Lymphocyte expansion molecule

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4586), putative

Species:

Leishmania braziliensis

UniProt:

A4HHQ4_LEIBR

TriTrypDb:

LbrM.29.2530 , LBRM2903_290032400

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	19
GO:0005815	microtubule organizing center	2	19
GO:0110165	cellular anatomical entity	1	19
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HHQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHQ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	30	34	PF00656	0.570
CLV_NRD_NRD_1	141	143	PF00675	0.234
CLV_NRD_NRD_1	199	201	PF00675	0.350
CLV_NRD_NRD_1	23	25	PF00675	0.183
CLV_NRD_NRD_1	249	251	PF00675	0.284
CLV_NRD_NRD_1	301	303	PF00675	0.314
CLV_NRD_NRD_1	335	337	PF00675	0.515
CLV_PCSK_KEX2_1	140	142	PF00082	0.274
CLV_PCSK_KEX2_1	335	337	PF00082	0.558
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.283
CLV_PCSK_SKI1_1	142	146	PF00082	0.334
CLV_PCSK_SKI1_1	250	254	PF00082	0.352
CLV_PCSK_SKI1_1	42	46	PF00082	0.289
CLV_PCSK_SKI1_1	62	66	PF00082	0.155
DEG_COP1_1	255	262	PF00400	0.383
DOC_ANK_TNKS_1	109	116	PF00023	0.480
DOC_CYCLIN_yCln2_LP_2	209	215	PF00134	0.557
DOC_PP2B_LxvP_1	209	212	PF13499	0.534
DOC_PP4_FxxP_1	11	14	PF00568	0.484
DOC_PP4_FxxP_1	213	216	PF00568	0.494
DOC_USP7_MATH_1	108	112	PF00917	0.524
DOC_USP7_MATH_1	216	220	PF00917	0.565
DOC_USP7_MATH_1	241	245	PF00917	0.473
DOC_USP7_MATH_1	34	38	PF00917	0.602
DOC_USP7_UBL2_3	253	257	PF12436	0.472
DOC_USP7_UBL2_3	90	94	PF12436	0.438
LIG_14-3-3_CanoR_1	103	108	PF00244	0.480
LIG_14-3-3_CanoR_1	24	28	PF00244	0.547
LIG_14-3-3_CanoR_1	320	325	PF00244	0.537
LIG_APCC_ABBA_1	287	292	PF00400	0.473
LIG_BIR_III_2	33	37	PF00653	0.586
LIG_EH_1	281	285	PF12763	0.473
LIG_eIF4E_1	168	174	PF01652	0.555
LIG_FHA_1	254	260	PF00498	0.480
LIG_FHA_1	325	331	PF00498	0.511
LIG_LIR_Gen_1	123	132	PF02991	0.520
LIG_LIR_Gen_1	61	68	PF02991	0.459
LIG_LIR_Nem_3	101	107	PF02991	0.543
LIG_LIR_Nem_3	116	121	PF02991	0.490
LIG_LIR_Nem_3	167	173	PF02991	0.490
LIG_LIR_Nem_3	232	238	PF02991	0.557
LIG_LIR_Nem_3	265	271	PF02991	0.547
LIG_LIR_Nem_3	4	10	PF02991	0.466
LIG_LIR_Nem_3	61	67	PF02991	0.459
LIG_Pex14_2	284	288	PF04695	0.461
LIG_Pex14_2	60	64	PF04695	0.484
LIG_PTB_Apo_2	174	181	PF02174	0.470
LIG_PTB_Phospho_1	174	180	PF10480	0.470
LIG_SH2_CRK	170	174	PF00017	0.459
LIG_SH2_CRK	7	11	PF00017	0.484
LIG_SH2_GRB2like	271	274	PF00017	0.383
LIG_SH2_NCK_1	238	242	PF00017	0.528
LIG_SH2_STAP1	271	275	PF00017	0.383
LIG_SH2_STAT5	16	19	PF00017	0.540
LIG_SH2_STAT5	222	225	PF00017	0.498
LIG_SH2_STAT5	39	42	PF00017	0.454
LIG_SH2_STAT5	59	62	PF00017	0.355
LIG_SH3_3	315	321	PF00018	0.505
LIG_TRAF2_1	146	149	PF00917	0.598
LIG_TRAF2_1	305	308	PF00917	0.534
LIG_TRAF2_2	52	57	PF00917	0.473
MOD_CK1_1	15	21	PF00069	0.538
MOD_CK1_1	244	250	PF00069	0.589
MOD_CK1_1	328	334	PF00069	0.558
MOD_CK2_1	103	109	PF00069	0.512
MOD_CK2_1	95	101	PF00069	0.554
MOD_GlcNHglycan	231	234	PF01048	0.294
MOD_GlcNHglycan	243	246	PF01048	0.270
MOD_GlcNHglycan	298	301	PF01048	0.294
MOD_GlcNHglycan	3	7	PF01048	0.282
MOD_GSK3_1	109	116	PF00069	0.498
MOD_GSK3_1	12	19	PF00069	0.451
MOD_GSK3_1	320	327	PF00069	0.487
MOD_GSK3_1	63	70	PF00069	0.473
MOD_NEK2_1	1	6	PF00069	0.592
MOD_NEK2_1	102	107	PF00069	0.542
MOD_NEK2_1	173	178	PF00069	0.524
MOD_NEK2_1	294	299	PF00069	0.474
MOD_NEK2_1	324	329	PF00069	0.548
MOD_NEK2_1	40	45	PF00069	0.571
MOD_PKA_1	164	170	PF00069	0.469
MOD_PKA_1	253	259	PF00069	0.459
MOD_PKA_1	90	96	PF00069	0.399
MOD_PKA_2	102	108	PF00069	0.480
MOD_PKA_2	109	115	PF00069	0.480
MOD_PKA_2	194	200	PF00069	0.376
MOD_PKA_2	23	29	PF00069	0.547
MOD_Plk_1	2	8	PF00069	0.482
MOD_Plk_1	324	330	PF00069	0.416
MOD_Plk_4	113	119	PF00069	0.540
MOD_Plk_4	12	18	PF00069	0.528
MOD_Plk_4	218	224	PF00069	0.583
MOD_Plk_4	258	264	PF00069	0.531
MOD_Plk_4	325	331	PF00069	0.494
MOD_SUMO_for_1	146	149	PF00179	0.457
MOD_SUMO_for_1	252	255	PF00179	0.473
MOD_SUMO_rev_2	131	138	PF00179	0.534
MOD_SUMO_rev_2	27	34	PF00179	0.481
MOD_SUMO_rev_2	57	65	PF00179	0.399
TRG_DiLeu_BaEn_4	150	156	PF01217	0.473
TRG_ENDOCYTIC_2	118	121	PF00928	0.515
TRG_ENDOCYTIC_2	126	129	PF00928	0.510
TRG_ENDOCYTIC_2	170	173	PF00928	0.534
TRG_ENDOCYTIC_2	7	10	PF00928	0.503
TRG_ER_diArg_1	334	336	PF00400	0.460
TRG_NLS_MonoCore_2	138	143	PF00514	0.490
TRG_NLS_MonoExtC_3	249	254	PF00514	0.478
TRG_NLS_MonoExtN_4	137	144	PF00514	0.472
TRG_NLS_MonoExtN_4	248	254	PF00514	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6K0	Leptomonas seymouri	65%	98%
A0A0S4IPI4	Bodo saltans	38%	100%
A0A0S4IYY4	Bodo saltans	28%	100%
A0A1X0NRI3	Trypanosomatidae	30%	100%
A0A1X0P929	Trypanosomatidae	50%	97%
A0A3Q8IGT8	Leishmania donovani	32%	100%
A0A3R7NAQ1	Trypanosoma rangeli	47%	98%
A0A3S7X2W5	Leishmania donovani	81%	99%
A4HGN9	Leishmania braziliensis	31%	100%
A4I3R2	Leishmania infantum	31%	100%
A4I4W9	Leishmania infantum	82%	83%
C9ZKZ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	85%
E9AEB8	Leishmania major	82%	100%
E9ALG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	80%
E9B005	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
Q4Q880	Leishmania major	31%	100%
V5DTV3	Trypanosoma cruzi	49%	98%