Putative heat shock protein 20

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

heat shock protein 20, putative

Species:

Leishmania braziliensis

UniProt:

A4HHP4_LEIBR

TriTrypDb:

LbrM.29.2420 , LBRM2903_290031000

Length:

155

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHP4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.306
CLV_NRD_NRD_1	88	90	PF00675	0.275
CLV_PCSK_SKI1_1	90	94	PF00082	0.286
CLV_PCSK_SKI1_1	98	102	PF00082	0.289
DEG_Nend_Nbox_1	1	3	PF02207	0.578
DOC_MAPK_DCC_7	43	52	PF00069	0.447
DOC_MAPK_FxFP_2	21	24	PF00069	0.445
DOC_MAPK_gen_1	69	75	PF00069	0.393
DOC_MAPK_MEF2A_6	43	52	PF00069	0.447
DOC_PP4_FxxP_1	114	117	PF00568	0.407
DOC_PP4_FxxP_1	21	24	PF00568	0.445
DOC_USP7_MATH_1	148	152	PF00917	0.388
DOC_USP7_UBL2_3	90	94	PF12436	0.344
LIG_14-3-3_CanoR_1	74	83	PF00244	0.393
LIG_14-3-3_CanoR_1	89	93	PF00244	0.246
LIG_APCC_ABBA_1	22	27	PF00400	0.379
LIG_APCC_ABBA_1	73	78	PF00400	0.393
LIG_CSL_BTD_1	1	4	PF09270	0.605
LIG_FHA_2	116	122	PF00498	0.331
LIG_FHA_2	126	132	PF00498	0.225
LIG_LIR_Apic_2	111	117	PF02991	0.393
LIG_LIR_Gen_1	56	66	PF02991	0.396
LIG_LIR_Nem_3	104	110	PF02991	0.322
LIG_LIR_Nem_3	16	22	PF02991	0.595
LIG_LIR_Nem_3	56	62	PF02991	0.268
LIG_MYND_1	20	24	PF01753	0.458
LIG_MYND_1	26	30	PF01753	0.453
LIG_Pex14_2	110	114	PF04695	0.393
LIG_Pex14_2	19	23	PF04695	0.544
LIG_Pex14_2	34	38	PF04695	0.405
LIG_PTB_Apo_2	32	39	PF02174	0.380
LIG_REV1ctd_RIR_1	35	45	PF16727	0.553
LIG_SH2_CRK	59	63	PF00017	0.224
LIG_SH2_NCK_1	59	63	PF00017	0.371
LIG_SH2_STAP1	59	63	PF00017	0.268
LIG_SH2_STAP1	76	80	PF00017	0.168
LIG_SH2_STAT5	59	62	PF00017	0.393
LIG_SH2_STAT5	76	79	PF00017	0.331
LIG_SH3_3	133	139	PF00018	0.392
LIG_UBA3_1	82	90	PF00899	0.331
LIG_WRC_WIRS_1	34	39	PF05994	0.565
MOD_CK1_1	146	152	PF00069	0.360
MOD_CK1_1	39	45	PF00069	0.434
MOD_GlcNHglycan	145	148	PF01048	0.326
MOD_GlcNHglycan	78	81	PF01048	0.218
MOD_GlcNHglycan	85	88	PF01048	0.310
MOD_GSK3_1	116	123	PF00069	0.331
MOD_GSK3_1	146	153	PF00069	0.451
MOD_GSK3_1	33	40	PF00069	0.547
MOD_GSK3_1	7	14	PF00069	0.646
MOD_GSK3_1	74	81	PF00069	0.415
MOD_NEK2_1	134	139	PF00069	0.291
MOD_NEK2_1	141	146	PF00069	0.350
MOD_NEK2_1	33	38	PF00069	0.542
MOD_PIKK_1	50	56	PF00454	0.230
MOD_PKA_2	141	147	PF00069	0.430
MOD_PKA_2	42	48	PF00069	0.391
MOD_PKA_2	88	94	PF00069	0.196
MOD_Plk_4	33	39	PF00069	0.505
MOD_Plk_4	42	48	PF00069	0.406
MOD_Plk_4	57	63	PF00069	0.299
MOD_Plk_4	78	84	PF00069	0.406
MOD_Plk_4	88	94	PF00069	0.221
MOD_SUMO_for_1	68	71	PF00179	0.256
TRG_DiLeu_BaEn_1	97	102	PF01217	0.331
TRG_ENDOCYTIC_2	59	62	PF00928	0.251

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHY2	Leptomonas seymouri	57%	100%
A0A0S4ITJ1	Bodo saltans	40%	100%
A0A1X0P9Y3	Trypanosomatidae	44%	100%
A0A3Q8IBN6	Leishmania donovani	81%	100%
A0A3R7N2L9	Trypanosoma rangeli	40%	100%
A4I4V9	Leishmania infantum	81%	100%
C9ZL02	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AEA7	Leishmania major	81%	100%
E9ALH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
O14368	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
O30851	Streptococcus thermophilus	30%	100%
P02519	Glycine max	30%	100%
P04793	Glycine max	29%	100%
P05478	Glycine max	32%	96%
P15992	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	72%
P19243	Pisum sativum	33%	98%
P19244	Pisum sativum	29%	79%
P30236	Glycine max	29%	81%
Q01545	Ipomoea nil	29%	93%
Q03928	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	34%	100%
Q06823	Stigmatella aurantiaca (strain DW4/3-1)	28%	92%
Q38806	Arabidopsis thaliana	30%	79%
Q4UJB1	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	28%	95%
Q4UKR8	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	27%	100%
Q53M11	Oryza sativa subsp. japonica	28%	75%
Q54I91	Dictyostelium discoideum	26%	70%
V5BXI2	Trypanosoma cruzi	43%	100%