Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHR2_LEIBR

TriTrypDb:

LbrM.29.2610 , LBRM2903_290033300

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHR2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHR2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	256	258	PF00675	0.334
CLV_NRD_NRD_1	422	424	PF00675	0.380
CLV_NRD_NRD_1	99	101	PF00675	0.460
CLV_PCSK_KEX2_1	256	258	PF00082	0.334
CLV_PCSK_KEX2_1	422	424	PF00082	0.380
CLV_PCSK_KEX2_1	99	101	PF00082	0.319
CLV_PCSK_SKI1_1	175	179	PF00082	0.419
CLV_PCSK_SKI1_1	318	322	PF00082	0.356
CLV_PCSK_SKI1_1	400	404	PF00082	0.386
DEG_COP1_1	290	297	PF00400	0.495
DOC_CDC14_PxL_1	255	263	PF14671	0.352
DOC_CYCLIN_RxL_1	420	429	PF00134	0.419
DOC_MAPK_gen_1	347	354	PF00069	0.520
DOC_MAPK_gen_1	87	95	PF00069	0.370
DOC_MAPK_MEF2A_6	292	299	PF00069	0.516
DOC_MAPK_MEF2A_6	347	354	PF00069	0.506
DOC_PP1_RVXF_1	421	428	PF00149	0.499
DOC_PP2B_LxvP_1	242	245	PF13499	0.288
DOC_USP7_MATH_1	202	206	PF00917	0.468
DOC_USP7_MATH_1	303	307	PF00917	0.279
DOC_USP7_MATH_1	340	344	PF00917	0.528
DOC_USP7_MATH_1	374	378	PF00917	0.531
DOC_USP7_MATH_1	58	62	PF00917	0.512
DOC_WW_Pin1_4	141	146	PF00397	0.655
DOC_WW_Pin1_4	196	201	PF00397	0.290
LIG_14-3-3_CanoR_1	230	235	PF00244	0.542
LIG_14-3-3_CanoR_1	391	399	PF00244	0.472
LIG_14-3-3_CanoR_1	436	440	PF00244	0.335
LIG_14-3-3_CanoR_1	75	83	PF00244	0.486
LIG_14-3-3_CanoR_1	9	18	PF00244	0.687
LIG_Actin_WH2_2	383	399	PF00022	0.517
LIG_BIR_II_1	1	5	PF00653	0.586
LIG_BRCT_BRCA1_1	24	28	PF00533	0.538
LIG_BRCT_BRCA1_1	415	419	PF00533	0.317
LIG_CaM_IQ_9	222	238	PF13499	0.511
LIG_DLG_GKlike_1	230	238	PF00625	0.423
LIG_FAT_LD_1	48	56	PF03623	0.562
LIG_FHA_1	217	223	PF00498	0.505
LIG_FHA_1	303	309	PF00498	0.419
LIG_FHA_1	319	325	PF00498	0.355
LIG_FHA_1	336	342	PF00498	0.437
LIG_FHA_1	382	388	PF00498	0.479
LIG_FHA_1	401	407	PF00498	0.511
LIG_FHA_2	230	236	PF00498	0.444
LIG_FHA_2	427	433	PF00498	0.415
LIG_FHA_2	79	85	PF00498	0.556
LIG_GBD_Chelix_1	203	211	PF00786	0.417
LIG_LIR_Gen_1	239	248	PF02991	0.423
LIG_LIR_Gen_1	296	303	PF02991	0.473
LIG_LIR_Gen_1	359	368	PF02991	0.540
LIG_LIR_Gen_1	401	410	PF02991	0.296
LIG_LIR_Nem_3	183	189	PF02991	0.604
LIG_LIR_Nem_3	239	244	PF02991	0.447
LIG_LIR_Nem_3	25	31	PF02991	0.698
LIG_LIR_Nem_3	296	302	PF02991	0.417
LIG_LIR_Nem_3	359	363	PF02991	0.472
LIG_LIR_Nem_3	401	407	PF02991	0.291
LIG_NRBOX	297	303	PF00104	0.483
LIG_PDZ_Class_2	436	441	PF00595	0.581
LIG_Pex14_1	431	435	PF04695	0.386
LIG_Pex14_2	427	431	PF04695	0.481
LIG_SH2_GRB2like	368	371	PF00017	0.609
LIG_SH2_NCK_1	368	372	PF00017	0.615
LIG_SH2_STAP1	368	372	PF00017	0.362
LIG_SH2_STAP1	73	77	PF00017	0.545
LIG_SH2_STAT3	223	226	PF00017	0.503
LIG_SH2_STAT5	11	14	PF00017	0.584
LIG_SH2_STAT5	157	160	PF00017	0.245
LIG_SH2_STAT5	223	226	PF00017	0.503
LIG_SH2_STAT5	254	257	PF00017	0.411
LIG_SH2_STAT5	356	359	PF00017	0.477
LIG_SH2_STAT5	368	371	PF00017	0.582
LIG_SH2_STAT5	420	423	PF00017	0.415
LIG_SH2_STAT5	426	429	PF00017	0.392
LIG_SH3_1	256	262	PF00018	0.473
LIG_SH3_3	256	262	PF00018	0.473
LIG_SUMO_SIM_par_1	110	116	PF11976	0.492
LIG_SUMO_SIM_par_1	349	355	PF11976	0.486
LIG_TRAF2_1	288	291	PF00917	0.295
LIG_TRAF2_1	61	64	PF00917	0.588
LIG_TRAF2_1	77	80	PF00917	0.329
LIG_TYR_ITIM	402	407	PF00017	0.289
LIG_Vh1_VBS_1	375	393	PF01044	0.442
LIG_WRC_WIRS_1	203	208	PF05994	0.508
MOD_CK1_1	146	152	PF00069	0.564
MOD_CK1_1	169	175	PF00069	0.440
MOD_CK1_1	325	331	PF00069	0.497
MOD_CK1_1	59	65	PF00069	0.497
MOD_CK1_1	78	84	PF00069	0.538
MOD_CK2_1	229	235	PF00069	0.431
MOD_CK2_1	339	345	PF00069	0.581
MOD_CK2_1	426	432	PF00069	0.399
MOD_CK2_1	58	64	PF00069	0.614
MOD_CK2_1	78	84	PF00069	0.531
MOD_GlcNHglycan	171	174	PF01048	0.496
MOD_GlcNHglycan	305	308	PF01048	0.525
MOD_GlcNHglycan	324	327	PF01048	0.356
MOD_GlcNHglycan	342	345	PF01048	0.520
MOD_GlcNHglycan	376	379	PF01048	0.307
MOD_GlcNHglycan	45	48	PF01048	0.493
MOD_GlcNHglycan	75	78	PF01048	0.432
MOD_GSK3_1	139	146	PF00069	0.519
MOD_GSK3_1	165	172	PF00069	0.467
MOD_GSK3_1	263	270	PF00069	0.556
MOD_GSK3_1	318	325	PF00069	0.333
MOD_GSK3_1	335	342	PF00069	0.353
MOD_GSK3_1	359	366	PF00069	0.363
MOD_GSK3_1	59	66	PF00069	0.525
MOD_N-GLC_1	169	174	PF02516	0.498
MOD_N-GLC_1	277	282	PF02516	0.470
MOD_NEK2_1	113	118	PF00069	0.376
MOD_NEK2_1	224	229	PF00069	0.491
MOD_NEK2_1	276	281	PF00069	0.433
MOD_NEK2_1	301	306	PF00069	0.511
MOD_NEK2_1	363	368	PF00069	0.475
MOD_NEK2_1	51	56	PF00069	0.515
MOD_NEK2_1	94	99	PF00069	0.437
MOD_NEK2_2	218	223	PF00069	0.282
MOD_PIKK_1	260	266	PF00454	0.629
MOD_PIKK_1	325	331	PF00454	0.417
MOD_PIKK_1	335	341	PF00454	0.399
MOD_PIKK_1	363	369	PF00454	0.497
MOD_PIKK_1	75	81	PF00454	0.446
MOD_PKA_2	229	235	PF00069	0.520
MOD_PKA_2	335	341	PF00069	0.568
MOD_PKA_2	435	441	PF00069	0.541
MOD_Plk_1	277	283	PF00069	0.470
MOD_Plk_1	400	406	PF00069	0.289
MOD_Plk_4	202	208	PF00069	0.439
MOD_Plk_4	218	224	PF00069	0.440
MOD_Plk_4	359	365	PF00069	0.375
MOD_Plk_4	51	57	PF00069	0.432
MOD_ProDKin_1	141	147	PF00069	0.656
MOD_ProDKin_1	196	202	PF00069	0.287
MOD_SUMO_rev_2	394	399	PF00179	0.477
MOD_SUMO_rev_2	76	83	PF00179	0.324
TRG_DiLeu_BaEn_1	359	364	PF01217	0.528
TRG_ENDOCYTIC_2	404	407	PF00928	0.299
TRG_ER_diArg_1	255	257	PF00400	0.319
TRG_ER_diArg_1	347	350	PF00400	0.510
TRG_ER_diArg_1	421	423	PF00400	0.379
TRG_ER_diArg_1	98	100	PF00400	0.311

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Y5	Leptomonas seymouri	50%	96%
A0A0S4IKI5	Bodo saltans	29%	97%
A0A1X0P918	Trypanosomatidae	37%	95%
A0A3Q8IFJ3	Leishmania donovani	79%	100%
A0A3R7K871	Trypanosoma rangeli	39%	100%
A4I4X2	Leishmania infantum	79%	100%
C9ZKY1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AEC6	Leishmania major	79%	100%
E9ALG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
V5BSL0	Trypanosoma cruzi	37%	100%