0.356

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PEV2 Leptomonas seymouri 64% 96%
A0A0S4J7K5 Bodo saltans 26% 88%
A0A0S4JIJ6 Bodo saltans 25% 92%
A0A1X0P963 Trypanosomatidae 45% 100%
A0A3Q8IAQ1 Leishmania donovani 33% 100%
A0A3Q8IC87 Leishmania donovani 30% 100%
A0A3Q8IIG1 Leishmania donovani 33% 100%
A0A3Q8INQ4 Leishmania donovani 25% 100%
A0A3S5H7M0 Leishmania donovani 77% 99%
A0A3S7WTN9 Leishmania donovani 29% 100%
A0A3S7WWE7 Leishmania donovani 23% 100%
A0A3S7WYP4 Leishmania donovani 27% 100%
A0A3S7X2W3 Leishmania donovani 30% 100%
A0A3S7X2Z6 Leishmania donovani 26% 100%
A0A3S7X933 Leishmania donovani 26% 100%
A0A3S7X9R4 Leishmania donovani 30% 100%
A4H459 Leishmania braziliensis 25% 100%
A4H8C4 Leishmania braziliensis 29% 100%
A4HBL4 Leishmania braziliensis 23% 100%
A4HCE6 Leishmania braziliensis 34% 100%
A4HDU3 Leishmania braziliensis 28% 100%
A4HED7 Leishmania braziliensis 25% 100%
A4HH03 Leishmania braziliensis 32% 100%
A4HHN1 Leishmania braziliensis 29% 100%
A4HI35 Leishmania braziliensis 27% 100%
A4HMJ3 Leishmania braziliensis 26% 100%
A4HN71 Leishmania braziliensis 31% 100%
A4HSE2 Leishmania infantum 24% 100%
A4HWP5 Leishmania infantum 29% 100%
A4HZA2 Leishmania infantum 24% 100%
A4HZV1 Leishmania infantum 30% 100%
A4HZW8 Leishmania infantum 33% 100%
A4I140 Leishmania infantum 27% 100%
A4I1T4 Leishmania infantum 25% 100%
A4I435 Leishmania infantum 33% 100%
A4I4U6 Leishmania infantum 30% 100%
A4I4X5 Leishmania infantum 77% 99%
A4I564 Leishmania infantum 26% 100%
A4IB73 Leishmania infantum 26% 100%
A4IBT4 Leishmania infantum 30% 100%
A4IBT9 Leishmania infantum 30% 100%
C9ZKX6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9AEC9 Leishmania major 76% 100%
E9AEZ4 Leishmania major 26% 100%
E9ALF7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 76% 99%
E9ALJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9AQF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9AUS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9AUY2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9AVR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9AVS7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9AX78 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9AXW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9B0C2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9B0G1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B650 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9B6S4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B6S9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
O60285 Homo sapiens 26% 78%
Q4Q7S2 Leishmania major 26% 100%
Q4Q7W2 Leishmania major 33% 100%
Q4Q9K2 Leishmania major 25% 100%
Q4QA98 Leishmania major 29% 100%
Q4QBQ2 Leishmania major 32% 100%
Q4QBR6 Leishmania major 30% 100%
Q4QCK0 Leishmania major 24% 100%
Q4QF23 Leishmania major 28% 100%
Q9GNR4 Leishmania major 30% 100%
Q9Y077 Leishmania major 29% 100%
V5C234 Trypanosoma cruzi 45% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS