Putative serine/threonine-protein kinase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine-protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HHQ5_LEIBR

TriTrypDb:

LbrM.29.2540 , LBRM2903_290032500

Length:

506

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 21

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 33
NetGPI	no	yes: 0, no: 33

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHQ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHQ5

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	34
GO:0006793	phosphorus metabolic process	3	34
GO:0006796	phosphate-containing compound metabolic process	4	34
GO:0006807	nitrogen compound metabolic process	2	34
GO:0008152	metabolic process	1	34
GO:0009987	cellular process	1	34
GO:0016310	phosphorylation	5	34
GO:0019538	protein metabolic process	3	34
GO:0036211	protein modification process	4	34
GO:0043170	macromolecule metabolic process	3	34
GO:0043412	macromolecule modification	4	34
GO:0044237	cellular metabolic process	2	34
GO:0044238	primary metabolic process	2	34
GO:0071704	organic substance metabolic process	2	34
GO:1901564	organonitrogen compound metabolic process	3	34

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	34
GO:0003824	catalytic activity	1	34
GO:0004672	protein kinase activity	3	34
GO:0004674	protein serine/threonine kinase activity	4	24
GO:0005488	binding	1	34
GO:0005524	ATP binding	5	34
GO:0016301	kinase activity	4	34
GO:0016740	transferase activity	2	34
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	34
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	34
GO:0017076	purine nucleotide binding	4	34
GO:0030554	adenyl nucleotide binding	5	34
GO:0032553	ribonucleotide binding	3	34
GO:0032555	purine ribonucleotide binding	4	34
GO:0032559	adenyl ribonucleotide binding	5	34
GO:0035639	purine ribonucleoside triphosphate binding	4	34
GO:0036094	small molecule binding	2	34
GO:0043167	ion binding	2	34
GO:0043168	anion binding	3	34
GO:0097159	organic cyclic compound binding	2	34
GO:0097367	carbohydrate derivative binding	2	34
GO:0140096	catalytic activity, acting on a protein	2	34
GO:1901265	nucleoside phosphate binding	3	34
GO:1901363	heterocyclic compound binding	2	34

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.283
CLV_C14_Caspase3-7	411	415	PF00656	0.520
CLV_C14_Caspase3-7	97	101	PF00656	0.340
CLV_NRD_NRD_1	21	23	PF00675	0.309
CLV_NRD_NRD_1	61	63	PF00675	0.357
CLV_PCSK_KEX2_1	21	23	PF00082	0.415
CLV_PCSK_KEX2_1	389	391	PF00082	0.397
CLV_PCSK_KEX2_1	44	46	PF00082	0.292
CLV_PCSK_KEX2_1	61	63	PF00082	0.224
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.383
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.292
CLV_PCSK_PC7_1	17	23	PF00082	0.294
CLV_PCSK_SKI1_1	109	113	PF00082	0.357
CLV_PCSK_SKI1_1	147	151	PF00082	0.355
CLV_PCSK_SKI1_1	21	25	PF00082	0.357
CLV_PCSK_SKI1_1	226	230	PF00082	0.318
CLV_PCSK_SKI1_1	233	237	PF00082	0.281
CLV_PCSK_SKI1_1	351	355	PF00082	0.547
DOC_CYCLIN_yCln2_LP_2	219	225	PF00134	0.322
DOC_MAPK_gen_1	147	156	PF00069	0.353
DOC_MAPK_gen_1	17	25	PF00069	0.212
DOC_USP7_MATH_1	281	285	PF00917	0.366
DOC_USP7_MATH_1	416	420	PF00917	0.600
DOC_USP7_MATH_1	485	489	PF00917	0.381
DOC_USP7_MATH_1	5	9	PF00917	0.525
DOC_USP7_MATH_1	50	54	PF00917	0.355
DOC_USP7_MATH_2	248	254	PF00917	0.432
DOC_USP7_UBL2_3	159	163	PF12436	0.384
DOC_USP7_UBL2_3	229	233	PF12436	0.301
DOC_USP7_UBL2_3	24	28	PF12436	0.330
DOC_USP7_UBL2_3	40	44	PF12436	0.242
DOC_WW_Pin1_4	183	188	PF00397	0.355
LIG_14-3-3_CanoR_1	38	47	PF00244	0.359
LIG_BIR_II_1	1	5	PF00653	0.541
LIG_BRCT_BRCA1_1	89	93	PF00533	0.200
LIG_CtBP_PxDLS_1	248	252	PF00389	0.322
LIG_deltaCOP1_diTrp_1	205	213	PF00928	0.371
LIG_eIF4E_1	20	26	PF01652	0.495
LIG_FHA_1	149	155	PF00498	0.333
LIG_FHA_1	214	220	PF00498	0.415
LIG_FHA_1	244	250	PF00498	0.337
LIG_FHA_2	225	231	PF00498	0.360
LIG_FHA_2	55	61	PF00498	0.314
LIG_LIR_Apic_2	186	192	PF02991	0.346
LIG_LIR_Gen_1	90	99	PF02991	0.287
LIG_LIR_Nem_3	18	23	PF02991	0.289
LIG_MAD2	234	242	PF02301	0.287
LIG_MAD2	69	77	PF02301	0.283
LIG_NRBOX	227	233	PF00104	0.307
LIG_PCNA_yPIPBox_3	473	483	PF02747	0.402
LIG_PDZ_Class_2	501	506	PF00595	0.502
LIG_PTB_Apo_2	10	17	PF02174	0.312
LIG_SH2_CRK	20	24	PF00017	0.261
LIG_SH2_CRK	240	244	PF00017	0.342
LIG_SH2_NCK_1	240	244	PF00017	0.283
LIG_SH2_SRC	240	243	PF00017	0.283
LIG_SH2_SRC	98	101	PF00017	0.328
LIG_SH2_STAT3	385	388	PF00017	0.430
LIG_SH2_STAT5	138	141	PF00017	0.332
LIG_SH2_STAT5	189	192	PF00017	0.352
LIG_SH2_STAT5	277	280	PF00017	0.377
LIG_SH2_STAT5	385	388	PF00017	0.449
LIG_SH2_STAT5	46	49	PF00017	0.315
LIG_SH3_1	308	314	PF00018	0.553
LIG_SH3_3	113	119	PF00018	0.317
LIG_SH3_3	308	314	PF00018	0.604
LIG_SH3_3	325	331	PF00018	0.619
LIG_SH3_3	371	377	PF00018	0.552
LIG_SH3_3	71	77	PF00018	0.288
LIG_TRAF2_1	358	361	PF00917	0.648
LIG_TRAF2_1	370	373	PF00917	0.611
LIG_TYR_ITIM	212	217	PF00017	0.343
LIG_UBA3_1	341	349	PF00899	0.587
LIG_WRC_WIRS_1	282	287	PF05994	0.413
MOD_CK1_1	55	61	PF00069	0.331
MOD_CK2_1	27	33	PF00069	0.321
MOD_CK2_1	303	309	PF00069	0.540
MOD_CK2_1	331	337	PF00069	0.591
MOD_CK2_1	465	471	PF00069	0.462
MOD_CK2_1	54	60	PF00069	0.331
MOD_Cter_Amidation	42	45	PF01082	0.283
MOD_GlcNHglycan	418	421	PF01048	0.678
MOD_GlcNHglycan	436	439	PF01048	0.443
MOD_GlcNHglycan	52	55	PF01048	0.277
MOD_GSK3_1	179	186	PF00069	0.354
MOD_GSK3_1	250	257	PF00069	0.401
MOD_GSK3_1	360	367	PF00069	0.695
MOD_GSK3_1	422	429	PF00069	0.591
MOD_GSK3_1	430	437	PF00069	0.540
MOD_GSK3_1	485	492	PF00069	0.380
MOD_GSK3_1	50	57	PF00069	0.350
MOD_N-GLC_1	201	206	PF02516	0.254
MOD_NEK2_1	15	20	PF00069	0.570
MOD_NEK2_1	155	160	PF00069	0.366
MOD_NEK2_1	167	172	PF00069	0.341
MOD_NEK2_1	173	178	PF00069	0.307
MOD_NEK2_1	194	199	PF00069	0.301
MOD_NEK2_1	213	218	PF00069	0.410
MOD_NEK2_1	254	259	PF00069	0.304
MOD_NEK2_1	273	278	PF00069	0.384
MOD_NEK2_1	36	41	PF00069	0.288
MOD_NEK2_1	458	463	PF00069	0.502
MOD_PIKK_1	322	328	PF00454	0.689
MOD_PKA_2	265	271	PF00069	0.339
MOD_Plk_1	273	279	PF00069	0.279
MOD_Plk_1	360	366	PF00069	0.510
MOD_Plk_1	87	93	PF00069	0.386
MOD_Plk_4	168	174	PF00069	0.271
MOD_Plk_4	254	260	PF00069	0.319
MOD_Plk_4	273	279	PF00069	0.330
MOD_Plk_4	430	436	PF00069	0.563
MOD_Plk_4	87	93	PF00069	0.324
MOD_ProDKin_1	183	189	PF00069	0.355
MOD_SUMO_rev_2	296	305	PF00179	0.485
MOD_SUMO_rev_2	381	391	PF00179	0.364
TRG_DiLeu_BaEn_1	475	480	PF01217	0.394
TRG_DiLeu_BaEn_1	87	92	PF01217	0.327
TRG_ENDOCYTIC_2	20	23	PF00928	0.289
TRG_ENDOCYTIC_2	214	217	PF00928	0.383
TRG_ENDOCYTIC_2	240	243	PF00928	0.320
TRG_ER_diArg_1	20	22	PF00400	0.438
TRG_Pf-PMV_PEXEL_1	303	307	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	9	14	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY86	Leptomonas seymouri	78%	97%
A0A0N1I9A0	Leptomonas seymouri	31%	78%
A0A0S4IKH2	Bodo saltans	68%	100%
A0A0S4J3Y5	Bodo saltans	27%	100%
A0A0S4J6L4	Bodo saltans	27%	100%
A0A0S4JIJ6	Bodo saltans	29%	90%
A0A0S4JN22	Bodo saltans	31%	66%
A0A0S4JNA1	Bodo saltans	37%	100%
A0A1X0NKF2	Trypanosomatidae	29%	85%
A0A1X0NTL6	Trypanosomatidae	29%	100%
A0A1X0NUB2	Trypanosomatidae	33%	87%
A0A1X0P9C4	Trypanosomatidae	73%	100%
A0A3Q8IAQ1	Leishmania donovani	38%	100%
A0A3Q8IB74	Leishmania donovani	26%	100%
A0A3Q8IC87	Leishmania donovani	28%	100%
A0A3Q8IFK8	Leishmania donovani	39%	100%
A0A3Q8IHH8	Leishmania donovani	86%	100%
A0A3Q8IIG1	Leishmania donovani	29%	100%
A0A3Q8INQ4	Leishmania donovani	26%	100%
A0A3R7RIN5	Trypanosoma rangeli	73%	100%
A0A3S5H5G0	Leishmania donovani	25%	100%
A0A3S7WWE7	Leishmania donovani	26%	100%
A0A3S7WYP4	Leishmania donovani	29%	100%
A0A3S7X2W3	Leishmania donovani	27%	100%
A0A3S7X5M4	Leishmania donovani	32%	77%
A0A3S7X7D5	Leishmania donovani	26%	100%
A0A3S7X7Y2	Leishmania donovani	27%	100%
A0A3S7X9S2	Leishmania donovani	30%	100%
A0A422N3U8	Trypanosoma rangeli	28%	70%
A4HAS1	Leishmania braziliensis	28%	100%
A4HBL4	Leishmania braziliensis	24%	100%
A4HCE6	Leishmania braziliensis	37%	100%
A4HDU3	Leishmania braziliensis	30%	100%
A4HH03	Leishmania braziliensis	30%	100%
A4HHE4	Leishmania braziliensis	24%	86%
A4HHN1	Leishmania braziliensis	27%	100%
A4HJW2	Leishmania braziliensis	42%	100%
A4HKG9	Leishmania braziliensis	34%	77%
A4HLR0	Leishmania braziliensis	36%	100%
A4HSE2	Leishmania infantum	25%	100%
A4HZA2	Leishmania infantum	26%	100%
A4HZV1	Leishmania infantum	28%	100%
A4HZW8	Leishmania infantum	38%	100%
A4I140	Leishmania infantum	29%	100%
A4I1T4	Leishmania infantum	26%	100%
A4I435	Leishmania infantum	29%	100%
A4I4U6	Leishmania infantum	27%	100%
A4I4X0	Leishmania infantum	87%	100%
A4I7A1	Leishmania infantum	39%	100%
A4I7Z6	Leishmania infantum	32%	77%
A4I9H1	Leishmania infantum	26%	100%
A4I9Y5	Leishmania infantum	27%	100%
D0A118	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	66%
E9AEB9	Leishmania major	86%	100%
E9AFM1	Leishmania major	30%	100%
E9ALG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9ALJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9ARW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AVR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AVS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AX78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AXW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B0C2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B296	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9B2V8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	77%
E9B4G9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B4Z4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B5Y5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
O08875	Rattus norvegicus	28%	100%
P87248	Colletotrichum lindemuthianum	29%	75%
Q4Q1S4	Leishmania major	29%	100%
Q4Q2Z2	Leishmania major	27%	100%
Q4Q598	Leishmania major	33%	77%
Q4Q5W2	Leishmania major	39%	100%
Q4Q7W2	Leishmania major	29%	100%
Q4Q9K2	Leishmania major	26%	100%
Q4QA98	Leishmania major	28%	100%
Q4QBQ2	Leishmania major	38%	100%
Q4QBR6	Leishmania major	28%	100%
Q4QCK0	Leishmania major	24%	100%
Q4QJJ0	Leishmania major	26%	100%
Q63553	Rattus norvegicus	26%	68%
Q8C0Q4	Mus musculus	30%	81%
Q8INB9	Drosophila melanogaster	27%	83%
Q9SN43	Arabidopsis thaliana	27%	100%
Q9Y077	Leishmania major	27%	100%
V5BHW8	Trypanosoma cruzi	29%	80%
V5BLW4	Trypanosoma cruzi	44%	66%
V5C224	Trypanosoma cruzi	73%	100%
V5DFW9	Trypanosoma cruzi	33%	87%