Phosphodiesterase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Phosphodiesterase

Gene product:

3'5'-cyclic nucleotide phosphodiesterase, putative

Species:

Leishmania braziliensis

UniProt:

A4HHP3_LEIBR

TriTrypDb:

LbrM.29.2410 , LBRM2903_290030900

Length:

734

Annotations

LeishMANIAdb annotations

Phosphodiesterase, with probable N-terminal lipidation signal. Not embedded in membrane, like its homologs.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0020016	ciliary pocket	2	1
GO:0110165	cellular anatomical entity	1	4
GO:0016020	membrane	2	3

Expansion

Sequence features

A4HHP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHP3

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	14
GO:0009987	cellular process	1	14
GO:0050789	regulation of biological process	2	14
GO:0050794	regulation of cellular process	3	14
GO:0065007	biological regulation	1	14

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0004112	cyclic-nucleotide phosphodiesterase activity	6	14
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	7	14
GO:0005488	binding	1	14
GO:0008081	phosphoric diester hydrolase activity	5	14
GO:0016787	hydrolase activity	2	14
GO:0016788	hydrolase activity, acting on ester bonds	3	14
GO:0042578	phosphoric ester hydrolase activity	4	14
GO:0043167	ion binding	2	14
GO:0043169	cation binding	3	14
GO:0046872	metal ion binding	4	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.430
CLV_C14_Caspase3-7	184	188	PF00656	0.557
CLV_NRD_NRD_1	184	186	PF00675	0.545
CLV_NRD_NRD_1	194	196	PF00675	0.520
CLV_NRD_NRD_1	245	247	PF00675	0.510
CLV_NRD_NRD_1	379	381	PF00675	0.553
CLV_NRD_NRD_1	446	448	PF00675	0.498
CLV_NRD_NRD_1	645	647	PF00675	0.346
CLV_NRD_NRD_1	706	708	PF00675	0.602
CLV_PCSK_KEX2_1	245	247	PF00082	0.479
CLV_PCSK_KEX2_1	446	448	PF00082	0.498
CLV_PCSK_KEX2_1	706	708	PF00082	0.584
CLV_PCSK_SKI1_1	107	111	PF00082	0.537
CLV_PCSK_SKI1_1	304	308	PF00082	0.540
CLV_PCSK_SKI1_1	356	360	PF00082	0.410
CLV_PCSK_SKI1_1	446	450	PF00082	0.385
CLV_PCSK_SKI1_1	530	534	PF00082	0.318
CLV_PCSK_SKI1_1	582	586	PF00082	0.350
CLV_PCSK_SKI1_1	605	609	PF00082	0.392
CLV_PCSK_SKI1_1	92	96	PF00082	0.518
CLV_Separin_Metazoa	543	547	PF03568	0.397
DEG_APCC_DBOX_1	445	453	PF00400	0.443
DEG_SCF_FBW7_1	718	724	PF00400	0.495
DEG_SCF_FBW7_1	78	84	PF00400	0.502
DOC_CKS1_1	718	723	PF01111	0.497
DOC_CKS1_1	78	83	PF01111	0.507
DOC_CYCLIN_RxL_1	643	653	PF00134	0.438
DOC_CYCLIN_yClb5_NLxxxL_5	300	306	PF00134	0.565
DOC_MAPK_gen_1	446	452	PF00069	0.491
DOC_MAPK_gen_1	600	608	PF00069	0.397
DOC_MAPK_gen_1	646	652	PF00069	0.447
DOC_MAPK_MEF2A_6	600	608	PF00069	0.321
DOC_MAPK_MEF2A_6	727	734	PF00069	0.509
DOC_PP4_FxxP_1	204	207	PF00568	0.537
DOC_PP4_FxxP_1	506	509	PF00568	0.358
DOC_SPAK_OSR1_1	447	451	PF12202	0.491
DOC_USP7_MATH_1	286	290	PF00917	0.580
DOC_USP7_MATH_1	451	455	PF00917	0.447
DOC_USP7_MATH_1	721	725	PF00917	0.744
DOC_USP7_MATH_2	207	213	PF00917	0.298
DOC_USP7_MATH_2	347	353	PF00917	0.519
DOC_USP7_UBL2_3	632	636	PF12436	0.459
DOC_WW_Pin1_4	179	184	PF00397	0.466
DOC_WW_Pin1_4	213	218	PF00397	0.557
DOC_WW_Pin1_4	34	39	PF00397	0.696
DOC_WW_Pin1_4	650	655	PF00397	0.318
DOC_WW_Pin1_4	717	722	PF00397	0.488
DOC_WW_Pin1_4	77	82	PF00397	0.693
LIG_14-3-3_CanoR_1	105	110	PF00244	0.525
LIG_14-3-3_CanoR_1	235	241	PF00244	0.497
LIG_14-3-3_CanoR_1	51	58	PF00244	0.502
LIG_14-3-3_CanoR_1	590	597	PF00244	0.402
LIG_14-3-3_CanoR_1	605	611	PF00244	0.302
LIG_APCC_ABBA_1	114	119	PF00400	0.514
LIG_APCC_ABBA_1	652	657	PF00400	0.358
LIG_BIR_III_4	384	388	PF00653	0.358
LIG_BRCT_BRCA1_1	634	638	PF00533	0.358
LIG_BRCT_BRCA1_1	689	693	PF00533	0.255
LIG_CtBP_PxDLS_1	207	211	PF00389	0.550
LIG_eIF4E_1	423	429	PF01652	0.392
LIG_FHA_1	106	112	PF00498	0.616
LIG_FHA_1	132	138	PF00498	0.522
LIG_FHA_1	167	173	PF00498	0.494
LIG_FHA_1	229	235	PF00498	0.522
LIG_FHA_1	266	272	PF00498	0.630
LIG_FHA_1	407	413	PF00498	0.459
LIG_FHA_1	422	428	PF00498	0.364
LIG_FHA_1	47	53	PF00498	0.631
LIG_FHA_1	539	545	PF00498	0.451
LIG_FHA_1	690	696	PF00498	0.476
LIG_FHA_1	8	14	PF00498	0.737
LIG_FHA_1	82	88	PF00498	0.659
LIG_FHA_2	141	147	PF00498	0.446
LIG_FHA_2	182	188	PF00498	0.495
LIG_FHA_2	189	195	PF00498	0.489
LIG_FHA_2	267	273	PF00498	0.617
LIG_FHA_2	553	559	PF00498	0.380
LIG_FHA_2	565	571	PF00498	0.287
LIG_IBAR_NPY_1	459	461	PF08397	0.386
LIG_Integrin_isoDGR_2	388	390	PF01839	0.326
LIG_IRF3_LxIS_1	648	653	PF10401	0.424
LIG_LIR_Apic_2	201	207	PF02991	0.556
LIG_LIR_Apic_2	505	509	PF02991	0.318
LIG_LIR_Gen_1	187	198	PF02991	0.510
LIG_LIR_Gen_1	199	210	PF02991	0.436
LIG_LIR_Gen_1	394	402	PF02991	0.407
LIG_LIR_Gen_1	406	415	PF02991	0.342
LIG_LIR_Gen_1	424	434	PF02991	0.342
LIG_LIR_Gen_1	541	550	PF02991	0.379
LIG_LIR_Gen_1	73	82	PF02991	0.519
LIG_LIR_Nem_3	159	163	PF02991	0.404
LIG_LIR_Nem_3	187	193	PF02991	0.483
LIG_LIR_Nem_3	199	205	PF02991	0.521
LIG_LIR_Nem_3	221	226	PF02991	0.503
LIG_LIR_Nem_3	24	30	PF02991	0.514
LIG_LIR_Nem_3	394	399	PF02991	0.384
LIG_LIR_Nem_3	406	410	PF02991	0.395
LIG_LIR_Nem_3	424	429	PF02991	0.363
LIG_LIR_Nem_3	492	498	PF02991	0.421
LIG_LIR_Nem_3	541	545	PF02991	0.399
LIG_LIR_Nem_3	671	675	PF02991	0.320
LIG_LIR_Nem_3	96	100	PF02991	0.581
LIG_PDZ_Class_2	729	734	PF00595	0.508
LIG_Pex14_1	160	164	PF04695	0.388
LIG_Pex14_1	336	340	PF04695	0.358
LIG_PTAP_UEV_1	65	70	PF05743	0.503
LIG_PTB_Apo_2	544	551	PF02174	0.395
LIG_PTB_Apo_2	698	705	PF02174	0.538
LIG_PTB_Phospho_1	544	550	PF10480	0.421
LIG_PTB_Phospho_1	698	704	PF10480	0.537
LIG_Rb_LxCxE_1	330	349	PF01857	0.338
LIG_Rb_pABgroove_1	317	325	PF01858	0.618
LIG_REV1ctd_RIR_1	161	169	PF16727	0.401
LIG_SH2_CRK	202	206	PF00017	0.452
LIG_SH2_CRK	407	411	PF00017	0.420
LIG_SH2_CRK	97	101	PF00017	0.581
LIG_SH2_GRB2like	437	440	PF00017	0.497
LIG_SH2_GRB2like	461	464	PF00017	0.330
LIG_SH2_NCK_1	142	146	PF00017	0.580
LIG_SH2_NCK_1	30	34	PF00017	0.518
LIG_SH2_NCK_1	407	411	PF00017	0.420
LIG_SH2_PTP2	476	479	PF00017	0.216
LIG_SH2_SRC	323	326	PF00017	0.573
LIG_SH2_STAP1	138	142	PF00017	0.461
LIG_SH2_STAP1	202	206	PF00017	0.403
LIG_SH2_STAP1	249	253	PF00017	0.612
LIG_SH2_STAP1	30	34	PF00017	0.518
LIG_SH2_STAP1	423	427	PF00017	0.331
LIG_SH2_STAP1	627	631	PF00017	0.397
LIG_SH2_STAT3	340	343	PF00017	0.333
LIG_SH2_STAT3	675	678	PF00017	0.421
LIG_SH2_STAT5	138	141	PF00017	0.545
LIG_SH2_STAT5	142	145	PF00017	0.594
LIG_SH2_STAT5	225	228	PF00017	0.303
LIG_SH2_STAT5	270	273	PF00017	0.633
LIG_SH2_STAT5	30	33	PF00017	0.521
LIG_SH2_STAT5	340	343	PF00017	0.407
LIG_SH2_STAT5	423	426	PF00017	0.379
LIG_SH2_STAT5	437	440	PF00017	0.427
LIG_SH2_STAT5	476	479	PF00017	0.319
LIG_SH2_STAT5	522	525	PF00017	0.330
LIG_SH2_STAT5	639	642	PF00017	0.403
LIG_SH2_STAT5	675	678	PF00017	0.318
LIG_SH2_STAT5	93	96	PF00017	0.453
LIG_SH3_3	223	229	PF00018	0.547
LIG_SH3_3	357	363	PF00018	0.435
LIG_SH3_3	63	69	PF00018	0.709
LIG_SH3_3	715	721	PF00018	0.473
LIG_SUMO_SIM_par_1	107	113	PF11976	0.573
LIG_SUMO_SIM_par_1	448	454	PF11976	0.471
LIG_TRAF2_1	308	311	PF00917	0.542
LIG_TRAF2_1	342	345	PF00917	0.487
LIG_TRAF2_1	490	493	PF00917	0.376
LIG_TRFH_1	359	363	PF08558	0.437
LIG_TYR_ITIM	435	440	PF00017	0.477
MOD_CDK_SPxK_1	179	185	PF00069	0.512
MOD_CDK_SPxxK_3	179	186	PF00069	0.503
MOD_CK1_1	133	139	PF00069	0.512
MOD_CK1_1	166	172	PF00069	0.394
MOD_CK1_1	174	180	PF00069	0.431
MOD_CK1_1	21	27	PF00069	0.701
MOD_CK1_1	368	374	PF00069	0.520
MOD_CK1_1	592	598	PF00069	0.435
MOD_CK1_1	67	73	PF00069	0.714
MOD_CK1_1	717	723	PF00069	0.491
MOD_CK2_1	125	131	PF00069	0.389
MOD_CK2_1	140	146	PF00069	0.449
MOD_CK2_1	241	247	PF00069	0.663
MOD_CK2_1	369	375	PF00069	0.444
MOD_CK2_1	487	493	PF00069	0.362
MOD_CK2_1	528	534	PF00069	0.318
MOD_CK2_1	564	570	PF00069	0.349
MOD_CK2_1	596	602	PF00069	0.384
MOD_GlcNHglycan	14	17	PF01048	0.722
MOD_GlcNHglycan	283	287	PF01048	0.622
MOD_GlcNHglycan	384	388	PF01048	0.477
MOD_GlcNHglycan	453	456	PF01048	0.414
MOD_GlcNHglycan	66	69	PF01048	0.725
MOD_GlcNHglycan	684	687	PF01048	0.434
MOD_GSK3_1	121	128	PF00069	0.450
MOD_GSK3_1	136	143	PF00069	0.448
MOD_GSK3_1	172	179	PF00069	0.484
MOD_GSK3_1	196	203	PF00069	0.519
MOD_GSK3_1	209	216	PF00069	0.564
MOD_GSK3_1	236	243	PF00069	0.582
MOD_GSK3_1	262	269	PF00069	0.603
MOD_GSK3_1	282	289	PF00069	0.566
MOD_GSK3_1	3	10	PF00069	0.748
MOD_GSK3_1	327	334	PF00069	0.601
MOD_GSK3_1	361	368	PF00069	0.356
MOD_GSK3_1	46	53	PF00069	0.612
MOD_GSK3_1	592	599	PF00069	0.378
MOD_GSK3_1	64	71	PF00069	0.695
MOD_GSK3_1	717	724	PF00069	0.490
MOD_GSK3_1	77	84	PF00069	0.615
MOD_LATS_1	5	11	PF00433	0.535
MOD_N-GLC_1	236	241	PF02516	0.407
MOD_N-GLC_1	34	39	PF02516	0.499
MOD_N-GLC_1	632	637	PF02516	0.392
MOD_N-GLC_1	648	653	PF02516	0.318
MOD_N-GLC_1	82	87	PF02516	0.591
MOD_N-GLC_2	213	215	PF02516	0.347
MOD_N-GLC_2	696	698	PF02516	0.525
MOD_NEK2_1	100	105	PF00069	0.488
MOD_NEK2_1	110	115	PF00069	0.505
MOD_NEK2_1	125	130	PF00069	0.278
MOD_NEK2_1	163	168	PF00069	0.376
MOD_NEK2_1	171	176	PF00069	0.432
MOD_NEK2_1	240	245	PF00069	0.551
MOD_NEK2_1	331	336	PF00069	0.563
MOD_NEK2_1	383	388	PF00069	0.358
MOD_NEK2_1	421	426	PF00069	0.323
MOD_NEK2_1	46	51	PF00069	0.739
MOD_NEK2_1	606	611	PF00069	0.319
MOD_NEK2_1	648	653	PF00069	0.397
MOD_NEK2_2	188	193	PF00069	0.557
MOD_NEK2_2	255	260	PF00069	0.553
MOD_NEK2_2	481	486	PF00069	0.216
MOD_NEK2_2	522	527	PF00069	0.318
MOD_NMyristoyl	1	7	PF02799	0.652
MOD_PIKK_1	262	268	PF00454	0.642
MOD_PIKK_1	468	474	PF00454	0.376
MOD_PKA_1	706	712	PF00069	0.590
MOD_PKA_2	50	56	PF00069	0.502
MOD_PKA_2	564	570	PF00069	0.332
MOD_PKA_2	589	595	PF00069	0.421
MOD_PKA_2	706	712	PF00069	0.582
MOD_Plk_1	236	242	PF00069	0.651
MOD_Plk_1	255	261	PF00069	0.573
MOD_Plk_1	282	288	PF00069	0.558
MOD_Plk_1	368	374	PF00069	0.507
MOD_Plk_1	468	474	PF00069	0.330
MOD_Plk_1	528	534	PF00069	0.321
MOD_Plk_1	648	654	PF00069	0.421
MOD_Plk_1	82	88	PF00069	0.641
MOD_Plk_2-3	369	375	PF00069	0.296
MOD_Plk_4	105	111	PF00069	0.592
MOD_Plk_4	121	127	PF00069	0.430
MOD_Plk_4	133	139	PF00069	0.326
MOD_Plk_4	200	206	PF00069	0.442
MOD_Plk_4	266	272	PF00069	0.569
MOD_Plk_4	331	337	PF00069	0.571
MOD_Plk_4	369	375	PF00069	0.393
MOD_Plk_4	422	428	PF00069	0.330
MOD_Plk_4	522	528	PF00069	0.318
MOD_Plk_4	564	570	PF00069	0.330
MOD_Plk_4	668	674	PF00069	0.372
MOD_ProDKin_1	179	185	PF00069	0.461
MOD_ProDKin_1	213	219	PF00069	0.559
MOD_ProDKin_1	34	40	PF00069	0.696
MOD_ProDKin_1	650	656	PF00069	0.318
MOD_ProDKin_1	717	723	PF00069	0.491
MOD_ProDKin_1	77	83	PF00069	0.689
MOD_SUMO_rev_2	643	648	PF00179	0.451
MOD_SUMO_rev_2	719	729	PF00179	0.500
TRG_DiLeu_BaEn_1	559	564	PF01217	0.468
TRG_DiLeu_BaLyEn_6	558	563	PF01217	0.430
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.462
TRG_ENDOCYTIC_2	202	205	PF00928	0.512
TRG_ENDOCYTIC_2	407	410	PF00928	0.369
TRG_ENDOCYTIC_2	426	429	PF00928	0.322
TRG_ENDOCYTIC_2	437	440	PF00928	0.365
TRG_ENDOCYTIC_2	475	478	PF00928	0.330
TRG_ENDOCYTIC_2	550	553	PF00928	0.335
TRG_ENDOCYTIC_2	97	100	PF00928	0.573
TRG_ER_diArg_1	445	447	PF00400	0.497
TRG_ER_diArg_1	705	707	PF00400	0.578
TRG_NES_CRM1_1	349	362	PF08389	0.450
TRG_Pf-PMV_PEXEL_1	279	283	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	390	394	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	530	534	PF00026	0.330
TRG_Pf-PMV_PEXEL_1	561	566	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Y4	Leptomonas seymouri	71%	100%
A0A0S4IPG9	Bodo saltans	43%	99%
A0A0S4IRJ2	Bodo saltans	44%	100%
A0A1X0P701	Trypanosomatidae	32%	100%
A0A1X0P936	Trypanosomatidae	53%	100%
A0A3R7KV25	Trypanosoma rangeli	54%	100%
A0A3S7X2R6	Leishmania donovani	82%	100%
A4I4V8	Leishmania infantum	82%	100%
C9ZL03	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AEA6	Leishmania major	81%	100%
E9ALI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
V5DTU5	Trypanosoma cruzi	53%	100%