SAM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 24

Species:

Leishmania braziliensis

UniProt:

A4HHR1_LEIBR

TriTrypDb:

LbrM.29.2600 , LBRM2903_290033200

Length:

1238

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5
GO:0005741	mitochondrial outer membrane	5	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

A4HHR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHR1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1139	1143	PF00656	0.633
CLV_C14_Caspase3-7	1200	1204	PF00656	0.710
CLV_C14_Caspase3-7	41	45	PF00656	0.573
CLV_C14_Caspase3-7	429	433	PF00656	0.738
CLV_C14_Caspase3-7	532	536	PF00656	0.666
CLV_C14_Caspase3-7	685	689	PF00656	0.560
CLV_C14_Caspase3-7	791	795	PF00656	0.746
CLV_C14_Caspase3-7	811	815	PF00656	0.618
CLV_NRD_NRD_1	128	130	PF00675	0.484
CLV_NRD_NRD_1	300	302	PF00675	0.370
CLV_NRD_NRD_1	35	37	PF00675	0.410
CLV_NRD_NRD_1	710	712	PF00675	0.336
CLV_NRD_NRD_1	888	890	PF00675	0.416
CLV_NRD_NRD_1	925	927	PF00675	0.376
CLV_NRD_NRD_1	950	952	PF00675	0.295
CLV_PCSK_FUR_1	855	859	PF00082	0.443
CLV_PCSK_KEX2_1	1051	1053	PF00082	0.305
CLV_PCSK_KEX2_1	127	129	PF00082	0.483
CLV_PCSK_KEX2_1	282	284	PF00082	0.385
CLV_PCSK_KEX2_1	300	302	PF00082	0.301
CLV_PCSK_KEX2_1	35	37	PF00082	0.409
CLV_PCSK_KEX2_1	710	712	PF00082	0.404
CLV_PCSK_KEX2_1	854	856	PF00082	0.426
CLV_PCSK_KEX2_1	857	859	PF00082	0.441
CLV_PCSK_KEX2_1	888	890	PF00082	0.455
CLV_PCSK_KEX2_1	925	927	PF00082	0.376
CLV_PCSK_PC1ET2_1	1051	1053	PF00082	0.267
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.433
CLV_PCSK_PC1ET2_1	854	856	PF00082	0.305
CLV_PCSK_PC1ET2_1	857	859	PF00082	0.298
CLV_PCSK_PC7_1	123	129	PF00082	0.484
CLV_PCSK_SKI1_1	101	105	PF00082	0.412
CLV_PCSK_SKI1_1	1155	1159	PF00082	0.384
CLV_PCSK_SKI1_1	157	161	PF00082	0.352
CLV_PCSK_SKI1_1	282	286	PF00082	0.384
CLV_PCSK_SKI1_1	296	300	PF00082	0.291
CLV_PCSK_SKI1_1	336	340	PF00082	0.344
CLV_PCSK_SKI1_1	495	499	PF00082	0.451
CLV_PCSK_SKI1_1	502	506	PF00082	0.400
CLV_PCSK_SKI1_1	846	850	PF00082	0.497
CLV_PCSK_SKI1_1	854	858	PF00082	0.524
CLV_PCSK_SKI1_1	978	982	PF00082	0.348
CLV_Separin_Metazoa	704	708	PF03568	0.614
DEG_APCC_DBOX_1	100	108	PF00400	0.534
DEG_APCC_DBOX_1	335	343	PF00400	0.679
DEG_APCC_DBOX_1	781	789	PF00400	0.601
DEG_APCC_DBOX_1	924	932	PF00400	0.589
DEG_APCC_DBOX_1	977	985	PF00400	0.548
DEG_Kelch_Keap1_1	812	817	PF01344	0.620
DEG_MDM2_SWIB_1	148	156	PF02201	0.614
DEG_SPOP_SBC_1	553	557	PF00917	0.637
DOC_ANK_TNKS_1	73	80	PF00023	0.569
DOC_ANK_TNKS_1	791	798	PF00023	0.604
DOC_CDC14_PxL_1	1061	1069	PF14671	0.560
DOC_CYCLIN_RxL_1	1027	1038	PF00134	0.639
DOC_CYCLIN_yCln2_LP_2	486	492	PF00134	0.513
DOC_MAPK_gen_1	1145	1153	PF00069	0.483
DOC_MAPK_gen_1	854	862	PF00069	0.502
DOC_MAPK_gen_1	925	932	PF00069	0.560
DOC_MAPK_MEF2A_6	502	509	PF00069	0.565
DOC_MAPK_RevD_3	115	129	PF00069	0.571
DOC_PP2B_LxvP_1	1067	1070	PF13499	0.600
DOC_PP2B_LxvP_1	139	142	PF13499	0.583
DOC_PP2B_LxvP_1	486	489	PF13499	0.587
DOC_PP2B_PxIxI_1	1026	1032	PF00149	0.481
DOC_PP4_FxxP_1	159	162	PF00568	0.534
DOC_USP7_MATH_1	140	144	PF00917	0.654
DOC_USP7_MATH_1	163	167	PF00917	0.612
DOC_USP7_MATH_1	318	322	PF00917	0.646
DOC_USP7_MATH_1	46	50	PF00917	0.615
DOC_USP7_MATH_1	553	557	PF00917	0.586
DOC_USP7_MATH_1	715	719	PF00917	0.631
DOC_USP7_MATH_1	744	748	PF00917	0.600
DOC_USP7_MATH_1	790	794	PF00917	0.655
DOC_USP7_MATH_1	870	874	PF00917	0.637
DOC_USP7_MATH_1	976	980	PF00917	0.596
DOC_USP7_MATH_2	292	298	PF00917	0.498
DOC_USP7_MATH_2	743	749	PF00917	0.508
DOC_USP7_UBL2_3	1074	1078	PF12436	0.613
DOC_USP7_UBL2_3	821	825	PF12436	0.580
DOC_WW_Pin1_4	1222	1227	PF00397	0.683
DOC_WW_Pin1_4	128	133	PF00397	0.680
DOC_WW_Pin1_4	164	169	PF00397	0.643
DOC_WW_Pin1_4	225	230	PF00397	0.661
DOC_WW_Pin1_4	256	261	PF00397	0.630
DOC_WW_Pin1_4	42	47	PF00397	0.704
DOC_WW_Pin1_4	632	637	PF00397	0.543
LIG_14-3-3_CanoR_1	1103	1108	PF00244	0.649
LIG_14-3-3_CanoR_1	127	132	PF00244	0.760
LIG_14-3-3_CanoR_1	157	162	PF00244	0.595
LIG_14-3-3_CanoR_1	313	318	PF00244	0.541
LIG_14-3-3_CanoR_1	328	332	PF00244	0.593
LIG_14-3-3_CanoR_1	336	342	PF00244	0.570
LIG_14-3-3_CanoR_1	475	483	PF00244	0.519
LIG_14-3-3_CanoR_1	746	750	PF00244	0.526
LIG_14-3-3_CanoR_1	84	91	PF00244	0.583
LIG_14-3-3_CanoR_1	846	852	PF00244	0.520
LIG_14-3-3_CanoR_1	861	870	PF00244	0.480
LIG_14-3-3_CanoR_1	925	929	PF00244	0.546
LIG_14-3-3_CanoR_1	951	957	PF00244	0.598
LIG_Actin_WH2_2	1095	1112	PF00022	0.500
LIG_Actin_WH2_2	270	288	PF00022	0.576
LIG_Actin_WH2_2	973	990	PF00022	0.599
LIG_BIR_III_2	411	415	PF00653	0.590
LIG_BIR_III_4	432	436	PF00653	0.541
LIG_BIR_III_4	794	798	PF00653	0.611
LIG_BRCT_BRCA1_1	453	457	PF00533	0.613
LIG_BRCT_BRCA1_1	634	638	PF00533	0.646
LIG_CtBP_PxDLS_1	2	6	PF00389	0.368
LIG_deltaCOP1_diTrp_1	149	159	PF00928	0.477
LIG_FHA_1	156	162	PF00498	0.667
LIG_FHA_1	177	183	PF00498	0.619
LIG_FHA_1	468	474	PF00498	0.567
LIG_FHA_1	499	505	PF00498	0.592
LIG_FHA_1	640	646	PF00498	0.627
LIG_FHA_1	737	743	PF00498	0.627
LIG_FHA_1	941	947	PF00498	0.658
LIG_FHA_1	951	957	PF00498	0.603
LIG_FHA_2	1018	1024	PF00498	0.630
LIG_FHA_2	1041	1047	PF00498	0.591
LIG_FHA_2	1157	1163	PF00498	0.586
LIG_FHA_2	1231	1237	PF00498	0.663
LIG_FHA_2	179	185	PF00498	0.676
LIG_FHA_2	188	194	PF00498	0.524
LIG_FHA_2	226	232	PF00498	0.690
LIG_FHA_2	442	448	PF00498	0.660
LIG_FHA_2	475	481	PF00498	0.486
LIG_FHA_2	555	561	PF00498	0.704
LIG_FHA_2	580	586	PF00498	0.730
LIG_FHA_2	751	757	PF00498	0.612
LIG_FHA_2	84	90	PF00498	0.629
LIG_FHA_2	940	946	PF00498	0.665
LIG_Integrin_RGD_1	968	970	PF01839	0.291
LIG_LIR_Apic_2	158	162	PF02991	0.522
LIG_LIR_Gen_1	1096	1107	PF02991	0.493
LIG_LIR_Gen_1	1120	1130	PF02991	0.490
LIG_LIR_Gen_1	184	191	PF02991	0.627
LIG_LIR_Gen_1	251	260	PF02991	0.522
LIG_LIR_Gen_1	269	278	PF02991	0.532
LIG_LIR_Gen_1	567	578	PF02991	0.547
LIG_LIR_Gen_1	635	645	PF02991	0.558
LIG_LIR_Gen_1	680	690	PF02991	0.590
LIG_LIR_Gen_1	737	744	PF02991	0.572
LIG_LIR_Nem_3	1023	1028	PF02991	0.636
LIG_LIR_Nem_3	1096	1102	PF02991	0.644
LIG_LIR_Nem_3	1120	1125	PF02991	0.501
LIG_LIR_Nem_3	149	155	PF02991	0.583
LIG_LIR_Nem_3	184	189	PF02991	0.621
LIG_LIR_Nem_3	251	256	PF02991	0.518
LIG_LIR_Nem_3	269	273	PF02991	0.544
LIG_LIR_Nem_3	304	310	PF02991	0.617
LIG_LIR_Nem_3	567	573	PF02991	0.539
LIG_LIR_Nem_3	635	641	PF02991	0.571
LIG_LIR_Nem_3	654	660	PF02991	0.552
LIG_LIR_Nem_3	680	686	PF02991	0.585
LIG_LIR_Nem_3	828	834	PF02991	0.545
LIG_LIR_Nem_3	882	886	PF02991	0.614
LIG_MYND_1	1065	1069	PF01753	0.590
LIG_NRBOX	294	300	PF00104	0.487
LIG_PCNA_PIPBox_1	1126	1135	PF02747	0.492
LIG_PCNA_yPIPBox_3	1002	1015	PF02747	0.588
LIG_PCNA_yPIPBox_3	1124	1133	PF02747	0.598
LIG_PCNA_yPIPBox_3	491	503	PF02747	0.629
LIG_PDZ_Class_3	1233	1238	PF00595	0.597
LIG_Pex14_2	148	152	PF04695	0.609
LIG_Rb_LxCxE_1	1184	1203	PF01857	0.599
LIG_SH2_CRK	657	661	PF00017	0.483
LIG_SH2_PTP2	1028	1031	PF00017	0.480
LIG_SH2_STAT5	1028	1031	PF00017	0.591
LIG_SH2_STAT5	1228	1231	PF00017	0.590
LIG_SH2_STAT5	178	181	PF00017	0.581
LIG_SH3_3	1062	1068	PF00018	0.706
LIG_SH3_3	339	345	PF00018	0.585
LIG_SH3_3	40	46	PF00018	0.635
LIG_SUMO_SIM_anti_2	1176	1185	PF11976	0.587
LIG_SUMO_SIM_anti_2	196	202	PF11976	0.552
LIG_SUMO_SIM_anti_2	437	442	PF11976	0.567
LIG_SUMO_SIM_anti_2	6	14	PF11976	0.365
LIG_SUMO_SIM_anti_2	945	950	PF11976	0.647
LIG_SUMO_SIM_par_1	1030	1035	PF11976	0.640
LIG_SUMO_SIM_par_1	113	119	PF11976	0.654
LIG_SUMO_SIM_par_1	187	193	PF11976	0.594
LIG_SUMO_SIM_par_1	337	344	PF11976	0.567
LIG_TRAF2_1	1115	1118	PF00917	0.560
LIG_TRAF2_1	238	241	PF00917	0.624
LIG_TRAF2_1	416	419	PF00917	0.680
LIG_TRAF2_1	529	532	PF00917	0.705
LIG_TRAF2_1	620	623	PF00917	0.490
LIG_TRAF2_1	718	721	PF00917	0.711
LIG_TRAF2_1	874	877	PF00917	0.613
LIG_TRAF2_1	879	882	PF00917	0.584
LIG_UBA3_1	1047	1051	PF00899	0.463
LIG_WRC_WIRS_1	156	161	PF05994	0.509
LIG_WRC_WIRS_1	183	188	PF05994	0.472
MOD_CDK_SPxxK_3	128	135	PF00069	0.751
MOD_CK1_1	1222	1228	PF00069	0.705
MOD_CK1_1	130	136	PF00069	0.635
MOD_CK1_1	225	231	PF00069	0.577
MOD_CK1_1	4	10	PF00069	0.500
MOD_CK1_1	45	51	PF00069	0.442
MOD_CK1_1	65	71	PF00069	0.472
MOD_CK1_1	681	687	PF00069	0.540
MOD_CK2_1	1006	1012	PF00069	0.421
MOD_CK2_1	1017	1023	PF00069	0.411
MOD_CK2_1	1034	1040	PF00069	0.537
MOD_CK2_1	1112	1118	PF00069	0.586
MOD_CK2_1	1156	1162	PF00069	0.479
MOD_CK2_1	1230	1236	PF00069	0.684
MOD_CK2_1	140	146	PF00069	0.592
MOD_CK2_1	164	170	PF00069	0.559
MOD_CK2_1	178	184	PF00069	0.560
MOD_CK2_1	187	193	PF00069	0.505
MOD_CK2_1	337	343	PF00069	0.465
MOD_CK2_1	401	407	PF00069	0.479
MOD_CK2_1	474	480	PF00069	0.402
MOD_CK2_1	554	560	PF00069	0.643
MOD_CK2_1	579	585	PF00069	0.673
MOD_CK2_1	684	690	PF00069	0.522
MOD_CK2_1	715	721	PF00069	0.584
MOD_CK2_1	750	756	PF00069	0.424
MOD_CK2_1	790	796	PF00069	0.534
MOD_CK2_1	834	840	PF00069	0.387
MOD_CK2_1	939	945	PF00069	0.531
MOD_CK2_1	976	982	PF00069	0.494
MOD_CK2_1	998	1004	PF00069	0.529
MOD_GlcNHglycan	1037	1040	PF01048	0.523
MOD_GlcNHglycan	1114	1117	PF01048	0.554
MOD_GlcNHglycan	1221	1224	PF01048	0.653
MOD_GlcNHglycan	135	138	PF01048	0.587
MOD_GlcNHglycan	143	146	PF01048	0.636
MOD_GlcNHglycan	211	214	PF01048	0.527
MOD_GlcNHglycan	320	323	PF01048	0.650
MOD_GlcNHglycan	632	635	PF01048	0.462
MOD_GlcNHglycan	717	720	PF01048	0.581
MOD_GlcNHglycan	785	788	PF01048	0.539
MOD_GlcNHglycan	872	875	PF01048	0.411
MOD_GlcNHglycan	957	960	PF01048	0.491
MOD_GlcNHglycan	994	997	PF01048	0.650
MOD_GSK3_1	123	130	PF00069	0.591
MOD_GSK3_1	178	185	PF00069	0.621
MOD_GSK3_1	189	196	PF00069	0.584
MOD_GSK3_1	209	216	PF00069	0.430
MOD_GSK3_1	223	230	PF00069	0.491
MOD_GSK3_1	385	392	PF00069	0.462
MOD_GSK3_1	4	11	PF00069	0.498
MOD_GSK3_1	42	49	PF00069	0.536
MOD_GSK3_1	677	684	PF00069	0.479
MOD_GSK3_1	940	947	PF00069	0.515
MOD_GSK3_1	998	1005	PF00069	0.514
MOD_N-GLC_1	163	168	PF02516	0.536
MOD_N-GLC_1	213	218	PF02516	0.487
MOD_N-GLC_1	553	558	PF02516	0.448
MOD_N-GLC_1	630	635	PF02516	0.571
MOD_N-GLC_1	750	755	PF02516	0.466
MOD_NEK2_1	1032	1037	PF00069	0.481
MOD_NEK2_1	155	160	PF00069	0.593
MOD_NEK2_1	182	187	PF00069	0.551
MOD_NEK2_1	468	473	PF00069	0.500
MOD_NEK2_1	498	503	PF00069	0.431
MOD_NEK2_1	639	644	PF00069	0.432
MOD_NEK2_1	679	684	PF00069	0.519
MOD_NEK2_1	706	711	PF00069	0.378
MOD_NEK2_1	83	88	PF00069	0.552
MOD_NEK2_1	924	929	PF00069	0.454
MOD_NEK2_2	579	584	PF00069	0.397
MOD_PIKK_1	1032	1038	PF00454	0.394
MOD_PIKK_1	401	407	PF00454	0.404
MOD_PIKK_1	606	612	PF00454	0.392
MOD_PIKK_1	968	974	PF00454	0.333
MOD_PK_1	1002	1008	PF00069	0.343
MOD_PKA_1	127	133	PF00069	0.616
MOD_PKA_2	127	133	PF00069	0.598
MOD_PKA_2	327	333	PF00069	0.440
MOD_PKA_2	401	407	PF00069	0.588
MOD_PKA_2	474	480	PF00069	0.423
MOD_PKA_2	706	712	PF00069	0.518
MOD_PKA_2	745	751	PF00069	0.453
MOD_PKA_2	83	89	PF00069	0.477
MOD_PKA_2	834	840	PF00069	0.337
MOD_PKA_2	924	930	PF00069	0.448
MOD_PKA_2	950	956	PF00069	0.424
MOD_PKA_2	987	993	PF00069	0.622
MOD_Plk_1	230	236	PF00069	0.613
MOD_Plk_1	46	52	PF00069	0.383
MOD_Plk_1	559	565	PF00069	0.401
MOD_Plk_1	736	742	PF00069	0.528
MOD_Plk_1	744	750	PF00069	0.425
MOD_Plk_1	944	950	PF00069	0.530
MOD_Plk_2-3	1190	1196	PF00069	0.691
MOD_Plk_2-3	533	539	PF00069	0.531
MOD_Plk_2-3	808	814	PF00069	0.746
MOD_Plk_2-3	909	915	PF00069	0.558
MOD_Plk_4	1002	1008	PF00069	0.343
MOD_Plk_4	116	122	PF00069	0.548
MOD_Plk_4	178	184	PF00069	0.469
MOD_Plk_4	196	202	PF00069	0.400
MOD_Plk_4	294	300	PF00069	0.341
MOD_Plk_4	327	333	PF00069	0.405
MOD_Plk_4	337	343	PF00069	0.338
MOD_Plk_4	389	395	PF00069	0.452
MOD_Plk_4	468	474	PF00069	0.454
MOD_Plk_4	609	615	PF00069	0.527
MOD_Plk_4	65	71	PF00069	0.400
MOD_Plk_4	737	743	PF00069	0.552
MOD_Plk_4	78	84	PF00069	0.399
MOD_Plk_4	8	14	PF00069	0.328
MOD_Plk_4	944	950	PF00069	0.564
MOD_ProDKin_1	1222	1228	PF00069	0.618
MOD_ProDKin_1	128	134	PF00069	0.608
MOD_ProDKin_1	164	170	PF00069	0.557
MOD_ProDKin_1	225	231	PF00069	0.588
MOD_ProDKin_1	256	262	PF00069	0.537
MOD_ProDKin_1	42	48	PF00069	0.645
MOD_ProDKin_1	632	638	PF00069	0.412
MOD_SUMO_for_1	464	467	PF00179	0.463
MOD_SUMO_for_1	769	772	PF00179	0.438
MOD_SUMO_rev_2	235	243	PF00179	0.491
MOD_SUMO_rev_2	289	298	PF00179	0.356
MOD_SUMO_rev_2	417	426	PF00179	0.512
MOD_SUMO_rev_2	817	827	PF00179	0.477
MOD_SUMO_rev_2	934	942	PF00179	0.390
TRG_DiLeu_BaEn_1	294	299	PF01217	0.341
TRG_DiLeu_BaEn_1	882	887	PF01217	0.323
TRG_DiLeu_BaEn_4	1166	1172	PF01217	0.502
TRG_DiLeu_BaEn_4	703	709	PF01217	0.348
TRG_DiLeu_LyEn_5	773	778	PF01217	0.334
TRG_ENDOCYTIC_2	1028	1031	PF00928	0.487
TRG_ENDOCYTIC_2	657	660	PF00928	0.612
TRG_ER_diArg_1	127	129	PF00400	0.525
TRG_ER_diArg_1	299	301	PF00400	0.501
TRG_ER_diArg_1	887	889	PF00400	0.563
TRG_ER_diArg_1	924	926	PF00400	0.453
TRG_NES_CRM1_1	385	400	PF08389	0.405
TRG_NLS_MonoExtC_3	853	858	PF00514	0.381
TRG_NLS_MonoExtN_4	852	858	PF00514	0.381
TRG_Pf-PMV_PEXEL_1	1051	1055	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	1131	1135	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	978	982	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6J6	Leptomonas seymouri	42%	99%
A0A1X0P9W2	Trypanosomatidae	23%	76%
A0A3Q8IBP4	Leishmania donovani	65%	100%
A0A3R7MCK0	Trypanosoma rangeli	23%	77%
A4I4T9	Leishmania infantum	65%	100%
C9ZKY2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	75%
E9AEC5	Leishmania major	65%	100%
E9ALG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
V5C230	Trypanosoma cruzi	24%	78%