SP-RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MIZ/SP-RING zinc finger, putative

Species:

Leishmania braziliensis

UniProt:

A4HHQ1_LEIBR

TriTrypDb:

LbrM.29.2490 , LBRM2903_290031800

Length:

405

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHQ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHQ1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	186	188	PF00675	0.464
CLV_NRD_NRD_1	20	22	PF00675	0.539
CLV_NRD_NRD_1	393	395	PF00675	0.659
CLV_NRD_NRD_1	98	100	PF00675	0.393
CLV_PCSK_FUR_1	186	190	PF00082	0.527
CLV_PCSK_KEX2_1	186	188	PF00082	0.443
CLV_PCSK_KEX2_1	20	22	PF00082	0.549
CLV_PCSK_KEX2_1	391	393	PF00082	0.637
CLV_PCSK_KEX2_1	98	100	PF00082	0.411
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.530
CLV_PCSK_PC1ET2_1	391	393	PF00082	0.661
DEG_SPOP_SBC_1	157	161	PF00917	0.604
DEG_SPOP_SBC_1	324	328	PF00917	0.591
DOC_CKS1_1	140	145	PF01111	0.498
DOC_CKS1_1	219	224	PF01111	0.632
DOC_CKS1_1	240	245	PF01111	0.515
DOC_CKS1_1	374	379	PF01111	0.802
DOC_CYCLIN_yCln2_LP_2	219	225	PF00134	0.624
DOC_MAPK_gen_1	20	28	PF00069	0.470
DOC_MAPK_gen_1	391	397	PF00069	0.629
DOC_MAPK_MEF2A_6	258	267	PF00069	0.453
DOC_MAPK_MEF2A_6	382	390	PF00069	0.524
DOC_PP2B_LxvP_1	69	72	PF13499	0.647
DOC_PP4_FxxP_1	140	143	PF00568	0.500
DOC_PP4_FxxP_1	240	243	PF00568	0.321
DOC_USP7_MATH_1	150	154	PF00917	0.377
DOC_USP7_MATH_1	292	296	PF00917	0.500
DOC_USP7_MATH_1	312	316	PF00917	0.244
DOC_USP7_MATH_1	324	328	PF00917	0.514
DOC_USP7_MATH_1	50	54	PF00917	0.525
DOC_USP7_MATH_1	81	85	PF00917	0.533
DOC_WW_Pin1_4	139	144	PF00397	0.453
DOC_WW_Pin1_4	158	163	PF00397	0.587
DOC_WW_Pin1_4	218	223	PF00397	0.613
DOC_WW_Pin1_4	239	244	PF00397	0.521
DOC_WW_Pin1_4	331	336	PF00397	0.488
DOC_WW_Pin1_4	373	378	PF00397	0.748
LIG_14-3-3_CanoR_1	105	111	PF00244	0.571
LIG_14-3-3_CanoR_1	189	194	PF00244	0.437
LIG_14-3-3_CanoR_1	20	28	PF00244	0.529
LIG_14-3-3_CanoR_1	280	286	PF00244	0.589
LIG_14-3-3_CanoR_1	358	367	PF00244	0.769
LIG_14-3-3_CanoR_1	87	92	PF00244	0.379
LIG_AP2alpha_2	224	226	PF02296	0.588
LIG_BIR_II_1	1	5	PF00653	0.669
LIG_Clathr_ClatBox_1	267	271	PF01394	0.481
LIG_eIF4E_1	174	180	PF01652	0.278
LIG_FHA_1	121	127	PF00498	0.593
LIG_FHA_1	132	138	PF00498	0.528
LIG_FHA_1	140	146	PF00498	0.535
LIG_FHA_1	207	213	PF00498	0.476
LIG_FHA_1	23	29	PF00498	0.568
LIG_FHA_1	236	242	PF00498	0.571
LIG_FHA_1	282	288	PF00498	0.573
LIG_FHA_1	295	301	PF00498	0.577
LIG_FHA_1	305	311	PF00498	0.403
LIG_FHA_1	346	352	PF00498	0.575
LIG_FHA_2	107	113	PF00498	0.645
LIG_FHA_2	219	225	PF00498	0.557
LIG_FHA_2	228	234	PF00498	0.656
LIG_LIR_Apic_2	238	243	PF02991	0.331
LIG_LIR_Gen_1	107	116	PF02991	0.639
LIG_LIR_Gen_1	281	290	PF02991	0.629
LIG_LIR_Gen_1	65	76	PF02991	0.706
LIG_LIR_Nem_3	107	113	PF02991	0.633
LIG_LIR_Nem_3	192	196	PF02991	0.407
LIG_LIR_Nem_3	30	35	PF02991	0.561
LIG_LIR_Nem_3	65	71	PF02991	0.742
LIG_NRBOX	193	199	PF00104	0.528
LIG_Rb_pABgroove_1	174	182	PF01858	0.283
LIG_SH2_CRK	32	36	PF00017	0.303
LIG_SH2_NCK_1	110	114	PF00017	0.630
LIG_SH2_NCK_1	316	320	PF00017	0.600
LIG_SH2_SRC	110	113	PF00017	0.630
LIG_SH2_STAP1	316	320	PF00017	0.600
LIG_SH2_STAT3	129	132	PF00017	0.525
LIG_SH2_STAT5	108	111	PF00017	0.675
LIG_SH2_STAT5	193	196	PF00017	0.529
LIG_SH2_STAT5	68	71	PF00017	0.747
LIG_SH3_3	161	167	PF00018	0.391
LIG_SH3_3	219	225	PF00018	0.591
LIG_SH3_3	284	290	PF00018	0.628
LIG_SH3_3	371	377	PF00018	0.783
LIG_SH3_3	69	75	PF00018	0.680
LIG_SUMO_SIM_par_1	211	218	PF11976	0.554
LIG_UBA3_1	35	40	PF00899	0.411
LIG_WRC_WIRS_1	270	275	PF05994	0.431
MOD_CDK_SPxK_1	239	245	PF00069	0.520
MOD_CK1_1	153	159	PF00069	0.638
MOD_CK1_1	2	8	PF00069	0.651
MOD_CK1_1	227	233	PF00069	0.666
MOD_CK1_1	281	287	PF00069	0.629
MOD_CK1_1	326	332	PF00069	0.689
MOD_CK1_1	334	340	PF00069	0.583
MOD_CK1_1	61	67	PF00069	0.485
MOD_CK2_1	211	217	PF00069	0.418
MOD_CK2_1	227	233	PF00069	0.659
MOD_GlcNHglycan	1	4	PF01048	0.715
MOD_GlcNHglycan	154	158	PF01048	0.677
MOD_GlcNHglycan	203	206	PF01048	0.379
MOD_GlcNHglycan	329	332	PF01048	0.540
MOD_GlcNHglycan	364	367	PF01048	0.753
MOD_GlcNHglycan	52	55	PF01048	0.429
MOD_GlcNHglycan	60	63	PF01048	0.467
MOD_GSK3_1	120	127	PF00069	0.598
MOD_GSK3_1	152	159	PF00069	0.649
MOD_GSK3_1	211	218	PF00069	0.453
MOD_GSK3_1	235	242	PF00069	0.517
MOD_GSK3_1	274	281	PF00069	0.546
MOD_GSK3_1	294	301	PF00069	0.388
MOD_GSK3_1	320	327	PF00069	0.639
MOD_GSK3_1	343	350	PF00069	0.533
MOD_GSK3_1	358	365	PF00069	0.646
MOD_GSK3_1	58	65	PF00069	0.712
MOD_GSK3_1	70	77	PF00069	0.626
MOD_N-GLC_1	215	220	PF02516	0.574
MOD_NEK2_1	103	108	PF00069	0.482
MOD_NEK2_1	215	220	PF00069	0.484
MOD_NEK2_1	38	43	PF00069	0.558
MOD_NEK2_2	120	125	PF00069	0.639
MOD_NEK2_2	294	299	PF00069	0.524
MOD_PIKK_1	128	134	PF00454	0.309
MOD_PIKK_1	206	212	PF00454	0.536
MOD_PIKK_1	246	252	PF00454	0.528
MOD_PIKK_1	274	280	PF00454	0.446
MOD_PIKK_1	304	310	PF00454	0.498
MOD_PIKK_1	45	51	PF00454	0.550
MOD_PIKK_1	81	87	PF00454	0.525
MOD_PKA_2	104	110	PF00069	0.618
MOD_PKA_2	22	28	PF00069	0.605
MOD_PKB_1	187	195	PF00069	0.311
MOD_Plk_1	215	221	PF00069	0.523
MOD_Plk_1	235	241	PF00069	0.581
MOD_Plk_4	125	131	PF00069	0.426
MOD_Plk_4	189	195	PF00069	0.307
MOD_Plk_4	235	241	PF00069	0.541
MOD_Plk_4	248	254	PF00069	0.442
MOD_Plk_4	269	275	PF00069	0.405
MOD_Plk_4	87	93	PF00069	0.384
MOD_ProDKin_1	139	145	PF00069	0.447
MOD_ProDKin_1	158	164	PF00069	0.584
MOD_ProDKin_1	218	224	PF00069	0.613
MOD_ProDKin_1	239	245	PF00069	0.520
MOD_ProDKin_1	331	337	PF00069	0.482
MOD_ProDKin_1	373	379	PF00069	0.750
TRG_DiLeu_BaEn_2	235	241	PF01217	0.370
TRG_ENDOCYTIC_2	110	113	PF00928	0.663
TRG_ENDOCYTIC_2	32	35	PF00928	0.427
TRG_ENDOCYTIC_2	68	71	PF00928	0.747
TRG_ER_diArg_1	186	189	PF00400	0.449
TRG_ER_diArg_1	19	21	PF00400	0.561
TRG_ER_diArg_1	392	394	PF00400	0.677
TRG_ER_diArg_1	98	100	PF00400	0.415
TRG_NLS_MonoCore_2	390	395	PF00514	0.677
TRG_NLS_MonoExtC_3	390	396	PF00514	0.675
TRG_NLS_MonoExtN_4	186	191	PF00514	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I530	Leptomonas seymouri	55%	100%
A0A1X0P9D0	Trypanosomatidae	26%	100%
A0A3R7LU18	Trypanosoma rangeli	28%	100%
A0A3S7X2U8	Leishmania donovani	78%	100%
A4I4W6	Leishmania infantum	78%	100%
C9ZKZ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AEB4	Leishmania major	79%	99%
E9ALH2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
V5C220	Trypanosoma cruzi	28%	100%