Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HHP2_LEIBR

TriTrypDb:

LbrM.29.2400 , LBRM2903_290030800

Length:

765

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHP2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.708
CLV_C14_Caspase3-7	494	498	PF00656	0.638
CLV_C14_Caspase3-7	77	81	PF00656	0.658
CLV_C14_Caspase3-7	93	97	PF00656	0.517
CLV_NRD_NRD_1	344	346	PF00675	0.489
CLV_NRD_NRD_1	376	378	PF00675	0.702
CLV_NRD_NRD_1	396	398	PF00675	0.727
CLV_NRD_NRD_1	487	489	PF00675	0.646
CLV_NRD_NRD_1	50	52	PF00675	0.526
CLV_NRD_NRD_1	527	529	PF00675	0.622
CLV_NRD_NRD_1	706	708	PF00675	0.713
CLV_NRD_NRD_1	711	713	PF00675	0.656
CLV_PCSK_KEX2_1	346	348	PF00082	0.576
CLV_PCSK_KEX2_1	376	378	PF00082	0.702
CLV_PCSK_KEX2_1	396	398	PF00082	0.727
CLV_PCSK_KEX2_1	487	489	PF00082	0.646
CLV_PCSK_KEX2_1	50	52	PF00082	0.526
CLV_PCSK_KEX2_1	526	528	PF00082	0.620
CLV_PCSK_KEX2_1	574	576	PF00082	0.802
CLV_PCSK_KEX2_1	623	625	PF00082	0.737
CLV_PCSK_KEX2_1	749	751	PF00082	0.579
CLV_PCSK_PC1ET2_1	346	348	PF00082	0.576
CLV_PCSK_PC1ET2_1	574	576	PF00082	0.709
CLV_PCSK_PC1ET2_1	623	625	PF00082	0.737
CLV_PCSK_PC1ET2_1	749	751	PF00082	0.579
CLV_PCSK_SKI1_1	191	195	PF00082	0.532
CLV_PCSK_SKI1_1	284	288	PF00082	0.541
CLV_PCSK_SKI1_1	507	511	PF00082	0.735
CLV_PCSK_SKI1_1	528	532	PF00082	0.537
CLV_PCSK_SKI1_1	642	646	PF00082	0.563
CLV_PCSK_SKI1_1	663	667	PF00082	0.624
CLV_PCSK_SKI1_1	707	711	PF00082	0.712
CLV_PCSK_SKI1_1	749	753	PF00082	0.526
DEG_APCC_DBOX_1	259	267	PF00400	0.532
DEG_APCC_DBOX_1	561	569	PF00400	0.542
DEG_SCF_FBW7_2	258	265	PF00400	0.534
DEG_SCF_FBW7_2	538	545	PF00400	0.553
DEG_SPOP_SBC_1	133	137	PF00917	0.539
DOC_CKS1_1	469	474	PF01111	0.549
DOC_CKS1_1	557	562	PF01111	0.659
DOC_CKS1_1	619	624	PF01111	0.556
DOC_CKS1_1	672	677	PF01111	0.571
DOC_CYCLIN_yCln2_LP_2	427	433	PF00134	0.511
DOC_MAPK_DCC_7	562	570	PF00069	0.682
DOC_MAPK_gen_1	185	195	PF00069	0.534
DOC_MAPK_gen_1	476	484	PF00069	0.515
DOC_MAPK_gen_1	526	534	PF00069	0.532
DOC_MAPK_MEF2A_6	476	484	PF00069	0.515
DOC_PP1_RVXF_1	189	196	PF00149	0.506
DOC_PP2B_LxvP_1	147	150	PF13499	0.491
DOC_PP2B_LxvP_1	240	243	PF13499	0.569
DOC_PP2B_LxvP_1	279	282	PF13499	0.699
DOC_PP2B_LxvP_1	757	760	PF13499	0.550
DOC_PP4_FxxP_1	4	7	PF00568	0.464
DOC_USP7_MATH_1	15	19	PF00917	0.662
DOC_USP7_MATH_1	227	231	PF00917	0.492
DOC_USP7_MATH_1	251	255	PF00917	0.610
DOC_USP7_MATH_1	369	373	PF00917	0.698
DOC_USP7_MATH_1	383	387	PF00917	0.623
DOC_USP7_MATH_1	389	393	PF00917	0.646
DOC_USP7_MATH_1	435	439	PF00917	0.639
DOC_USP7_MATH_1	458	462	PF00917	0.599
DOC_USP7_UBL2_3	749	753	PF12436	0.595
DOC_WW_Pin1_4	23	28	PF00397	0.479
DOC_WW_Pin1_4	258	263	PF00397	0.677
DOC_WW_Pin1_4	3	8	PF00397	0.472
DOC_WW_Pin1_4	355	360	PF00397	0.697
DOC_WW_Pin1_4	367	372	PF00397	0.586
DOC_WW_Pin1_4	416	421	PF00397	0.572
DOC_WW_Pin1_4	468	473	PF00397	0.551
DOC_WW_Pin1_4	510	515	PF00397	0.672
DOC_WW_Pin1_4	538	543	PF00397	0.766
DOC_WW_Pin1_4	556	561	PF00397	0.695
DOC_WW_Pin1_4	574	579	PF00397	0.621
DOC_WW_Pin1_4	60	65	PF00397	0.581
DOC_WW_Pin1_4	618	623	PF00397	0.583
DOC_WW_Pin1_4	653	658	PF00397	0.687
DOC_WW_Pin1_4	671	676	PF00397	0.573
DOC_WW_Pin1_4	695	700	PF00397	0.766
LIG_14-3-3_CanoR_1	132	139	PF00244	0.648
LIG_14-3-3_CanoR_1	185	191	PF00244	0.557
LIG_14-3-3_CanoR_1	318	322	PF00244	0.667
LIG_14-3-3_CanoR_1	402	408	PF00244	0.609
LIG_14-3-3_CanoR_1	425	430	PF00244	0.530
LIG_14-3-3_CanoR_1	440	444	PF00244	0.494
LIG_14-3-3_CanoR_1	467	472	PF00244	0.551
LIG_14-3-3_CanoR_1	526	534	PF00244	0.622
LIG_14-3-3_CanoR_1	642	651	PF00244	0.546
LIG_14-3-3_CanoR_1	707	714	PF00244	0.654
LIG_FHA_1	134	140	PF00498	0.697
LIG_FHA_1	350	356	PF00498	0.616
LIG_FHA_1	529	535	PF00498	0.564
LIG_FHA_1	539	545	PF00498	0.617
LIG_FHA_1	552	558	PF00498	0.673
LIG_FHA_1	595	601	PF00498	0.637
LIG_FHA_1	82	88	PF00498	0.542
LIG_FHA_2	170	176	PF00498	0.564
LIG_FHA_2	553	559	PF00498	0.731
LIG_FHA_2	686	692	PF00498	0.494
LIG_FHA_2	75	81	PF00498	0.601
LIG_LIR_Apic_2	486	492	PF02991	0.690
LIG_LIR_Apic_2	690	696	PF02991	0.524
LIG_LIR_Gen_1	384	394	PF02991	0.635
LIG_LIR_Gen_1	80	87	PF02991	0.598
LIG_LIR_Nem_3	336	342	PF02991	0.545
LIG_LIR_Nem_3	384	390	PF02991	0.634
LIG_LIR_Nem_3	43	49	PF02991	0.513
LIG_LIR_Nem_3	80	86	PF02991	0.620
LIG_MYND_1	736	740	PF01753	0.499
LIG_MYND_3	490	494	PF01753	0.520
LIG_RPA_C_Fungi	435	447	PF08784	0.534
LIG_SH2_CRK	165	169	PF00017	0.583
LIG_SH2_CRK	424	428	PF00017	0.610
LIG_SH2_CRK	693	697	PF00017	0.528
LIG_SH2_GRB2like	28	31	PF00017	0.520
LIG_SH2_NCK_1	127	131	PF00017	0.558
LIG_SH2_NCK_1	693	697	PF00017	0.533
LIG_SH2_PTP2	489	492	PF00017	0.688
LIG_SH2_SRC	489	492	PF00017	0.688
LIG_SH2_SRC	693	696	PF00017	0.505
LIG_SH2_STAT5	342	345	PF00017	0.491
LIG_SH2_STAT5	489	492	PF00017	0.603
LIG_SH3_1	244	250	PF00018	0.523
LIG_SH3_1	693	699	PF00018	0.537
LIG_SH3_3	100	106	PF00018	0.522
LIG_SH3_3	154	160	PF00018	0.616
LIG_SH3_3	210	216	PF00018	0.659
LIG_SH3_3	244	250	PF00018	0.551
LIG_SH3_3	356	362	PF00018	0.695
LIG_SH3_3	42	48	PF00018	0.518
LIG_SH3_3	445	451	PF00018	0.718
LIG_SH3_3	452	458	PF00018	0.569
LIG_SH3_3	511	517	PF00018	0.647
LIG_SH3_3	554	560	PF00018	0.621
LIG_SH3_3	561	567	PF00018	0.630
LIG_SH3_3	584	590	PF00018	0.636
LIG_SH3_3	601	607	PF00018	0.625
LIG_SH3_3	61	67	PF00018	0.471
LIG_SH3_3	610	616	PF00018	0.627
LIG_SH3_3	633	639	PF00018	0.670
LIG_SH3_3	662	668	PF00018	0.545
LIG_SH3_3	669	675	PF00018	0.506
LIG_SH3_3	693	699	PF00018	0.594
LIG_SH3_3	737	743	PF00018	0.507
LIG_SUMO_SIM_par_1	480	486	PF11976	0.592
LIG_SUMO_SIM_par_1	529	535	PF11976	0.540
LIG_SUMO_SIM_par_1	615	621	PF11976	0.658
LIG_TRAF2_1	172	175	PF00917	0.558
LIG_TRAF2_1	492	495	PF00917	0.608
LIG_TRAF2_1	509	512	PF00917	0.670
LIG_TRAF2_1	68	71	PF00917	0.626
LIG_TRAF2_1	688	691	PF00917	0.497
LIG_WW_2	247	250	PF00397	0.528
MOD_CDK_SPK_2	618	623	PF00069	0.555
MOD_CDK_SPxK_1	468	474	PF00069	0.576
MOD_CDK_SPxK_1	556	562	PF00069	0.635
MOD_CDK_SPxK_1	618	624	PF00069	0.556
MOD_CDK_SPxK_1	671	677	PF00069	0.527
MOD_CDK_SPxxK_3	3	10	PF00069	0.462
MOD_CK1_1	135	141	PF00069	0.605
MOD_CK1_1	189	195	PF00069	0.560
MOD_CK1_1	303	309	PF00069	0.562
MOD_CK1_1	333	339	PF00069	0.611
MOD_CK1_1	341	347	PF00069	0.504
MOD_CK1_1	400	406	PF00069	0.632
MOD_CK1_1	552	558	PF00069	0.616
MOD_CK1_1	63	69	PF00069	0.555
MOD_CK1_1	650	656	PF00069	0.713
MOD_CK1_1	671	677	PF00069	0.550
MOD_CK1_1	685	691	PF00069	0.511
MOD_CK1_1	74	80	PF00069	0.729
MOD_CK1_1	89	95	PF00069	0.573
MOD_CK2_1	169	175	PF00069	0.576
MOD_CK2_1	211	217	PF00069	0.646
MOD_CK2_1	285	291	PF00069	0.577
MOD_CK2_1	389	395	PF00069	0.753
MOD_CK2_1	552	558	PF00069	0.733
MOD_CK2_1	685	691	PF00069	0.572
MOD_CK2_1	70	76	PF00069	0.598
MOD_GlcNHglycan	110	113	PF01048	0.606
MOD_GlcNHglycan	115	118	PF01048	0.586
MOD_GlcNHglycan	253	256	PF01048	0.690
MOD_GlcNHglycan	355	358	PF01048	0.592
MOD_GlcNHglycan	378	381	PF01048	0.783
MOD_GlcNHglycan	383	386	PF01048	0.677
MOD_GlcNHglycan	408	411	PF01048	0.677
MOD_GlcNHglycan	528	531	PF01048	0.569
MOD_GlcNHglycan	534	537	PF01048	0.546
MOD_GlcNHglycan	580	583	PF01048	0.549
MOD_GlcNHglycan	652	655	PF01048	0.610
MOD_GlcNHglycan	684	687	PF01048	0.667
MOD_GlcNHglycan	98	101	PF01048	0.739
MOD_GSK3_1	113	120	PF00069	0.650
MOD_GSK3_1	189	196	PF00069	0.500
MOD_GSK3_1	211	218	PF00069	0.730
MOD_GSK3_1	219	226	PF00069	0.602
MOD_GSK3_1	287	294	PF00069	0.595
MOD_GSK3_1	298	305	PF00069	0.524
MOD_GSK3_1	326	333	PF00069	0.556
MOD_GSK3_1	349	356	PF00069	0.613
MOD_GSK3_1	396	403	PF00069	0.747
MOD_GSK3_1	431	438	PF00069	0.588
MOD_GSK3_1	458	465	PF00069	0.617
MOD_GSK3_1	5	12	PF00069	0.529
MOD_GSK3_1	526	533	PF00069	0.670
MOD_GSK3_1	549	556	PF00069	0.654
MOD_GSK3_1	574	581	PF00069	0.734
MOD_GSK3_1	594	601	PF00069	0.588
MOD_GSK3_1	649	656	PF00069	0.619
MOD_GSK3_1	70	77	PF00069	0.560
MOD_GSK3_1	703	710	PF00069	0.655
MOD_GSK3_1	86	93	PF00069	0.775
MOD_LATS_1	321	327	PF00433	0.561
MOD_N-GLC_1	169	174	PF02516	0.657
MOD_N-GLC_1	272	277	PF02516	0.532
MOD_N-GLC_1	462	467	PF02516	0.575
MOD_N-GLC_1	552	557	PF02516	0.563
MOD_N-GLC_1	74	79	PF02516	0.682
MOD_N-GLC_1	96	101	PF02516	0.590
MOD_NEK2_1	125	130	PF00069	0.689
MOD_NEK2_1	302	307	PF00069	0.561
MOD_NEK2_1	483	488	PF00069	0.520
MOD_NEK2_1	644	649	PF00069	0.545
MOD_NEK2_1	87	92	PF00069	0.641
MOD_NEK2_2	186	191	PF00069	0.560
MOD_PIKK_1	28	34	PF00454	0.745
MOD_PIKK_1	309	315	PF00454	0.629
MOD_PIKK_1	425	431	PF00454	0.690
MOD_PIKK_1	5	11	PF00454	0.535
MOD_PIKK_1	90	96	PF00454	0.726
MOD_PKA_1	376	382	PF00069	0.630
MOD_PKA_1	396	402	PF00069	0.660
MOD_PKA_1	526	532	PF00069	0.622
MOD_PKA_1	707	713	PF00069	0.710
MOD_PKA_1	749	755	PF00069	0.531
MOD_PKA_2	133	139	PF00069	0.568
MOD_PKA_2	298	304	PF00069	0.592
MOD_PKA_2	317	323	PF00069	0.578
MOD_PKA_2	376	382	PF00069	0.656
MOD_PKA_2	396	402	PF00069	0.691
MOD_PKA_2	439	445	PF00069	0.536
MOD_PKA_2	475	481	PF00069	0.564
MOD_PKA_2	526	532	PF00069	0.622
MOD_PKA_2	749	755	PF00069	0.531
MOD_PKA_2	9	15	PF00069	0.443
MOD_PKA_2	90	96	PF00069	0.599
MOD_PKB_1	113	121	PF00069	0.629
MOD_PKB_1	132	140	PF00069	0.482
MOD_PKB_1	526	534	PF00069	0.539
MOD_Plk_1	272	278	PF00069	0.532
MOD_Plk_1	552	558	PF00069	0.590
MOD_Plk_4	15	21	PF00069	0.658
MOD_Plk_4	153	159	PF00069	0.671
MOD_Plk_4	338	344	PF00069	0.500
MOD_Plk_4	350	356	PF00069	0.590
MOD_Plk_4	677	683	PF00069	0.532
MOD_ProDKin_1	23	29	PF00069	0.480
MOD_ProDKin_1	258	264	PF00069	0.676
MOD_ProDKin_1	3	9	PF00069	0.466
MOD_ProDKin_1	355	361	PF00069	0.698
MOD_ProDKin_1	367	373	PF00069	0.588
MOD_ProDKin_1	416	422	PF00069	0.575
MOD_ProDKin_1	468	474	PF00069	0.551
MOD_ProDKin_1	510	516	PF00069	0.671
MOD_ProDKin_1	538	544	PF00069	0.768
MOD_ProDKin_1	556	562	PF00069	0.697
MOD_ProDKin_1	574	580	PF00069	0.618
MOD_ProDKin_1	60	66	PF00069	0.581
MOD_ProDKin_1	618	624	PF00069	0.584
MOD_ProDKin_1	653	659	PF00069	0.683
MOD_ProDKin_1	671	677	PF00069	0.569
MOD_ProDKin_1	695	701	PF00069	0.768
MOD_SUMO_for_1	509	512	PF00179	0.735
MOD_SUMO_for_1	717	720	PF00179	0.593
TRG_DiLeu_BaEn_4	175	181	PF01217	0.458
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.666
TRG_ENDOCYTIC_2	165	168	PF00928	0.619
TRG_ENDOCYTIC_2	237	240	PF00928	0.629
TRG_ENDOCYTIC_2	424	427	PF00928	0.534
TRG_ER_diArg_1	131	134	PF00400	0.564
TRG_ER_diArg_1	345	348	PF00400	0.492
TRG_ER_diArg_1	487	489	PF00400	0.618
TRG_ER_diArg_1	49	51	PF00400	0.533
TRG_ER_diArg_1	525	528	PF00400	0.624
TRG_NLS_MonoCore_2	745	750	PF00514	0.519
TRG_NLS_MonoExtC_3	745	750	PF00514	0.519
TRG_NLS_MonoExtN_4	743	750	PF00514	0.520
TRG_Pf-PMV_PEXEL_1	425	429	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0L3	Leptomonas seymouri	34%	89%
A0A3S7X2R9	Leishmania donovani	51%	100%
A4I4V7	Leishmania infantum	53%	97%
E9AEA5	Leishmania major	50%	97%
E9ALI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	97%