Doublecortin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHQ7_LEIBR

TriTrypDb:

LbrM.29.2560 , LBRM2903_290032700

Length:

701

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHQ7

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	6
GO:0009987	cellular process	1	6
GO:0035556	intracellular signal transduction	3	6
GO:0050789	regulation of biological process	2	6
GO:0050794	regulation of cellular process	3	6
GO:0065007	biological regulation	1	6

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	343	347	PF00656	0.738
CLV_C14_Caspase3-7	519	523	PF00656	0.465
CLV_C14_Caspase3-7	665	669	PF00656	0.566
CLV_NRD_NRD_1	195	197	PF00675	0.806
CLV_NRD_NRD_1	294	296	PF00675	0.581
CLV_NRD_NRD_1	417	419	PF00675	0.768
CLV_NRD_NRD_1	465	467	PF00675	0.566
CLV_NRD_NRD_1	573	575	PF00675	0.799
CLV_NRD_NRD_1	6	8	PF00675	0.667
CLV_PCSK_KEX2_1	195	197	PF00082	0.806
CLV_PCSK_KEX2_1	227	229	PF00082	0.786
CLV_PCSK_KEX2_1	294	296	PF00082	0.581
CLV_PCSK_KEX2_1	417	419	PF00082	0.757
CLV_PCSK_KEX2_1	590	592	PF00082	0.773
CLV_PCSK_KEX2_1	6	8	PF00082	0.667
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.786
CLV_PCSK_PC1ET2_1	590	592	PF00082	0.773
CLV_PCSK_SKI1_1	107	111	PF00082	0.583
CLV_PCSK_SKI1_1	128	132	PF00082	0.512
CLV_PCSK_SKI1_1	228	232	PF00082	0.578
CLV_PCSK_SKI1_1	401	405	PF00082	0.612
CLV_PCSK_SKI1_1	479	483	PF00082	0.553
CLV_PCSK_SKI1_1	574	578	PF00082	0.572
CLV_PCSK_SKI1_1	619	623	PF00082	0.588
CLV_PCSK_SKI1_1	650	654	PF00082	0.405
CLV_Separin_Metazoa	444	448	PF03568	0.587
DEG_COP1_1	157	166	PF00400	0.562
DEG_SCF_FBW7_1	231	236	PF00400	0.552
DEG_SCF_FBW7_1	353	360	PF00400	0.770
DEG_SPOP_SBC_1	221	225	PF00917	0.585
DEG_SPOP_SBC_1	247	251	PF00917	0.556
DEG_SPOP_SBC_1	388	392	PF00917	0.566
DEG_SPOP_SBC_1	553	557	PF00917	0.771
DEG_SPOP_SBC_1	569	573	PF00917	0.560
DOC_CKS1_1	241	246	PF01111	0.554
DOC_CKS1_1	397	402	PF01111	0.639
DOC_CYCLIN_RxL_1	644	656	PF00134	0.357
DOC_CYCLIN_yCln2_LP_2	442	448	PF00134	0.580
DOC_MAPK_DCC_7	590	599	PF00069	0.525
DOC_MAPK_gen_1	644	653	PF00069	0.584
DOC_MAPK_HePTP_8	641	653	PF00069	0.582
DOC_MAPK_MEF2A_6	115	122	PF00069	0.552
DOC_MAPK_MEF2A_6	509	517	PF00069	0.398
DOC_MAPK_MEF2A_6	590	599	PF00069	0.525
DOC_MAPK_MEF2A_6	644	653	PF00069	0.584
DOC_MAPK_RevD_3	36	50	PF00069	0.429
DOC_PP1_RVXF_1	126	132	PF00149	0.522
DOC_PP1_RVXF_1	426	432	PF00149	0.559
DOC_PP1_RVXF_1	464	471	PF00149	0.559
DOC_PP1_RVXF_1	637	644	PF00149	0.583
DOC_PP1_RVXF_1	648	654	PF00149	0.397
DOC_PP2B_LxvP_1	169	172	PF13499	0.744
DOC_PP2B_LxvP_1	190	193	PF13499	0.550
DOC_PP2B_LxvP_1	38	41	PF13499	0.388
DOC_PP4_FxxP_1	239	242	PF00568	0.796
DOC_PP4_FxxP_1	680	683	PF00568	0.616
DOC_PP4_MxPP_1	266	269	PF00568	0.530
DOC_SPAK_OSR1_1	679	683	PF12202	0.576
DOC_USP7_MATH_1	138	142	PF00917	0.605
DOC_USP7_MATH_1	247	251	PF00917	0.786
DOC_USP7_MATH_1	289	293	PF00917	0.559
DOC_USP7_MATH_1	344	348	PF00917	0.765
DOC_USP7_MATH_1	355	359	PF00917	0.636
DOC_USP7_MATH_1	371	375	PF00917	0.560
DOC_USP7_MATH_1	53	57	PF00917	0.500
DOC_USP7_MATH_1	553	557	PF00917	0.691
DOC_USP7_MATH_1	569	573	PF00917	0.554
DOC_USP7_MATH_1	580	584	PF00917	0.570
DOC_USP7_MATH_1	93	97	PF00917	0.389
DOC_USP7_UBL2_3	691	695	PF12436	0.485
DOC_WW_Pin1_4	229	234	PF00397	0.734
DOC_WW_Pin1_4	240	245	PF00397	0.603
DOC_WW_Pin1_4	287	292	PF00397	0.756
DOC_WW_Pin1_4	324	329	PF00397	0.761
DOC_WW_Pin1_4	353	358	PF00397	0.787
DOC_WW_Pin1_4	396	401	PF00397	0.775
DOC_WW_Pin1_4	558	563	PF00397	0.604
DOC_WW_Pin1_4	574	579	PF00397	0.630
LIG_14-3-3_CanoR_1	107	113	PF00244	0.600
LIG_14-3-3_CanoR_1	155	159	PF00244	0.752
LIG_14-3-3_CanoR_1	222	231	PF00244	0.573
LIG_14-3-3_CanoR_1	311	317	PF00244	0.552
LIG_14-3-3_CanoR_1	447	451	PF00244	0.566
LIG_14-3-3_CanoR_1	472	481	PF00244	0.564
LIG_14-3-3_CanoR_1	619	624	PF00244	0.566
LIG_BIR_II_1	1	5	PF00653	0.712
LIG_BIR_III_4	384	388	PF00653	0.549
LIG_BIR_III_4	654	658	PF00653	0.546
LIG_BRCT_BRCA1_1	357	361	PF00533	0.554
LIG_BRCT_BRCA1_1	404	408	PF00533	0.556
LIG_EH1_1	129	137	PF00400	0.315
LIG_FHA_1	158	164	PF00498	0.798
LIG_FHA_1	377	383	PF00498	0.551
LIG_FHA_1	388	394	PF00498	0.535
LIG_FHA_1	402	408	PF00498	0.508
LIG_FHA_1	463	469	PF00498	0.553
LIG_FHA_1	540	546	PF00498	0.596
LIG_FHA_1	618	624	PF00498	0.569
LIG_FHA_1	627	633	PF00498	0.442
LIG_FHA_1	636	642	PF00498	0.568
LIG_FHA_2	215	221	PF00498	0.786
LIG_FHA_2	559	565	PF00498	0.579
LIG_IRF3_LxIS_1	442	449	PF10401	0.548
LIG_LIR_Apic_2	236	242	PF02991	0.749
LIG_LIR_Apic_2	678	683	PF02991	0.610
LIG_LIR_Gen_1	27	36	PF02991	0.379
LIG_LIR_Gen_1	455	464	PF02991	0.543
LIG_LIR_LC3C_4	133	137	PF02991	0.332
LIG_LIR_Nem_3	186	190	PF02991	0.523
LIG_LIR_Nem_3	27	31	PF02991	0.370
LIG_LIR_Nem_3	455	461	PF02991	0.549
LIG_LIR_Nem_3	615	621	PF02991	0.596
LIG_MYND_1	351	355	PF01753	0.764
LIG_NRBOX	662	668	PF00104	0.572
LIG_PTAP_UEV_1	243	248	PF05743	0.554
LIG_PTB_Apo_2	607	614	PF02174	0.546
LIG_PTB_Phospho_1	607	613	PF10480	0.538
LIG_Rb_pABgroove_1	647	655	PF01858	0.552
LIG_SH2_CRK	618	622	PF00017	0.572
LIG_SH2_CRK	627	631	PF00017	0.450
LIG_SH2_GRB2like	608	611	PF00017	0.540
LIG_SH2_SRC	608	611	PF00017	0.540
LIG_SH2_STAP1	613	617	PF00017	0.602
LIG_SH2_STAT5	499	502	PF00017	0.313
LIG_SH2_STAT5	98	101	PF00017	0.414
LIG_SH3_3	168	174	PF00018	0.758
LIG_SH3_3	207	213	PF00018	0.660
LIG_SH3_3	241	247	PF00018	0.774
LIG_SH3_3	276	282	PF00018	0.711
LIG_SH3_3	335	341	PF00018	0.551
LIG_SH3_3	394	400	PF00018	0.566
LIG_SH3_3	559	565	PF00018	0.719
LIG_SH3_3	589	595	PF00018	0.573
LIG_SUMO_SIM_par_1	64	70	PF11976	0.343
LIG_SUMO_SIM_par_1	659	665	PF11976	0.556
LIG_ULM_U2AF65_1	466	471	PF00076	0.572
LIG_WRC_WIRS_1	109	114	PF05994	0.614
LIG_WRC_WIRS_1	25	30	PF05994	0.385
MOD_CDK_SPK_2	396	401	PF00069	0.558
MOD_CDK_SPxxK_3	287	294	PF00069	0.565
MOD_CDK_SPxxK_3	574	581	PF00069	0.695
MOD_CK1_1	165	171	PF00069	0.812
MOD_CK1_1	223	229	PF00069	0.575
MOD_CK1_1	240	246	PF00069	0.556
MOD_CK1_1	250	256	PF00069	0.588
MOD_CK1_1	284	290	PF00069	0.587
MOD_CK1_1	310	316	PF00069	0.585
MOD_CK1_1	327	333	PF00069	0.752
MOD_CK1_1	364	370	PF00069	0.554
MOD_CK1_1	389	395	PF00069	0.581
MOD_CK1_1	438	444	PF00069	0.411
MOD_CK1_1	531	537	PF00069	0.659
MOD_CK1_1	543	549	PF00069	0.585
MOD_CK1_1	558	564	PF00069	0.767
MOD_CK1_1	583	589	PF00069	0.614
MOD_CK2_1	214	220	PF00069	0.786
MOD_CK2_1	248	254	PF00069	0.566
MOD_CK2_1	316	322	PF00069	0.545
MOD_CK2_1	36	42	PF00069	0.612
MOD_CK2_1	389	395	PF00069	0.581
MOD_CK2_1	438	444	PF00069	0.381
MOD_CK2_1	558	564	PF00069	0.582
MOD_CK2_1	64	70	PF00069	0.343
MOD_CK2_1	653	659	PF00069	0.545
MOD_Cter_Amidation	645	648	PF01082	0.610
MOD_GlcNHglycan	197	200	PF01048	0.747
MOD_GlcNHglycan	201	204	PF01048	0.732
MOD_GlcNHglycan	250	253	PF01048	0.565
MOD_GlcNHglycan	283	286	PF01048	0.599
MOD_GlcNHglycan	334	337	PF01048	0.555
MOD_GlcNHglycan	342	345	PF01048	0.560
MOD_GlcNHglycan	363	366	PF01048	0.653
MOD_GlcNHglycan	37	41	PF01048	0.576
MOD_GlcNHglycan	373	377	PF01048	0.713
MOD_GlcNHglycan	419	422	PF01048	0.711
MOD_GlcNHglycan	424	427	PF01048	0.593
MOD_GlcNHglycan	437	440	PF01048	0.366
MOD_GlcNHglycan	489	492	PF01048	0.561
MOD_GlcNHglycan	542	545	PF01048	0.659
MOD_GlcNHglycan	557	560	PF01048	0.752
MOD_GlcNHglycan	654	658	PF01048	0.556
MOD_GlcNHglycan	674	677	PF01048	0.251
MOD_GSK3_1	195	202	PF00069	0.761
MOD_GSK3_1	229	236	PF00069	0.553
MOD_GSK3_1	242	249	PF00069	0.511
MOD_GSK3_1	294	301	PF00069	0.790
MOD_GSK3_1	303	310	PF00069	0.641
MOD_GSK3_1	340	347	PF00069	0.772
MOD_GSK3_1	353	360	PF00069	0.577
MOD_GSK3_1	372	379	PF00069	0.497
MOD_GSK3_1	475	482	PF00069	0.566
MOD_GSK3_1	53	60	PF00069	0.410
MOD_GSK3_1	536	543	PF00069	0.588
MOD_GSK3_1	554	561	PF00069	0.777
MOD_GSK3_1	570	577	PF00069	0.569
MOD_GSK3_1	668	675	PF00069	0.310
MOD_NEK2_1	237	242	PF00069	0.555
MOD_NEK2_1	361	366	PF00069	0.556
MOD_NEK2_1	435	440	PF00069	0.490
MOD_NEK2_1	446	451	PF00069	0.516
MOD_NEK2_1	475	480	PF00069	0.573
MOD_NEK2_1	500	505	PF00069	0.534
MOD_NEK2_1	653	658	PF00069	0.567
MOD_NEK2_2	93	98	PF00069	0.374
MOD_PIKK_1	53	59	PF00454	0.411
MOD_PKA_1	195	201	PF00069	0.801
MOD_PKA_1	294	300	PF00069	0.567
MOD_PKA_1	417	423	PF00069	0.729
MOD_PKA_2	154	160	PF00069	0.728
MOD_PKA_2	195	201	PF00069	0.804
MOD_PKA_2	221	227	PF00069	0.714
MOD_PKA_2	294	300	PF00069	0.589
MOD_PKA_2	310	316	PF00069	0.497
MOD_PKA_2	416	422	PF00069	0.749
MOD_PKA_2	446	452	PF00069	0.574
MOD_PKA_2	473	479	PF00069	0.593
MOD_PKA_2	531	537	PF00069	0.740
MOD_PKA_2	539	545	PF00069	0.601
MOD_Plk_1	313	319	PF00069	0.592
MOD_Plk_1	409	415	PF00069	0.732
MOD_Plk_1	41	47	PF00069	0.600
MOD_Plk_2-3	24	30	PF00069	0.386
MOD_Plk_2-3	662	668	PF00069	0.355
MOD_Plk_4	316	322	PF00069	0.664
MOD_Plk_4	453	459	PF00069	0.581
MOD_Plk_4	632	638	PF00069	0.549
MOD_Plk_4	662	668	PF00069	0.409
MOD_Plk_4	684	690	PF00069	0.358
MOD_ProDKin_1	229	235	PF00069	0.736
MOD_ProDKin_1	240	246	PF00069	0.602
MOD_ProDKin_1	287	293	PF00069	0.757
MOD_ProDKin_1	324	330	PF00069	0.761
MOD_ProDKin_1	353	359	PF00069	0.789
MOD_ProDKin_1	396	402	PF00069	0.775
MOD_ProDKin_1	558	564	PF00069	0.723
MOD_ProDKin_1	574	580	PF00069	0.627
MOD_SUMO_for_1	179	182	PF00179	0.554
MOD_SUMO_rev_2	483	491	PF00179	0.580
MOD_SUMO_rev_2	640	649	PF00179	0.562
TRG_DiLeu_BaEn_1	662	667	PF01217	0.488
TRG_DiLeu_BaLyEn_6	647	652	PF01217	0.350
TRG_ENDOCYTIC_2	618	621	PF00928	0.574
TRG_ENDOCYTIC_2	627	630	PF00928	0.446
TRG_ER_diArg_1	195	197	PF00400	0.793
TRG_ER_diArg_1	293	295	PF00400	0.583
TRG_ER_diArg_1	472	475	PF00400	0.398
TRG_NLS_MonoExtC_3	465	471	PF00514	0.565
TRG_NLS_MonoExtN_4	644	651	PF00514	0.384
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.634
TRG_Pf-PMV_PEXEL_1	466	471	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	650	654	PF00026	0.395
TRG_PTS2	1	14	PF00400	0.673

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IRL3	Leishmania donovani	67%	100%
A4I4T5	Leishmania infantum	67%	100%
E9AEC1	Leishmania major	68%	99%
E9ALG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%