Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HHP8_LEIBR

TriTrypDb:

LbrM.29.2460 , LBRM2903_290031500

Length:

447

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHP8

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	16
GO:0006793	phosphorus metabolic process	3	16
GO:0006796	phosphate-containing compound metabolic process	4	16
GO:0006807	nitrogen compound metabolic process	2	16
GO:0008152	metabolic process	1	16
GO:0009987	cellular process	1	16
GO:0016310	phosphorylation	5	16
GO:0019538	protein metabolic process	3	16
GO:0036211	protein modification process	4	16
GO:0043170	macromolecule metabolic process	3	16
GO:0043412	macromolecule modification	4	16
GO:0044237	cellular metabolic process	2	16
GO:0044238	primary metabolic process	2	16
GO:0071704	organic substance metabolic process	2	16
GO:1901564	organonitrogen compound metabolic process	3	16

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0003824	catalytic activity	1	16
GO:0004672	protein kinase activity	3	16
GO:0005488	binding	1	16
GO:0005524	ATP binding	5	16
GO:0016301	kinase activity	4	16
GO:0016740	transferase activity	2	16
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	16
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	16
GO:0017076	purine nucleotide binding	4	16
GO:0030554	adenyl nucleotide binding	5	16
GO:0032553	ribonucleotide binding	3	16
GO:0032555	purine ribonucleotide binding	4	16
GO:0032559	adenyl ribonucleotide binding	5	16
GO:0035639	purine ribonucleoside triphosphate binding	4	16
GO:0036094	small molecule binding	2	16
GO:0043167	ion binding	2	16
GO:0043168	anion binding	3	16
GO:0097159	organic cyclic compound binding	2	16
GO:0097367	carbohydrate derivative binding	2	16
GO:0140096	catalytic activity, acting on a protein	2	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16
GO:0004674	protein serine/threonine kinase activity	4	4
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	256	258	PF00675	0.352
CLV_NRD_NRD_1	325	327	PF00675	0.302
CLV_PCSK_KEX2_1	324	326	PF00082	0.305
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.388
CLV_PCSK_SKI1_1	162	166	PF00082	0.489
CLV_PCSK_SKI1_1	258	262	PF00082	0.385
CLV_PCSK_SKI1_1	289	293	PF00082	0.317
CLV_PCSK_SKI1_1	395	399	PF00082	0.220
CLV_PCSK_SKI1_1	48	52	PF00082	0.542
DEG_SPOP_SBC_1	378	382	PF00917	0.162
DOC_ANK_TNKS_1	116	123	PF00023	0.482
DOC_CYCLIN_RxL_1	159	168	PF00134	0.467
DOC_MAPK_gen_1	257	265	PF00069	0.335
DOC_MAPK_gen_1	289	299	PF00069	0.332
DOC_MAPK_MEF2A_6	231	239	PF00069	0.268
DOC_MAPK_MEF2A_6	264	272	PF00069	0.257
DOC_MAPK_MEF2A_6	40	47	PF00069	0.378
DOC_MAPK_MEF2A_6	407	416	PF00069	0.275
DOC_MAPK_NFAT4_5	407	415	PF00069	0.162
DOC_PP2B_LxvP_1	128	131	PF13499	0.602
DOC_USP7_MATH_1	131	135	PF00917	0.685
DOC_USP7_MATH_1	155	159	PF00917	0.526
DOC_WW_Pin1_4	139	144	PF00397	0.696
DOC_WW_Pin1_4	326	331	PF00397	0.281
DOC_WW_Pin1_4	382	387	PF00397	0.350
LIG_14-3-3_CanoR_1	147	154	PF00244	0.376
LIG_14-3-3_CanoR_1	257	265	PF00244	0.379
LIG_14-3-3_CanoR_1	40	44	PF00244	0.372
LIG_14-3-3_CanoR_1	424	431	PF00244	0.326
LIG_BIR_II_1	1	5	PF00653	0.509
LIG_BRCT_BRCA1_1	405	409	PF00533	0.391
LIG_Clathr_ClatBox_1	307	311	PF01394	0.257
LIG_FHA_1	317	323	PF00498	0.299
LIG_FHA_2	200	206	PF00498	0.351
LIG_FHA_2	344	350	PF00498	0.270
LIG_FHA_2	360	366	PF00498	0.210
LIG_FHA_2	88	94	PF00498	0.412
LIG_FXI_DFP_1	363	367	PF00024	0.273
LIG_GBD_Chelix_1	268	276	PF00786	0.300
LIG_LIR_Apic_2	331	337	PF02991	0.289
LIG_LIR_Gen_1	406	417	PF02991	0.388
LIG_LIR_Gen_1	71	81	PF02991	0.389
LIG_LIR_Nem_3	158	164	PF02991	0.404
LIG_LIR_Nem_3	365	369	PF02991	0.246
LIG_LIR_Nem_3	406	412	PF02991	0.419
LIG_LIR_Nem_3	66	70	PF02991	0.505
LIG_SH2_CRK	161	165	PF00017	0.369
LIG_SH2_SRC	225	228	PF00017	0.302
LIG_SH2_STAP1	332	336	PF00017	0.388
LIG_SH2_STAP1	405	409	PF00017	0.302
LIG_SH2_STAT5	118	121	PF00017	0.395
LIG_SH2_STAT5	225	228	PF00017	0.302
LIG_SH2_STAT5	278	281	PF00017	0.239
LIG_SH2_STAT5	403	406	PF00017	0.296
LIG_SH2_STAT5	54	57	PF00017	0.552
LIG_SH3_1	135	141	PF00018	0.438
LIG_SH3_3	135	141	PF00018	0.663
LIG_SH3_3	236	242	PF00018	0.324
LIG_SH3_3	361	367	PF00018	0.388
LIG_Sin3_3	150	157	PF02671	0.334
LIG_SUMO_SIM_anti_2	187	193	PF11976	0.382
LIG_SUMO_SIM_anti_2	294	300	PF11976	0.248
LIG_SUMO_SIM_anti_2	303	309	PF11976	0.233
LIG_SUMO_SIM_par_1	187	193	PF11976	0.373
LIG_TYR_ITIM	223	228	PF00017	0.257
LIG_TYR_ITIM	65	70	PF00017	0.407
LIG_UBA3_1	222	231	PF00899	0.162
LIG_UBA3_1	296	302	PF00899	0.162
MOD_CK1_1	382	388	PF00069	0.258
MOD_CK1_1	88	94	PF00069	0.521
MOD_CK2_1	199	205	PF00069	0.422
MOD_CK2_1	377	383	PF00069	0.221
MOD_CK2_1	384	390	PF00069	0.166
MOD_CK2_1	87	93	PF00069	0.475
MOD_GlcNHglycan	372	375	PF01048	0.402
MOD_GlcNHglycan	87	90	PF01048	0.450
MOD_GSK3_1	339	346	PF00069	0.271
MOD_GSK3_1	378	385	PF00069	0.221
MOD_GSK3_1	4	11	PF00069	0.368
MOD_GSK3_1	81	88	PF00069	0.453
MOD_N-GLC_1	196	201	PF02516	0.388
MOD_N-GLC_2	19	21	PF02516	0.347
MOD_NEK2_1	153	158	PF00069	0.389
MOD_NEK2_1	20	25	PF00069	0.307
MOD_NEK2_1	226	231	PF00069	0.371
MOD_NEK2_1	339	344	PF00069	0.262
MOD_NEK2_1	377	382	PF00069	0.359
MOD_NEK2_1	8	13	PF00069	0.333
MOD_NEK2_1	97	102	PF00069	0.570
MOD_PIKK_1	105	111	PF00454	0.597
MOD_PIKK_1	30	36	PF00454	0.437
MOD_PK_1	264	270	PF00069	0.257
MOD_PKA_2	146	152	PF00069	0.455
MOD_PKA_2	39	45	PF00069	0.376
MOD_PKA_2	423	429	PF00069	0.328
MOD_Plk_1	199	205	PF00069	0.351
MOD_Plk_1	226	232	PF00069	0.273
MOD_Plk_4	264	270	PF00069	0.322
MOD_Plk_4	274	280	PF00069	0.329
MOD_Plk_4	318	324	PF00069	0.311
MOD_Plk_4	426	432	PF00069	0.262
MOD_ProDKin_1	139	145	PF00069	0.696
MOD_ProDKin_1	326	332	PF00069	0.281
MOD_ProDKin_1	382	388	PF00069	0.350
MOD_SUMO_for_1	291	294	PF00179	0.336
MOD_SUMO_rev_2	246	252	PF00179	0.364
MOD_SUMO_rev_2	342	348	PF00179	0.207
MOD_SUMO_rev_2	390	400	PF00179	0.162
MOD_SUMO_rev_2	439	447	PF00179	0.309
TRG_DiLeu_BaEn_1	294	299	PF01217	0.280
TRG_DiLeu_BaEn_1	303	308	PF01217	0.229
TRG_DiLeu_BaEn_1	408	413	PF01217	0.275
TRG_ENDOCYTIC_2	161	164	PF00928	0.349
TRG_ENDOCYTIC_2	225	228	PF00928	0.257
TRG_ENDOCYTIC_2	67	70	PF00928	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2X9	Leptomonas seymouri	26%	100%
A0A0N1HT76	Leptomonas seymouri	71%	100%
A0A0N1HTF0	Leptomonas seymouri	24%	71%
A0A0N1I6Q7	Leptomonas seymouri	24%	100%
A0A0N1PC01	Leptomonas seymouri	27%	100%
A0A0S4IXR9	Bodo saltans	27%	97%
A0A0S4JK24	Bodo saltans	26%	100%
A0A0S4JQP0	Bodo saltans	26%	91%
A0A1X0NWR7	Trypanosomatidae	25%	87%
A0A1X0PA19	Trypanosomatidae	46%	90%
A0A3Q8IAQ1	Leishmania donovani	26%	100%
A0A3Q8IDY1	Leishmania donovani	83%	100%
A0A3R7K1T4	Trypanosoma rangeli	46%	89%
A0A3S5H4Z4	Leishmania donovani	28%	84%
A0A3S7X2W9	Leishmania donovani	23%	100%
A0A422P2B2	Trypanosoma rangeli	26%	98%
A0A422P3P9	Trypanosoma rangeli	28%	90%
A4HCE6	Leishmania braziliensis	25%	100%
A4HHS9	Leishmania braziliensis	24%	100%
A4HRM6	Leishmania infantum	28%	84%
A4HZW8	Leishmania infantum	26%	100%
A4I4W3	Leishmania infantum	83%	100%
A4I4Y0	Leishmania infantum	23%	100%
A9SR33	Physcomitrium patens	25%	100%
C9ZK32	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	72%
C9ZKZ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	95%
C9ZL78	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZW20	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	77%
C9ZX15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	89%
E9ACA4	Leishmania major	28%	84%
E9AEB1	Leishmania major	82%	100%
E9AJJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	83%
E9ALF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9ALH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
O95747	Homo sapiens	27%	85%
P27450	Arabidopsis thaliana	27%	100%
P57760	Rattus norvegicus	24%	100%
P59895	Rattus norvegicus	26%	100%
Q17IE8	Aedes aegypti	27%	89%
Q2V419	Arabidopsis thaliana	25%	100%
Q4QFK4	Leishmania major	24%	71%
Q5R495	Pongo abelii	27%	85%
Q6P9R2	Mus musculus	27%	85%
Q863I2	Sus scrofa	27%	84%
Q9NI63	Drosophila melanogaster	26%	84%
Q9VT57	Drosophila melanogaster	26%	98%
V5B8E0	Trypanosoma cruzi	29%	100%
V5BSK0	Trypanosoma cruzi	48%	90%
V5DAY8	Trypanosoma cruzi	25%	100%
V5DUH0	Trypanosoma cruzi	26%	81%