LeishMANIAdb
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Transcription factor

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transcription factor
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HHQ2_LEIBR
TriTrypDb:
LbrM.29.2500 , LBRM2903_290031900
Length:
67

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHQ2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHQ2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 1 3 PF00675 0.551
DEG_Nend_UBRbox_1 1 4 PF02207 0.564
DOC_PP4_MxPP_1 38 41 PF00568 0.665
DOC_USP7_MATH_1 14 18 PF00917 0.555
DOC_WW_Pin1_4 10 15 PF00397 0.525
LIG_14-3-3_CanoR_1 2 8 PF00244 0.515
LIG_FHA_1 11 17 PF00498 0.538
LIG_SH3_3 38 44 PF00018 0.628
MOD_CK2_1 3 9 PF00069 0.527
MOD_GSK3_1 30 37 PF00069 0.565
MOD_GSK3_1 8 15 PF00069 0.524
MOD_N-GLC_1 3 8 PF02516 0.406
MOD_PIKK_1 30 36 PF00454 0.499
MOD_Plk_1 3 9 PF00069 0.404
MOD_Plk_1 34 40 PF00069 0.649
MOD_Plk_4 14 20 PF00069 0.579
MOD_ProDKin_1 10 16 PF00069 0.531
TRG_DiLeu_BaLyEn_6 41 46 PF01217 0.497

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6J3 Leptomonas seymouri 70% 100%
A0A0S4IVA2 Bodo saltans 53% 93%
A0A3S7X2S9 Leishmania donovani 84% 100%
A4I4W7 Leishmania infantum 84% 100%
C9ZKZ3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 49% 91%
E9AEB5 Leishmania major 82% 100%
E9ALH1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 100%
V5BSW6 Trypanosoma cruzi 51% 96%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS