PlsC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HHP0_LEIBR

TriTrypDb:

LbrM.29.2380 , LBRM2903_290030600

Length:

415

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 7
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HHP0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHP0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008374	O-acyltransferase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11
GO:0005488	binding	1	2
GO:0005509	calcium ion binding	5	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	238	240	PF00675	0.484
CLV_NRD_NRD_1	406	408	PF00675	0.576
CLV_NRD_NRD_1	58	60	PF00675	0.573
CLV_NRD_NRD_1	98	100	PF00675	0.240
CLV_PCSK_KEX2_1	406	408	PF00082	0.526
CLV_PCSK_KEX2_1	58	60	PF00082	0.573
CLV_PCSK_KEX2_1	98	100	PF00082	0.240
CLV_PCSK_SKI1_1	146	150	PF00082	0.381
CLV_PCSK_SKI1_1	306	310	PF00082	0.467
CLV_PCSK_SKI1_1	402	406	PF00082	0.619
CLV_PCSK_SKI1_1	59	63	PF00082	0.602
DEG_APCC_DBOX_1	58	66	PF00400	0.401
DEG_APCC_KENBOX_2	239	243	PF00400	0.332
DEG_SCF_FBW7_1	121	128	PF00400	0.427
DOC_CKS1_1	12	17	PF01111	0.660
DOC_CKS1_1	122	127	PF01111	0.499
DOC_MAPK_gen_1	239	245	PF00069	0.305
DOC_MAPK_HePTP_8	302	317	PF00069	0.175
DOC_MAPK_MEF2A_6	181	190	PF00069	0.320
DOC_PP1_RVXF_1	57	64	PF00149	0.340
DOC_PP2B_LxvP_1	26	29	PF13499	0.577
DOC_PP2B_LxvP_1	92	95	PF13499	0.614
DOC_USP7_MATH_1	150	154	PF00917	0.334
DOC_USP7_MATH_1	216	220	PF00917	0.371
DOC_USP7_UBL2_3	371	375	PF12436	0.405
DOC_WW_Pin1_4	11	16	PF00397	0.666
DOC_WW_Pin1_4	121	126	PF00397	0.512
LIG_14-3-3_CanoR_1	146	155	PF00244	0.412
LIG_14-3-3_CanoR_1	181	189	PF00244	0.449
LIG_14-3-3_CanoR_1	253	260	PF00244	0.311
LIG_14-3-3_CanoR_1	347	355	PF00244	0.275
LIG_14-3-3_CanoR_1	383	389	PF00244	0.364
LIG_14-3-3_CanoR_1	98	103	PF00244	0.578
LIG_APCC_ABBA_1	287	292	PF00400	0.253
LIG_BIR_II_1	1	5	PF00653	0.718
LIG_BRCT_BRCA1_1	243	247	PF00533	0.356
LIG_BRCT_BRCA1_1	348	352	PF00533	0.323
LIG_CaM_NSCaTE_8	35	42	PF13499	0.450
LIG_deltaCOP1_diTrp_1	223	233	PF00928	0.450
LIG_eIF4E_1	355	361	PF01652	0.376
LIG_FHA_1	158	164	PF00498	0.337
LIG_FHA_1	181	187	PF00498	0.385
LIG_FHA_1	73	79	PF00498	0.381
LIG_FHA_1	8	14	PF00498	0.655
LIG_FHA_1	80	86	PF00498	0.358
LIG_FHA_2	122	128	PF00498	0.545
LIG_FHA_2	264	270	PF00498	0.286
LIG_FHA_2	365	371	PF00498	0.324
LIG_LIR_Apic_2	168	173	PF02991	0.381
LIG_LIR_Gen_1	127	137	PF02991	0.507
LIG_LIR_Gen_1	183	193	PF02991	0.391
LIG_LIR_Gen_1	223	234	PF02991	0.422
LIG_LIR_Gen_1	23	33	PF02991	0.505
LIG_LIR_Nem_3	127	132	PF02991	0.510
LIG_LIR_Nem_3	153	158	PF02991	0.369
LIG_LIR_Nem_3	183	188	PF02991	0.354
LIG_LIR_Nem_3	223	229	PF02991	0.399
LIG_LIR_Nem_3	23	28	PF02991	0.585
LIG_LIR_Nem_3	244	248	PF02991	0.357
LIG_LIR_Nem_3	349	355	PF02991	0.327
LIG_LIR_Nem_3	395	401	PF02991	0.300
LIG_LIR_Nem_3	403	408	PF02991	0.311
LIG_MLH1_MIPbox_1	243	247	PF16413	0.328
LIG_NRBOX	61	67	PF00104	0.346
LIG_PCNA_yPIPBox_3	375	389	PF02747	0.313
LIG_Pex14_1	174	178	PF04695	0.345
LIG_Pex14_1	68	72	PF04695	0.362
LIG_Pex14_2	144	148	PF04695	0.344
LIG_Pex14_2	155	159	PF04695	0.349
LIG_Pex14_2	327	331	PF04695	0.274
LIG_PTAP_UEV_1	281	286	PF05743	0.328
LIG_SH2_CRK	122	126	PF00017	0.550
LIG_SH2_CRK	197	201	PF00017	0.387
LIG_SH2_NCK_1	122	126	PF00017	0.602
LIG_SH2_NCK_1	197	201	PF00017	0.241
LIG_SH2_SRC	170	173	PF00017	0.368
LIG_SH2_SRC	355	358	PF00017	0.354
LIG_SH2_STAT5	16	19	PF00017	0.639
LIG_SH2_STAT5	166	169	PF00017	0.369
LIG_SH2_STAT5	228	231	PF00017	0.420
LIG_SH2_STAT5	25	28	PF00017	0.544
LIG_SH2_STAT5	72	75	PF00017	0.317
LIG_SH3_3	279	285	PF00018	0.263
LIG_SH3_3	360	366	PF00018	0.308
LIG_SH3_3	9	15	PF00018	0.658
LIG_TRAF2_1	366	369	PF00917	0.350
LIG_TYR_ITIM	353	358	PF00017	0.355
LIG_WRC_WIRS_1	233	238	PF05994	0.253
MOD_CK1_1	180	186	PF00069	0.308
MOD_CK1_1	206	212	PF00069	0.486
MOD_CK1_1	235	241	PF00069	0.266
MOD_CK1_1	394	400	PF00069	0.299
MOD_CK2_1	204	210	PF00069	0.563
MOD_CK2_1	235	241	PF00069	0.245
MOD_CK2_1	263	269	PF00069	0.326
MOD_CK2_1	364	370	PF00069	0.320
MOD_CK2_1	46	52	PF00069	0.427
MOD_GSK3_1	121	128	PF00069	0.552
MOD_GSK3_1	146	153	PF00069	0.361
MOD_GSK3_1	180	187	PF00069	0.355
MOD_GSK3_1	264	271	PF00069	0.182
MOD_GSK3_1	7	14	PF00069	0.695
MOD_N-GLC_1	216	221	PF02516	0.325
MOD_N-GLC_1	241	246	PF02516	0.532
MOD_NEK2_1	137	142	PF00069	0.304
MOD_NEK2_1	159	164	PF00069	0.315
MOD_NEK2_1	309	314	PF00069	0.288
MOD_NEK2_1	346	351	PF00069	0.298
MOD_NEK2_1	384	389	PF00069	0.301
MOD_NEK2_1	79	84	PF00069	0.308
MOD_NEK2_2	150	155	PF00069	0.395
MOD_PKA_1	98	104	PF00069	0.427
MOD_PKA_2	180	186	PF00069	0.324
MOD_PKA_2	252	258	PF00069	0.332
MOD_PKA_2	346	352	PF00069	0.327
MOD_PKA_2	4	10	PF00069	0.541
MOD_PKA_2	98	104	PF00069	0.493
MOD_Plk_1	216	222	PF00069	0.325
MOD_Plk_1	241	247	PF00069	0.331
MOD_Plk_1	268	274	PF00069	0.175
MOD_Plk_1	309	315	PF00069	0.352
MOD_Plk_1	394	400	PF00069	0.292
MOD_Plk_4	150	156	PF00069	0.290
MOD_Plk_4	232	238	PF00069	0.297
MOD_Plk_4	241	247	PF00069	0.251
MOD_Plk_4	254	260	PF00069	0.250
MOD_Plk_4	271	277	PF00069	0.277
MOD_Plk_4	384	390	PF00069	0.319
MOD_ProDKin_1	11	17	PF00069	0.662
MOD_ProDKin_1	121	127	PF00069	0.511
MOD_SUMO_rev_2	206	214	PF00179	0.463
MOD_SUMO_rev_2	368	376	PF00179	0.403
MOD_SUMO_rev_2	394	404	PF00179	0.379
TRG_DiLeu_BaEn_1	210	215	PF01217	0.466
TRG_DiLeu_BaLyEn_6	356	361	PF01217	0.373
TRG_ENDOCYTIC_2	129	132	PF00928	0.497
TRG_ENDOCYTIC_2	202	205	PF00928	0.574
TRG_ENDOCYTIC_2	25	28	PF00928	0.573
TRG_ENDOCYTIC_2	324	327	PF00928	0.287
TRG_ENDOCYTIC_2	355	358	PF00928	0.354
TRG_ER_diArg_1	405	407	PF00400	0.378
TRG_ER_diArg_1	97	99	PF00400	0.442
TRG_ER_diLys_1	412	415	PF00400	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C8	Leptomonas seymouri	60%	99%
A0A0S4IPK1	Bodo saltans	45%	86%
A0A1X0P927	Trypanosomatidae	44%	88%
A0A3R7NZP9	Trypanosoma rangeli	50%	91%
A0A3S7X2X4	Leishmania donovani	82%	100%
A4I4V5	Leishmania infantum	82%	100%
C9ZL05	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	89%
E9AEA3	Leishmania major	83%	100%
E9ALI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q0KHU5	Drosophila melanogaster	30%	78%
Q1LWG4	Danio rerio	30%	80%
Q502J0	Danio rerio	32%	78%
Q643R3	Homo sapiens	33%	79%
Q6NVG1	Mus musculus	34%	79%
Q8BYI6	Mus musculus	31%	76%
Q8S8S2	Arabidopsis thaliana	30%	77%