FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4HHN9_LEIBR

TriTrypDb:

LbrM.29.2370 , LBRM2903_290030500

Length:

248

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HHN9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHN9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.480
CLV_C14_Caspase3-7	38	42	PF00656	0.485
CLV_PCSK_KEX2_1	225	227	PF00082	0.425
CLV_PCSK_KEX2_1	35	37	PF00082	0.566
CLV_PCSK_KEX2_1	89	91	PF00082	0.268
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.349
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.505
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.268
CLV_PCSK_SKI1_1	160	164	PF00082	0.406
CLV_PCSK_SKI1_1	211	215	PF00082	0.523
CLV_PCSK_SKI1_1	83	87	PF00082	0.210
CLV_PCSK_SKI1_1	98	102	PF00082	0.357
DEG_APCC_DBOX_1	238	246	PF00400	0.240
DEG_COP1_1	18	30	PF00400	0.364
DOC_CYCLIN_yCln2_LP_2	57	60	PF00134	0.385
DOC_MAPK_gen_1	225	234	PF00069	0.347
DOC_MAPK_gen_1	89	96	PF00069	0.418
DOC_MAPK_gen_1	98	108	PF00069	0.204
DOC_MAPK_MEF2A_6	68	75	PF00069	0.312
DOC_PP2B_LxvP_1	57	60	PF13499	0.327
DOC_PP4_FxxP_1	184	187	PF00568	0.377
DOC_USP7_MATH_1	15	19	PF00917	0.614
DOC_USP7_MATH_1	175	179	PF00917	0.326
DOC_USP7_MATH_1	28	32	PF00917	0.404
DOC_WW_Pin1_4	164	169	PF00397	0.266
DOC_WW_Pin1_4	212	217	PF00397	0.486
DOC_WW_Pin1_4	243	248	PF00397	0.523
LIG_14-3-3_CanoR_1	176	180	PF00244	0.352
LIG_14-3-3_CanoR_1	211	216	PF00244	0.349
LIG_FHA_1	140	146	PF00498	0.303
LIG_FHA_1	165	171	PF00498	0.382
LIG_FHA_1	17	23	PF00498	0.649
LIG_FHA_1	196	202	PF00498	0.304
LIG_FHA_2	4	10	PF00498	0.670
LIG_GBD_Chelix_1	71	79	PF00786	0.247
LIG_LIR_Apic_2	182	187	PF02991	0.377
LIG_LIR_Apic_2	86	91	PF02991	0.268
LIG_LIR_Nem_3	204	209	PF02991	0.439
LIG_MAD2	160	168	PF02301	0.268
LIG_PDZ_Class_1	243	248	PF00595	0.359
LIG_Pex14_2	206	210	PF04695	0.305
LIG_SH2_CRK	88	92	PF00017	0.268
LIG_SH2_STAP1	116	120	PF00017	0.247
LIG_SH2_STAP1	81	85	PF00017	0.333
LIG_SH2_STAT3	192	195	PF00017	0.347
LIG_SH3_3	183	189	PF00018	0.381
LIG_SH3_3	22	28	PF00018	0.547
LIG_SUMO_SIM_anti_2	159	165	PF11976	0.305
LIG_SUMO_SIM_anti_2	198	204	PF11976	0.361
LIG_SUMO_SIM_par_1	159	165	PF11976	0.314
LIG_SUMO_SIM_par_1	23	29	PF11976	0.391
LIG_SUMO_SIM_par_1	68	74	PF11976	0.296
LIG_SxIP_EBH_1	51	62	PF03271	0.401
LIG_UBA3_1	96	103	PF00899	0.377
LIG_WW_3	59	63	PF00397	0.361
MOD_CK1_1	31	37	PF00069	0.604
MOD_CK1_1	39	45	PF00069	0.543
MOD_GlcNHglycan	28	31	PF01048	0.523
MOD_GlcNHglycan	38	41	PF01048	0.501
MOD_GlcNHglycan	47	50	PF01048	0.497
MOD_GSK3_1	17	24	PF00069	0.482
MOD_GSK3_1	221	228	PF00069	0.420
MOD_GSK3_1	3	10	PF00069	0.656
MOD_GSK3_1	41	48	PF00069	0.515
MOD_GSK3_1	49	56	PF00069	0.514
MOD_GSK3_1	75	82	PF00069	0.326
MOD_NEK2_1	45	50	PF00069	0.658
MOD_NEK2_1	53	58	PF00069	0.590
MOD_NEK2_1	7	12	PF00069	0.537
MOD_NEK2_1	75	80	PF00069	0.232
MOD_NEK2_1	96	101	PF00069	0.357
MOD_NEK2_2	28	33	PF00069	0.637
MOD_PIKK_1	8	14	PF00454	0.672
MOD_PK_1	197	203	PF00069	0.202
MOD_PKA_1	225	231	PF00069	0.351
MOD_PKA_2	175	181	PF00069	0.295
MOD_PKA_2	225	231	PF00069	0.443
MOD_Plk_1	195	201	PF00069	0.285
MOD_Plk_1	75	81	PF00069	0.283
MOD_Plk_1	83	89	PF00069	0.283
MOD_Plk_4	166	172	PF00069	0.366
MOD_Plk_4	175	181	PF00069	0.260
MOD_Plk_4	197	203	PF00069	0.317
MOD_Plk_4	3	9	PF00069	0.565
MOD_Plk_4	41	47	PF00069	0.661
MOD_Plk_4	49	55	PF00069	0.645
MOD_Plk_4	75	81	PF00069	0.283
MOD_ProDKin_1	164	170	PF00069	0.266
MOD_ProDKin_1	212	218	PF00069	0.479
TRG_DiLeu_BaLyEn_6	149	154	PF01217	0.326
TRG_Pf-PMV_PEXEL_1	160	165	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Z9	Leptomonas seymouri	38%	85%
A0A1X0P5T3	Trypanosomatidae	43%	78%
A0A3R7LAC9	Trypanosoma rangeli	45%	69%
A0A422N4T2	Trypanosoma rangeli	27%	73%
A0A422P410	Trypanosoma rangeli	38%	69%
A4HFZ5	Leishmania braziliensis	28%	86%
C9ZL07	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	68%
D0A3Q0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	93%
E9AEA2	Leishmania major	84%	100%
E9ALI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	83%
Q8BX07	Mus musculus	27%	92%
Q9PTJ6	Gallus gallus	27%	90%