Putative kinesin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative kinesin

Gene product:

kinesin, putative

Species:

Leishmania braziliensis

UniProt:

A4HHN8_LEIBR

TriTrypDb:

LbrM.29.2360 , LBRM2903_290030300

Length:

588

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005871	kinesin complex	3	1
GO:0005874	microtubule	6	3
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0099080	supramolecular complex	2	3
GO:0099081	supramolecular polymer	3	3
GO:0099512	supramolecular fiber	4	3
GO:0099513	polymeric cytoskeletal fiber	5	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HHN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HHN8

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	14
GO:0007018	microtubule-based movement	3	14
GO:0009987	cellular process	1	14
GO:0006810	transport	3	1
GO:0010970	transport along microtubule	4	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0046907	intracellular transport	3	1
GO:0047496	vesicle transport along microtubule	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	1
GO:0051648	vesicle localization	3	1
GO:0051649	establishment of localization in cell	3	1
GO:0051650	establishment of vesicle localization	4	1
GO:0051656	establishment of organelle localization	3	1
GO:0072383	plus-end-directed vesicle transport along microtubule	6	1
GO:0072384	organelle transport along microtubule	4	1
GO:0072386	plus-end-directed organelle transport along microtubule	5	1
GO:0099111	microtubule-based transport	4	1
GO:0099518	vesicle cytoskeletal trafficking	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	14
GO:0003774	cytoskeletal motor activity	1	14
GO:0003777	microtubule motor activity	2	14
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	14
GO:0005515	protein binding	2	14
GO:0005524	ATP binding	5	14
GO:0008017	microtubule binding	5	14
GO:0008092	cytoskeletal protein binding	3	14
GO:0015631	tubulin binding	4	14
GO:0016787	hydrolase activity	2	5
GO:0017076	purine nucleotide binding	4	14
GO:0030554	adenyl nucleotide binding	5	14
GO:0032553	ribonucleotide binding	3	14
GO:0032555	purine ribonucleotide binding	4	14
GO:0032559	adenyl ribonucleotide binding	5	14
GO:0035639	purine ribonucleoside triphosphate binding	4	14
GO:0036094	small molecule binding	2	14
GO:0043167	ion binding	2	14
GO:0043168	anion binding	3	14
GO:0097159	organic cyclic compound binding	2	14
GO:0097367	carbohydrate derivative binding	2	14
GO:0140657	ATP-dependent activity	1	14
GO:1901265	nucleoside phosphate binding	3	14
GO:1901363	heterocyclic compound binding	2	14
GO:0016462	pyrophosphatase activity	5	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	386	390	PF00656	0.568
CLV_NRD_NRD_1	171	173	PF00675	0.383
CLV_NRD_NRD_1	193	195	PF00675	0.455
CLV_NRD_NRD_1	262	264	PF00675	0.478
CLV_NRD_NRD_1	281	283	PF00675	0.337
CLV_NRD_NRD_1	424	426	PF00675	0.503
CLV_NRD_NRD_1	43	45	PF00675	0.229
CLV_NRD_NRD_1	455	457	PF00675	0.369
CLV_NRD_NRD_1	494	496	PF00675	0.546
CLV_PCSK_KEX2_1	171	173	PF00082	0.405
CLV_PCSK_KEX2_1	423	425	PF00082	0.537
CLV_PCSK_KEX2_1	43	45	PF00082	0.412
CLV_PCSK_KEX2_1	431	433	PF00082	0.535
CLV_PCSK_KEX2_1	455	457	PF00082	0.429
CLV_PCSK_KEX2_1	462	464	PF00082	0.424
CLV_PCSK_KEX2_1	47	49	PF00082	0.446
CLV_PCSK_PC1ET2_1	431	433	PF00082	0.689
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.427
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.458
CLV_PCSK_PC7_1	43	49	PF00082	0.229
CLV_PCSK_SKI1_1	115	119	PF00082	0.443
CLV_PCSK_SKI1_1	148	152	PF00082	0.347
CLV_PCSK_SKI1_1	354	358	PF00082	0.582
CLV_PCSK_SKI1_1	374	378	PF00082	0.395
CLV_PCSK_SKI1_1	388	392	PF00082	0.574
CLV_PCSK_SKI1_1	455	459	PF00082	0.558
CLV_PCSK_SKI1_1	466	470	PF00082	0.517
CLV_PCSK_SKI1_1	490	494	PF00082	0.460
CLV_PCSK_SKI1_1	577	581	PF00082	0.394
CLV_PCSK_SKI1_1	69	73	PF00082	0.359
CLV_Separin_Metazoa	191	195	PF03568	0.418
DEG_APCC_DBOX_1	408	416	PF00400	0.541
DEG_APCC_DBOX_1	506	514	PF00400	0.236
DOC_CKS1_1	475	480	PF01111	0.347
DOC_CYCLIN_RxL_1	112	120	PF00134	0.470
DOC_MAPK_gen_1	20	30	PF00069	0.540
DOC_MAPK_gen_1	282	289	PF00069	0.253
DOC_MAPK_gen_1	447	454	PF00069	0.467
DOC_MAPK_gen_1	459	469	PF00069	0.395
DOC_MAPK_gen_1	495	501	PF00069	0.526
DOC_MAPK_gen_1	6	15	PF00069	0.591
DOC_MAPK_MEF2A_6	213	222	PF00069	0.363
DOC_MAPK_MEF2A_6	282	291	PF00069	0.253
DOC_MAPK_MEF2A_6	388	395	PF00069	0.443
DOC_MAPK_MEF2A_6	6	15	PF00069	0.488
DOC_MAPK_NFAT4_5	388	396	PF00069	0.531
DOC_MAPK_RevD_3	28	44	PF00069	0.621
DOC_MAPK_RevD_3	481	496	PF00069	0.342
DOC_PP2B_LxvP_1	150	153	PF13499	0.363
DOC_PP4_FxxP_1	560	563	PF00568	0.352
DOC_USP7_MATH_1	275	279	PF00917	0.347
DOC_WW_Pin1_4	314	319	PF00397	0.347
DOC_WW_Pin1_4	474	479	PF00397	0.363
DOC_WW_Pin1_4	563	568	PF00397	0.378
LIG_14-3-3_CanoR_1	176	181	PF00244	0.470
LIG_14-3-3_CanoR_1	200	207	PF00244	0.470
LIG_14-3-3_CanoR_1	274	280	PF00244	0.344
LIG_14-3-3_CanoR_1	407	413	PF00244	0.535
LIG_14-3-3_CanoR_1	432	438	PF00244	0.683
LIG_14-3-3_CanoR_1	449	455	PF00244	0.458
LIG_14-3-3_CanoR_1	524	528	PF00244	0.432
LIG_14-3-3_CanoR_1	577	582	PF00244	0.465
LIG_14-3-3_CanoR_1	8	14	PF00244	0.505
LIG_Actin_WH2_2	341	359	PF00022	0.658
LIG_Actin_WH2_2	377	394	PF00022	0.573
LIG_APCC_ABBA_1	140	145	PF00400	0.347
LIG_APCC_ABBA_1	163	168	PF00400	0.353
LIG_BIR_II_1	1	5	PF00653	0.723
LIG_BRCT_BRCA1_1	222	226	PF00533	0.470
LIG_BRCT_BRCA1_1	284	288	PF00533	0.425
LIG_BRCT_BRCA1_1	300	304	PF00533	0.266
LIG_BRCT_BRCA1_1	441	445	PF00533	0.562
LIG_BRCT_BRCA1_1	504	508	PF00533	0.438
LIG_BRCT_BRCA1_1	530	534	PF00533	0.467
LIG_BRCT_BRCA1_2	441	447	PF00533	0.553
LIG_Clathr_ClatBox_1	578	582	PF01394	0.412
LIG_CtBP_PxDLS_1	498	502	PF00389	0.447
LIG_FHA_1	130	136	PF00498	0.470
LIG_FHA_1	24	30	PF00498	0.502
LIG_FHA_1	295	301	PF00498	0.334
LIG_FHA_1	308	314	PF00498	0.334
LIG_FHA_1	322	328	PF00498	0.334
LIG_FHA_1	478	484	PF00498	0.436
LIG_FHA_1	573	579	PF00498	0.489
LIG_FHA_1	92	98	PF00498	0.363
LIG_FHA_2	248	254	PF00498	0.434
LIG_FHA_2	543	549	PF00498	0.337
LIG_LIR_Gen_1	223	234	PF02991	0.405
LIG_LIR_Gen_1	285	296	PF02991	0.350
LIG_LIR_Gen_1	49	56	PF02991	0.229
LIG_LIR_Gen_1	526	534	PF02991	0.388
LIG_LIR_Gen_1	580	586	PF02991	0.499
LIG_LIR_Gen_1	62	72	PF02991	0.379
LIG_LIR_Gen_1	94	101	PF02991	0.434
LIG_LIR_Nem_3	223	229	PF02991	0.363
LIG_LIR_Nem_3	285	291	PF02991	0.350
LIG_LIR_Nem_3	440	446	PF02991	0.532
LIG_LIR_Nem_3	49	55	PF02991	0.229
LIG_LIR_Nem_3	526	530	PF02991	0.353
LIG_LIR_Nem_3	580	584	PF02991	0.486
LIG_LIR_Nem_3	62	67	PF02991	0.364
LIG_LIR_Nem_3	73	79	PF02991	0.381
LIG_LIR_Nem_3	94	98	PF02991	0.388
LIG_MAD2	511	519	PF02301	0.337
LIG_MYND_1	563	567	PF01753	0.438
LIG_NRBOX	295	301	PF00104	0.382
LIG_Pex14_2	52	56	PF04695	0.375
LIG_Rb_pABgroove_1	112	120	PF01858	0.482
LIG_Rb_pABgroove_1	528	536	PF01858	0.337
LIG_RPA_C_Fungi	420	432	PF08784	0.542
LIG_SH2_CRK	95	99	PF00017	0.470
LIG_SH2_STAP1	332	336	PF00017	0.339
LIG_SH2_STAT5	174	177	PF00017	0.382
LIG_SH2_STAT5	54	57	PF00017	0.229
LIG_SH2_STAT5	540	543	PF00017	0.338
LIG_SUMO_SIM_par_1	235	242	PF11976	0.363
LIG_UBA3_1	189	195	PF00899	0.363
LIG_UBA3_1	485	490	PF00899	0.331
LIG_WRC_WIRS_1	276	281	PF05994	0.347
LIG_WRC_WIRS_1	578	583	PF05994	0.480
MOD_CK1_1	199	205	PF00069	0.370
MOD_CK1_1	211	217	PF00069	0.324
MOD_CK1_1	294	300	PF00069	0.338
MOD_CK1_1	326	332	PF00069	0.458
MOD_CK1_1	571	577	PF00069	0.333
MOD_CK1_1	91	97	PF00069	0.363
MOD_CK2_1	135	141	PF00069	0.356
MOD_CK2_1	247	253	PF00069	0.349
MOD_CK2_1	275	281	PF00069	0.389
MOD_CK2_1	287	293	PF00069	0.471
MOD_CK2_1	541	547	PF00069	0.384
MOD_GlcNHglycan	184	187	PF01048	0.510
MOD_GlcNHglycan	253	257	PF01048	0.434
MOD_GlcNHglycan	56	59	PF01048	0.446
MOD_GlcNHglycan	90	93	PF01048	0.363
MOD_GSK3_1	129	136	PF00069	0.412
MOD_GSK3_1	207	214	PF00069	0.341
MOD_GSK3_1	243	250	PF00069	0.332
MOD_GSK3_1	287	294	PF00069	0.358
MOD_GSK3_1	312	319	PF00069	0.356
MOD_GSK3_1	321	328	PF00069	0.334
MOD_GSK3_1	486	493	PF00069	0.584
MOD_GSK3_1	542	549	PF00069	0.340
MOD_GSK3_1	568	575	PF00069	0.567
MOD_N-GLC_1	196	201	PF02516	0.387
MOD_N-GLC_1	207	212	PF02516	0.349
MOD_N-GLC_1	265	270	PF02516	0.334
MOD_N-GLC_1	321	326	PF02516	0.363
MOD_N-GLC_2	80	82	PF02516	0.363
MOD_NEK2_1	207	212	PF00069	0.350
MOD_NEK2_1	291	296	PF00069	0.358
MOD_NEK2_1	300	305	PF00069	0.337
MOD_NEK2_1	312	317	PF00069	0.317
MOD_NEK2_1	323	328	PF00069	0.334
MOD_NEK2_1	337	342	PF00069	0.426
MOD_NEK2_1	408	413	PF00069	0.625
MOD_NEK2_1	541	546	PF00069	0.378
MOD_NEK2_2	129	134	PF00069	0.462
MOD_NEK2_2	450	455	PF00069	0.498
MOD_PIKK_1	220	226	PF00454	0.334
MOD_PIKK_1	397	403	PF00454	0.666
MOD_PK_1	176	182	PF00069	0.470
MOD_PKA_1	282	288	PF00069	0.463
MOD_PKA_1	43	49	PF00069	0.229
MOD_PKA_2	199	205	PF00069	0.347
MOD_PKA_2	247	253	PF00069	0.332
MOD_PKA_2	291	297	PF00069	0.334
MOD_PKA_2	408	414	PF00069	0.519
MOD_PKA_2	43	49	PF00069	0.364
MOD_PKA_2	523	529	PF00069	0.476
MOD_Plk_1	129	135	PF00069	0.443
MOD_Plk_1	265	271	PF00069	0.334
MOD_Plk_1	439	445	PF00069	0.551
MOD_Plk_2-3	100	106	PF00069	0.388
MOD_Plk_2-3	159	165	PF00069	0.382
MOD_Plk_2-3	225	231	PF00069	0.253
MOD_Plk_4	135	141	PF00069	0.347
MOD_Plk_4	236	242	PF00069	0.377
MOD_Plk_4	265	271	PF00069	0.334
MOD_Plk_4	307	313	PF00069	0.344
MOD_Plk_4	439	445	PF00069	0.577
MOD_Plk_4	528	534	PF00069	0.434
MOD_Plk_4	93	99	PF00069	0.347
MOD_ProDKin_1	314	320	PF00069	0.347
MOD_ProDKin_1	474	480	PF00069	0.355
MOD_ProDKin_1	563	569	PF00069	0.378
MOD_SUMO_rev_2	2	7	PF00179	0.544
MOD_SUMO_rev_2	225	234	PF00179	0.429
MOD_SUMO_rev_2	278	285	PF00179	0.483
MOD_SUMO_rev_2	290	297	PF00179	0.409
MOD_SUMO_rev_2	347	356	PF00179	0.504
TRG_DiLeu_BaEn_4	386	392	PF01217	0.559
TRG_DiLeu_BaLyEn_6	295	300	PF01217	0.382
TRG_ENDOCYTIC_2	76	79	PF00928	0.434
TRG_ENDOCYTIC_2	95	98	PF00928	0.216
TRG_ER_diArg_1	13	16	PF00400	0.540
TRG_ER_diArg_1	153	156	PF00400	0.355
TRG_ER_diArg_1	171	173	PF00400	0.295
TRG_ER_diArg_1	406	409	PF00400	0.596
TRG_ER_diArg_1	422	425	PF00400	0.537
TRG_ER_diArg_1	454	456	PF00400	0.325
TRG_NES_CRM1_1	233	247	PF08389	0.378
TRG_NLS_MonoExtC_3	43	48	PF00514	0.229
TRG_NLS_MonoExtN_4	43	48	PF00514	0.229
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.485
TRG_Pf-PMV_PEXEL_1	298	302	PF00026	0.347
TRG_Pf-PMV_PEXEL_1	456	461	PF00026	0.316

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P569	Leptomonas seymouri	27%	67%
A0A0N1I0Y5	Leptomonas seymouri	31%	96%
A0A0S4IKE6	Bodo saltans	49%	100%
A0A0S4IP49	Bodo saltans	27%	73%
A0A0S4JFN9	Bodo saltans	34%	69%
A0A0S4JJ54	Bodo saltans	30%	84%
A0A0S4JLW3	Bodo saltans	31%	100%
A0A0S4JMJ1	Bodo saltans	29%	97%
A0A0S4KL43	Bodo saltans	28%	100%
A0A1X0NJN6	Trypanosomatidae	30%	100%
A0A1X0NNQ8	Trypanosomatidae	26%	91%
A0A1X0NQ03	Trypanosomatidae	27%	71%
A0A1X0P9E3	Trypanosomatidae	56%	99%
A0A1X0P9H3	Trypanosomatidae	33%	68%
A0A1X0P9T0	Trypanosomatidae	32%	100%
A0A1X0PAG9	Trypanosomatidae	59%	99%
A0A3Q8IEL2	Leishmania donovani	88%	100%
A0A3R7LY66	Trypanosoma rangeli	33%	72%
A0A3R7MDH9	Trypanosoma rangeli	30%	83%
A0A422MZ05	Trypanosoma rangeli	28%	87%
A0A422N2N4	Trypanosoma rangeli	30%	68%
A0A422NE49	Trypanosoma rangeli	31%	66%
A0A422NXU3	Trypanosoma rangeli	59%	100%
A0JN40	Bos taurus	34%	74%
A4H4R6	Leishmania braziliensis	28%	67%
A4HAQ7	Leishmania braziliensis	27%	100%
A4HHY2	Leishmania braziliensis	30%	97%
A4HSA6	Leishmania infantum	33%	100%
A4I4V3	Leishmania infantum	87%	100%
B9G2X9	Oryza sativa subsp. japonica	33%	97%
C9ZI82	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	66%
C9ZL08	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	99%
C9ZTA5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZV26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	78%
E9AEA1	Leishmania major	87%	100%
E9AKY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	66%
E9ALI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9ALI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
E9B0F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	96%
O14782	Homo sapiens	34%	74%
O35066	Mus musculus	34%	74%
O55165	Rattus norvegicus	34%	74%
Q1MTQ1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	94%
Q4Q7S4	Leishmania major	31%	97%
Q4QIX3	Leishmania major	28%	66%
Q4R918	Macaca fascicularis	27%	100%
Q5R706	Pongo abelii	34%	74%
Q5ZKV8	Gallus gallus	30%	83%
Q651Z7	Oryza sativa subsp. japonica	33%	68%
Q6H638	Oryza sativa subsp. japonica	31%	67%
Q6ZMV9	Homo sapiens	33%	72%
Q8W5R6	Arabidopsis thaliana	28%	66%
Q922S8	Mus musculus	30%	82%
Q9NF78	Leishmania major	31%	100%
Q9UTL2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q9V877	Drosophila melanogaster	28%	94%
V5B8M1	Trypanosoma cruzi	34%	96%
V5B8X9	Trypanosoma cruzi	28%	84%
V5BAA8	Trypanosoma cruzi	31%	72%
V5BAR9	Trypanosoma cruzi	33%	92%
V5BHY4	Trypanosoma cruzi	31%	79%
V5BIC1	Trypanosoma cruzi	31%	92%
V5BK25	Trypanosoma cruzi	29%	82%
V5BLH7	Trypanosoma cruzi	29%	68%
V5DMS2	Trypanosoma cruzi	36%	100%
V5DTU1	Trypanosoma cruzi	60%	100%