Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HHP1_LEIBR

TriTrypDb:

LbrM.29.2390 , LBRM2903_290030700

Length:

697

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HHP1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHP1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	259	263	PF00656	0.533
CLV_C14_Caspase3-7	265	269	PF00656	0.475
CLV_C14_Caspase3-7	420	424	PF00656	0.539
CLV_C14_Caspase3-7	426	430	PF00656	0.582
CLV_NRD_NRD_1	145	147	PF00675	0.599
CLV_NRD_NRD_1	218	220	PF00675	0.517
CLV_NRD_NRD_1	226	228	PF00675	0.448
CLV_NRD_NRD_1	23	25	PF00675	0.580
CLV_NRD_NRD_1	254	256	PF00675	0.447
CLV_NRD_NRD_1	277	279	PF00675	0.490
CLV_NRD_NRD_1	307	309	PF00675	0.646
CLV_NRD_NRD_1	326	328	PF00675	0.284
CLV_NRD_NRD_1	446	448	PF00675	0.509
CLV_NRD_NRD_1	487	489	PF00675	0.446
CLV_NRD_NRD_1	490	492	PF00675	0.461
CLV_NRD_NRD_1	495	497	PF00675	0.471
CLV_NRD_NRD_1	572	574	PF00675	0.503
CLV_NRD_NRD_1	613	615	PF00675	0.402
CLV_PCSK_FUR_1	216	220	PF00082	0.587
CLV_PCSK_FUR_1	488	492	PF00082	0.454
CLV_PCSK_FUR_1	611	615	PF00082	0.446
CLV_PCSK_KEX2_1	145	147	PF00082	0.629
CLV_PCSK_KEX2_1	152	154	PF00082	0.533
CLV_PCSK_KEX2_1	218	220	PF00082	0.473
CLV_PCSK_KEX2_1	23	25	PF00082	0.459
CLV_PCSK_KEX2_1	254	256	PF00082	0.345
CLV_PCSK_KEX2_1	276	278	PF00082	0.454
CLV_PCSK_KEX2_1	307	309	PF00082	0.572
CLV_PCSK_KEX2_1	326	328	PF00082	0.287
CLV_PCSK_KEX2_1	446	448	PF00082	0.509
CLV_PCSK_KEX2_1	486	488	PF00082	0.448
CLV_PCSK_KEX2_1	490	492	PF00082	0.457
CLV_PCSK_KEX2_1	504	506	PF00082	0.443
CLV_PCSK_KEX2_1	571	573	PF00082	0.501
CLV_PCSK_KEX2_1	613	615	PF00082	0.413
CLV_PCSK_KEX2_1	80	82	PF00082	0.491
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.637
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.595
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.491
CLV_PCSK_PC7_1	442	448	PF00082	0.498
CLV_PCSK_PC7_1	486	492	PF00082	0.586
CLV_PCSK_SKI1_1	165	169	PF00082	0.566
CLV_PCSK_SKI1_1	23	27	PF00082	0.576
CLV_PCSK_SKI1_1	247	251	PF00082	0.642
CLV_PCSK_SKI1_1	330	334	PF00082	0.463
DEG_APCC_DBOX_1	257	265	PF00400	0.492
DEG_COP1_1	236	244	PF00400	0.566
DEG_COP1_1	259	269	PF00400	0.474
DEG_SCF_FBW7_1	462	469	PF00400	0.764
DEG_SPOP_SBC_1	422	426	PF00917	0.626
DEG_SPOP_SBC_1	515	519	PF00917	0.565
DEG_SPOP_SBC_1	581	585	PF00917	0.609
DOC_CKS1_1	337	342	PF01111	0.558
DOC_CKS1_1	344	349	PF01111	0.595
DOC_CKS1_1	450	455	PF01111	0.639
DOC_CKS1_1	467	472	PF01111	0.420
DOC_CYCLIN_yCln2_LP_2	34	40	PF00134	0.448
DOC_CYCLIN_yCln2_LP_2	344	350	PF00134	0.556
DOC_MAPK_DCC_7	128	138	PF00069	0.548
DOC_MAPK_gen_1	121	131	PF00069	0.698
DOC_MAPK_gen_1	176	186	PF00069	0.491
DOC_MAPK_gen_1	355	364	PF00069	0.738
DOC_MAPK_MEF2A_6	124	131	PF00069	0.668
DOC_MAPK_RevD_3	242	255	PF00069	0.381
DOC_PP2B_LxvP_1	34	37	PF13499	0.431
DOC_PP4_FxxP_1	467	470	PF00568	0.473
DOC_USP7_MATH_1	200	204	PF00917	0.664
DOC_USP7_MATH_1	295	299	PF00917	0.598
DOC_USP7_MATH_1	382	386	PF00917	0.708
DOC_USP7_MATH_1	414	418	PF00917	0.601
DOC_USP7_MATH_1	435	439	PF00917	0.701
DOC_USP7_MATH_1	440	444	PF00917	0.710
DOC_USP7_MATH_1	515	519	PF00917	0.671
DOC_USP7_MATH_1	523	527	PF00917	0.692
DOC_USP7_MATH_1	537	541	PF00917	0.518
DOC_USP7_MATH_1	579	583	PF00917	0.630
DOC_USP7_MATH_1	62	66	PF00917	0.583
DOC_USP7_UBL2_3	202	206	PF12436	0.606
DOC_WW_Pin1_4	129	134	PF00397	0.632
DOC_WW_Pin1_4	336	341	PF00397	0.485
DOC_WW_Pin1_4	343	348	PF00397	0.486
DOC_WW_Pin1_4	378	383	PF00397	0.604
DOC_WW_Pin1_4	431	436	PF00397	0.664
DOC_WW_Pin1_4	449	454	PF00397	0.618
DOC_WW_Pin1_4	462	467	PF00397	0.623
DOC_WW_Pin1_4	593	598	PF00397	0.499
DOC_WW_Pin1_4	659	664	PF00397	0.620
LIG_14-3-3_CanoR_1	227	235	PF00244	0.435
LIG_14-3-3_CanoR_1	377	382	PF00244	0.648
LIG_14-3-3_CanoR_1	446	451	PF00244	0.632
LIG_14-3-3_CanoR_1	623	629	PF00244	0.604
LIG_14-3-3_CanoR_1	631	637	PF00244	0.603
LIG_14-3-3_CanoR_1	81	91	PF00244	0.551
LIG_BIR_II_1	1	5	PF00653	0.512
LIG_BIR_III_4	429	433	PF00653	0.607
LIG_BRCT_BRCA1_1	423	427	PF00533	0.584
LIG_deltaCOP1_diTrp_1	331	341	PF00928	0.588
LIG_FHA_1	15	21	PF00498	0.659
LIG_FHA_1	364	370	PF00498	0.741
LIG_FHA_1	467	473	PF00498	0.566
LIG_FHA_1	86	92	PF00498	0.641
LIG_FHA_2	331	337	PF00498	0.340
LIG_FHA_2	379	385	PF00498	0.595
LIG_FHA_2	402	408	PF00498	0.579
LIG_LIR_Apic_2	203	208	PF02991	0.712
LIG_LIR_Apic_2	465	470	PF02991	0.474
LIG_LIR_Gen_1	54	63	PF02991	0.479
LIG_LIR_Nem_3	331	337	PF02991	0.448
LIG_LIR_Nem_3	339	344	PF02991	0.632
LIG_LIR_Nem_3	54	59	PF02991	0.488
LIG_LIR_Nem_3	585	591	PF02991	0.673
LIG_PCNA_yPIPBox_3	23	34	PF02747	0.423
LIG_PTB_Apo_2	461	468	PF02174	0.491
LIG_SH2_CRK	56	60	PF00017	0.485
LIG_SH2_NCK_1	197	201	PF00017	0.547
LIG_SH2_SRC	421	424	PF00017	0.680
LIG_SH2_STAP1	94	98	PF00017	0.516
LIG_SH2_STAT5	421	424	PF00017	0.680
LIG_SH2_STAT5	603	606	PF00017	0.493
LIG_SH3_1	124	130	PF00018	0.467
LIG_SH3_3	124	130	PF00018	0.620
LIG_SH3_3	135	141	PF00018	0.656
LIG_SH3_3	183	189	PF00018	0.526
LIG_SH3_3	334	340	PF00018	0.561
LIG_SH3_3	56	62	PF00018	0.632
LIG_SUMO_SIM_anti_2	182	188	PF11976	0.527
LIG_SUMO_SIM_par_1	476	482	PF11976	0.354
LIG_TRAF2_1	167	170	PF00917	0.490
LIG_TRAF2_1	234	237	PF00917	0.389
LIG_TYR_ITSM	52	59	PF00017	0.489
LIG_WRC_WIRS_1	666	671	PF05994	0.514
MOD_CDK_SPK_2	378	383	PF00069	0.635
MOD_CK1_1	376	382	PF00069	0.746
MOD_CK1_1	417	423	PF00069	0.629
MOD_CK1_1	431	437	PF00069	0.613
MOD_CK1_1	449	455	PF00069	0.539
MOD_CK1_1	51	57	PF00069	0.577
MOD_CK1_1	518	524	PF00069	0.546
MOD_CK1_1	574	580	PF00069	0.706
MOD_CK1_1	582	588	PF00069	0.696
MOD_CK1_1	632	638	PF00069	0.647
MOD_CK1_1	657	663	PF00069	0.581
MOD_CK2_1	227	233	PF00069	0.511
MOD_CK2_1	330	336	PF00069	0.555
MOD_CK2_1	401	407	PF00069	0.500
MOD_CK2_1	465	471	PF00069	0.511
MOD_CK2_1	55	61	PF00069	0.684
MOD_Cter_Amidation	150	153	PF01082	0.433
MOD_DYRK1A_RPxSP_1	659	663	PF00069	0.491
MOD_GlcNHglycan	142	145	PF01048	0.718
MOD_GlcNHglycan	194	197	PF01048	0.495
MOD_GlcNHglycan	247	250	PF01048	0.576
MOD_GlcNHglycan	34	37	PF01048	0.558
MOD_GlcNHglycan	393	396	PF01048	0.552
MOD_GlcNHglycan	412	415	PF01048	0.470
MOD_GlcNHglycan	429	433	PF01048	0.556
MOD_GlcNHglycan	453	456	PF01048	0.701
MOD_GlcNHglycan	525	528	PF01048	0.675
MOD_GlcNHglycan	539	542	PF01048	0.481
MOD_GlcNHglycan	574	577	PF01048	0.634
MOD_GlcNHglycan	637	640	PF01048	0.674
MOD_GlcNHglycan	64	67	PF01048	0.704
MOD_GlcNHglycan	693	696	PF01048	0.667
MOD_GSK3_1	10	17	PF00069	0.548
MOD_GSK3_1	365	372	PF00069	0.697
MOD_GSK3_1	373	380	PF00069	0.641
MOD_GSK3_1	382	389	PF00069	0.596
MOD_GSK3_1	410	417	PF00069	0.596
MOD_GSK3_1	431	438	PF00069	0.596
MOD_GSK3_1	442	449	PF00069	0.630
MOD_GSK3_1	458	465	PF00069	0.588
MOD_GSK3_1	47	54	PF00069	0.552
MOD_GSK3_1	473	480	PF00069	0.431
MOD_GSK3_1	514	521	PF00069	0.624
MOD_GSK3_1	571	578	PF00069	0.517
MOD_GSK3_1	580	587	PF00069	0.537
MOD_GSK3_1	62	69	PF00069	0.592
MOD_GSK3_1	631	638	PF00069	0.577
MOD_GSK3_1	653	660	PF00069	0.698
MOD_GSK3_1	661	668	PF00069	0.718
MOD_GSK3_1	673	680	PF00069	0.458
MOD_N-GLC_1	654	659	PF02516	0.686
MOD_NEK2_1	369	374	PF00069	0.635
MOD_NEK2_1	428	433	PF00069	0.600
MOD_NEK2_1	586	591	PF00069	0.710
MOD_NEK2_1	609	614	PF00069	0.369
MOD_NEK2_2	48	53	PF00069	0.481
MOD_NEK2_2	665	670	PF00069	0.563
MOD_PIKK_1	221	227	PF00454	0.551
MOD_PIKK_1	440	446	PF00454	0.724
MOD_PIKK_1	642	648	PF00454	0.643
MOD_PIKK_1	657	663	PF00454	0.598
MOD_PIKK_1	673	679	PF00454	0.750
MOD_PK_1	308	314	PF00069	0.485
MOD_PKA_1	227	233	PF00069	0.354
MOD_PKA_1	446	452	PF00069	0.510
MOD_PKA_1	571	577	PF00069	0.423
MOD_PKA_2	357	363	PF00069	0.629
MOD_PKA_2	376	382	PF00069	0.673
MOD_PKA_2	410	416	PF00069	0.604
MOD_PKA_2	445	451	PF00069	0.690
MOD_PKA_2	571	577	PF00069	0.489
MOD_PKA_2	622	628	PF00069	0.561
MOD_Plk_1	221	227	PF00069	0.551
MOD_Plk_1	330	336	PF00069	0.423
MOD_Plk_1	422	428	PF00069	0.450
MOD_Plk_1	48	54	PF00069	0.481
MOD_Plk_1	505	511	PF00069	0.532
MOD_Plk_1	617	623	PF00069	0.401
MOD_Plk_1	69	75	PF00069	0.655
MOD_Plk_2-3	262	268	PF00069	0.468
MOD_Plk_2-3	423	429	PF00069	0.612
MOD_Plk_4	417	423	PF00069	0.671
MOD_Plk_4	473	479	PF00069	0.629
MOD_Plk_4	586	592	PF00069	0.550
MOD_ProDKin_1	129	135	PF00069	0.630
MOD_ProDKin_1	336	342	PF00069	0.489
MOD_ProDKin_1	343	349	PF00069	0.484
MOD_ProDKin_1	378	384	PF00069	0.602
MOD_ProDKin_1	431	437	PF00069	0.635
MOD_ProDKin_1	449	455	PF00069	0.615
MOD_ProDKin_1	462	468	PF00069	0.620
MOD_ProDKin_1	593	599	PF00069	0.494
MOD_ProDKin_1	659	665	PF00069	0.618
MOD_SUMO_rev_2	164	173	PF00179	0.588
TRG_ENDOCYTIC_2	56	59	PF00928	0.485
TRG_ENDOCYTIC_2	94	97	PF00928	0.550
TRG_ER_diArg_1	145	147	PF00400	0.632
TRG_ER_diArg_1	215	218	PF00400	0.528
TRG_ER_diArg_1	23	25	PF00400	0.614
TRG_ER_diArg_1	276	278	PF00400	0.504
TRG_ER_diArg_1	306	308	PF00400	0.663
TRG_ER_diArg_1	325	327	PF00400	0.272
TRG_ER_diArg_1	486	488	PF00400	0.509
TRG_ER_diArg_1	490	492	PF00400	0.522
TRG_ER_diArg_1	571	573	PF00400	0.507
TRG_ER_diArg_1	611	614	PF00400	0.499
TRG_Pf-PMV_PEXEL_1	218	222	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	326	331	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Y8	Leptomonas seymouri	53%	100%
A0A0S4IQ31	Bodo saltans	28%	100%
A0A0S4JIT3	Bodo saltans	28%	100%
A0A0S4JQK5	Bodo saltans	26%	100%
A0A1X0P950	Trypanosomatidae	35%	100%
A0A3Q8IRK3	Leishmania donovani	76%	100%
A0A3R7MS13	Trypanosoma rangeli	34%	100%
A4I4V6	Leishmania infantum	76%	83%
E9AEA4	Leishmania major	71%	97%
E9ALI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
V5BC37	Trypanosoma cruzi	34%	100%