Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHQ9_LEIBR

TriTrypDb:

LbrM.29.2580 , LBRM2903_290033000

Length:

712

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHQ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHQ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	332	336	PF00656	0.497
CLV_C14_Caspase3-7	702	706	PF00656	0.353
CLV_NRD_NRD_1	697	699	PF00675	0.368
CLV_PCSK_KEX2_1	27	29	PF00082	0.531
CLV_PCSK_KEX2_1	389	391	PF00082	0.603
CLV_PCSK_KEX2_1	697	699	PF00082	0.364
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.531
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.483
CLV_PCSK_SKI1_1	349	353	PF00082	0.527
CLV_PCSK_SKI1_1	355	359	PF00082	0.472
CLV_PCSK_SKI1_1	514	518	PF00082	0.538
CLV_PCSK_SKI1_1	530	534	PF00082	0.504
CLV_PCSK_SKI1_1	704	708	PF00082	0.467
DEG_APCC_DBOX_1	529	537	PF00400	0.486
DEG_APCC_DBOX_1	648	656	PF00400	0.525
DEG_APCC_DBOX_1	686	694	PF00400	0.516
DEG_SCF_FBW7_1	561	567	PF00400	0.641
DEG_SPOP_SBC_1	359	363	PF00917	0.428
DEG_SPOP_SBC_1	566	570	PF00917	0.610
DOC_CKS1_1	561	566	PF01111	0.640
DOC_CYCLIN_RxL_1	527	535	PF00134	0.555
DOC_CYCLIN_yClb5_NLxxxL_5	498	504	PF00134	0.382
DOC_MAPK_gen_1	346	354	PF00069	0.567
DOC_MAPK_MEF2A_6	233	240	PF00069	0.530
DOC_PP1_RVXF_1	580	586	PF00149	0.460
DOC_PP2B_LxvP_1	161	164	PF13499	0.606
DOC_PP4_FxxP_1	4	7	PF00568	0.578
DOC_USP7_MATH_1	112	116	PF00917	0.591
DOC_USP7_MATH_1	176	180	PF00917	0.606
DOC_USP7_MATH_1	198	202	PF00917	0.504
DOC_USP7_MATH_1	206	210	PF00917	0.481
DOC_USP7_MATH_1	267	271	PF00917	0.546
DOC_USP7_MATH_1	359	363	PF00917	0.656
DOC_WW_Pin1_4	166	171	PF00397	0.634
DOC_WW_Pin1_4	172	177	PF00397	0.608
DOC_WW_Pin1_4	271	276	PF00397	0.538
DOC_WW_Pin1_4	50	55	PF00397	0.529
DOC_WW_Pin1_4	541	546	PF00397	0.454
DOC_WW_Pin1_4	560	565	PF00397	0.583
LIG_14-3-3_CanoR_1	233	237	PF00244	0.596
LIG_14-3-3_CanoR_1	255	262	PF00244	0.485
LIG_14-3-3_CanoR_1	408	418	PF00244	0.546
LIG_14-3-3_CanoR_1	67	77	PF00244	0.542
LIG_14-3-3_CanoR_1	681	687	PF00244	0.452
LIG_14-3-3_CanoR_1	79	87	PF00244	0.660
LIG_14-3-3_CanoR_1	92	98	PF00244	0.590
LIG_Actin_WH2_2	340	357	PF00022	0.496
LIG_Actin_WH2_2	493	511	PF00022	0.384
LIG_Actin_WH2_2	56	72	PF00022	0.588
LIG_BIR_II_1	1	5	PF00653	0.634
LIG_BRCT_BRCA1_1	447	451	PF00533	0.452
LIG_BRCT_BRCA1_2	447	453	PF00533	0.454
LIG_FHA_1	233	239	PF00498	0.549
LIG_FHA_1	309	315	PF00498	0.523
LIG_FHA_1	361	367	PF00498	0.448
LIG_FHA_1	386	392	PF00498	0.486
LIG_FHA_1	518	524	PF00498	0.628
LIG_FHA_1	532	538	PF00498	0.514
LIG_FHA_1	542	548	PF00498	0.482
LIG_FHA_1	567	573	PF00498	0.594
LIG_FHA_1	585	591	PF00498	0.561
LIG_FHA_1	97	103	PF00498	0.635
LIG_FHA_2	38	44	PF00498	0.570
LIG_FHA_2	415	421	PF00498	0.514
LIG_FHA_2	447	453	PF00498	0.454
LIG_FHA_2	601	607	PF00498	0.387
LIG_FHA_2	666	672	PF00498	0.520
LIG_FHA_2	674	680	PF00498	0.429
LIG_FHA_2	700	706	PF00498	0.352
LIG_Integrin_isoDGR_2	298	300	PF01839	0.567
LIG_LIR_Apic_2	2	7	PF02991	0.581
LIG_LIR_Gen_1	21	30	PF02991	0.598
LIG_LIR_Gen_1	31	37	PF02991	0.486
LIG_LIR_Gen_1	74	85	PF02991	0.523
LIG_LIR_Nem_3	21	26	PF02991	0.614
LIG_LIR_Nem_3	221	225	PF02991	0.403
LIG_LIR_Nem_3	29	35	PF02991	0.489
LIG_LIR_Nem_3	524	529	PF02991	0.568
LIG_MLH1_MIPbox_1	447	451	PF16413	0.452
LIG_NRBOX	304	310	PF00104	0.425
LIG_NRBOX	429	435	PF00104	0.470
LIG_NRBOX	532	538	PF00104	0.485
LIG_PCNA_PIPBox_1	444	453	PF02747	0.504
LIG_PDZ_Class_1	707	712	PF00595	0.432
LIG_Rb_LxCxE_1	257	277	PF01857	0.539
LIG_RPA_C_Fungi	676	688	PF08784	0.361
LIG_SH2_NCK_1	558	562	PF00017	0.484
LIG_SH2_PTP2	330	333	PF00017	0.496
LIG_SH2_SRC	546	549	PF00017	0.419
LIG_SH2_SRC	558	561	PF00017	0.604
LIG_SH2_STAT3	217	220	PF00017	0.543
LIG_SH2_STAT5	330	333	PF00017	0.496
LIG_SH2_STAT5	353	356	PF00017	0.472
LIG_SH2_STAT5	450	453	PF00017	0.468
LIG_SH2_STAT5	546	549	PF00017	0.419
LIG_SH3_1	558	564	PF00018	0.644
LIG_SH3_3	10	16	PF00018	0.584
LIG_SH3_3	479	485	PF00018	0.491
LIG_SH3_3	51	57	PF00018	0.512
LIG_SH3_3	558	564	PF00018	0.701
LIG_SH3_3	627	633	PF00018	0.478
LIG_TRAF2_1	201	204	PF00917	0.502
LIG_TRAF2_1	654	657	PF00917	0.523
LIG_TRAF2_1	676	679	PF00917	0.510
LIG_TRAF2_1	9	12	PF00917	0.669
LIG_TYR_ITIM	328	333	PF00017	0.495
LIG_WW_1	15	18	PF00397	0.581
MOD_CK1_1	100	106	PF00069	0.667
MOD_CK1_1	169	175	PF00069	0.723
MOD_CK1_1	274	280	PF00069	0.511
MOD_CK1_1	393	399	PF00069	0.463
MOD_CK1_1	565	571	PF00069	0.752
MOD_CK1_1	72	78	PF00069	0.584
MOD_CK2_1	198	204	PF00069	0.501
MOD_CK2_1	333	339	PF00069	0.422
MOD_CK2_1	359	365	PF00069	0.665
MOD_CK2_1	37	43	PF00069	0.561
MOD_CK2_1	446	452	PF00069	0.451
MOD_CK2_1	507	513	PF00069	0.418
MOD_CK2_1	568	574	PF00069	0.537
MOD_CK2_1	600	606	PF00069	0.391
MOD_CK2_1	651	657	PF00069	0.558
MOD_CK2_1	665	671	PF00069	0.373
MOD_CK2_1	673	679	PF00069	0.430
MOD_CK2_1	68	74	PF00069	0.418
MOD_CK2_1	80	86	PF00069	0.462
MOD_GlcNHglycan	114	117	PF01048	0.601
MOD_GlcNHglycan	147	150	PF01048	0.606
MOD_GlcNHglycan	208	211	PF01048	0.510
MOD_GlcNHglycan	222	225	PF01048	0.423
MOD_GlcNHglycan	324	327	PF01048	0.515
MOD_GlcNHglycan	335	338	PF01048	0.544
MOD_GlcNHglycan	370	373	PF01048	0.576
MOD_GlcNHglycan	454	457	PF01048	0.494
MOD_GlcNHglycan	46	49	PF01048	0.624
MOD_GlcNHglycan	500	503	PF01048	0.373
MOD_GlcNHglycan	538	541	PF01048	0.454
MOD_GlcNHglycan	550	554	PF01048	0.583
MOD_GlcNHglycan	564	567	PF01048	0.780
MOD_GSK3_1	101	108	PF00069	0.619
MOD_GSK3_1	171	178	PF00069	0.700
MOD_GSK3_1	192	199	PF00069	0.453
MOD_GSK3_1	267	274	PF00069	0.577
MOD_GSK3_1	329	336	PF00069	0.513
MOD_GSK3_1	377	384	PF00069	0.676
MOD_GSK3_1	414	421	PF00069	0.521
MOD_GSK3_1	512	519	PF00069	0.542
MOD_GSK3_1	536	543	PF00069	0.481
MOD_GSK3_1	560	567	PF00069	0.623
MOD_GSK3_1	570	577	PF00069	0.645
MOD_GSK3_1	656	663	PF00069	0.535
MOD_GSK3_1	68	75	PF00069	0.691
MOD_GSK3_1	93	100	PF00069	0.625
MOD_N-GLC_1	100	105	PF02516	0.488
MOD_N-GLC_1	498	503	PF02516	0.384
MOD_N-GLC_1	682	687	PF02516	0.361
MOD_N-GLC_2	438	440	PF02516	0.525
MOD_NEK2_1	102	107	PF00069	0.510
MOD_NEK2_1	145	150	PF00069	0.630
MOD_NEK2_1	153	158	PF00069	0.547
MOD_NEK2_1	232	237	PF00069	0.483
MOD_NEK2_1	308	313	PF00069	0.617
MOD_NEK2_1	322	327	PF00069	0.454
MOD_NEK2_1	333	338	PF00069	0.499
MOD_NEK2_1	358	363	PF00069	0.464
MOD_NEK2_1	36	41	PF00069	0.552
MOD_NEK2_1	446	451	PF00069	0.451
MOD_NEK2_1	504	509	PF00069	0.539
MOD_NEK2_1	536	541	PF00069	0.518
MOD_NEK2_1	665	670	PF00069	0.518
MOD_NEK2_1	707	712	PF00069	0.460
MOD_NEK2_1	73	78	PF00069	0.498
MOD_NEK2_1	80	85	PF00069	0.468
MOD_NEK2_2	682	687	PF00069	0.361
MOD_PIKK_1	267	273	PF00454	0.494
MOD_PIKK_1	308	314	PF00454	0.591
MOD_PIKK_1	377	383	PF00454	0.646
MOD_PIKK_1	521	527	PF00454	0.520
MOD_PIKK_1	574	580	PF00454	0.652
MOD_PIKK_1	600	606	PF00454	0.391
MOD_PIKK_1	633	639	PF00454	0.459
MOD_PIKK_1	699	705	PF00454	0.429
MOD_PKA_2	232	238	PF00069	0.531
MOD_PKA_2	254	260	PF00069	0.477
MOD_PKA_2	37	43	PF00069	0.561
MOD_PKA_2	393	399	PF00069	0.572
MOD_PKA_2	44	50	PF00069	0.623
MOD_PKA_2	69	75	PF00069	0.605
MOD_PKA_2	78	84	PF00069	0.611
MOD_Plk_1	105	111	PF00069	0.501
MOD_Plk_1	359	365	PF00069	0.438
MOD_Plk_1	472	478	PF00069	0.515
MOD_Plk_1	504	510	PF00069	0.475
MOD_Plk_1	512	518	PF00069	0.532
MOD_Plk_1	660	666	PF00069	0.609
MOD_Plk_1	682	688	PF00069	0.366
MOD_Plk_1	73	79	PF00069	0.579
MOD_Plk_2-3	360	366	PF00069	0.441
MOD_Plk_2-3	472	478	PF00069	0.511
MOD_Plk_2-3	660	666	PF00069	0.382
MOD_Plk_4	105	111	PF00069	0.518
MOD_Plk_4	153	159	PF00069	0.539
MOD_Plk_4	192	198	PF00069	0.536
MOD_Plk_4	421	427	PF00069	0.555
MOD_Plk_4	446	452	PF00069	0.451
MOD_Plk_4	660	666	PF00069	0.482
MOD_Plk_4	73	79	PF00069	0.579
MOD_ProDKin_1	166	172	PF00069	0.633
MOD_ProDKin_1	271	277	PF00069	0.538
MOD_ProDKin_1	50	56	PF00069	0.523
MOD_ProDKin_1	541	547	PF00069	0.455
MOD_ProDKin_1	560	566	PF00069	0.601
MOD_SUMO_for_1	138	141	PF00179	0.453
MOD_SUMO_for_1	26	29	PF00179	0.608
MOD_SUMO_for_1	401	404	PF00179	0.459
MOD_SUMO_rev_2	592	597	PF00179	0.556
TRG_DiLeu_BaEn_4	296	302	PF01217	0.563
TRG_DiLeu_BaEn_4	342	348	PF01217	0.564
TRG_DiLeu_BaLyEn_6	304	309	PF01217	0.422
TRG_DiLeu_BaLyEn_6	429	434	PF01217	0.544
TRG_DiLeu_BaLyEn_6	630	635	PF01217	0.480
TRG_ENDOCYTIC_2	23	26	PF00928	0.628
TRG_ENDOCYTIC_2	330	333	PF00928	0.496
TRG_Pf-PMV_PEXEL_1	135	140	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	307	312	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	338	342	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	478	483	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	498	503	PF00026	0.335
TRG_Pf-PMV_PEXEL_1	509	513	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	530	535	PF00026	0.633
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	667	671	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	698	703	PF00026	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I841	Leptomonas seymouri	44%	96%
A0A3S7X2Z5	Leishmania donovani	72%	99%
A4I4T7	Leishmania infantum	73%	99%
E9AEC3	Leishmania major	74%	100%
E9ALG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	99%